Patents Assigned to Sciences
  • Patent number: 12285426
    Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: April 29, 2025
    Assignees: The Research Foundation for The State University of New York, Rosalind Franklin University of Medicine and Science, Board of Trustees of Michigan State University
    Inventors: Christopher Roy Bishop, Anthony West, Fredric Manfredsson
  • Patent number: 12285007
    Abstract: An intelligent air-assisted spraying device for orchards includes a traction mechanism, a spaying system, a collecting system, and a processing-controlling system. The traction mechanism is provided with a spray tank. The spaying system includes a main body connected to the spray tank and multiple spraying tubes, first ends of the spraying tube are communicated with the main body, and second ends of the spraying tubes are capable of rotating. The collecting system is configured to collect a contour and a volume of the canopy, and branch and leaf density of a fruit tree. The processing-controlling system is configured to obtain multiple spraying areas, calculate an air outlet angle of each spraying tube, and control a rotation of the second end of each spraying tube according to the air outlet angle. The device can adjust the spraying direction of each spraying tube, and the quality of pesticide application can be improved.
    Type: Grant
    Filed: May 21, 2024
    Date of Patent: April 29, 2025
    Assignee: Intelligent Equipment Research Center, Beijing Academy of Agriculture and Forestry Sciences
    Inventors: Liping Chen, Hanjie Dou, Changyuan Zhai, Fan Feng, Wei Zou, Si Li, Shuo Yang, Jian Song
  • Patent number: 12286225
    Abstract: Techniques for traversing in an environment that includes at least one obstacle, by a mobile autonomous system, to a destination in the environment, are presented. The techniques can include generating, prior to the mobile autonomous system commencing activity in the environment, a graph including a plurality of vertices representing positions in the environment and a plurality of edges between vertices representing feasible transitions by the mobile autonomous vehicle in the environment; annotating the graph with at least one edge connecting a representation of a present position of the mobile autonomous system to a vertex of the graph; determining, based on the graph, a path from the present position of the mobile autonomous system in the environment to the destination; and traversing the environment to the destination, by the mobile autonomous system, based on the path.
    Type: Grant
    Filed: February 8, 2024
    Date of Patent: April 29, 2025
    Assignee: Aurora Flight Sciences Corporation, a subsidiary of The Boeing Company
    Inventors: Craig John Bonnoit, Jeffery Saunders
  • Patent number: 12288679
    Abstract: A method for full Os isotope static measurement by NTIMS includes steps of: selecting and weighing rock samples, and dissolving the rock samples to obtain dissolution liquid; chemically separating Os from the dissolution liquid to obtain purified Os solution; loading the purified Os solution on a Pt filament to obtain a sample to be determined; selecting Faraday cups and ion counters, as well as 1012? and 1013? amplifiers in NTIMS based on natural abundances of different Os isotopes, thereby establishing a cup configuration for the full Os isotope static measurement; establishing a yield calibration method for ICs; performing full Os isotopes static measurement based on the yield-calibrated ion counters and gain-calibrated faraday cups; and processing analytical data to obtain a final data of Os isotopic composition. The method enables the determination of the full Os isotope and oxygen isotope compositions of low-content or small-size samples.
    Type: Grant
    Filed: April 22, 2024
    Date of Patent: April 29, 2025
    Assignees: Guangzhou Institute of Geochemistry (GIG), Chinese Academy of Sciences (CAS)
    Inventor: Guiqin Wang
  • Patent number: 12286581
    Abstract: The present disclosure relates to a colored radiative cooling device that includes a selective heat transfer layer between a spectral selective filter and a thermal emitter, and a method of cooling an object by using the colored radiative cooling device.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: April 29, 2025
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Jonghwa Shin, Suwan Jeon
  • Patent number: 12286393
    Abstract: The invention provides a process for refining bio-based propylene glycol, wherein impurities having boiling points close to that of propylene glycol are separated. In this process, C5-C20 oleophilic alcohol compounds, C5-C20 alkanes and/or C4-C20 oleophilic ketone compounds are subjected to azeotropism as an azeotropic solvent together with the bio-based propylene glycol to obtain an azeotrope containing propylene glycol. Then the azeotropic solvent in the azeotrope is separated to obtain a crude propylene glycol which is further purified to obtain propylene glycol.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: April 29, 2025
    Assignee: Changchun Meihe Science and Technology Development Co., Ltd.
