Abstract: A method for estimating a Remaining Useful Life of a subject equipment, with a preliminary phase including the following steps: acquire test observations (step 10) and produce test time series (Sx) of at least one signature; partition the test time series to obtain severity classes corresponding to the ageing phases of the test equipment devices (step 14); carry out an initial learning of a diagnosis model on the test equipment devices (step 45); perform a second learning of a signature prediction model (step 51). There is also an operational phase including the following steps: acquire observations when in operation on the subject equipment and produce an extrapolated time series using the prediction model; classify the extrapolated time series using the diagnosis model and derive the remaining useful life of the subject equipment.

Abstract: Disclosed is a device including a detector producing a signal depending on variations of the pupil diameter of an eye of a subject, a display for presenting, to the subject, a light pattern subdivided into a plurality of regions, and an analyzer receiving the signal of the detector and analyzing the frequential content thereof. The display is controlled such that each region has a light intensity modulated at a respective modulation frequency, the modulation frequencies being different from one region to the next.

Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).

Abstract: The present invention relates to antibodies having specificity for BTN2A and uses thereof, in particular for the treatment of cancer.

Abstract: A medical analysis device with cellular impedance signal processing features a memory arranged to receive pulse data sets, with each pulse data set including impedance value data that are associated each time with a time marker. The pulse data sets together represent a curve of cellular impedance values that are measured as a cell passes through a polarised opening. The device further includes a classifier in communication with the memory. The classifier may feature a convolutional neural network that receives the pulse data sets as input. The classifier is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

Abstract: A probe device for nanoscale thermal measurements including an insulating lever, a tip protruding from the insulating lever, a microstructured layer of Niobium Nitride (NbN) extending over only a part of the tip and covering an apex of the tip and/or covering at least one area adjoining the apex of the tip and/or covering, only partly, the insulating lever and at least two conductive leads extending from the insulating lever to the microstructured NbN layer.

Abstract: A method for genotyping a plasmodium comprising: (a) providing a sample containing a Plasmodium; and (b) detecting the presence of an increased copy number of the genomic plasmepsin2-3 cluster. A method for the detection of a plasmodium infection in a patient comprising: (a) providing a blood sample from a patient and (b) detecting the presence or absence of an increased copy number of the genomic plasmepsin2-3 cluster in the blood sample. Kits for genotyping a plasmodium and/or detection of a plasmodium infection. Methods of treating a plasmodium infection.

Abstract: A process for obtaining a nitride (N) layer preferably obtained from at least one of gallium (Ga), indium (In) and aluminium (Al), may include: on a stack including a substrate and at least the following layers successively disposed from the substrate: a creep layer having a glass transition temperature, Tglass transition, and a crystalline layer, forming pads by etching the stack so that each pad includes at least a creep segment formed by at least a portion of the creep layer, and a crystalline segment formed by the crystalline layer; and growing by epitaxy a crystallite on each of the pads and continuing the epitaxial growth of the crystallites so as to form the nitride layer. The epitaxial growth may be carried out at a temperature Tepitaxy, such that Tepitaxy?k1×Tglass transition, with k1 being 0.8.

Abstract: A method for diagnosing or prognosing, multiple sclerosis including the steps of (a) measuring the amount of at least one first protein as set forth in SEQ ID NO: 1, the at least first protein belonging to the group of proteins: a first protein, a second protein, a third protein, a fourth protein and a fifth protein, as set forth in SEQ ID NO 1 to 5, (b) comparing the amount of the at least first protein with the amount of the same protein in a control sample, and (c) determining the status of the biological sample.

Abstract: The present invention relates to the allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and sepsis but none of them have determined its impact on allergies and/or asthma which is a global health burden. Inventors have obtained preliminary data on wild-type (PCSK9+/+) or PCSK9-deficient mice (PCSK9?/?) and shown that, under basal condition and in the absence of a particular stimulus, PCSK9 deficiency significantly increases the percentage of regulatory T cells in the spleen, the mesenteric lymph nodes and Peyer's patches. Moreover, inventors have shown the effect of allergic challenge on primary human bronchial epithelial cells on PCSK9 expression and secretion. Very interestingly, their first results obtained by Q-PCR showed that HDM and LPS increase PCSK9 mRNA levels. Accordingly, the present invention relates to inhibitors of PCSK9 for use in the treatment of asthma and/or allergic disease, such as food allergy.

Abstract: A hook fusion protein, which includes a hook domain and at least one cytoplasmic carboxyl endoplasmic reticulum (ER) retention signal and/or at least one cytoplasmic amino terminal endoplasmic reticulum (ER) retention signal; wherein the hook fusion protein is a soluble protein that localizes in the cytoplasm. Also, a nucleic acid system for intracellular targeting control including a nucleic acid encoding a target fusion protein including a hook fusion protein, and a nucleic acid encoding a target fusion protein including a hook-binding domain; wherein the target fusion protein is a membrane protein; and wherein the hook fusion protein localizes in the ER when bound to the target fusion protein. Additionally, a vector system, viral particle system, host cell and kit include these nucleic acids. Further, the vector system, viral particle system, host cell or kit for use as a medicament, in particular for immunotherapy.

