Abstract: Systems, devices, and methods for using Multi-Pattern Viterbi Algorithm for joint decoding of multiple patterns are disclosed. An exemplary method may receive a plurality of sets of time-sequential signal observations for each of a number K of signal repetitions. Further, each set of signal observations is associated with a respective dimension of a K-dimensional time grid having time-indexed points. Moreover, at each of a plurality of the time-indexed points, a state cost metric is calculated with a processor for each state in a set of states of a hidden Markov model (HMM). In addition, each state in the set of states and for a given time-indexed point, the state cost metric calculation provides a most-likely predecessor state and a corresponding most-likely predecessor time-indexed point. The exemplary method may also determine a sequence of states using the calculated state cost metrics and determine a corresponding cumulative probability measure for the HMM.

Abstract: Disclosed is a composite material wherein adhesion between a silicon surface and a plating material is enhanced. A method and an apparatus for producing the composite material are also disclosed.

Abstract: The invention relates to a polyisocyanurate comprising isocyanurate rings linked by linker groups coupled to the nitrogen atoms of said rings. The polyisocyanurate may be microporous or mesoporous or both microporous and mesoporous.

Abstract: The present invention relates to a scaleable bioreactor comprising at least one cassette comprising a manifold and an arrangement of hollow fibre membranes; an upper headplate; and a lower headplate, wherein the cassette(s) are modular components adapted to co-operate with each other and the headplates to define an internal extracapillary culture space (ECS) and wherein the arrangement of hollow fibre membranes includes a discrete inlet and outlet. The invention further relates to a kit for such a bioreactor, a cassette for use in such a bioreactor and a process for exploiting the metabolism of cells and/or microorganisms, the process including the step of utilising a bioreactor according to the invention.

Abstract: A method for detecting apoptosis of embryonic stages of parasitic helminthes. The method comprises isolating of intra uterine embryonic stages from an adult female parasite. The embryonic stages are cultured in vitro and treated. The said embryonic stages are subjected to flow cytometric analysis. An assay for apoptosis is performed being capable of high throughput screening and identification of compounds having apoptogenic activity towards the embryonic stages of helminthic parasites.

Abstract: A cell collecting device having a housing with an inlet for receiving cells, a cell attractant cavity have a cell attractant, a cell collection channel running from the inlet to the cell attractant cavity, and a plurality of electrodes positioned to detect the presence of cells is disclosed. The cell attractant cavity may include a porous medium, such as, a hydrogel, containing the cell attractant, such as, epidermal growth factor. The channel may include a plurality of restrictions and expansions to assist in maintaining the porous medium while permitting the passage of attractant and cells. The device may be implanted into a patient for an extended period of time, and then removed and examined. A method for collecting cells, an implantable attractant dispersing device, and a porous medium for controlled releasing of a compound are also disclosed.

Abstract: The present invention relates to a method of preparing heavy metal nanoparticles using a heavy metal-binding protein. More specifically, relates to a method for preparing heavy metal structures, comprising the steps of: culturing a microorganism transformed with a gene encoding a heavy metal-binding protein, in a heavy metal ion-containing medium, to produce heavy metal structures in the microorganism; and collecting the produced heavy metal structures, as well as nanoparticles of heavy metal structures prepared according to said method. Unlike prior methods of preparing quantum dots by physically binding metal materials, en the quantum dots disclosed herein can be efficiently produced by expressing the heavy metal-binding protein in cells. In addition, the quantum dots are useful because they can solve an optical stability problem that is the shortcoming of organic fluorophores.

Abstract: A melt-kneaded product includes: a disperse medium selected from an a rubber, elastomer, thermoplastic resin, or thermosetting resin; and a filling material constituted by nano-size filler particles having a mutually aggregating nature, said nano-size filler particles being uniformly dispersed in the disperse medium.

Abstract: A process for the fabrication of high efficiency thermoelectric materials using non-equilibrium synthesis routes is described. In one embodiment a molten alloy comprising a predetermined ratio of elements which will constitute the thermoelectric material is quenched at a cooling rate in excess of, for example, 105 or 106 K/s using a process such as melt spinning. The rapidly solidified particles are then placed into a mold having the desired size and shape. The particles in the mold are simultaneously compressed and sintered at elevated temperatures for a short duration using, for example, hot pressing or spark plasma sintering. The overall process provides improved microstructural control and greatly expands the accessible phase space, permitting the formation of dense, single-phase structures with nanosized grain boundaries and minimal or no impurity segregation.

Abstract: Method of producing ?4-Tibolone by contacting tibolone with Fusarium lini (ATCC 9593) is reported.

Abstract: The present invention provides the use of an aerosol formulation comprising fosfomycin and tobramycin in the treatment of patients with chronic obstructive pulmonary disease (COPD) who are experiencing or are at risk of experiencing acute exacerbations of COPD. Formulations for such use and methods of treating humans with COPD are also provided.

Abstract: The invention provides methods, compositions and transformation systems for modifying the levels of transcription factors in plants such as Solanaceous plants, and introducing disease resistance genes into plants, to produce products with elevated levels of antioxidant compounds, including but not limited to flavonols and chlorogenic acid, as well as exhibiting enhanced disease resistance, and optionally altered appearance. Preferred plants are those in which introduced genes are from Solanaceous species.

Abstract: The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the blocking agent.

Abstract: Processes for preparing polyurethane hydrogels which include free-radically cross-linking: A) hydrophilic polyurethanes having one or more olefinically unsaturated groups selected from the group consisting of acrylate and methacrylate groups; in the presence of B) water; and C) a redox system including a water-soluble oxidizing agent and a water-soluble reducing agent, the oxidizing agent being capable in terms of redox potential of reacting with the water-soluble reducing agent by free-radical formation, wherein the hydrophilic polyurethanes are based on hydroxyl-functional polyalkylene oxides.

Abstract: Systems, methods, compositions and apparatus relating to genome selection are disclosed.

Abstract: A power gating circuit includes a logic circuit, a switching element and a retention flip-flop. The logic circuit is coupled between a first power rail and a virtual power rail. The switching element selectively couples the virtual power rail to a second power rail in response to a mode control signal indicating an active mode or a standby mode. The retention flip-flop selectively performs a flip-flop operation or a data retention operation in response to a voltage of the virtual power rail.

Abstract: Systems, methods, compositions and apparatus relating to genome selection are disclosed.

Abstract: A robot apparatus having a plurality of movable sections includes a motion control section that generates a control signal for the periodic motion of at least part of the movable sections according to the output of an oscillator showing self-oscillation and entrainment characteristics, an environment measuring section that measures the motion according to the control signal for the movable sections or the physical environment at the time of the motion of the movable sections, a periodic oscillator control section that inputs a periodic signal to the oscillator as feedback according to the outcome of the measurement by the environment measuring section and generates an entrainment phenomenon and a non-periodic oscillator control section that inputs a non-periodic or temporary feedback signal to the oscillator.

Abstract: Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.

Abstract: A feedback controller comprises first and second feedback circuits. The first feedback circuit is connected between an input node and an output node and has an error node. The first feedback circuit comprising a feedback amplifier for comparing a feedback signal to a reference signal and providing an error signal, and a comparator for comparing the error signal to a second reference signal and providing an output signal. The second feedback circuit is connected between the input node and the error node and comprises a current source coupled to the error node and a controller coupled to the input node for controlling the current source in response to a value of the feedback signal being above or below a threshold value.