    Inventor: Yi Yuan
  • Patent number: 12287359
    Abstract: An RF characterization system includes a processor that executes program instructions to determine how a radome affects RF characteristics of an antenna by retrieving near field measurement data of the radome and antenna, receiving an electronic image representation of the radome, and obtaining near field RF properties of the radome and antenna by combining the near field measurement data and the electronic image representation.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: April 29, 2025
    Assignee: Resonant Sciences, LLC
    Inventors: Jonothan Pryor, Brent Collins, Nathan Thomas Kornbau, Jeremy Micah North, Kurt Strickler, Mark Scott
  • Patent number: 12285356
    Abstract: The present disclosure relates to relates to systems and methods for on-demand delivery of a therapeutic agent from an eye mounted device. Particularly, aspects of the present invention are directed to a method of delivering a therapeutic agent, the method including receiving, at a controller of a therapeutic agent release and delivery device, a first command signal for delivery of a therapeutic agent based on a dosing time window. Upon receipt of the first command signal, the controller determines whether one or more compliance conditions are satisfied. When the one or more conditions are satisfied, the controller initiate a release and delivery protocol that commands a signal generator to generate and send a second command signal causing a capacitor or one or more circuits to deliver an actuation signal causing one or more therapeutic agent delivery mechanisms to open and release the therapeutic agent from one or more reservoirs.
    Type: Grant
    Filed: September 9, 2022
    Date of Patent: April 29, 2025
    Assignee: Verily Life Sciences LLC
    Inventor: Christian Gutierrez
  • Patent number: 12286468
    Abstract: The invention relates to a polypeptide, such as an Affimer polypeptide, comprising an amino acid sequence having at least 80% identity to amino acid residues 1 to 11, 13 to 15, 17 to 19, 21 to 25, 27 to 28, 35 to 37, 39, 41, 43 to 44, 46 to 47, 49 to 50, 52 to 53, 55 to 58, 63 to 64, 66, 68 to 82, 84 to 85, and 87 to 98 of SEQ ID NO: 1; characterized in that said polypeptide comprises one or mutations relative to SEQ ID NO: 1. The invention also relates to various methods and nucleic acids.
    Type: Grant
    Filed: February 8, 2024
    Date of Patent: April 29, 2025
    Assignee: Avacta Life Sciences Limited
    Inventors: Geoffrey William Platt, Graham Robert Pye-Smith Spence
  • Patent number: 12287321
    Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.
    Type: Grant
    Filed: September 8, 2023
    Date of Patent: April 29, 2025
    Assignee: Truvian Sciences, Inc.
    Inventors: Dena Marrinucci, Nicholas Haase, Ryan Morgan, Michael Adams, Derek Arndt, Graeme Cross, Jeffrey A. Hawkins, David Hecht, Johnny Steve Rachele, Roger Taylor, Scott Thompson, Kyoung-Ho Kim, David Luke McDonald, Michael White, Kevin Yang
  • Patent number: 12285009
    Abstract: A system and method facilitates transfers of specimen containers (e.g., vials with caps) between storage cassettes and carrier cassettes. The storage cassettes are designed to be stored in cryogenic refrigerators while the carrier cassettes are designed to be temporarily stored in a portable carrier. A workstation includes a well and removable buckets positioned in the well. The buckets are sized to hold the storage cassettes and carrier cassettes. One or more arrays of antennas underlie the well to allow interrogation of wireless transponders carried by the specimen containers. Improved storage cassettes and carrier cassettes are also described.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: April 29, 2025
    Assignee: TMRW Life Sciences, Inc.
