Patents Assigned to Science-Union et Cie
  • Patent number: 4570001
    Abstract: Compounds of the structure ##STR1## wherein R is hydrogen, lower alkyl containing 1 to 5 carbon atoms, cycloalkyl containing 3 to 7 carbon atoms, phenyl or phenyl substituted with halogen, trifluoromethyl, or lower alkyl or lower alkoxy having 1 to 4 carbon atoms and R.sub.1 is hydrogen, lower alkyl having 1 to 4 carbon atoms, phenyl or phenyl lower alkyl wherein the lower alkyl has 1 to 4 carbon atoms, are formed by cyclizing a compound of the structure ##STR2## wherein R and R.sub.1 are as defined above, in the presence of an acid.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: February 11, 1986
    Assignee: Science Union et Cie
    Inventors: Joseph Auerbach, Martin Kantor
  • Patent number: 4479952
    Abstract: Monosubstituted piperazines of the formula: ##STR1## in which: A is --(CH.sub.2).sub.n --, n being 1, 2 or 3, or ##STR2## R being alkyl up to C.sub.5 inclusive, trifluoromethyl, phenyl, halophenyl, lower-alkylphenyl, lower-alkoxyphenyl or trifluoromethylphenyl andAr is phenyl, halophenyl, lower-alkylphenyl, lower-alkoxyphenyl, methylenedioxyphenyl, hydroxyphenyl, or ##STR3## in which X is a single bond, oxygen, sulfur or carbonyl and Y is hydrogen, halogen, lower alkyl or lower alkoxy.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammation with immunological component.
    Type: Grant
    Filed: April 9, 1979
    Date of Patent: October 30, 1984
    Assignee: Science Union Et Cie
    Inventors: Gilbert R/e/ gnier, Jacques Bur/e/
  • Patent number: 4459306
    Abstract: This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.
    Type: Grant
    Filed: April 6, 1981
    Date of Patent: July 10, 1984
    Assignee: Science Union et Cie
    Inventors: Charles Malen, Jean-Claude Poignant
  • Patent number: 4407801
    Abstract: The subject of the invention is a novel pharmaceutical composition, especially having an anti-ischaemic action, containing, in combination, a high dosage (within the range of from 20 to 80 mg) of the dihydrochloride (or another mineral or organic salt) of 1-(2,3,4-trimethoxybenzyl)piperazine and a disintegrating agent, such as mannitol or sodium carboxymethyl starch, that has the effect of liberating the salt of 1-(2,3,4-trimethoxybenzyl)piperazine virtually instantaneously in the organism, this composition being, furthermore, advantageously enclosed in a thin coating film or held together by a binder that is itself readily disintegrated in situ in the organism in such a manner that it makes possible a "flash" action, that is to say a virtually instantaneous action, of the above-mentioned salt in situ. This composition is administered to the patient at a dosage of from 20 to 80 mg/day.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: October 4, 1983
    Assignee: Science Union Et Cie
    Inventors: Jean-Claude Arnaud, Michelle Devissaguet
  • Patent number: 4404206
    Abstract: Bicyclic imino acids, particularly 2-carboxylic acid derivatives of azabicycloalkanes and process for preparing them.These compounds have therapeutical activity and may be used as medicines, particularly as cardiovascular and antihypertensive drugs in human or veterinary medicine.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: September 13, 1983
    Assignee: Science Union et Cie
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4404215
    Abstract: This invention relates to novel arylethanol and to process for producing the said compounds.The arylethanols of the invention have valuable pharmacological properties and find a use in human or animal therapy.
    Type: Grant
    Filed: November 18, 1981
    Date of Patent: September 13, 1983
    Assignee: Science Union et Cie
    Inventors: Michel Vincent, Georges Remond, Jacques Bure
  • Patent number: 4397857
    Abstract: Compounds of the formula ##STR1## in which A represents a vinylene or dimethylene radical, q is 0 or 1, R is an alkyl radical which can carry an amino group, X represents --S-- or --NH--, and R.sub.1 is a hydrogen atom or a radical of formula ##STR2## in which R.sub.2 is a hydroxy or alkoxy and R.sub.3 is a hydrogen atom or an alkyl, cycloalkylalkyl or phenylalkyl radical each having no more than a total of 8 carbon atoms, or an unsubstituted or substituted alkylthioalkyl radical.These compounds are useful as medicaments, especially anti-hypertensive medicaments.
