Abstract: The present disclosure relates to a device that can image magnetic particles through a Field Free Line (FFL) formed in a single direction. The single side magnetic particle imaging device according to an embodiment of the present disclosure includes: a pair of selection coils arranged in parallel in an x-axial direction and configured to create a y-axial Field Free Line (FFL) in a Field of View (FOV); a driver coil disposed under the pair of selection coils and configured to move the FFL in a z-axial direction by generating a magnetic field; An excitation coil disposed over the pair of selection coils and configured to excite magnetic fields in the FOV by generating a magnetic field in the FOV; and a pair of receiver coils arranged in parallel in a y-axial direction over the excitation coil and configured to receive signals generated by the magnetic particles, respectively.

Abstract: The present disclosure is directed to providing novel coelenterazine derivatives that exhibit high luminescence brightness and have enzyme specificity, and the solution is a coelenterazine derivative represented by the following general formula (1) or (2): in the general formula (1), R1 has a certain bicyclic structure, R2 is represented by —R2? or —CH2—R2? where R2? has a certain ring structure, and R3 has a certain ring structure; and in the general formula (2), R4 is represented by —(CH2)n—OR4-1, —N(R4-1)2, or —CF3 where each R4-1 is independently hydrogen or a hydrocarbon group with 1 to 3 carbon atoms, n is an integer from 0 to 3, R5 has a certain ring structure, and R6 is hydrogen or a hydrocarbon group with 1 to 3 carbon atoms.

Abstract: Disclosed is an unsupervised deep learning method, which simultaneously performs registration between diffusion weighted magnetic resonance images and quantification of diffusion parameters. The unsupervised deep learning method decreases a registration error caused by a contrast difference by comparing a similarity between images of the same contrast, increases the performance of registration, and increases the accuracy of quantifying magnetic resonance diffusion parameters.

Abstract: Provided herein are polypeptides, compositions, and methods for use thereof for genetic and epigenomic engineering, including, genome editing and gene regulation. These polypeptides and compositions include nucleic acid binding domains that bind to a target nucleic acid of interest. The nucleic acid binding domains include repeat units derived from repeat units identified in proteins from animal pathogens such as bacterium of the order Legionellales and the species Legionella and Francisella.

Abstract: Provided is a novel PDGFR kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. Further provided are use and a method of the compound of formula (I) for preventing or treating conditions associated with PDGFR kinase activity, particularly use and a method for preventing or treating conditions associated with PDGFR? and/or PDGFR? kinase activity.

Abstract: The disclosure relates to the technical field of experimental detection. A portable experimental device for hazardous chemical and an experimental method thereof are provided. The technical scheme of the disclosure integrates hazardous chemicals information and data of a portable meeting-water air release test device data to construct a perfect hazardous chemicals database, and realizes rapid prediction and response to a fire scene through scene data collection, preprocessing and matching. The scene data of the portable device is received and processed, and is compared with the database information, the random forest model is used to train the chemical reaction prediction model, and the real-time detection data is predicted to obtain the second prediction result. and the test experimental results are shared to each mobile terminal in time to realize the rapid transmission and sharing of information.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Genome-wide data is obtained, and data cleansing, data sparsity processing and bioinformatics feature extraction are performed on the obtained genome-wide data; model construction is performed based on the sparsity-processed genome-wide data and the bioinformatics features to obtain a preliminary hybrid model; model training, regularization, and interpretability enhancement are performed on the preliminary hybrid model to obtain a trained model weight and an interpretability analysis corresponding to the trained model weight; learning and uncertainty estimation are performed based on the trained model weight and to-be-predicted genome-wide data on the hybrid model to obtain an integrated prediction result and uncertainties corresponding to the integrated prediction result; and personalized medical advice and decision assistance are performed based on the integrated prediction result, the interpretability analysis, and the uncertainties corresponding to the integrated prediction result.

Abstract: A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of the hydrogel microneedle patch are also provided.

Abstract: A method for performing a 3D point cloud object detection is provided. The method includes: receiving an object data comprising a point cloud of a plurality of sensed points; performing a grid-based key-points extraction on raw data points of the point cloud, so as to obtain one or more key-points; performing a hierarchical point-wise convolution on the raw data points of the point cloud according to the key-points, so as to obtain a plurality of target point-wise features; performing a location-aware 3D RoI pooling operation according to the target point-wise features, so as to obtain pooled point-wise features and pooled 3D voxels corresponding to the pooled point-wise features; performing 3D convolution operations on the pooled 3D voxels, so as to obtain represent data points, wherein each of the represent data points includes a represent feature; and inputting the represent data points into multi-layer perceptrons to obtain final predictions.

Abstract: A device positioning an object according to a given direction, including a frame, a holder for holding the object, the holder being movable relative to the frame according to the given direction, a main lever extending between a first point and a second point, said main lever being rotatably mounted to the frame via a first pivot link connecting the main lever and the frame at the first point of the main lever, the main lever being connected to the holder at a third point which is arranged between the first point and the second point, so that a displacement of the second point of the main lever relative to the frame according to the given direction causes displacement of the holder in said given direction.