    Inventors: Brian Joseph Bixon, Cynthia Hudson, Alan Leroy Murray
  • Patent number: 12288957
    Abstract: Embodiments of the microwave amplification system are described. In an embodiment, a microwave amplification system includes a microwave amplifier that contains a paramagnetic material with an impurity. The impurity has a plurality of nuclear spin and electron spin-based energy levels. The system includes an input to receive a pumping signal which is transmitted to the microwave amplifier to cause a population inversion in the impurity and excite it to one of the nuclear spin and electron spin-based energy levels. The system further includes another input to receive an input signal to be amplified by the microwave amplifier, the input signal having a lower power than the pumping signal. Once transmitted to the microwave amplifier, the input signal is amplified by the excited state of the impurity in the microwave amplifier thereby generating an amplified signal.
    Type: Grant
    Filed: June 12, 2023
    Date of Patent: April 29, 2025
    Assignee: Okinawa Institute of Science and Technology School Corporation
    Inventors: Yuimaru Kubo, Jason Robert Ball, Petr Moroshkin, Denis Konstantinov
  • Patent number: 12285469
    Abstract: Methods of making the M or L complex of the botulinum neurotoxin E with its associated neurotoxin binding protein(s) (NBP), and methods of using to treat pain and wrinkles by injecting locally. Methods of making and isolating the L and M complex comprise a multi-step process of: providing a bacterial cultured media comprising the complex of botulinum neurotoxin E and neurotoxin binding proteins; centrifuging and pelletizing the cultured media; stirring the pelletized culture at 0 to 10° C. over a period of 4 to 24 hours; centrifuging the stirred solution to obtain a supernatant; precipitating the supernatant and filtering to obtain the precipitate; and dissolving the precipitate, centrifuging and filtering to obtain a solution comprising M complex and/or L complex of botulinum neurotoxin E and its NBP; and passing the solution through a functionalized sephadex ion exchange column to isolate the complex.
    Type: Grant
    Filed: March 11, 2024
    Date of Patent: April 29, 2025
    Assignee: Institute of Advanced Sciences, Inc.
    Inventors: Bal Ram Singh, Raj Kumar
  • Patent number: 12285918
    Abstract: The present invention relates to a printing device and a printing method. The combination mode between materials in an additive manufacturing process is improved. A calculation unit is used for controlling an A pole unit and a B pole unit to be in contact with the materials, to form an energized circuit. The surface temperature of phase change material in the material between the A pole unit and the B pole unit is greater than or equal to a preset temperature so that the materials at a distance can be simultaneously combined.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: April 29, 2025
    Assignee: Qingdao University of Science and Technology
    Inventors: Yan He, Dianming Chu, Wenjuan Bai
  • Patent number: 12286765
    Abstract: A single-hole ultrasonic detection device for continuous integrity and a rock entry depth of a concrete diaphragm wall and a method using the same are provided. the single-hole ultrasonic detection device includes an apparatus host, an ultrasonic transducer and an ultrasonic signal feedback device, and the apparatus host is respectively connected to the ultrasonic transducer and the ultrasonic signal feedback device via a corresponding one of signal lines, the apparatus host includes an ultrasonic transmitter and an ultrasonic signal collector, the ultrasonic transmitter is configured to generate ultrasonic waves and the ultrasonic waves are transmitted via the ultrasonic transducer, the ultrasonic transducer is configured to collect and recover a reflected wave of the ultrasonic waves, convert signals of the reflected wave of the ultrasonic waves into electric signals, and send the electric signals back into the apparatus host.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: April 29, 2025
    Assignee: Jiangxi Academy of Water Science and Engineering
    Inventors: Jianglin Gao, Da Liu, Songtao Hu, Yan Li, Fang Chen, Hongyou Guo, Liang Sun, Jianqing Zhang
  • Publication number: 20250130039
    Abstract: The present invention provides a quantitative analysis method on influence of black carbon emission to glacier change.