Abstract: The present invention relates to novel degradable branched-block copolymers, comprising a star-shaped copolymer central core or a linear copolymer central core, functionalized with photoreactive groups chosen among aryl-azide, (meth)acrylate or thiol groups. The present invention also relates to the use of these degradable branched-block copolymers as photo-crosslinkers to provide degradable photo-crosslinked elastomers as biomaterials suitable for medical and tissue engineering applications. A method for preparing a degradable photo-crosslinked polymer, preferably a degradable photo-crosslinked elastomer, starting from the branched-block copolymer of the invention via a shaping process and an irradiation step is also provided.

Abstract: Disclosed is a method for characterising an object, comprising: emission of ultrasonic waves that enter an object by passing through an external interface, then reflect off an internal interface, then exit the object by passing through the external interface again, the ultrasonic waves comprising first waves having a mode that varies according to a first variation during their propagation in the object, and second waves having a mode that varies according to a second variation during their propagation in the object; reception of echo signals comprising first signals representing echoes of the first waves, and second signals representing echoes of the second waves, construction of a plurality of images showing the object, the plurality of images being constructed from the echo signals, under the assumption that two characteristics of the object are equal to two candidate values, and comprising a first image constructed from the first signals, and a second constructed from the second signals; construction of a

Abstract: The invention relates to a chemical synthesis method, the said method comprising “Spray Flash Evaporation”, also commonly referred to by the corresponding initialism SFE, which comprises the chemical reaction of at least one first compound with at least one second compound, under conditions in which the first compound and the second compound react to form at least one third compound. The invention also relates to a device for implementing this method and the compounds obtained by this method.

Abstract: The invention relates to the field of molecular biology and particularly novel genes that encode pesticidal proteins useful for controlling pests, particularly plant pests. These proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal compositions and in the production of transgenic pest-resistant plants.

Abstract: The present description relates to an injectable emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to methods comprising administering such an injectable emulsion in, for example, ultrasound ablation surgery (FIG. 3).

Abstract: A method for tracking the activity of animals confined in a facility including at least one cage, a plurality of antennae arranged underneath the at least one cage, an RFID reader to which the plurality of antennae are connected, a computer capable of controlling transmission and reception by the RFID reader, and an RFID tag to be fitted to an animal confined in the cage, the method including that the following steps are carried out:—the animal is fitted with the tag,—the RFID reader generates the transmission of an electromagnetic wave at the plurality of antennae,—the RFID reader identifies which antenna(e) has/have received the response transmitted by the tag,—the computer analyses over a given period which antennae have received a signal transmitted by the tag, thus determining the consecutive positions of the animal.

Abstract: A method for producing nanostructures having a metal oxide shell, carried by a top face of a substrate whose greatest dimension is greater than or equal to 100 mm by MOCVD metalorganic chemical vapour deposition, including successive steps carried out in a reactor configured for MOCVD deposition of nucleation and growth. The nucleation step includes forming non-contiguous metal nuclei by depositing a metal by MOCVD using a metalorganic precursor on the top face of the substrate and oxidising the metal of the metal nuclei, to form oxidised nuclei and ensure stabilisation of the nuclei. The growth step includes depositing a metal by MOCVD using the metalorganic precursor, to form non-contiguous nanostructures by growth of the oxidised nanostructures, and oxidising the deposited metal of the nanostructures formed in the nucleation to form oxidised nanostructures.

Abstract: A method for processing a signal from a lidar including digitizing the amplified electrical signal (s0e(t)), applying at least one time correction function, referred to as the correcting filter (Ce(t)), to the digitizing amplified electrical signal in order to generate a processed signal (sf(t)), the correcting filter (Ce(t)) being determined based on the impulse response and a predetermined time analysis function, the analysis function having at least one non-zero value, referred to as the discontinuity, at a given time referred to as the discontinuity time, with a return to substantially zero values around the discontinuity; and determining a distance (di) of the at least one element (Ei) based on the processed signal.

Abstract: A quantum device includes several spin qubits arranged as a matrix and each comprising a quantum dot; several electrometers each electrostatically coupled to a potential well of one of the quantum dots; and circuits for applying an excitation signal to an input electrode of each electrometer. The circuits are configured such that a value of the frequency, phase or maximum amplitude of each excitation signal is different from that of the other excitation signals, and the circuits apply a same excitation signal on electrometers coupled to a same row of qubits. The device also includes a transimpedance amplifier having an input coupled to output electrodes of the electrometers and a demultiplexing circuit including an input electrically coupled to an output of the transimpedance amplifier and configured to demultiplex the output signals to be delivered by the electrometers.