Patents Assigned to SCIENTIFIQUE (CNRS)
  • BIOCOMPATIBLE OILY FERROFLUID AND PREPARATION PROCESS
    Publication number: 20230005647
    Abstract: The invention concerns a biocompatible oily ferrofluid comprising iron-oxide based magnetic nanoparticles and an oil phase comprising at least one fatty acid ester, characterized in that said magnetic nanoparticles are surface functionalized by molecules of one or more phospholipids, and in particular a biocompatible oily ferrofluid comprising iron-oxide based magnetic nanoparticles and an oil phase comprising at least one fatty acid ester, said iron-oxide based magnetic nanoparticles forming a colloidal dispersion in said oil phase from a temperature belonging to the range from 20 to 80° C.
    Type: Application
    Filed: November 26, 2020
    Publication date: January 5, 2023
    Applicants: UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX
    Inventors: Stéphane MORNET, Clément VECCO-GARDA, Sylvie CRAUSTE-MANCIET, Olivier SANDRE, Franck COUILLAUD, Pauline JEANJEAN, Coralie GENEVOIS
  • LUMINESCENT ZWITTERIONIC POLYMERIC NANOPARTICLES
    Publication number: 20230003727
    Abstract: Zwitterionic luminescent polymeric nanoparticles, which include at least one luminescent dye and at least one random copolymer, and the method of preparing the zwitterionic luminescent polymeric nanoparticles. Also, the use of these zwitterionic luminescent polymeric nanoparticles in the medical field and in the biological research field for in vitro or in vivo detection or tracking of a target biological molecule.
    Type: Application
    Filed: December 2, 2020
    Publication date: January 5, 2023
    Applicants: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Andrii KLYMCHENKO, Andreas REISCH, Anne RUNSER, Denis DUJARDIN
  • Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
    Patent number: 11541023
    Abstract: The invention relates to compounds exhibiting kallikrein inhibitory activity, and to compositions comprising at least one of these compounds for use in the treatment of diseases or disorders in which kallikrein activity is dysregulated, particularly neurodegenerative and inflammatory diseases.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: January 3, 2023
    Assignees: SARBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE, UNIVERSITÉ DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
    Inventors: Chahrazade El Amri, Feryel Soualmia, Nicolas Masurier, Sabrina Aït Amiri, Brahim Nait Oumesmar, Cyrille Deboux
  • CROSSLINKABLE ELECTROACTIVE FLUOROPOLYMERS COMPRISING PHOTOACTIVE GROUPS
    Publication number: 20220411550
    Abstract: A copolymer including fluorinated units of formula (I): —CX1X2—CX3X4—??(I) in which each of the X1, X2, X3 and X4 is independently chosen from H, F and alkyl groups including from 1 to 3 carbon atoms which are optionally partially or totally fluorinated; and fluorinated units of formula (II): —CX5X6—CX7Z—??(II) in which each of the X5, X6 and X7 is independently chosen from H, F and alkyl groups including from 1 to 3 carbon atoms which are optionally partially or totally fluorinated, and in which Z is a photoactive group of formula —Y—Ar—R, Y representing an oxygen atom or an NH group or a sulfur atom, Ar representing an aryl group, and R being a monodentate or bidentate group including from 1 to 30 carbon atoms. Also, a process for preparing this copolymer, a composition including this copolymer, and a film obtained from this copolymer.
    Type: Application
    Filed: December 16, 2019
    Publication date: December 29, 2022
    Applicants: ARKEMA FRANCE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Fabrice DOMINGUES DOS SANTOS, Thibaut SOULESTIN, Georges HADZIIOANNOU, Eric CLOUTET, Cyril BROCHON, Konstantinos KALLITSIS
  • METHOD FOR PREDICTING THE VIRULENCE AND PATHOGENICITY OF GRAM-NEGATIVE BACTERIAL STRAINS
    Publication number: 20220411846
    Abstract: A method for predicting the pathogenicity and virulence of a strain of Gram-negative bacteria of the Enterobacteriaceae family, wherein the amount of 2-hydroxymyristate and/or 2-hydroxymyristic acid present in the lipopolysaccharides of the bacteria is identified and measured, the amount of 2-hydroxymyristate and/or 2-hydroxymyristic acid is compared with a reference value, and wherein it is concluded that the strain is virulent if the amount of 2-hydroxymyristate is greater than the reference value. Also, the use of the 2-hydroxymyristic acid ester as a marker of pathogenicity and virulence of a Gram-negative bacterial strain and an in vitro diagnosis kit implementing this marker.
