Patents Assigned to SCIENTIFIQUE (CNRS)
  • Patent number: 10161741
    Abstract: A method and a system for the optical detection, with hyperacuity, of a contrasted target, allowing the detection of the relative position of said target in relation to said detection system and therefore the acquisition and the pursuit of such a target. One or more embodiments is applicable to the field of autonomous robotic systems, especially for the positioning of drones or robots on a target.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: December 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX-MARSEILLE
    Inventors: Stephane Viollet, Franck Ruffier, Augustin Manecy, Julien Diperi
  • Patent number: 10159738
    Abstract: The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: December 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE VERSAILLES-SAINT QUENTIN EN YVELINES, UNIVERSITE PARIS-SUD
    Inventors: Ruxandra Gref, Valentina Agostoni, Samia Daoud-Mahammed, Violeta Rodriguez-Ruiz, Milo Malanga, Laszlo Jicsinszky, Patricia Horcajada-Cortes, Christian Serre
  • Publication number: 20180362550
    Abstract: The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I) : with X, Y and R1 as defined in claim 1, and to the salts thereof with an anion, the solvates and hydrates thereof; with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 20, 2018
    Applicants: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Oliver MAURY, Eric GIRARD, Sylvain ENGILBERGE, François RIOBE
  • Publication number: 20180361480
    Abstract: A method of fabricating an abradable coating of varying density, and such an abradable coating of varying density. According to the invention, the method comprises the following steps: providing a substrate (32) having a first portion with its surface situated at a first level (A), and a second portion with its surface situated at a second level (B) different from the first level; depositing a precursor material on the first and second portions of the substrate (32); compressing the precursor material between the substrate and a bearing surface; and sintering the precursor material as compressed in this way in order to obtain an abradable coating (36) having a first portion (36a) on the first portion of the substrate, and possessing a first density, and a second portion (36b) on the second portion of the substrate, and possessing a second density distinct from the first.
    Type: Application
    Filed: December 13, 2016
    Publication date: December 20, 2018
    Applicants: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
    Inventors: Philippe Charles Alain Le Biez, Geoffroy CHEVALLIER, Romain EPHERRE, Claude ESTOURNES, Jean-Baptiste MOTTIN, Serge Georges Vladimir SELEZNEFF
  • Patent number: 10155842
    Abstract: The present invention relates to a composition containing, besides a thermosetting resin of epoxy type and a hardener of anhydride type, at least one catalyst comprising an organometallic titanium complex. This composition enables the manufacture of vitrimer resins, that is to say resins that can be deformed in the thermoset state. It also relates to a kit for manufacturing this composition, an object obtained from this composition and a kit for manufacturing this object. Another subject of the invention relates to an organometallic titanium complex corresponding to the structure titanium bis(3-phenoxy-1,2-propane dioxide) (Ti(PPD)2), and the use thereof as vitrimer effect catalyst in systems based on epoxy resin and on hardener of anhydride type.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: December 18, 2018
    Assignees: ARKEMA FRANCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Christophe Duquenne, Sebastien-Jun Mougnier, Francois-Genes Tournilhac, Ludwik Leibler
  • Patent number: 10155054
    Abstract: The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: December 18, 2018
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Lafaye, Jean-Pierre Bourgeois, Francois Rougeon
  • Patent number: 10155065
    Abstract: The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: December 18, 2018
    Assignees: LABORATORIES URGO, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Xavier Coqueret, Sadananda Das, Stéphane Auguste
  • Patent number: 10157726
    Abstract: The invention relates to a cathodoluminescence detection system comprising: a collecting optic (112) collecting light radiation (108) from a sample illuminated by a beam of charged particles and reflecting said radiation (108) onto analysis means, said collecting optic (112) being placed in a chamber, called a vacuum chamber, wherein the pressure is below atmospheric pressure; and means (316) for adapting the light radiation, placed downstream of the collecting optic (112) and designed to adapt said light radiation (108) at the inlet of the analysis means. Said system is characterized in that all or part of the adapting means (316) is placed in an environment where the pressure is higher than the pressure in said vacuum chamber.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: December 18, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SUD 11
