Abstract: The present invention relates to antagonist antibodies or fragments thereof that bind to human OX40. More specifically, the present invention relates to an antagonist antibody or fragment thereof that binds to human OX40 comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6.
Type:
Grant
Filed:
June 30, 2022
Date of Patent:
April 22, 2025
Assignee:
Ichnos Sciences SA
Inventors:
Antoine Attinger, Stanislas Blein, Jonathan Albert Back, Rami Lissilaa, Samuel Hou
Abstract: A method for directly preparing a trivalent chromium compound by electrochemical oxidation of ferrochrome is provided. The method includes: putting ferrochrome as an anode, and placing the anode into an electrolyte solution containing a complexing agent together with a cathode, then turning on a power supply for electrolysis reaction so that chromium and iron in ferrochrome are directly converted into free Cr3+ and Fe3+ respectively, allowing one of Cr3+ and fe3+ to form a stable soluble metal complex together with the complexing agent, and allowing the other of Cr3+ and Fe3+ to form a metal hydroxide solid together with OH? generated by electrolysis reaction, so as to obtain an electrolysis completion slurry. Compared with the prior art, the present application has no hexavalent chromium salt stage, thereby shortening the process flow and avoiding the generation of chromium-containing waste residue.
Type:
Grant
Filed:
April 23, 2023
Date of Patent:
April 22, 2025
Assignee:
QINGHAI INSTITUTE OF SALT LAKES, CHINESE ACADEMY OF SCIENCES
Inventors:
Bo Li, Haitao Feng, Yaping Dong, Zhengrong Niu, Wu Li
Abstract: Provided are an apparatus and method for honeycomb artifacts removal for removing honeycomb artifacts in images received from an optical fiber imaging device through a honeycomb artifact removal model. The honeycomb artifact removal apparatus according to an embodiment includes a control unit configured to create a training dataset, build the honeycomb artifact removal model with the created training data, remove a honeycomb artifact in an input image through the built honeycomb artifact removal model and output a corrected image, wherein the control unit is configured to perform preprocessing of a raw image, acquire a honeycomb artifact image through the optical fiber imaging device, and synthesize the preprocessed raw image with the honeycomb artifact image to generate a honeycomb artifact synthesized image, and the training dataset is created by mapping the honeycomb artifact synthesized image as input data and the preprocessed raw image as output data.
Type:
Grant
Filed:
May 11, 2022
Date of Patent:
April 22, 2025
Assignee:
Korea Institute of Science and Technology
Abstract: Methods provided by the present disclosure utilize extracorporeal shockwaves, mechanical impacts and/or principles of lithotripsy to break up a tissue sample into smaller fragments—clusters of cells and/or single cells—after which a desired cellular fraction can be isolated from the sample. Devices provided by the present disclosure deploy focused and/or directed shockwaves, and/or focused and directed mechanical impacts, to break apart a tissue sample. The devices maintain the sample in a sterile, closed environment during exposure to the shockwaves or mechanical impacts. Therefore, the shockwaves and/or mechanical impacts are generated outside of a closed device and are transmitted through one or more walls of the device into its interior, where the sample is located.
Abstract: The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.
Type:
Grant
Filed:
March 13, 2020
Date of Patent:
April 22, 2025
Assignees:
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, KAGOSHIMA UNIVERSITY, NAGASAKI UNIVERSITY
Abstract: One example method for improving robotic surgical safety via video processing includes identifying, during a robotic surgical procedure, one or more surgical tools using one or more images of the surgical procedure captured by a camera, the robotic surgical procedure employing a robotic surgical device controlling the one or more identified surgical tools; predicting, for at least one of the one or more images, one or more loaded surgical tools that are controlled by the robotic surgical device and should be in a field of view of the camera; comparing the one or more identified surgical tools with the one or more loaded surgical tools; determining that at least one of the one or more loaded surgical tools does not match any of the one or more identified surgical tools; and causing the at least one loaded tool of the robotic surgical device to be disabled.
Type:
Grant
Filed:
September 2, 2022
Date of Patent:
April 22, 2025
Assignee:
Verily Life Sciences LLC
Inventors:
Caitlin Donhowe, Joëlle Barral, Xing Jin
Abstract: A method analyzes global average grayscale change of tundish ink tracing experiment. The method includes the following steps: building a water model based on a prototype size and production parameters of a tundish; carrying out experiments by using the water model to obtain a video file of the ink tracing; processing the video file and extracting a characteristic curve of a global average grayscale changing with the time; analyzing the characteristic curve, and extracting a global peak grayscale time, a global tracer residual volume and a global emptying time as indicators for evaluating a tundish structure and flow characteristics of the tundish structure.
Type:
Grant
Filed:
July 26, 2024
Date of Patent:
April 22, 2025
Assignees:
North China University of Technology, University of Science and Technology Beijing
Abstract: A sequence time window amplitude-phase-frequency characteristics analysis method and system for underwater vehicle power frequency electromagnetic field disturbance are provided. The method includes: establishing a power grid dipole group model, emulating and calculating to obtain background field intensity data of a test location, and constructing an emulated background field database; acquiring measured background field data, comparing the emulated data with the measured data, and providing a relative error; calculating a background field intensity and underwater vehicle target disturbance under the action of the above dipole group, and establishing a measured target signal database; and performing actual measurement according to an underwater vehicle motion and detection topology, performing a Fourier transform and Fourier sliding window decomposition after acquiring original data, and acquiring an amplitude spectrum and a spectrogram of an underwater vehicle target disturbance signal.