    Type: Application
    Filed: November 19, 2020
    Publication date: December 29, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SACLAY
    Inventors: Pierre TISSIERES, Luis AUGUSTO, Nadège BOURGEOIS-NICOLAOS, Richard CHABY, Aude BRETON, Florence DOUCET-POPULAIRE
  • KIT AND METHOD FOR CAPTURING A MOLECULE WITH MAGNETIC MEANS
    Publication number: 20220412969
    Abstract: A kit and a method for capturing a molecule contained in a sample utilizing at least one magnetic layer including a, possibly repeated, juxtaposition of at least one first and one second region, the first region including magnetic particles polarized in a first direction and the second region including magnetic particles that are non-polarized or polarized in a second direction different from the first direction of polarization of the magnetic particles of the first region, so as to generate a magnetic field having at least one variation in intensity of at least 0.1 mT at a distance of at least 1 ?m from the at least one magnetic layer, the variation defining a maximum of the standard of the intensity of the magnetic field and level therewith a zone for capturing magnetic nanoparticles on the capture support.
    Type: Application
    Filed: August 31, 2020
    Publication date: December 29, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Guillaume BLAIRE, Orphée CUGAT, Victor VIEILLE
  • RESONATING PATCH AND ACOUSTIC TREATMENT CELL PROVIDED WITH SUCH A PATCH
    Publication number: 20220412289
    Abstract: Resonating patch for acoustic treatment comprising a resonant plate, a transducer and an electrical circuit electrically connected to the transducer, the resonant plate comprising a peripheral strip extending along the perimeter of the resonant plate. The patch comprises cutouts together defining deformable lamellae having at least one end connected to the peripheral strip.
    Type: Application
    Filed: November 19, 2020
    Publication date: December 29, 2022
    Applicants: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DU MANS
    Inventors: Josselin David Florian REGNARD, Thibault ABILY, Stéphane Bernard DURAND
  • Acoustic tweezers
    Patent number: 11534761
    Abstract: Electroacoustic device that includes a body, an electrode to be electrically powered, named hot electrode, and an electrode to be electrically grounded, named ground electrode. The body includes a piezoelectric part or the electroacoustic device further including a piezoelectric part different from the body. The hot electrode includes a hot track spiraling around a spiral axis. The radial step between two consecutive coils of the hot track decreasing radially from the spiral axis. The hot electrode and the ground electrode are arranged on the piezoelectric part such as to define a wave transducer configured to generate a focalised ultrasonic vortex propagating in the body and/or, when a fluid medium is acoustically coupled with the electroacoustic device, in the fluid medium.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: December 27, 2022
    Assignees: UNIVERSITE DE LILLE, ECOLE CENTRALE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE
    Inventors: Michaël Aymeric Cyril Baudoin, Olivier Khalil Nizar Bou Matar-Lacaze, Antoine Jean-Pierre René Riaud, Jean-Louis Pierre Thomas
  • DEVICE AND METHOD FOR MACHINING A FAN BLADE
    Publication number: 20220403747
    Abstract: A method for removing a component fixed to an aeronautical part, the aeronautical part comprising a first material, and the component comprising a second material different from the first material, the method comprising steps of determining the thicknesses of the component as a function of the position on the component, and of removing the component by means of a pressurized water jet moving over the component as a function of the thicknesses determined in the determination step.