    Type: Grant
    Filed: October 20, 1981
    Date of Patent: August 9, 1983
    Assignee: Science Union et Cie
    Inventors: Michel Vincent, Georges Remond, Michel Laubie
  • Patent number: 4378366
    Abstract: This invention relates to trifluorethylamines and to a process for producing the same.These trifluorethylamines are substituted on the nitrogen atom with a lower alkyl or a cyclo lower alkyl radical.They are endowed with interesting pharmacological properties.
    Type: Grant
    Filed: August 24, 1981
    Date of Patent: March 29, 1983
    Assignee: Science Union et Cie
    Inventors: Charles Malen, Pierre Roger, Michel Laubie
  • Patent number: 4364946
    Abstract: A method of treating insufficiencies in hematosis, such as hypoxemia, cardiac insufficiency, and polyglobulia, involving treatment of a patient suffering from such insufficiency with the compound almitrine or a pharmaceutically-acceptable salt thereof in extremely low daily dosages, between 0.5 and 3 mg/kg orally or 0.05 to 0.3 mg/kg intravenously, an oral unit dosage form of the said active ingredient, containing between 20 and 70 mg of active ingredient together with a pharmaceutically-acceptable carrier or diluent, preferably about 50 mg of the active ingredient.
    Type: Grant
    Filed: August 18, 1981
    Date of Patent: December 21, 1982
    Assignee: Science Union et Cie
    Inventors: Etienne Labeyrie, Jean-Pierre Poirier, Francoise Arnaud
  • Patent number: 4338323
    Abstract: Piperidylbenzimidazolinone derivatives of the formula: ##STR1## in which: R.sub.1 is lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, methylenedioxyphenyl, ethylenedioxyphenyl, thienyl, furyl or pyridyl.R.sub.2 is R'.sub.1 COO-- or R'.sub.1 --COO--CH.sub.2 -- in which R'.sub.1 has the same meanings as R.sub.1, R.sub.1 and R'.sub.1 being the same or different, or R.sub.3 NH-- in which R.sub.3 is formyl, acetyl mesyl, carbamoyl, sulfamoyl or ethoxalyl.Z is hydrogen, lower-alkyl or lower alkenyl, andT is hydrogen, lower alkyl or lower alkoxy.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and antiinflammatory diseases and in the treatment of dyspnea especially asthmatic and bronchial dyspnea.
    Type: Grant
    Filed: November 10, 1980
    Date of Patent: July 6, 1982
    Assignee: Science Union et Cie
    Inventors: Gilbert Regnier, Alain Dhainaut, Jacques Duhault, Michelle Boulanger
  • Patent number: 4315019
    Abstract: This invention relates to novel substituted aryl lower alkamine and more precisely to arylmethylamine, the methyl group of which is substituted with one more polyfluoromethyl radicals.This invention also relates to the process for producing said compounds.The resulting compounds have pharmacological utility and may be used as a drug in human and veterinary medicine.
    Type: Grant
    Filed: August 18, 1980
    Date of Patent: February 9, 1982
    Assignee: Science Union et Cie
    Inventors: Charles Malen, Pierre Roger, Michel Laubie
  • Patent number: 4315031
    Abstract: This invention relates to thiosubstituted cyclic amino acids, to a process for their preparation and to pharmaceutical compositions containing them together with an inert non toxic pharmaceutical carrier.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: February 9, 1982
    Assignee: Science Union et Cie
    Inventors: Michel Vincent, Georges Remond, Jacques Bure
  • Patent number: 4315020
    Abstract: Certain phenyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.
