Patents Assigned to Science Incorporated
  • Timing device
    Patent number: 6236624
    Abstract: A fluid operated timing device in which the timing interval is determined by the rate at which the fluid flows through a precisely configured rate control frit upon being forced through the frit by an energy source in the form of a compressible elastomeric member.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: May 22, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, William W. Feng, Farhad Kazemzadeh
  • Variable rate infusion apparatus with indicator and adjustable rate control
    Patent number: 6231545
    Abstract: An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: May 15, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Steven M. Arnold, James Garrison, Farhad Kazemzadeh
  • Method and apparatus for determining wave characteristics from wave phenomena
    Patent number: 6219142
    Abstract: An apparatus and method for determining wave characteristics from wave phenomena. The apparatus and method employ eigenvectors to yield a variety of wave characteristics from wave phenomena data.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: April 17, 2001
    Assignee: Southwest Sciences Incorporated
    Inventor: Daniel J. Kane
  • Method and apparatus for making fluid delivery device
    Patent number: 6209608
    Abstract: A method and apparatus for the high volume manufacture of fluid infusion devices which embody a self-contained, stored-energy source for expelling fluids from the reservoir of the device into an ambulatory patient at precisely controlled rates over extended periods of time. In accordance with the method of the invention, the base and cover infusion components of the devices of the invention are manufactured in injection molded arrays which comprise a cover array which is superimposed over and connected to a base array with the elastomeric membrane being captured therebetween. The elastomeric membrane material, which forms the stored-energy source of the infusion devices, is continuously unrolled from a large roll of film-backed membrane material which is rotatably mounted on a turret assembly upon which a second back-up roll of elastomeric membrane material is also mounted.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: April 3, 2001
    Assignee: Science Incorporated
    Inventor: Marshall S. Kriesel
  • Fluid delivery device with temperature controlled energy source
    Patent number: 6200293
    Abstract: A fluid delivery apparatus for infusing medicinal fluids into a patient which is of a compact, low profile, laminate construction. The apparatus embodies a novel thermal expanding polymer material which uniquely functions as an internal energy source for expelling the medicinal fluids from the device. The apparatus can be used for subdermal, intradermal and intramuscular infusion of fluids and in one form of the invention, includes a novel delivery cannula having a body portion disposed within a circuitous channel formed within the base superstructure of the apparatus and a pierceable portion which extends outwardly from the base of the apparatus. By constructing the cannula in a circuitous configuration and dynamically connecting it to the base assembly, movement of the cannula relative to the base assembly is permitted thereby minimizing needle related tissue necrosis.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: March 13, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Thomas N. Thompson
  • Variable rate infusion apparatus with indicator and adjustable rate control
    Patent number: 6183441
    Abstract: An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a novel adjustable flow rate control means for precisely adjustably controlling the rate of fluid flow from the reservoir of the device.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: February 6, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Thomas N. Thompson
  • Fluid delivery apparatus with flow indicator and vial fill
    Patent number: 6176845
    Abstract: An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: January 23, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Steven M. Arnold, James Garrison, Farhad Kazemzadeh, William F. Kuester, III, Rolf Hogan
  • Fluid delivery device with temperature controlled energy source
    Patent number: 6174300
    Abstract: A fluid delivery apparatus for infusing medicinal fluids into a patient which is of a compact, low profile, laminate construction. The apparatus embodies a novel thermal expanding polymer material which uniquely functions as an internal energy source for expelling the medicinal fluids from the device. The apparatus can be used for subdermal, intradermal and intramuscular infusion of fluids and in one form of the invention, includes a novel delivery cannula having a body portion disposed within a circuitous channel formed within the base superstructure of the apparatus and a pierceable portion which extends outwardly from the base of the apparatus. By constructing the cannula in a circuitous configuration and dynamically connecting it to the base assembly, movement of the cannula relative to the base assembly is permitted thereby minimizing needle related tissue necrosis.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: January 16, 2001
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Thomas N. Thompson
  • Fluid delivery apparatus with flow indicator and vial fill
    Patent number: 6159180
    Abstract: An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet. The apparatus also includes a highly novel fluid flow indicator that provides a readily discernible visible indication of fluid flow through the apparatus. Additionally, the apparatus includes a fill assembly comprising a prefilled vial that can be used to fill the fluid reservoir of the device with a selected medicinal fluid.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: December 12, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Steven M. Arnold, James Garrison, Farhad Kazemzadeh
  • Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
    Patent number: 6136989
    Abstract: A method of isolating paclitaxel from pactitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueous supernatant and a precipitate, wherein the precipitate contains at least 3-times higher paclitaxel content than the paclitaxel extract. The acetone/water precipitation step provides a high yield of highly pure paclitaxel that is suitable for industrial scale isolation using conventional normal-phase silica chromatography steps, and the preparation of pharmaceutical compositions containing paclitaxel.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: October 24, 2000
    Assignee: Phytogen Life Sciences, Incorporated
    Inventors: Samuel Siang Kiang Foo, Yili Bai, Martin Ehlert
  • Fluid delivery device with collapsible needle cover
    Patent number: 6126637
