Patents Assigned to Sciences
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Publication number: 20250195571Abstract: Provided herein are a method for isolation and transplantation of intact mitochondria to a lymphoid organ (a primary lymphoid tissue or a secondary lymphoid tissue), a composition of cells prepared by using a method described herein, and a method for manufacturing cells described herein. In particular, provided herein are methods of isolating intact mitochondria from a donor cell. Also provided herein are methods of transplanting mitochondria into a recipient cell. In some aspects, the methods can be performed in vivo. Further provided are a composition of cells that include the cells prepared using the methods of the present invention.Type: ApplicationFiled: March 5, 2025Publication date: June 19, 2025Applicant: LUCA Science Inc.Inventors: Masashi SUGANUMA, Hideyoshi HARASHIMA, Yuma YAMADA, Daisuke SASAKI, Takafumi YOKOTA
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Publication number: 20250199011Abstract: Provided herein are compositions and methods for the identification of an expression profile in a single cell or population of cells. Kits for use with the disclosed methods are also provided, including antibodies, with a unique molecular identifier and antibody identifier, and primers for amplification of the antibody identifier sequence.Type: ApplicationFiled: December 12, 2024Publication date: June 19, 2025Applicant: Verily Life Sciences LLCInventors: Ian Peikon, Gary Tong, Daniel Liu, Ci Chu
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Publication number: 20250203321Abstract: Provided is a method and system for tracking a physical location of a user equipment (UE) in a mobile communication network that may specify a physical location by monitoring an uplink signal of a target UE, the method including generating a specific traffic pattern by generating voice and short message service (SMS) traffic and tracking a radio network traffic identifier (RNTI) of a target UE using fingerprinting based on the specific traffic pattern; fixing the RNTI of the target UE and continuously receiving scheduling information on an uplink signal transmitted from the target UE by decoding a downlink control information (DCI) message transmitted from a base station; and tracking a physical location by monitoring the uplink signal of the target UE based on the scheduling information.Type: ApplicationFiled: February 9, 2024Publication date: June 19, 2025Applicant: Korea Advanced Institute of Science and TechnologyInventors: Yongdae Kim, Taekkyung Oh
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Patent number: 12333408Abstract: Various embodiments provide an electronic device for generating data and improving task performance by using only a very small amount of data without prior knowledge of an associative domain and an operating method thereof. According to various embodiments, the electronic device may be configured to construct a plurality of data pairs from at least three data points, acquire relative information between the data points with respect to each of the data pairs, and learn a transformation function between the data points based on the relative information. According to various embodiments, the transformation function which can be learnt without a data overfitting problem even in a very small amount of data can be provided.Type: GrantFiled: August 25, 2021Date of Patent: June 17, 2025Assignee: Korea Advanced Institute of Science and TechnologyInventors: Sang Wan Lee, Chang Hwa Lee
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Patent number: 12329455Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising—generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.Type: GrantFiled: December 18, 2020Date of Patent: June 17, 2025Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De ParisInventors: Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
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Patent number: 12331241Abstract: A heat transfer mixture includes a base fluid, a dispersant, a stabilizing agent, aluminum oxide nanoparticles and exfoliated graphite nanoplatelets.Type: GrantFiled: March 8, 2022Date of Patent: June 17, 2025Assignee: HT Materials Science (IP) LimitedInventors: Francesco Micali, Arturo De Risi, Piero Negro
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Patent number: 12331321Abstract: The present disclosure discloses an ?-herpesvirus insensitive monoclonal cell strain, and a preparation method therefor and use thereof, belonging to the technical field of biomedicine. In order to perform targeted research of intercellular transmission of an ?-herpesvirus and an action mechanism thereof, the present disclosure discloses the ?-herpesvirus insensitive monoclonal cell strain. The cell strain is named as a human liver cancer continuous cell line Huh7-C10 and has a potential of being applied to developing a new generation of enhanced oncolytic herpesvirus and single-round infection attenuated live vaccine.Type: GrantFiled: November 29, 2024Date of Patent: June 17, 2025Assignee: Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (China Animal Health and Epidemiology Center Harbin Branch Center)Inventors: Xin Yin, Menghang Wang, Xing Liu