    Type: Grant
    Filed: October 15, 1980
    Date of Patent: February 9, 1982
    Assignee: Science Union et Cie
    Inventors: Charles E. Malen, Pierre Roger, Michel Laubie
  • Patent number: 4312869
    Abstract: Biphenylalkylene-thiazolyl-piperazines of the formula ##STR1## wherein Ar and A are as defined herein, e.g., 1-[4-(4-phenylsulfinylbenzyl)-2-thiazolyl]piperazine, and 1-[4-(4-biphenylylmethyl)-2-thiazolyl]piperazine, and their physiologically tolerable salts are provided. These compounds are useful as medicines for the treatment of inflammation with an immunological component, and are useful as hypolipemic and hypocholesterolemic agents and to assist lowering of lipid and cholesterol content in the blood.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: January 26, 1982
    Assignee: Science Union et Cie
    Inventors: Gilbert Regnier, Jacques Bure
  • Patent number: 4288453
    Abstract: There are now described some novel alpha-[1-aryl-2,2,2-trifluoroethoxy (or-ethylthio)]alkanoic acids that are useful for reducing triglycerides and cholesterol levels in the blood of animals. The percentage reduction in test rats has been observed to be from 20 to 65 for triglycerides and from 15 to 50 for cholesterol. A representative compound of the invention is alpha-(2,2,2-trifluoro-1-phenyl-1-ethoxy)butyric acid. Most of the compounds have an LD.sub.50 greater than 800 mg/kg, intraperitoneally, in male mice.A method of use, compositions, and a process for synthesis are also described.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: September 8, 1981
    Assignee: Science Union et Cie
    Inventors: Michel Vincent, Jacques Duhault, Michelle Boullanger, Georges Remond
  • Patent number: 4285943
    Abstract: This invention relates to pharmaceutical compositions containing as active ingredient an aryltrifluoroethanol, and a process for producing the same.These pharmaceutical compositions are useful for treating or alleviating pain, hyperpyretic conditions and/or inflammatory states.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: August 25, 1981
    Assignee: Science Union Et Cie
    Inventors: Michel Vincent, Georges Remond, Jacques Bure
  • Patent number: 4283407
    Abstract: This invention relates to omega-mercaptopropionylamides, the nitrogen atom of which is included as a ring atom of a cyclic amino acid.The application also discloses a process for producing said compounds which comprises reacting an omega-mercaptopropionic acid, or a functional derivative thereof, with a cyclic amino acid.This invention further relates to pharmaceutical compositions incorporating such an omega-mercaptopropionylamide as active ingredient together with a pharmaceutically-acceptable carrier or vehicle, and a method of employing said compounds.They find a use in human therapy, namely, as antihypertensive agents.
    Type: Grant
    Filed: September 25, 1978
    Date of Patent: August 11, 1981
    Assignee: Science Union et Cie
    Inventors: Charles Malen, Pierre Roger, Michel Laubie
  • Patent number: 4267345
    Abstract: Certain arylmethyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.
    Type: Grant
    Filed: April 19, 1979
    Date of Patent: May 12, 1981
    Assignee: Science Union et Cie
    Inventors: Charles E. Malen, Pierre Roger, Michel Laubie
  • Patent number: 4267178
    Abstract: Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2,m is 0 or 1, andHet is pyridyl, pyrimidinyl, pyrazinyl, thiazolyl or thiadiazolyl each optionally substituted by one or more alkyl having from 1 to 5 carbon atoms inclusive.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of hypertension.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: May 12, 1981
    Assignee: Science Union et Cie, Societe Francaise de Recherche Med.
    Inventors: Gilbert Regnier, Michel Laubie, Jean-Claude Poignant
  • Patent number: 4264613
    Abstract: Piperidylbenzimidazolinone compounds of the formula: ##STR1## in which: R is hydrogen, hydroxy, hydroxymethyl, methoxycarbonyl, formamido, acetamido, mesylamino, oxalamino, ethoxalylamino, carbamoyl ##STR2## ureido ##STR3## or sulfamoylamino ##STR4## in which R' and R" are hydrogen or lower alkyl, T is hydrogen, halogen, lower alkyl or lower alkoxy, andZ is hydrogen, lower alkyl or lower alkenyl each in straight or branched chain.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of autoimmune, allergic and inflammatory diseases and in the treatment of respiratory insufficiency of asthma.
    Type: Grant
    Filed: August 1, 1979
    Date of Patent: April 28, 1981
    Assignee: Science Union et cie, Societe Francaise de Recherche Medicale
    Inventors: Gilbert Regnier, Alain Dhainaut, Jacques Duhault, Michelle Boulanger