Abstract: Compounds of the structure ##STR1## wherein R is hydrogen, lower alkyl containing 1 to 5 carbon atoms, cycloalkyl containing 3 to 7 carbon atoms, phenyl or phenyl substituted with halogen, trifluoromethyl, or lower alkyl or lower alkoxy having 1 to 4 carbon atoms and R.sub.1 is hydrogen, lower alkyl having 1 to 4 carbon atoms, phenyl or phenyl lower alkyl wherein the lower alkyl has 1 to 4 carbon atoms, are formed by cyclizing a compound of the structure ##STR2## wherein R and R.sub.1 are as defined above, in the presence of an acid.

Abstract: Monosubstituted piperazines of the formula: ##STR1## in which: A is --(CH.sub.2).sub.n --, n being 1, 2 or 3, or ##STR2## R being alkyl up to C.sub.5 inclusive, trifluoromethyl, phenyl, halophenyl, lower-alkylphenyl, lower-alkoxyphenyl or trifluoromethylphenyl andAr is phenyl, halophenyl, lower-alkylphenyl, lower-alkoxyphenyl, methylenedioxyphenyl, hydroxyphenyl, or ##STR3## in which X is a single bond, oxygen, sulfur or carbonyl and Y is hydrogen, halogen, lower alkyl or lower alkoxy.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammation with immunological component.

Abstract: This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.

Abstract: The subject of the invention is a novel pharmaceutical composition, especially having an anti-ischaemic action, containing, in combination, a high dosage (within the range of from 20 to 80 mg) of the dihydrochloride (or another mineral or organic salt) of 1-(2,3,4-trimethoxybenzyl)piperazine and a disintegrating agent, such as mannitol or sodium carboxymethyl starch, that has the effect of liberating the salt of 1-(2,3,4-trimethoxybenzyl)piperazine virtually instantaneously in the organism, this composition being, furthermore, advantageously enclosed in a thin coating film or held together by a binder that is itself readily disintegrated in situ in the organism in such a manner that it makes possible a "flash" action, that is to say a virtually instantaneous action, of the above-mentioned salt in situ. This composition is administered to the patient at a dosage of from 20 to 80 mg/day.

Abstract: This invention relates to novel arylethanol and to process for producing the said compounds.The arylethanols of the invention have valuable pharmacological properties and find a use in human or animal therapy.

Abstract: Bicyclic imino acids, particularly 2-carboxylic acid derivatives of azabicycloalkanes and process for preparing them.These compounds have therapeutical activity and may be used as medicines, particularly as cardiovascular and antihypertensive drugs in human or veterinary medicine.

Abstract: Compounds of the formula ##STR1## in which A represents a vinylene or dimethylene radical, q is 0 or 1, R is an alkyl radical which can carry an amino group, X represents --S-- or --NH--, and R.sub.1 is a hydrogen atom or a radical of formula ##STR2## in which R.sub.2 is a hydroxy or alkoxy and R.sub.3 is a hydrogen atom or an alkyl, cycloalkylalkyl or phenylalkyl radical each having no more than a total of 8 carbon atoms, or an unsubstituted or substituted alkylthioalkyl radical.These compounds are useful as medicaments, especially anti-hypertensive medicaments.

Abstract: This invention relates to trifluorethylamines and to a process for producing the same.These trifluorethylamines are substituted on the nitrogen atom with a lower alkyl or a cyclo lower alkyl radical.They are endowed with interesting pharmacological properties.

Abstract: A method of treating insufficiencies in hematosis, such as hypoxemia, cardiac insufficiency, and polyglobulia, involving treatment of a patient suffering from such insufficiency with the compound almitrine or a pharmaceutically-acceptable salt thereof in extremely low daily dosages, between 0.5 and 3 mg/kg orally or 0.05 to 0.3 mg/kg intravenously, an oral unit dosage form of the said active ingredient, containing between 20 and 70 mg of active ingredient together with a pharmaceutically-acceptable carrier or diluent, preferably about 50 mg of the active ingredient.

