Patents Assigned to Sciences
  • Differentiation of hepatocyte-like cells from stem cells
    Patent number: 10323228
    Abstract: Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: June 18, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Hanry Yu, Derek Phan, Yi-chin Toh, Farah Tasnim
  • Workstation, medical imaging apparatus having the same and method for controlling thereof
    Patent number: 10321886
    Abstract: Disclosed herein are workstation, medical imaging apparatus having the same and method for controlling thereof. The medical imaging apparatus includes an X-ray source configured to irradiate X-rays; an X-ray detector configured to obtain raw data by detecting X-rays irradiated from the X-ray source; and an image processor configured to determine a motion parameter to represent motion of at least one of an object, the X-ray source, and the X-ray detector from a medical image reconstructed based on the obtained raw data, and reconstruct a motion-compensated medical image of the object based on a virtual trajectory of the X-ray source generated based on the determined motion parameter.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 18, 2019
    Assignees: Samsung Electronics Co., Ltd., Korea Advanced Institute of Science and Technology
    Inventors: Ji Young Choi, Jong Beom Ra, Seok Hwan Jang, Seung Eon Kim, Duhgoon Lee
  • Poisson-binomial based image recognition method and system
    Patent number: 10325183
    Abstract: An improved system and method for digital image classification is provided. A host computer having a processor is coupled to a memory storing thereon reference feature data. A graphics processing unit (GPU) having a processor is coupled to the host computer and is configured to obtain, from the host computer, feature data corresponding to the digital image; to access, from the memory, the one or more reference feature data; and to determine a semi-metric distance based on a Poisson-Binomial distribution between the feature data and the one or more reference feature data. The host computer is configured to classify the digital image using the determined semi-metric distance.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 18, 2019
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Muthukaruppan Swaminathan, Tobias Sjoblom, Ian Cheong, Obdulio Piloto
  • Method and system for layout optimization of secondary coil for wireless power transfer
    Patent number: 10325718
    Abstract: Disclosed is a method for optimizing a layout of a secondary coil for a wireless power transfer. The method includes reconstructing a secondary coil based on a fixed grid, corresponding to a design domain, to set a relative turn of each fixed grid and obtaining at least one or more of an electromagnetic measure and a physical measure of the secondary coil to optimize a layout of the secondary coil; applying an effective turn to the optimized layout of the secondary coil to perform post-processing; and deriving a layout of a physical coil about the secondary coil. The effective turn corresponds to a difference between the relative turns existing at a same position.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: June 18, 2019
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: In Gwun Jang, Seung Beop Lee
  • Crystal oriented ceramicscrystal oriented ceramics, the production process, and heat radiation material
    Patent number: 10323168
    Abstract: A production process for a crystal oriented ceramics includes: a first step of preparing composite particles formed of particles having magnetic anisotropy having magnetic susceptibility anisotropy and seed particles having magnetic susceptibility anisotropy less than or equal to 1/10 of the magnetic susceptibility anisotropy of the particles having magnetic anisotropy and are formed of an inorganic compound having an anisotropic shape in which a crystal axis intended to be corresponds to a minor axis or a major axis; a second step of adding raw material powder including the composite particles to a solvent to prepare a slurry a third step of preparing a green compact by disposing the slurry in a static magnetic field of ?0.1 tesla and drying the slurry in a state in which crystal axes of the seed particles in a major axis direction are in one direction; and a fourth step of sintering the green compact.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: June 18, 2019
    Assignee: Kanagawa Institute of Industrial Science and Technology
    Inventors: Takuma Takahashi, Junichi Tatami, Nanako Sugimoto
  • INDUCTOR LAYOUT HAVING IMPROVED ISOLATION THROUGH BLOCKING OF COUPLING BETWEEN INDUCTORS, AND INTEGRATED CIRCUIT DEVICE USING SAME
    Publication number: 20190180931
    Abstract: Disclosed are an inductor layout and an integrated circuit device with improved isolation between inductors through shielding magnetic coupling between the inductors. first and second inductor coils are horizontally spaced apart from each other. A conductor loop is disposed in parallel above the first inductor coil and shields magnetic coupling between the first and second inductor coils in the manner that a part of magnetic flux of a first time-varying magnetic field generated by the second inductor coil is cancelled by magnetic flux of a second magnetic field generated by an induction current that flows in the conductor loop magnetically interlinked with the first time-varying magnetic field. The inductor layout can be applied to an RFIC device to reduce magnetic coupling between inductors of a power amplifier and an oscillator. Improved performance of the device and a very small RFIC can be achieved.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 13, 2019