    Inventors: Mathieu Kociak, Luiz Fernando Zagonel, Marcel Tence, Stefano Mazzucco
  • Patent number: 10156514
    Abstract: A device for analyzing and/or generating a polarization state of a measurement point of a target object includes a polarizer suitable for selecting, in an incident light wave, a light beam which is linearly polarized in a predefined direction; a first birefringent element suitable for having the light beam pass therethrough; a second birefringent element identical to the first element and suitable for having the light beam pass therethrough, the light beam then being directly or indirectly directed toward the object in order to be reflected in the form of a reflected beam. The device includes an optical assembly having one or more optical elements located in an optical path between the first element and the second element, and the optical assembly includes an odd number of mirrors, or, an odd number of half-wave plates, or, an odd number of a mix of mirrors and half-wave plates.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: December 18, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Jihad Zallat, Marc Torzynski, Alex Lallement, Christian Heinrich
  • Patent number: 10155869
    Abstract: The invention concerns a compound formed by functionalized micro- or nanoparticles associated covalently with rheology-modifying polymers. The invention is characterized in that the functionalized micro- or nanoparticles are functionalized micro- or nanoparticles of cerium oxide (CeO2) having a nominal diameter of between 1 and 1500 nm. The rheology-adapting or -modifying polymers are selected from among non-associative or associative polymers. The invention is used in skin protection or decontamination.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: December 18, 2018
    Assignees: UNIVERSITE NICE SOPHIA ANTIPOLIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS
    Inventors: Sonia Amigoni, Denis Josse, Thierry Devers, Arnaud Zenerino, Frédéric Guittard, Elisabeth Taffin de Givenchy, Cécile Bignon
  • Patent number: 10155969
    Abstract: The present invention relates to a process for preparing a compound having the formula (I), said process comprising the following steps: a) the addition of an oxygen source into a solution of a compound of formula (II), in a water-miscible solvent, b) the addition of a laccase in the solution obtained after step a); and c) the possible recovering of the compound of formula (I) thus obtained.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: December 18, 2018
    Assignees: UNIVERSITE DE BORDEAUX, INSTITUTE POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
    Inventors: Stéphane Grelier, Henri Cramail, Audrey Llevot, Stéphane Carlotti, Etienne Grau
  • Publication number: 20180356706
    Abstract: According to an aspect, the present description concerns a frequency-tunable laser source comprising: a set of N elementary sources (101-k), each elementary source being suitable for emitting a beam at a given central frequency (fk); an optical coupler (12) for coupling the beams emitted by each of the elementary sources in order to form a multi-spectral incident beam (Bin) regrouping all the frequencies of the N elementary sources in a same optical beam; a beam splitter (15) for forming, from the incident beam (Bin), a first beam (B1) and a second beam (B2), each regrouping all the frequencies of the elementary sources; a first tunable filter (16) for selecting, from the first beam (B1), a third beam (B3) at a first frequency (F1); a second tunable filter (17) for selecting, from the second beam (B2), a fourth beam (B4) at a second frequency (); a nonlinear frequency doubling crystal (18) for generating, from the third beam at the first frequency (Fj), a fifth beam (B5) having a frequency (F2j) which is twic
    Type: Application
    Filed: March 23, 2016
    Publication date: December 13, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Observatoire de Paris
    Inventor: Mohand Ouali Acef
  • Patent number: 10154235
    Abstract: A device for displaying an image sequence in the form of a pixel matrix, includes a control unit coupled to a projector. The control unit includes an input interface designed to receive asynchronous information representing, for each pixel of the matrix, events concerning the pixel, and a processor designed to control the activation of each pixel of the matrix at moments determined by the respective events indicated by the asynchronous information for the pixel. The projector is disposed on a support so as to illuminate the light receptors of the eye when the device is in use and is designed to project a light flux corresponding to the pixels activated by the control unit.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: December 11, 2018
    Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Ryad Benosman, Guillaume Chenegros, Serge Picaud, Siohoi Ieng, Jose-Alain Sahel
  • Patent number: 10149810