    Type: Application
    Filed: November 16, 2020
    Publication date: December 22, 2022
    Applicants: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PAUL SABATIER - TOULOUSE III
    Inventors: Mathieu Julien CHARLAS, Damien Bruno LAMOUCHE, Redouane ZITOUNE
  • Method for producing a pyrolytic carbon with predetermined microstructure
    Patent number: 11530166
    Abstract: A process for manufacturing pyrocarbon, includes forming pyrocarbon by a calefaction process from at least one C2 to C6 alcohol or polyalcohol precursor, the precursor being ethanol, rough laminar pyrocarbon being obtained by imposing a temperature of between 1250° C. and 1325° C. during calefaction.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 20, 2022
    Assignees: SAFRAN CERAMICS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Arnaud Delehouze, Amandine Lorriaux, Laurence Maille, Patrick David
  • Process for manufacturing a composite friction component
    Patent number: 11530727
    Abstract: A process for manufacturing a friction component made of composite material, includes the densification of a fibrous preform of carbon yarns by a matrix including at least pyrocarbon and at least one ZrOxCy phase, where 1?x?2 and 0?y?1, the matrix being formed by chemical vapor infiltration at least from a first gaseous precursor of pyrocarbon and a second gaseous precursor including zirconium, the second precursor being an alcohol or a C1 to C6 polyalcohol modified by linking the oxygen atom of at least one alcohol function to a group of formula —Zr—R3, the substituents R being identical or different, and R being selected from: —H, C1 to C5 carbon chains and halogen atoms.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: December 20, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN CERAMICS
    Inventors: Eric Bouillon, Arnaud Delehouze, Amandine Lorriaux, Laurence Maille
  • PROCESS FOR DELAYING AN OPTICAL SIGNAL
    Publication number: 20220397722
    Abstract: A process for delaying a useful optical signal (P1) having a wavelength value ? between 0.2 ?m and 3 ?m, with respect to a reference optical signal (P2) having the same wavelength value ?. The process includes having the useful optical signal propagate along a tapered fiber portion. A length of the tapered fiber portion can be varied using stretching means that are light, less cumbersome and less expensive compared to those necessary for a standard optical fiber. In addition, the delay value which is effective for the useful optical signal can be varied over a wide range. Such process can be useful for interferometry measurements in particular.
    Type: Application
    Filed: October 12, 2020
    Publication date: December 15, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE FRANCHE COMTE
    Inventors: Jean-Charles BEUGNOT, Jacques CHRETIEN, Adrien GODET
  • IRON-SCORE AND IN VITRO METHOD FOR IDENTIFYING MANTLE CELL LYMPHOMA (MCL) SUBJECTS AND THERAPEUTIC USES AND METHODS
    Publication number: 20220396840
    Abstract: The invention relates to the use of an iron-score based on the expression level of at least 1 gene, in particular at least 3, preferably at least 5, and even preferably 8 genes selected in the group consisting of APEX1, TFRC, HIF1A, ABCG2, SCARA3, IREB2, SFXN4 and SLC39A14 involved in the iron metabolism, as a prognosis marker in subjects having MCL, in particular for identifying subjects with a poor outcome such as a relapse and/or death.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 15, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITE DE MONTPELLIER, INSTITUT CURIE
    Inventors: Jérôme MOREAUX, Raphaël RODRIGUEZ, Julie DEVIN, Caroline BRET, Tatiana CANEQUE COBO
  • FLUORESCENT PROBE AND APPLICATIONS THEREOF
    Publication number: 20220390458
    Abstract: The invention relates a fluorescent compound of formula I: wherein A is selected from P, P?O and N; ·R1 is a residue comprising an oxygen atom·R2 is a residue comprising an oxygen atom, or a halogen, ·R3, R4 and R5 are alkyls, possibly substituted or a salt or a solvate thereof. The compound is useful as a fluorescent probe sensitive to membrane fluidity and for diagnosing cancer.