    Abstract: A fluid delivery device having a self-contained stored energy membrane for defining in conjunction with a base a fluid reservoir and for expelling fluids from the reservoir. The device includes novel reservoir filling syringe and filling adapter for conveniently filling the fluid reservoir of the device. Additionally, the device includes a unique crushable or collapsible needle cover which surrounds and protects the infusion cannula until time of use and then readily deforms as the device is connected to the patient so as to permit the needle to cleanly penetrate the patient's skin. The needle cover maintains the cannula in a substantially aseptic condition and enables self-administration by patients, such as young patients or needle adverse patients, which does not require their consciously inserting a needle into the skin.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: October 3, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Thomas N. Thompson
  • Patient controlled fluid delivery device
    Patent number: 6126642
    Abstract: A compact, patient controlled fluid dispenser for use in controllably dispensing fluid medicament at a selected uniform rate. The device is of an all mechanical construction and is ideally suited for the reliable patient administration of pain killing drugs in the home care environment. To positively regulate the patient administration of the medicament, the intervals at which a selected medicament can be administered, as well as the volume of the dose of the medicament to be administered, is preset by the treating physician and, once set, cannot be altered by the patient. More particularly, the device setting can only be operated by a small physician's key that remains in the possession and control of the treating physician or health care worker.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: October 3, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Farhad Kazemzadeh, William W. Feng, Thomas N. Thompson
  • Fluid delivery apparatus with reservoir fill assembly
    Patent number: 6105442
    Abstract: An apparatus for delivering fluids at a precisely controlled rate which comprises a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The dispensing component can be used for the precise infusion of pharmaceutical fluids to an ambulatory patient at controlled rates. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is partially received within a novel adapter subassembly that can readily be removably interconnected with the fluid dispensing component.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: August 22, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Steven M. Arnold, James Garrison, Farhad Kazemzadeh
  • In-line flow rate control device
    Patent number: 6095491
    Abstract: A readily adjustable flow rate control device having a movable flow control member which includes a plurality of spaced-apart flow restrictors which are adapted to be selectively positioned intermediate a fluid flow path extending between a fluid supply line and a fluid delivery line. The flow restrictors can take the form of porous rate control frits which can be selectively moved into index with the fluid flow path or microbores formed in a rotatable member which can be rotated to selectively move the microbores into index with the fluid flow path.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: August 1, 2000
    Assignee: Science Incorporated
    Inventor: Marshall S. Kriesel
  • Fluid dispenser with fill adapter
    Patent number: 6090071
    Abstract: An elastomeric bladder stored energy type infusion apparatus that can be filled with a medicinal fluid and, after being filled, can efficiently deliver the medicinal fluid to the patient at a selected, adjustable rate. The apparatus includes a built-in dose dialing mechanism which can be preset by the treating physician or health care worker so that a precise volume of the medicinal fluid can be introduced into the fluid reservoir of the device for delivery to the patient.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: July 18, 2000
    Assignee: Science Incorporated
    Inventor: Marshall S. Kriesel
  • Fluid dispenser with fill adapter
    Patent number: 6086560
    Abstract: An elastomeric bladder stored energy type medicament delivery apparatus which can be filled with a medicinal fluid using a closed-end, vial-type fill container and after being filled, can efficiently deliver the medicinal fluid to the patient at a controlled rate. The closed-end, vial-type fill means can be readily connected to and disconnected from the novel fluid delivery component of the apparatus. The fluid delivery device can also be filled by means of a secondary reservoir fill means.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 11, 2000
    Assignee: Science Incorporated
    Inventor: Marshall S. Kriesel
  • Fluid delivery apparatus with reservoir fill assembly
    Patent number: 6086561
    Abstract: An apparatus for delivering fluids at a precisely controlled rate which includes a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is factory filled with the medicinal fluid to be delivered to the patient. The dispenser component embodies a highly novel fluid flow indicator that provides a readily discernible visual indication of fluid flow status through the device.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 11, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Jmaes M. Garrison, Steven Arnold, Farhad Kazemzadeh
  • Medicament dispenser
    Patent number: 6063059
    Abstract: An injectable medicament dispenser for use in controllably dispensing fluid medicaments such as insulin, antibiotics, oncolytics and the like from a prefilled container at a uniform rate. The dispenser includes a unique stored energy source in the form of a compressively deformable, polymeric elastomeric member that provides the force necessary to controllably discharge the medicament from the prefilled container which is housed within the body of the device. After having been deformed, the polymeric, elastomeric member will return to its starting configuration in a highly predictable manner.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: May 16, 2000
    Assignee: Science Incorporated
    Inventor: Marshall S. Kriesel
  • Mixer for liquid chromatograph
    Patent number: 6048496
    Abstract: A mixer for a liquid chromatograph mixes plural kinds of liquids. It has a first mixer 45 for forcibly agitating the liquids and a second mixer 58 for agitating the liquids in accordance with a flow rate. Liquid passages of the first and second mixers 45, 58 are in communication with each other, and the first and second mixers 45, 58 are integrally mounted.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: April 11, 2000
    Assignee: GI Sciences Incorporated
    Inventors: Xiaojing Zhou, Yoshihiko Takano
  • Fluid delivery device with conformable ullage and fill assembly
    Patent number: 6045533
    Abstract: A fluid delivery apparatus for continuous basal infusion, together with controlled bolus infusion of injectable medicaments, which embodies a stored energy source such as distendable elastomeric membrane which cooperates with a base and a conformable ullage to define a fluid reservoir and one which includes a unique fill assembly for use in controllably filling the fluid reservoir. The novel fill assembly of the invention enables the fluid reservoir of the fluid delivery portion of the apparatus to be aseptically filled in the field with a wide variety of selected medicinal fluids.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: April 4, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S Kriesel, Farhad Kazemzadeh, Matthew B. Kriesel, William W Feng, Thomas N Thompson