Patents Assigned to SCIENTIFIQUE (CNRS)
  • DEEP-LEARNING GENERATIVE MODEL
    Publication number: 20220101105
    Abstract: A computer-implemented method for training a deep-learning generative model configured to output 3D modeled objects each representing a mechanical part or an assembly of mechanical parts. The method comprises obtaining a dataset of 3D modeled objects and training the deep-learning generative model based on the dataset. The training includes minimization of a loss. The loss includes a term that penalizes, for each output respective 3D modeled object, one or more functional scores of the respective 3D modeled object. Each functional score measures an extent of non-respect of a respective functional descriptor among one or more functional descriptors, by the mechanical part or the assembly of mechanical parts. This forms an improved solution with respect to outputting 3D modeled objects each representing a mechanical part or an assembly of mechanical parts.
    Type: Application
    Filed: September 27, 2021
    Publication date: March 31, 2022
    Applicants: DASSAULT SYSTEMES, ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Mariem MEZGHANNI, Maks OVSJANIKOV, Malika BOULKENAFED
  • Detection system for an electronic nose and an electronic nose comprising such a system
    Patent number: 11287377
    Abstract: The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, the detection system comprises a plurality of cross-reactivity detection sensors (D1, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that the detection system further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. The detection system further relates to an electronic nose comprising such a detection system.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: March 29, 2022
    Assignees: ARYBALLE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITÉ GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Yanxia Hou-Broutin, Sophie Brenet, Thierry Livache, Cyril Herrier, Tristan Rousselle
  • Immune cells defective for Suv39h1
    Patent number: 11285176
    Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: March 29, 2022
    Assignees: INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Sebastian Amigorena, Eliane Piaggio, Christel Goudot, Luigia Pace, Genevieve Almouzni, Leticia Niborski
  • Methods for in vitro investigating mitochondrial replication dysfunction in a biological sample, kits and uses thereof, therapeutic methods against progeroid-like syndromes or symptoms and screening method for identifying particular protease inhibitor(s) and/or nitroso-redox stress scavenger compound(s)
    Patent number: 11287433
    Abstract: The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: March 29, 2022
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIOUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Laurent Arnaud Chatre, Miria Ricchetti, Alain Sarasin, Denis Biard
  • Communication network access point, communication network, and method of wireless communication
    Patent number: 11290231
    Abstract: A communication network includes an access point, a control unit in communication with the access point, a wave shaping device in communication with the control unit, and a wireless communication device. The control unit determines parameters of the wave shaping device, the parameters being search parameters if the control unit does not receive a pilot signal, and optimization parameters if the control unit receives a pilot signal.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 29, 2022
    Assignees: GREENERWAVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPRÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Geoffroy Lerosey, Mathias Fink, Fabrice Lemoult, Alexandre Aubry, Timmy Floume
  • 2- or 3-imidazolines as carbapenemases inhibitors
    Patent number: 11285133
    Abstract: The present application relates to novel 3-imidazolines of formula (I?) and (I) below: (I?) (I) Wherein Ar1, Ar2, Ar3, and R1 to R6 are as defined in the claims. The 3-imidazolines of the invention are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The present invention also concerns a method for preparing more specifically the 3-imidazolines of formula (I). The present invention further relates to conjugates of said compounds with known antibiotics.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: March 29, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS-SUD, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Kevin Cariou, Robert Dodd, Eugénie Romero, Mohamed Benchekroun, Bogdan Iorga, Thierry Naas, Saoussen Oueslati
  • OPTICAL PARTICLE DETECTOR AND METHOD OF MANUFACTURING THE SAME
    Publication number: 20220091018
    Abstract: An optical particle detector including at least one channel intended to receive a fluid carrying at least one particle, and across which light rays are intended to pass such that the light rays are partially scattered by the at least one particle, a plurality of photodetectors capable of receiving said scattered light rays, wherein the detector includes at least one optical waveguide configured to collect, at least at one entrance of the waveguide, light rays that were not scattered by the at least one particle and having crossed the channel, and to reinject the unscattered light rays into the channel through at least one exit of the waveguide.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 24, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON FORMATION CONTINUE ET RECHERCHE, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Salim BOUTAMI, Maryse FOURNIER, Gabriel JOBERT, Christian SEASSAL, Cécile JAMOIS