Abstract: Provided are a cell-containing hydrogel body and a method of producing the same, which enable simple and effective control of the size of a boundary surface for an interaction between cells. The method of producing a cell-containing hydrogel body includes: forming, under a gas phase, a first hydrogel droplet on a surface of a substrate, the first hydrogel droplet containing first cells being dispersed therein and a first hydrogel polymer; forming, under a gas phase, a second hydrogel droplet on the surface, the second hydrogel droplet containing second cells being dispersed therein and a second hydrogel polymer, the second hydrogel droplet being combined with the first hydrogel droplet; and forming, under a gas phase, a cell-containing hydrogel body on the surface by gelling a hydrogel droplet-combined body including a first droplet portion derived from the first hydrogel droplet and a second droplet portion derived from the second hydrogel droplet.

Abstract: There is provided an apparatus for drawing a fibre, the apparatus comprising, a first outlet for dispensing a volume of a first polyionic polymer solution; and a second outlet for dispensing a volume of a second oppositely charged polyionic polymer solution; said second outlet disposed adjacent to the first outlet such that the polymer solutions dispensed therefrom are capable of contacting each other to form a fused droplet comprising a polyelectrolyte complex interface separating the first polyionic and second polyionic polymer solutions; wherein the fused droplet is arranged to move along a fibre drawing path under gravitational force in an opposing direction from the first and second outlets such that nascent fibre is drawn from the polyelectrolyte complex interface. There is also provided a method of drawing the fibre.

Abstract: The disclosure refers to a photosensitive pixel structure that includes a substrate layer and an interface layer. The interface layer is provided at least partially on a first surface of the substrate layer and the interface layer at least partially includes a first material layer and the interface layer at least partially includes a second material layer covering the first material layer such that the first material layer is at least partially sandwiched between the second material layer and the substrate. The second material layer has a thickness chosen from a range of 200 nm-600 nm, 300 nm-500 nm, or 320 nm-450 nm. The disclosure further refers to an array and an implant that includes a pixel structure and a method for providing a pixel structure.

Abstract: The present disclosure relates to the field of rock soil detection and in particular to a multi-probe nuclear magnetic resonance (NMR) rock soil in-situ monitoring system, which includes a multi-probe component, a spectrograph component, an industrial control computer and a power cable. The multi-probe component includes a shell and multiple nuclear magnetic probes disposed inside the shell. The multiple nuclear magnetic probes are respectively located at the soil layers of different depths and have different measurement frequencies. The spectrograph component is used to transmit and receive NMR-measured radio frequency signals, the industrial control computer is used to transmit a measurement instruction and perform real-time processing on the measurement data, and the power cable is connected with the multiple nuclear magnetic probes, the spectrograph component and the industrial control computer to supply power and transmit the measurement data.

Abstract: The present disclosure relates to a static cone penetration test device. The device includes a housing, an optical window and a friction cylinder coaxially connected. Light sources are mounted in the optical window and a static cone penetration assembly is disposed in the friction cylinder to detect a resistance the device suffers when the device is pressed into soil. An optical fiber sensor, a wireless transceiver, a data processing chip and a power supply are disposed in the housing. The optical fiber sensor is used to receive the reflected light of a target object and output spatial position information and spectrum information. The wireless transceiver is used to upload test data and receive a control signal. The data processing chip is used to analyze the test data. The present disclosure has the advantages of compact structure, high spectral resolution, quick imaging speed, and strong immunity to interference.

Abstract: A speed bridge which provides high verification productivity in a hardware emulation system by allowing for time-efficient communication between a host/server and a device under test is disclosed. The speed bridge emulates the host to the device and the device to the host simultaneously while being in communication with both. When the message/response between the host and the device is fixed, the virtual host communicates with the virtual device. When the message/response requires physical interaction, the speed bridge passes the message/response between the host/server and the device.

Abstract: An electrocardiogram (ECG) signal classification method based on contrastive learning and multi-scale feature extraction are provided. A squeeze-and-excitation—residual networks with next-generation aggregated transformations—context-aware network (SE-ResNeXt-CAN) network model includes a shallow feature extraction module, a first squeeze-and-excitation residual module (SERM), a second SERM, a first context-aware residual module (CARM), and a second CARM. Through the combination and optimization of these modules, the SE-ResNeXt-CAN network model adaptively learns a correlation between channels, and expands a receptive field to fully capture a key feature, improving the performance and generalization ability of an ECG signal classification task.

Abstract: A biocompatible antimicrobial composition effective against microbial biofilms, including in vivo biofilms containing gram-positive bacteria, can be delivered to and used near the spinal column of vertebrates. Once introduced to an area colonized with a bacterial biofilm, particularly an intervertebral disc, the antimicrobial composition weakens the EPS/ECPS macromolecules of the biofilm, which makes the entire biofilm structure susceptible to being dislodged from the affected area or biosorbed. Additionally or alternatively, certain of the subcomponents of the solute component, as well as perhaps the organic liquid(s) of the solvent component, might lyse microbes, particularly gram-positive bacteria, previously protected by the EPS/ECPS macromolecules. Swelling of and around previously impacted intervertebral discs can be reduced or eliminated, often resulting in appreciable reductions in patient pain levels.

Abstract: A method of extracting chemical substances from used molding sand includes: preparing a mixture of used molding sand and liquid, wherein the used molding sand includes a sand material and at least one chemical substance; and cleaning the mixture via an ultrasonic cleaning process to separate and extract the at least one chemical substance from the sand material.