    Type: Application
    Filed: September 22, 2020
    Publication date: December 8, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CPE LYON FORMATION CONTINUE ET RECHERCHE pouvant être précédée ou suivie par CPE LYON FCR, CENTRE LEON BERARD, HOSPICES CIVILS DE LYON
    Inventors: Thierry GRANJON, Ofelia MANITI, Olivier MARCILLAT, Peter GOEKJIAN, Mouhedine CHENIOUR, Arnaud VIGNERON, David GUEYRARD, Sébastien IBANEZ
  • Probiotic composition making it possible to promote juvenile livestock growth
    Patent number: 11517029
    Abstract: The probiotic composition comprises at least one lactic acid bacteria strain, preferably Lactobacillus with intestinal tropism, for use in promoting juvenile growth in livestock, with stimulation of linear growth and/or of IGF-1 level. Exemplary lactic acid bacteria include Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus casei, Lactobacillus paracasei and Lactobacillus rhamnosus. The strains can be selected in a mouse model. The invention also relates to a probiotic treatment method using this composition.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: December 6, 2022
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Francois Leulier, Martin Schwarzer
  • Little invasive detector of ionising radiation
    Patent number: 11520059
    Abstract: A detector of high-energy (higher than 100 eV) ionising radiation, including an optical fibre having an outside diameter, called the fibre diameter, smaller than 250 microns, including a fibre core, a first cladding, called the useful cladding, encircling the fibre core and a second cladding, called the protective cladding, encircling the useful cladding, and a scintillating layer provided to convert the ionising radiation into light; including a portion, called the detecting portion, arranged in a length of the fibre and having a void formed in the protective cladding, in the useful cladding, and possibly in the fibre core, the scintillating layer being arranged in the void in contact with the useful cladding and the fibre core.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 6, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE FRANCHE-COMTE
    Inventor: Thierry Grosjean
  • Sol-gel method for producing an anti-corrosion coating on a metal substrate
    Patent number: 11519072
    Abstract: A sol-gel method for producing an anti-corrosion coating consisting of at least one layer of an oxide on a metal substrate. A non-aqueous solution of a precursor of the oxide is prepared and deposited on one surface at least of the metal substrate in order to cover said surface at least partially with a film comprising the precursor of the oxide. Hydrolysis-condensation of the precursor of the oxide is carried out by exposing the film to a humid atmosphere in order to form an oxide network in the film. Then, a treatment for stabilizing the film on the surface of the substrate is carried out, followed by a heat treatment of the surface of the metal substrate in order to crystallize the network of oxide and form the anti-corrosion coating.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 6, 2022
    Assignees: ELECTRICITE DE FRANCE, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, COLLEGE DE FRANCE
    Inventors: Adele Astorg, Xavier Crozes, Lionel Nicole, Clement Sanchez
  • Method for the nanoscale etching of a germanium-tin alloy (GeSn) for a FET transistor
    Patent number: 11515394
    Abstract: A method for the nanoscale etching of a layer of Ge1-xSnx on a carrier for a FET transistor, x being the concentration of tin in the GeSn alloy, the etching method includes a step of plasma-etching the layer of Ge1-xSnx using a mixture comprising dichlorine (Cl2) and dinitrogen (N2) and under an etching pressure lower than or equal to 50 mTorr, preferably lower than or equal to 10 mTorr. A method for producing a conduction channel on a carrier for a FET transistor, comprising a step of forming a layer of Ge1-xSnx on the carrier, the layer being produced by epitaxial growth, and a step of etching the layer of Ge1-xSnx according to the etching method. A conduction channel made of Ge1-xSnx for a FET transistor, the channel being obtained according to the production method, and a FET transistor comprising a plurality of conduction channels made of Ge1-xSnx.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: November 29, 2022
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Etienne Eustache, Bassem Salem, Jean-Michel Hartmann, Franck Bassani, Mohamed-Aymen Mahjoub
  • Leaky wave antenna in AFSIW technology
    Patent number: 11515637
    Abstract: Leaky wave antenna of AFSIW structure comprising a top substrate layer and a bottom substrate layer sandwiching an intermediate layer comprising a longitudinal aperture of length L defining a waveguide and whose width W1 is delimited by two conductive lateral walls. The inner faces of the conductive lateral walls are coated with a layer of dielectric material of thickness w(z). The top layer has a longitudinal radiating slot of width Wf (z) facing the longitudinal aperture of the intermediate layer. The thickness w(z) of the dielectric coating varies along the longitudinal axis z according to a given law, defined so as to obtain variations along the axis z of the amplitude Alpha(z) and of the phase Beta(z) of the leaky wave of the guide.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: November 29, 2022
    Assignees: THALES, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Anthony Ghiotto, Ryan Raimond, Thierry Mazeau
  • Process for producing capsules made of an external shell of crosslinked hydrogel surrounding a central core
    Patent number: 11511254
    Abstract: The invention relates to a process for producing a plurality of capsules, each comprising an external shell of crosslinked hydrogel surrounding a central core, according to which a hydrogel solution and a composition of interest, intended to form the central core, are concentrically co-extruded so as to form mixed drops, each comprising a layer of hydrogel solution surrounding a drop of liquid composition of interest, characterized in that the co-extrusion step is carried out above a crosslinking aerosol so that the mixed drops pass through said crosslinking aerosol, such that the layer of hydrogel solution at least partially crosslinks around the drop of liquid composition of interest on contact with said aerosol.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: November 29, 2022
    Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT D'OBTIQUE THÉORIQUE ET APPLIQUÉE
    Inventors: Maxime Feyeux, Kevin Alessandri, Pierre Nassoy