  • Plasmonic rectenna device and method of manufacturing
    Patent number: 11283304
    Abstract: A rectenna device (400) for converting incident light to electrical energy is disclosed. The rectenna device comprises a substrate (402), a first metallic layer (404) having a predefined thickness deposited on top of the substrate, a rectifying element (405) deposited on top of the first metallic layer, a second metallic layer (408) deposited on top of said rectifying element and configured to collect electromagnetic waves of the incident light and to couple it into plasmonic waves within the rectenna device, the second metallic layer comprising an array of a plurality of metallic patches (410) spaced from each other according to a predefined spacing, each metallic patch having predefined dimensions.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 22, 2022
    Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE DE TOULON
    Inventors: David Duche, Ludovic Escoubas, Ujwol Palanchoke, Jean-Jacques Simon, Teodor Silvius Balaban
  • Method for preparing a conductive, transparent and flexible membrane
    Patent number: 11279998
    Abstract: The technique relates to a method for preparing a nanomesh metal membrane 5 transferable on a very wide variety of supports of different types and shapes comprising at least one step of de-alloying 1 a thin layer 6 of a metal alloy deposited on a substrate 7, said method being characterized in that said thin layer 6 has a thickness less than 100 nm, and in that said de-alloying step 1 is carried out by exposing said thin layer 6 to an acid vapor in the gas phase 8, in order to form said nanomesh metal membrane 5.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: March 22, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Nantes University
    Inventors: Abdel-Aziz El Mel, Pierre-Yves Tessier, Adrien Chauvin
  • Compounds, functionalised dioxaborolane or dioxaborinane derivatives, method for preparing same and uses thereof
    Patent number: 11279717
    Abstract: The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R?3 or R4 is a radical of formula —X; or one of R1, R2, R3, R?3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 22, 2022
    Assignees: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Ludwik Leibler, Renaud Nicolay
  • Use of a vinylidene fluoride copolymer for providing a film with properties of adhesion
    Patent number: 11279782
    Abstract: The present invention relates to the use of a fluorinated copolymer in the manufacture of a solid polymer film, to give said film properties of adhesion to a metal surface or to glass. It also relates to a process for improving the adhesion of a fluoropolymer to a metal, polymer or glassy substrate, and also to a composite part comprising a solid polymer film in direct contact with at least one metal or glassy element.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: March 22, 2022
    Assignees: ARKEMA FRANCE, UNIVERSITÉ DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Thierry Lannuzel, Fabrice Domingues Dos Santos, Vincent Ladmiral, Thibaut Soulestin, Bruno Ameduri
  • Crystallisation of amorphous silicon from a silicon-rich aluminium substrate
    Patent number: 11282978
    Abstract: The invention relates to a method for manufacturing a semiconductor component comprising a thin layer of crystalline silicon on a substrate, comprising the steps of: providing a silicon-rich aluminum substrate (S0), depositing a thin layer of amorphous silicon on the substrate (S1), and applying thermal annealing (S2) to the thin layer of amorphous silicon to obtain a thin layer of crystalline silicon on the substrate.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 22, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG
    Inventors: Abdelilah Slaoui, Pierre Bellanger, Alexander Ulyashin, Freddy Syvertsen
  • Liquid hydrocarbon copolymers having two cyclocarbonate ether end groups
    Patent number: 11279786
    Abstract: 1) Hydrocarbon-based copolymer comprising two end groups preceded by an ether function and chosen from a 2-oxo-1,3-dioxolan-4-yl (or cyclocarbonate), a dithiocyclocarbonate, and a 2-oxo-1,3-dioxolen-4-yl, the main chain of which comprises units (I) and (II) in which R0 is notably a methyl radical; and the number-average molecular mass Mn of which is between 400 and 100 000 g/mol. 2) Process for preparing said copolymer, comprising: (i) a step of heating a statistical bipolymer A chosen from a poly(butadiene-isoprene), a poly(butadiene-myrcene) and a poly(butadiene-farnesene); and then (ii) a step of heating the product formed, in the presence of a chain-transfer agent. 3) Use as adhesive, as a mixture with an amine compound comprising at least two amine groups.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: March 22, 2022
    Assignees: BOSTIK SA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
    Inventors: Guillaume Michaud, Stephane Fouquay, Frederic Simon, Sophie Guillaume, Jean-Francois Carpentier, Cyril Chauveau
  • RAAV with chemically modified capsid