    Applicants: Korea Advanced Institute of Science and Technology, Research & Business Foundation Sungkyunkwan University
    Inventors: Hyung-joun Yoo, Sang-sun Yoo, Kang-yoon Lee
  • SOIL CONDITIONER AND PREPARATION METHOD THEREFOR
    Publication number: 20190176197
    Abstract: Disclosed is a soil conditioner, comprising the following components in parts by weight: 10-20 parts of distiller's grains; 1-10 parts of cow dung; 1-10 parts of vermicompost; 1-10 parts of oil cake; 10-20 parts of dregs of decoction; 20-40 parts of fallow soil; and 20-40 parts of river sand. Also disclosed is a method for preparing a soil conditioner, comprising: first, separately fermenting distiller's grains, cow dung, vermicompost, oil cake, and dregs of decoction, and then mixing them with river sand and fallow soil for secondary solid fermentation to obtain the soil conditioner. The present invention has a remarkable restoration effect on obstructive soil, the microbial diversity index of the restored soil is increased, the microbial ecological structure of the soil is improved, and the quality of crops is enhanced.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 13, 2019
    Applicants: Guizhou Academy of Tobacco Science, Nanjing Agricultural University
    Inventors: Junxiong SHI, Xingming YANG, Yanxia LIU, Xiang LI, Qirong SHEN, Biao SHEN, Zhiwen CHEN
  • SOBETIROME IN THE TREATMENT OF MYELINATION DISEASES
    Publication number: 20190175531
    Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 13, 2019
    Publication date: June 13, 2019
    Applicants: Oregon Health & Science University, The United States Government as respresented by the Department of Veterans Affairs
    Inventors: Thomas S. Scanlan, Meredith Hartley, Andrew Placzek, Marco Righi, Dennis Bourdette, Gail Marracci, Priya Chaudhary
  • ASSAY ANALYSIS
    Publication number: 20190178802
    Abstract: Apparatus and assemblies for the detection of at least one analyte in a sample are shown and described. In one embodiment, the assembly generates a test result from an assay and includes an integrated reader and incubator, wherein the incubator incubates the assay as the reader generates the test result. The reader typically has an optical detector aligned with a light source for detecting a plurality of transmission of light on the assay. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Applicant: Charm Sciences, Inc.
    Inventors: Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Richard T. Skiffington
  • VR CONTENT SICKNESS EVALUATING APPARATUS USING DEEP LEARNING ANALYSIS OF MOTION MISMATCH AND METHOD THEREOF
    Publication number: 20190180448
    Abstract: A VR content sickness evaluating apparatus using a deep learning analysis of a motion mismatch and a method thereof are provided. The VR content sickness evaluating apparatus analyzes a motion mismatch phenomenon between visual recognition information and posture recognition information, which occurs when a user views VR content, using deep learning and predicts and evaluates a degree of VR sickness from a difference between motion features.
    Type: Application
    Filed: January 29, 2018
    Publication date: June 13, 2019
    Applicant: Korea Advanced Institute of Science and Technology
    Inventors: YongMan Ro, Hak Gu Kim
  • CRYSTALLINE FORM OF CHEMICAL COMPOUND, AND PREPARATION METHOD, COMPOSITION, AND APPLICATION THEREOF
    Publication number: 20190177312
    Abstract: Provided are a preparation method for a crystalline form of the compound represented by formula (A), as well as a method for preparation thereof, a composition thereof, and an application thereof in preparing an angiotensin II receptor antagonist or an application in preparing a drug for preventing and/or treating hypertension, chronic heart failure and diabetic nephropathy.
    Type: Application
    Filed: July 10, 2017
    Publication date: June 13, 2019
    Applicants: Wuhan LL Science and Technology Development Co., Ltd., Wuhan QR Pharmaceuticals Co., Ltd.
    Inventors: Sijun LEI, Xiang FANG, Yongkai CHEN, Wei FENG, Chaodong WANG
  • METHOD FOR ESTIMATING 6-DOF RELATIVE DISPLACEMENT USING VISION-BASED LOCALIZATION AND APPARATUS THEREFOR
    Publication number: 20190180134
    Abstract: A method for estimating 6-DOF relative displacement using vision-based localization and apparatus therefor are disclosed. A method for estimating 6-DOF relative displacement may include acquiring images of a first marker attached to a fixing member and a second marker attached to a dynamic member for assembling to the fixing member by using a camera, extracting a feature point of the first marker and a feature point of the second marker through image processing for the acquired images, and estimating 6-DOF relative displacement of the dynamic member for the fixing member based on the extracted feature point of the first marker and feature point of the second marker.
