Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Abstract: The present invention relates to proteomics, and techniques for predicting de novo sequencing of chains of amino acids, such as peptides, proteins, or combinations thereof. Particularly, aspects of the present invention are directed to a computer implemented method that includes obtaining a digital representation of a mass spectrum, the digital representation including a plurality of container elements, encoding, using an encoder portion of a bidirectional recurrent neural network of long short term memory cells and gated recurrent unit cells, each container element as an encoded vector, decoding, using a decoder portion of the bidirectional recurrent neural network, each of the encoded vectors into a sequence of amino acids; and recording the sequence of amino acids as a multi-dimensional data set of amino acids types and a probability of each of the amino acid types in each position of the complete amino acid sequence.

Abstract: Provided are an audio signal processing method, a training method, an apparatus and a storage medium, relating to the field of data processing, in particular to, the field of voice. The audio signal processing method includes: eliminating at least pail of a linear echo signal from a mixed voice signal, to obtain an intermediate processing signal, where the mixed voice signal is obtained by mixing a target voice signal with an echo signal, and the echo signal is generated in an environment where the target voice signal is located and includes the linear echo signal and a nonlinear echo signal; and removing the nonlinear echo signal and a residual part of the linear echo signal from the intermediate processing signal, by using a target full convolution neural network model, to obtain an approximate target voice signal, the target full convolution neural network model including at least two convolution layers.

Abstract: Percutaneous devices and methods for releasably engaging a guidewire against an inner surface of a tubular member are disclosed. A percutaneous device can include a tube member, a push member, and a fixation mechanism such as a fixation balloon. The tube member can define a lumen sized and shaped to receive one or more interventional medical devices therethrough and can have an outer diameter smaller than a lumen of a guide catheter. The push member can extend proximal of the tube member for slidably positioning a distal end portion of the tube member within and beyond a distal end of the guide catheter. The push member can include a lumen in fluid communication with an interior of the fixation balloon, for example, for delivering inflation fluid to, or removing fluid from, the balloon. The fixation balloon can be positioned can be positioned and configured to engage a guidewire against the inner surface of the guide catheter or of the tube member when inflated.

Abstract: The present invention relates to a hardware accelerator for hypergraph processing and its operating method, the hardware accelerator comprising: a data loader: for, in the presence of a data-centric load-trigger-reduce execution model, reading hypergraph partition data from an off-chip memory successively according to hypergraph data structure and an order of hypergraph partitions; an address translator, for deploying the hypergraph data into a private register of a processor and/or into a buffer memory according to a priority level of loaded data, and recording corresponding offset information; a task trigger, for generating computing tasks according to the loaded data, and scheduling the computing tasks into the processor; the processor, for receiving and executing the computing tasks; a reducer, for scheduling intermediate results into a first-priority-data reducer unit or a second-priority-data reducer unit depending on the priority level of the data so as to execute a reducing operation for the intermedi

Abstract: A collision detection method, an electronic device, and a storage medium are provided, which relate to a field of artificial intelligence technology, and in particular to fields of intelligent transportation and autonomous driving technologies. The method includes: determining a predicted travel range of a target object based on a planned travel trajectory of the target object and a historical travel trajectory of the target object; determining, in response to a target obstacle being detected, a predicted travel range of the target obstacle based on a current travel state of the target obstacle; and determining whether the target object has a risk of colliding with the target obstacle, based on the predicted travel range of the target object and the predicted travel range of the target obstacle.

Abstract: A composition of matter is provided comprising hierarchically ordered crystalline microporous material having well-defined long-range mesoporous ordering of lamellar symmetry. The composition possesses mesopores having walls of crystalline microporous material and a mass of mesostructure between mesopores of crystalline microporous material. Long-range ordering is defined by presence of secondary peaks in an X-ray diffraction (XRD) pattern and/or lamellar symmetry observable by microscopy.

Abstract: A graphics processing unit (GPU) task is executed in a confidential compute architecture. GPU software in a non-secure world configures, based on task code and a cache description of a GPU task, a stub data structure including cache areas allocated based on the cache description and metadata indicating each cache area. In a realm segment in a memory, a root world root monitor configures a real data structure corresponding to the stub data structure, and stores to-be-processed confidential data. The root monitor updates a granule protection table (GPT) table so that based on an updated GPT table, a target segment storing the metadata and the task code is accessible to a GPU and has realm world permission for all other objects. The root monitor modifies a target mapping relationship so that the GPU executes the GPU task by using the target segment and the real data structure.