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Patent number: 12333628Abstract: The present disclosure provides a system for modifying a virtual reality (VR) space, which generates a mutual movable space between an augmented reality (AR) host's reference space and a VR client's space, the system including an acquisition unit that acquires a size of the AR host's reference space, a processing unit that estimates a relative translation gain threshold by adjusting the client's walking speed for each axis of the VR space according to the size of the reference space, and a generation unit that generates the mutual movable space in which movement is possible in mixed reality (MR) with a relative translation gain based on the relative translation gain threshold.Type: GrantFiled: January 23, 2023Date of Patent: June 17, 2025Assignee: Korea Advanced Institute of Science and TechnologyInventors: Woontack Woo, Dooyoung Kim
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Patent number: 12329135Abstract: A device for wild Monopterus albus domestication includes a circular water tank, the circular water tank is placed on a bracket, a groove is arranged in the circular water tank, a drainpipe is arranged in the groove, a plug is detachably connected to the drainpipe, the plug extends out of the circular water tank, the plug passes through the bracket, a water inlet pipe is fixedly connected to the circular water tank, a valve is installed on the water inlet pipe, a water grass fixing frame is placed in the circular water tank, a material table is arranged in the circular water tank, a water quality monitoring instrument is placed in the circular water tank, multiple bubble stones and a heating rod are placed in the circular water tank, a hose is communicated with the bubble stones.Type: GrantFiled: January 15, 2025Date of Patent: June 17, 2025Assignee: Sugian Institute of Agricultural Sciences, Jiangsu Academy of Agricultural SciencesInventors: Xuanpeng Wang, Yongchun Ge, Gaowei Zhang, Hanlin Zhou
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Patent number: 12331106Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.Type: GrantFiled: October 12, 2022Date of Patent: June 17, 2025Assignees: Institute for Basic Science, Korea Advanced Instritute of Science and TechnologyInventors: Gou Young Koh, Jeomil Bae, Mi Jeong Kim, Jin-Sung Park, Su Jin Seo, Jaeryung Kim, Jang Ryul Park, Pilhan Kim, Wangyuhl Oh
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Patent number: 12329774Abstract: Compounds, compositions and methods of making and using for enhancing the quality and benefit of sleep and/or wakefulness in a subject in need thereof.Type: GrantFiled: April 5, 2021Date of Patent: June 17, 2025Assignee: BioLink Life Sciences, Inc.Inventors: Deanna J. Nelson, James R. Komorowski
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Patent number: 12336182Abstract: Provided are semiconductor devices having a three-dimensional stacked structure and methods of manufacturing the same. A semiconductor device includes a plurality of channel structures on a substrate and arranged in a three-dimensional array; a plurality of gate electrodes extending in a direction parallel to the substrate; and a plurality of source and drain electrodes extending in a direction perpendicular to the substrate. The gate electrodes are connected to the channel structures arranged in the direction parallel to the substrate, and the source and drain electrodes are connected to the channel structures arranged in the direction perpendicular to the substrate. The channel structures include a channel layer and a ferroelectric layer on the channel layer.Type: GrantFiled: March 7, 2022Date of Patent: June 17, 2025Assignees: Samsung Electronics Co., Ltd., Korea Advanced Institute of Science and TechnologyInventors: Youngkwan Cha, Jaechul Park, Sanghun Jeon
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Patent number: 12329965Abstract: Guidewires and methods for transmitting electrical stimuli to a heart and for guiding and supporting the delivery of elongate treatment devices within the heart are disclosed. A guidewire can comprise an elongate body, including first and second elongate conductors, and at least first and second electrodes. A distal end portion of the elongate body can include a preformed bias shape, such as a pigtail-shaped region, on which the first and second electrodes can be located. The preformed bias shape can optionally be non-coplanar relative to an intermediate portion of the elongate body. The first and second elongate conductors can be formed of a single structure or two or more electrically connected structures. The conductors can extend from proximal end portions to distal end portions that electrically connect to the first and second electrodes.Type: GrantFiled: July 12, 2022Date of Patent: June 17, 2025Assignee: Teleflex Life Sciences LLCInventors: David Daniels, Chad Kugler, John Bridgeman, Derek Stratton, Dean Peterson, Joshua Brenizer
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Patent number: 12333573Abstract: Methods, systems, and media for enhancing a blind URL escrow with real-time bidding exchanges are provided. In some embodiments, the method comprises: receiving, using a hardware processor, a URL associated with an advertisement placement from a seller, generating a rating for the URL received from the seller; determining metadata based on the URL and a domain name associated with the seller, generating an anonymous label corresponding to the URL that includes the generated rating and the determined metadata; transmitting the anonymous label to a real-time bidding exchange; and causing a verification beacon to be inserted into an advertisement to be displayed in the advertisement placement in response to a buyer purchasing an opportunity to place an advertisement in the advertisement placement using the anonymous label through the real-time bidding exchange.Type: GrantFiled: February 26, 2024Date of Patent: June 17, 2025Assignee: Integral Ad Science, Inc.Inventor: Izzet Agoren