    Abstract: The invention relates to a composition (C1) including: (a) at least one compound of formula (I) in which each of the radicals Z is a hydrogen atom or a monovalent radical (Z1); (b) at least one compound of formula (IV); (c) a compound of formula (V). The invention also relates to a method for preparing said composition and to the use thereof in cosmetics.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: December 11, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, 'ÉCOLE NATIONALE SUPÉRIEURE DE CHIMIE DE RENNES
    Inventors: Dimitri Perusse, Thierry Benvegnu, Jêrome Guilbot, Hervé Rolland
  • Patent number: 10149920
    Abstract: The disclosure relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising this material, to a method for producing such an implant, and to a method for producing a hybrid material. The implant material comprises a hybrid material comprising: a bioactive glass M based on SiO2 and CaO, optionally containing P2O5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in a solvent and chosen from among bioresorbable polysaccharides. The implant material has applications in the medical field.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: December 11, 2018
    Assignees: UNIVERSITE CLERMONT AUVERGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jonathan Claude Alexandre Lao, Joséphine Lacroix, Edouard Daniel Albert Jallot, Xavier Dieudonne
  • Publication number: 20180349671
    Abstract: The present invention is directed to a method for detection of microbial colonies on a surface, comprising the steps of obtaining one or a plurality of digital images I0, I1, I2, I3, I4 of the surface, said digital images I0, I1, I2, I3, I4 being represented by at least two-dimensional matrices of pixel values, calculating a statistical noise distribution based on at least one of the digital images I0, applying the statistical noise distribution calculated in the calculation step to the one or the plurality of digital images I0, I1, I2, I3, I4, and detecting an object of interest as a candidate for a microbial colony based on deviation of pixel values from the noise distribution.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 6, 2018
    Applicants: MERCK PATENT GMBH, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Marine BOUTHILLON, Luc FELDEN, Ola AHMAD, Christophe COLLET
  • Publication number: 20180346928
    Abstract: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo.
    Type: Application
    Filed: July 24, 2018
    Publication date: December 6, 2018
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Pierre CHARNEAU, Veronique ZENNOU, Francoise PFLUMIO, Aude SIRVEN, Anne DUBART KUPPERSCHMITT
  • Publication number: 20180346643
    Abstract: The invention relates to a process for controlling the structure of a block copolymer by selective copolymerization, by ring opening, of cyclic carbonate and lactone monomers in the presence of a catalyst based on methanesulfonic acid, the said process comprising a sequence of stages carried out strictly in the following order: a) dissolving the cyclic carbonate monomer in a nonchlorinated aromatic solvent, b) adding, to the monomer solution, a bifunctional initiator chosen from diols or water, c) adding methanesulfonic acid (MSA) as catalyst of the polymerization reaction, d) when all the cyclic carbonate has been consumed, a telechelic polycarbonate capable of acting as macroinitiator of polymerization of the lactone is obtained, e) adding the lactone to the reaction medium in order to selectively obtain a block copolymer.
    Type: Application
    Filed: November 29, 2016
    Publication date: December 6, 2018
    Applicants: ARKEMA FRANCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER (TOULOUSE III)
    Inventors: Christophe NAVARRO, Didier BOURISSOU, Blanca MARTIN-VACA, Aline COUFFIN, Franck KAYSER
  • Patent number: 10144192
    Abstract: A tape having a fully wound stable state and a fully unwound stable state, configured for space applications, the intermediate states between the fully wound state and the fully unwound state comprises a single continuous portion of wound tape with a first radius of curvature greater than a threshold value and a single continuous portion of unwound tape with a second radius of curvature less than the threshold value, the value of the second radius of curvature being continuous over the unwound portio; the tape comprises a stack comprising fibrous layers extending in a longitudinal direction, the resulting stack having symmetry with respect to a longitudinal plane of its fibres to compensate for torsional deformations generated by variations in temperature.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: December 4, 2018
    Assignees: THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, L'ECOLE CENTRALE DE MARSEILLE
    Inventors: François Guinot, Stéphane Vezain, Didier Stanek, Yannick Baudasse, Stéphane Bourgeois, Pernelle Marone-Hitz
  • Publication number: 20180339981
    Abstract: The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R? is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3) alkyl group.
    Type: Application
    Filed: July 31, 2018
    Publication date: November 29, 2018
    Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
    Inventors: Jamal TAZI, Florence MAHUTEAU, Romain NAJMAN, Didier SCHERRER, Julien SANTO