Type:
Grant
Filed:
December 30, 2022
Date of Patent:
April 22, 2025
Assignee:
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Tianxu Zhang, Yuhai Lv, Jiawei Wang, Qinghui Zhang, Cheng Yang, Tao Zhang, Jiandong Tan
Abstract: A phosphor having a favorable emission peak wavelength, narrow full width at half maximum, and/or high emission intensity is provided. Additionally, a light-emitting device, an illumination device, an image display device, and/or an indicator lamp for a vehicle having favorable color rendering, color reproducibility and/or favorable conversion efficiency are provided. The present invention relates to a phosphor including a crystal phase having a composition represented by a specific formula, and having a minimum reflectance of 20% or more in a specific wavelength region, in which the specific wavelength region is from the emission peak wavelength of the phosphor to 800 nm, and a light-emitting device comprising the phosphor.
Type:
Grant
Filed:
December 4, 2023
Date of Patent:
April 22, 2025
Assignees:
Mitsubishi Chemical Corporation, NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Abstract: An antenna array has a plurality of square or rectangular antenna assemblies. Each assembly includes a first antenna assembly surface with a solar cell and a second antenna assembly with one or more antenna elements. The antenna assemblies are interconnected without gaps therebetween to form a first contiguous array surface comprised of the first antenna assembly surfaces and a second contiguous array surface comprised of the second antenna assembly surfaces. The antenna assemblies are connected together by mechanically stored-energy connectors, such as spring tape, that self-deploy the array in space without the use of electric energy.
Type:
Grant
Filed:
January 10, 2024
Date of Patent:
April 22, 2025
Assignee:
AST & Science, LLC
Inventors:
Avi Braun, Aitor Martinez De Osaba Fernandez, Javier Hernandez Bahlsen, Abel Avellan, Huiwen Yao, Adam H. Halperin, Mariano T. Gomez
Abstract: A system and method of additive manufacturing is disclosed herein which when run or performed form a product with a powder-based additive manufacturing device by adding sequential layers of material on top of one another. As each sequential layer of material is added, the system and method can include monitoring the sequential layer with a defect analysis subsystem to detect whether the sequential layer has any defects. For a detected defect, it can be determined whether defect correction is required. For a required defect correction, one or more correction parameters for the required defect correction can be identified; and a correction command including the one or more correction parameters can be sent to the additive manufacturing device, the correction command causing the additive manufacturing device to help correct the detected defect in the sequential layer according to the correction parameters prior to moving on to a next sequential layer.
Abstract: An azimuth ambiguity suppression method for a spaceborne SAR in spatially non-uniform sampling relates to the technical field of radars. The method includes the following steps: step 1: compensating for a phase difference between the channels according to the locations of transmitting and receiving stations for channel echoes; step 2: calculating an equivalent azimuth sampling location of each channel at the moment of each pulse transmission; step 3: sorting the equivalent azimuth sampling locations of all channels and their corresponding echoes after the phase difference between the channels is compensated in ascending order; and step 4: calculating reconstructed echoes from the sorted equivalent azimuth sampling locations and corresponding echoes after the phase difference between the channels is compensated, by using an adaptive weight-conjugate gradient-Toeplitz matrix (ACT) algorithm.
Type:
Grant
Filed:
November 27, 2024
Date of Patent:
April 22, 2025
Assignee:
Aerospace Information Research Institute, Chinese Academy of Sciences
Inventors:
Yu Wang, ZhiYuan Xue, Liang Li, YongHua Cai, Bo Li, YiJiang Nan, PingPing Lu
Abstract: Disclosed herein are modified zeolites and methods for making modified zeolites. In one or more embodiments disclosed herein, a modified zeolite may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may further include organometallic moieties each bonded to a nitrogen atom of a secondary amine functional group comprising a nitrogen atom and a hydrogen atom. The organometallic moieties may comprise a hafnium atom that is bonded to the nitrogen atom of the secondary amine functional group. The nitrogen atom of the secondary amine function group may bridge the hafnium atom of the organometallic moiety and a silicon atom of the microporous framework.
Type:
Grant
Filed:
July 27, 2023
Date of Patent:
April 22, 2025
Assignees:
Saudi Arabian Oil Company, King Abdullah University of Science and Technology
Inventors:
Robert Peter Hodgkins, Omer Refa Koseoglu, Jean-Marie Maurice Basset, Kuo-Wei Huang, Anissa Bendjeriou Sedjerari, Sathiyamoorthy Murugesan, Manoj K. Gangwar
Abstract: The present invention relates to the technical field of electrocatalytic electrode preparation, and discloses a lead dioxide-carbon nanotube adsorptive electrochemical submicroelectrode, a preparation method, and use thereof. The electrochemical submicroelectrode according to the present invention comprises multiple layers of orderly arranged spherical lead dioxide submicroholes communicating with each other, where the carbon nanotubes are partially or completely inserted (in the form of twigs) in the lead dioxide hole and in the wall of the hole. The combined effect of adsorption and catalysis inside the submicroreactor effectively solves the problems of low catalytic efficiency and diffusion control associated with the conventional flat lead dioxide electrode, thus greatly improving the electrochemical catalytic performance of the electrode.
Type:
Grant
Filed:
September 2, 2020
Date of Patent:
April 22, 2025
Assignee:
NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A flexible actuator for curved surfaces and a control method thereof is used for curved surfaces and generates high vibration using a relatively low voltage.
Type:
Grant
Filed:
October 17, 2022
Date of Patent:
April 22, 2025
Assignees:
HYUNDAI MOTOR COMPANY, KIA CORPORATION, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Kyoung Jin Chang, Dong Chul Park, Ki Uk Kyung, Hyun Woo Kim, Min Ki Kim, Jong Seok Nam, Ji Hyeong Ma