Abstract: The present invention relates, in general terms, to TEAD targeting compounds and 5 methods thereof.

Abstract: Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A pulse that has an element of decay may be applied to a target for tissue ablation while the decay is modulated. In some examples, apparatus including a controller and switches may be used to modulate the decay and/or selectively apply the pulse to the target. The apparatus may further include resistors and/or other elements to modulate a magnitude of the pulse and/or a slope of a decay of the pulse.

Abstract: A method for manufacturing a TiAl alloy casting material includes a melting step of melting a raw material including Ti and Al to prepare a molten metal; a deoxidation material adding step of adding a deoxidation material including Ca to either or both of the raw material and the molten metal, the deoxidation material being added such that a Ca concentration in a total mass of the raw material and the deoxidation material is 0.2 mass % to 1.0 mass %; and a deoxidation step of heating the molten metal including the deoxidation material for maintaining a molten state to generate a fume including a reaction product of oxygen and Ca in the molten metal, so that the oxygen in the molten metal is removed.

Abstract: A protective sheath for inserting a manipulator arm into a glovebox, including a sealed coupling for removably fastening and connecting the manipulator arm, which is engaged in the protective sheath, to an effector, which is housed in the confined enclosure of a glovebox.

Abstract: An image prediction method and device are disclosed. The method includes: obtaining a first reference unit of an image unit, where respective predicted images are obtained for the image unit and the first reference unit by using a same affine model; obtaining motion information of basic motion compensation units at two or more preset positions in the first reference unit; and obtaining motion information of a basic motion compensation unit of the image unit according to the motion information. In this way, motion information of the first reference unit using a same affine motion prediction model is reused, and a more accurate motion vector of a current image unit is obtained, improving prediction accuracy and maintaining encoding and decoding complexity, thereby improving encoding and decoding performance.

Abstract: In an electrolyte for the lithium secondary battery, which is used in forming protective layers on the surfaces of positive and negative electrodes, the electrolyte contains 1-vinyl-1,2,4-triazole additives. In the instant case, vinylene carbonate further contained in the additives stabilizes the protective layer on the surface of the negative electrode, and 1,3-propane sultone further contained in the additives stabilizes the protective layer on the surface of the positive electrode, thereby improving the long-term life performance and high-temperature life characteristics of the lithium secondary battery.

Abstract: Provided are a thin-film liquid metal electrode, a method of fabricating the same using a sequential deposition, and a stretchable electronic device using the electrode fabricated therefrom.

Abstract: Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals.

Abstract: The present invention relates to a ship waste heat power generation system utilizing waste heat from ships. Specifically, the present invention relates to a ship waste heat power generation system utilizing waste heat from ships, wherein recovers exhaust gas waste heat and engine cooling water waste heat from ships using various fuels such as diesel, LNG, and dual-fuel. The recovered waste heat is used as a heat source, while seawater serves as the heat sink, generating electricity through the Organic Rankine Cycle (ORC). By combining exhaust gas waste heat and engine cooling water waste heat, which have different waste heat temperatures, in parallel or series to reduce the evaporation heat capacity, the ORC output is enhanced.

Abstract: A method of manufacturing a sealed fluid-filled compartment including the following steps: (a) forming at least a first cavity from a first face of a first substrate; (b) positioning a second face of a second substrate opposite the first face of said first substrate; (c) at least partially filling said at least one first cavity with a fluid; (d) bonding said first face of said first substrate to said second face of said second substrate by annealing and simultaneously pressing said first and second substrates together.

Abstract: The present invention relates to a spin-orbit torque magnetic device and a method of manufacturing the same. The spin-orbit torque magnetic device according to one embodiment may include a first heavy metal layer, a ferromagnetic layer formed on the first heavy metal layer, a second heavy metal layer formed on the ferromagnetic layer, and a gate oxide layer formed on the second heavy metal layer. Here, in the second heavy metal layer, when a gate voltage of a preset magnitude is applied to the gate oxide layer, the strength of spin-orbit interaction may be controlled.

Abstract: The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method.