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Patent number: 12331276Abstract: In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.Type: GrantFiled: April 30, 2024Date of Patent: June 17, 2025Assignee: Global Life Sciences Solutions USAInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 12330765Abstract: Disclosed is a power and freshwater supply system for an ocean integrated platform, falling within the field of offshore integrated power generation technologies and methods. A wind farm, a compressed air energy storage system with heat storage, a vortex tube, a temperature difference energy power generation system, and an energy management system are included. Leveraging the complementary characteristics of wind energy and temperature difference energy, a sustainable power and freshwater supply system for an ocean integrated platform is established, providing clean and reliable energy and freshwater resources for facilities such as islands in deep and distant sea, offshore oilfields, and mariculture.Type: GrantFiled: January 18, 2025Date of Patent: June 17, 2025Assignees: Jiangsu University of Science and Technology, MARINE TECHNOLOGY INNOVATION CENTER · YANGTZE DELTAInventors: Lixin Xu, Yajiao Liu, Peilin Dou, Xiu Li, Shuguang Zhang, Zhichao Hong, Chaoshuai Han
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Patent number: 12332713Abstract: The technology described herein is related to a two-phase deployment-initiated wakeup mechanism for a body-mountable electronic device. During a first phase of the two-phase wakeup mechanism, a motion sensor detects an acceleration event indicative of deployment of the device onto the body of the user. During a second phase of the two-phase mechanism, control circuitry can be adapted to be enabled by the acceleration event. Once enabled, the control circuitry can verify that the device has been launched onto the body of a user via a deployment applicator in which the device is retained until deployment. Once verified, the control circuitry can wake up the body-mountable electronic device by transitioning the device from a sleep state to a functional (or operational) state.Type: GrantFiled: July 14, 2023Date of Patent: June 17, 2025Assignees: Verily Life Sciences LLC, DexCom, Inc.Inventors: William James Biederman, III, Louis Hyunsuk Jung
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Patent number: 12331059Abstract: The present invention belongs to the field of medical technology and relates to a class of functional small molecules targeting proteolysis pathways, a preparation and an application thereof. Specifically, the present invention relates to functional small molecules represented by formula (M) and pharmaceutically acceptable salts thereof, as well as the application of said compounds and pharmaceutical compositions thereof in the preparation of tumor-treating drugs. The functional small molecules are obtained by means of linking a compound containing a peroxide bridge linkage and a substrate of an E3 ubiquitin ligase complex. The related functional molecules can promiscuously target and bind to multiple proteins comprising functional proteins in the proteolysis pathway and have anti-tumor biological activity.Type: GrantFiled: September 9, 2020Date of Patent: June 17, 2025Assignee: Institute of Materia Medica, Chinese Academy of Medical SciencesInventors: Chongjing Zhang, Fujia Wang, Zi Ye, Wanqi Yang, Ke Li
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Patent number: 12334619Abstract: In order to solve the problems of a conventional flat surface wave generator which has limitations on being applied to a curved structure due to more than a certain required thickness of a dielectric material, proposed are a flexible surface wave generator and system and method for surface wave communication using the same where the flexible surface wave generator is bendable by removing a third dielectric material and by making a first and a second dielectric material thin and at the same time reaches communication performance applicable to the ISM band by changing a pattern of a surface wave generation member and by forming a slit in a radiator material, so it is possible to easily establish a surface wave communication system even in environments where a conventional flat surface wave generator is difficult to be applied by being tightly attached to the surface of a metal medium with curvature.Type: GrantFiled: October 17, 2023Date of Patent: June 17, 2025Assignees: Korea Institute of Ocean Science & Technology, Sunny Wave Tech Co., Ltd.Inventors: Woo Seong Shim, Bu Young Kim, Jin Woo Kong
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Patent number: 12332172Abstract: A method for adjusting laser path of terahertz near-field system, belonging to the field of terahertz near-field imaging. It mainly addresses the issues where an optical microscope cannot clearly observe the laser spot on the probe cantilever, and the laser path adjustment is complex, slow, and inaccurate. The method employs a three-step process: adjusting the position of laser device to roughly adjust the emitted laser, adjusting the position of laser device to fine-tune the emitted laser, and a using a spot position detector to adjust the received laser. By using the shadow magnification projection method, the position of the laser spot on the probe cantilever can be directly and effectively observed and the laser light path can be quickly adjusted. This adjustment method is fast and easy to operate.Type: GrantFiled: January 16, 2025Date of Patent: June 17, 2025Assignee: Institute of Energy, Hefei Comprehensive National Science CenterInventors: Wenbing Zhang, Hongbo Cui, Chengyao Peng, Fengting Jiang, Zhenchun Yu