    Type: Application
    Filed: May 14, 2018
    Publication date: June 13, 2019
    Applicant: Korea Advanced Institute of Science and Technology
    Inventors: Hyeon Myeong, Su Young Choi, Wancheol Myeong
  • Failsafe operation of eye-mountable device
    Patent number: 10317702
    Abstract: An embodiment of an eye-mountable device includes an optical lens; an accommodation actuator to provide vision accommodation for the optical lens; a controller including an accommodation logic to select one of a plurality of vision accommodation states for the device, the plurality of vision accommodation states including at least a failsafe focal distance; and a failsafe subsystem including a system health detector, the system health detector to monitor for one or more operational indicators for the device, wherein the failsafe subsystem is to cause the device to transition to a failsafe mode upon the failsafe subsystem identifying a failure condition for the device, the failsafe mode includes setting the vision accommodation state to be the failsafe focal distance.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: June 11, 2019
    Assignee: Verily Life Sciences LLC
    Inventors: Shungneng Lee, Daniel James Yeager, Jennifer Han, Nathan Pletcher, Brian Otis
  • Geo-security method and system
    Patent number: 10321262
    Abstract: The geo-security method and system uses spatio-temporal radio channel information during authentication to grant permission to access, use and/or operate the intended device. The geo-security method and system uses a wideband radio channel impulse response (or transfer function of radio channel) from antenna of RF source to antenna of a RF receiver at the device position to determine the legitimacy of the intended device's location.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: June 11, 2019
    Assignee: Qatar Foundation for Education, Science and Community Development
    Inventors: Hassan Mohamed El-Sallabi, Mohamed Mahmoud Abdallah, Khalid Ali Qaraqe, Jean-Francois Chamberland, Gregory H. Huff
  • Process of synthesizing substituted pyridine and pyrimidine compound
    Patent number: 10316033
    Abstract: Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula III via a compound of formula II?, wherein the definition of each of groups is as described as the description. Compound with other methods, the method in the present invention has features of high yield and a result product being easier to separate.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 11, 2019
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
    Inventors: Jingkang Shen, Tao Meng, Ting Yu, Lanping Ma, Xin Wang, Lin Chen
  • Spacer for side loaded EWOD device
    Patent number: 10315911
    Abstract: An EWOD device includes a first and second substrate assemblies, and a spacer that spaces apart the first substrate assembly from the second substrate assembly to define a channel between them. The spacer defines fluid input ports that are in fluid communication with the channel, and the spacer is configured for directing fluid from the fluid input ports into the channel. The spacer has a combed spacer configuration to define the fluid input ports, including alternating teeth that extend into the channel from a base region, and the teeth isolate adjacent fluid input ports from each other. The spacer may contact only a portion of the first and second substrate assemblies to form a spacerless region within the EWOD device, and the spacer includes regions that are in contact with both the first and second substrate assemblies and extend into the channel to define a cell-gap of the channel.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: June 11, 2019
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Lesley Anne Parry-Jones, Emma Jayne Walton
  • Intraocular implants and methods and kits therefor
    Patent number: 10314742
    Abstract: Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and maintains the patency of the canal without substantially interfering with transmural fluid flow across the canal. The devices utilize the natural drainage process of the eye and can be implanted with minimal trauma to the eye. Kits include a support and an introducer for implanting the support within Schlemm's canal. Methods include implanting a support within Schlemm's canal, wherein the support is capable of maintaining the patency of the canal without substantial interference with transmural fluid flow across the canal.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: June 11, 2019
    Assignee: Sight Sciences, Inc.
    Inventors: David Y. Badawi, Paul Badawi
  • Chromatography column assembly with snap fit end cap and adaptor shaft
    Patent number: 10315134
    Abstract: The invention relates to a chromatography column assembly that offers an affordable self-packed column for performing chromatographic separation. The chromatography column assembly comprises a column tube having a first and a second opening at substantially opposite ends, and an end cap of either a snap fit design or a bolted design. The column assembly may further include an adaptor shaft inserted into the column through the end cap for achieving a desired bed volume. The column assembly may also include a second end cap enclosing the second opening, and an optional adaptor shaft may be inserted into the column through the second end cap, enabling further adjustment of the bed volume.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: June 11, 2019
    Assignee: GE Healthcare Bio-Science AB
    Inventors: Veena Rao, Manoj Ramakrishna, Nikhil Kamble
  • Catalyst used for dehydrogenation of formic acid, method for dehydrogenating formic acid, and method for producing hydrogen
    Patent number: 10315190
    Abstract: A catalyst including, as effective ingredient, complex represented by Formula (1) which contains bidentate ligand including aromatic heterocyclic 5-membered ring having 2 or more nitrogen atoms, or represented by Formula (2) which contains bidentate ligand including: aromatic heterocyclic 5-membered ring having 2 or more nitrogen atoms; and 6-membered ring having 1 or more nitrogen atoms, isomer or salt of the complex: where M1 and M2 denote transition metal such as iridium; X1 to X16 each independently denote nitrogen or carbon; R1 to R13 denote, for example, hydrogen atom, alkyl group, or hydroxy group, provided that when Xi (where i denotes 13 to 16) is nitrogen, Ri is absent at position corresponding to the nitrogen; L1 and L2 denote, for example, an aromatic anionic ligand; Z1 and Z2 denote any ligand or are absent; and m and n denote positive integer, 0, or negative integer.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: June 11, 2019
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Yuichiro Himeda, Wan-Hui Wang, Yuichi Manaka, Yuki Amamoto
  • Tank-binding kinase inhibitor compounds
    Patent number: 10316049
    Abstract: Compounds having the following formula (I) and methods of their use and preparation are disclosed:
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 11, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Zhimin Du, David Dornan, Juan A. Guerrero, Joshua A. Kaplan, John E. Knox, Devan Naduthambi, Barton W. Phillips, Susanna Y. Stinson, Chandrasekar Venkataramani, Peiyuan Wang, William J. Watkins