    Type: Application
    Filed: December 26, 2024
    Publication date: April 24, 2025
    Applicant: Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences
    Inventors: Wentao Du, Jizu Chen, Shichang Kang, Weijun Sun, Youyan Jiang, Xiang Qin
  • Publication number: 20250130197
    Abstract: The present invention relates to an all-solid-state ion-selective electrode having an insertion material, and a method of manufacturing such an all-solid-state ion-selective electrode. The all-solid-state potassium ion-selective electrode (1) includes: a conductor (2); an insertion material (10) formed on a surface of the conductor (2); and a potassium ion-sensitive membrane (20) covering the insertion material (10). The insertion material (10) includes at least a Prussian blue analog represented by a structural formula KxFe[Fe(CN)6]y·nH2O, where x is a numerical number larger than 0 and less than or equal to 2, y is a numerical number larger than 0 and less than or equal to 1, and n is a numerical number larger than or equal to 0.
    Type: Application
    Filed: August 15, 2022
    Publication date: April 24, 2025
    Applicants: KOA CORPORATION, Tokyo University of Science Foundation
    Inventors: Toshiharu TAKAYAMA, Takahiro MATSUI, Tomoyuki KURIBAYASHI, Yuko TAKEI, Shinichi KOMABA, Ryoichi TATARA, Kenta ISHIHARA
  • Publication number: 20250129716
    Abstract: A method includes modeling a reservoir using a lab scale set of models and a field scale set of models. The reservoir is modeled using the lab scale set of models by scanning a sample of the reservoir into the lab scale set of models to create modeled fractures, estimating hydraulic properties of the modeled fractures, estimating multi-phase dynamic properties of the modeled fractures, and determining characteristics of a flow regime of a fluid flowing through the modeled fractures. The reservoir is modeled using the field scale set of models by modeling a discrete fracture network of the reservoir, upscaling the discrete fracture network, and calibrating the discrete fracture network. An enhanced oil recovery operation is designed and performed on the reservoir using the calibrated discrete fracture network.
    Type: Application
    Filed: October 23, 2023
    Publication date: April 24, 2025
    Applicants: SAUDI ARABIAN OIL COMPANY, King Abdullah University of Science and Technology
    Inventors: Xupeng He, Marwah M. AlSinan, Yiteng Li, Zhen Zhang, Hyung Tae Kwak, Hussein Hoteit, Xiang Rao
  • Publication number: 20250127098
    Abstract: Provided herein are chassis (100, 200, 322, 400, 500, 600) for positioning and mounting a fluid delivery device onto a plant to distribute a liquid formulation to the plant, and the method of using the chassis (100, 200, 322, 400, 500, 600)
    Type: Application
    Filed: June 15, 2022
    Publication date: April 24, 2025
    Applicant: Invalo Sciences Internatjional GmbH
    Inventors: Thomas GERSTER, Marius LERF, Benjamin MEIER, Beat MÜLLER, Michael Christian OEHL, Pascal TROMMENSCHLAGER, Urs WIDMER
  • Publication number: 20250130340
    Abstract: The present invention belongs to the technical field of geological exploration deep Earth. The system of the present invention is configured to: collect seismic data, and preprocess original seismic data to obtain standardized gamma ray logging parameters; extract features from the standardized gamma ray logging parameters to obtain a variance attribute curve while drilling; obtaining a formation thickness prediction model of each set based on the variance attribute curve while drilling; acquire frequency-division seismic data based on the standardized seismic data by means of a frequency-division processing method based on wavelet transform; acquire optimal seismic frequency band information based on a predicted formation thickness value of each set; establish a geological prediction model of the current formation based on the frequency-division seismic data, the optimal seismic frequency band information, historical gamma ray logging parameters and the standardized gamma ray logging parameters.
    Type: Application
    Filed: January 14, 2024
    Publication date: April 24, 2025
    Applicant: Institute of Geology and Geophysics, Chinese Academy of Sciences
    Inventors: Fei TIAN, Qingyun DI, Wenhao ZHENG, Yongyou YANG, Wenjing CAO