Abstract: Piperidylbenzimidazolinone derivatives of the formula: ##STR1## in which: R.sub.1 is lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, methylenedioxyphenyl, ethylenedioxyphenyl, thienyl, furyl or pyridyl.R.sub.2 is R'.sub.1 COO-- or R'.sub.1 --COO--CH.sub.2 -- in which R'.sub.1 has the same meanings as R.sub.1, R.sub.1 and R'.sub.1 being the same or different, or R.sub.3 NH-- in which R.sub.3 is formyl, acetyl mesyl, carbamoyl, sulfamoyl or ethoxalyl.Z is hydrogen, lower-alkyl or lower alkenyl, andT is hydrogen, lower alkyl or lower alkoxy.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and antiinflammatory diseases and in the treatment of dyspnea especially asthmatic and bronchial dyspnea.

Abstract: This invention relates to novel substituted aryl lower alkamine and more precisely to arylmethylamine, the methyl group of which is substituted with one more polyfluoromethyl radicals.This invention also relates to the process for producing said compounds.The resulting compounds have pharmacological utility and may be used as a drug in human and veterinary medicine.

Abstract: Certain phenyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.

Abstract: This invention relates to thiosubstituted cyclic amino acids, to a process for their preparation and to pharmaceutical compositions containing them together with an inert non toxic pharmaceutical carrier.

Abstract: Biphenylalkylene-thiazolyl-piperazines of the formula ##STR1## wherein Ar and A are as defined herein, e.g., 1-[4-(4-phenylsulfinylbenzyl)-2-thiazolyl]piperazine, and 1-[4-(4-biphenylylmethyl)-2-thiazolyl]piperazine, and their physiologically tolerable salts are provided. These compounds are useful as medicines for the treatment of inflammation with an immunological component, and are useful as hypolipemic and hypocholesterolemic agents and to assist lowering of lipid and cholesterol content in the blood.

Abstract: There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD.sub.50 greater than 800 mg/kg, intraperitoneally, in male mice.A method of use, compositions, and a process for synthesis are also described.

Abstract: This invention relates to pharmaceutical compositions containing as active ingredient an aryltrifluoroethanol, and a process for producing the same.These pharmaceutical compositions are useful for treating or alleviating pain, hyperpyretic conditions and/or inflammatory states.

Abstract: This invention relates to omega-mercaptopropionylamides, the nitrogen atom of which is included as a ring atom of a cyclic amino acid.The application also discloses a process for producing said compounds which comprises reacting an omega-mercaptopropionic acid, or a functional derivative thereof, with a cyclic amino acid.This invention further relates to pharmaceutical compositions incorporating such an omega-mercaptopropionylamide as active ingredient together with a pharmaceutically-acceptable carrier or vehicle, and a method of employing said compounds.They find a use in human therapy, namely, as antihypertensive agents.

Abstract: Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2,m is 0 or 1, andHet is pyridyl, pyrimidinyl, pyrazinyl, thiazolyl or thiadiazolyl each optionally substituted by one or more alkyl having from 1 to 5 carbon atoms inclusive.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of hypertension.

Abstract: Certain arylmethyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.

Abstract: Piperidylbenzimidazolinone compounds of the formula: ##STR1## in which: R is hydrogen, hydroxy, hydroxymethyl, methoxycarbonyl, formamido, acetamido, mesylamino, oxalamino, ethoxalylamino, carbamoyl ##STR2## ureido ##STR3## or sulfamoylamino ##STR4## in which R' and R" are hydrogen or lower alkyl, T is hydrogen, halogen, lower alkyl or lower alkoxy, andZ is hydrogen, lower alkyl or lower alkenyl each in straight or branched chain.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and inflammatory diseases and in the treatment of respiratory insufficiency of asthma.