    Patent number: 11278631
    Abstract: The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: March 22, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE NANTES, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
  • Use of a cyclic tripeptide for improving cellular energy metabolism
    Patent number: 11278589
    Abstract: The present invention relates to the use of a cyclic peptide comprising the tripeptide reproducing a binding site of fertilin beta to the oocyte integrin, for improving cellular energy metabolism. More particularly, the invention concerns the use of a cyclic peptide comprising the tripeptide FEEc for stimulating the energy metabolism of gametes or embryonic cells in the context of medically assisted procreation (MAP) protocols, in particular promoting the in vitro maturation of the oocyte, the fertilization rate and the birth rate.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: March 22, 2022
    Assignees: ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Philippe Wolf, Anne Lombes, Morgane Bomsel
  • In situ preparation of cyano-bridged metal nanoparticles within a biocompatible reverse micellar system
    Patent number: 11278568
    Abstract: The present invention relates to a method for in situ preparation of cyano-bridged coordination polymers as metal nanoparticles within a biocompatible reverse micellar system by mixing at least two reverse micellar systems, each one containing at least one metal salt precursor. The invention also relates to the stabilization of theses nanoparticles by using a biocompatible reverse micellar system. This system takes part of the synthesis as a nanoreactor which comprises at least an acylglycerol, a sterol, lecithin, ethanol and water for the preparation of stable cyano-bridged metal nanoparticles without any use of additional stabilizer agent.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: March 22, 2022
    Assignees: MEDESIS PHARMA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER
    Inventors: Jean-Claude Maurel, Elsa Compte, Cyril Lavaud, Yannick Guari, Joulia Guari, Jérôme Long
  • SYSTEM AND METHOD TO MEASURE AND MONITOR NEURODEGENERATION
    Publication number: 20220079507
    Abstract: A system to measure and monitor neurodegeneration of a subject, which includes: an acquisition module configured to acquire electroencephalographic signals with multiple EEG channels from a subject perceptually isolated; a calculation module configured to extract at least one EEG metric representative of neurodegeneration; and an evaluation module configured to evaluate the at least one EEG metric and extract a neurodegeneration index.
    Type: Application
    Filed: December 20, 2019
    Publication date: March 17, 2022
    Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITÉ
    Inventors: Stephane EPELBAUM, Sinead GAUBERT, Federico RAIMONDO, Jacobo D SITT, Lionel NACCACHE
  • ORGANIC ELECTROCHEMICAL TRANSISTOR HAVING AN IMPROVED CONDUCTIVE CHANNEL
    Publication number: 20220085309
    Abstract: An organic electrochemical device including a substrate on which a source and drain are located, a gate electrode, and either a conductive channel of at least one organic conductive track or a conductive channel including at least one organic conductive track. Also, a method of manufacturing the organic electrochemical device.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 17, 2022
    Applicants: VALOTEC, UNIVERSITÉ DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Dany CAPITAO, Antoine MAURIN, Vincent NOËL, Giorgio MATTANA, Benoît PIRO, Caroline ABREU
  • ANTENNA WITH IMPROVED COVERAGE OVER A WIDER FREQUENCY BAND
    Publication number: 20220085500
    Abstract: The invention relates to an antenna comprising a radiative antenna element able to emit a signal in at least two disjoint frequency bands and a waveguide covered by the radiative antenna element, comprising two nested resonant cavities, each single-mode or mostly single-mode in a separate frequency band.
    Type: Application
    Filed: September 3, 2021
    Publication date: March 17, 2022
    Applicants: ARIANEGROUP SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
    Inventors: Nicolas ATTAJA, Mauro ETTORRE, Ronan SAULEAU, Davy GUIHARD
  • Method for producing a multicolour optoelectronic device comprising multiple photoactive materials and optoelectronic device thus produced
    Patent number: 11277095
    Abstract: A method for producing a multicoloured optoelectronic device is provided as well as a device produced with that method. An electrically conducting substrate including a first and second portion adjacent to the first portion is obtained. Then a first photoactive material having optical properties in a first frequency range is deposited on the first portion and a second photoactive material differing from the first photoactive material having optical properties in a second frequency range is deposited on the second portion, the first photoactive material contacting the second photoactive material, forming a photoactive layer of the multicoloured optoelectronic device.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: March 15, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX-MARSEILLE
    Inventors: Jörg Ackermann, Sadok Ben Dkhil, Olivier Margeat, David Duché, Ludovic Escoubas, Jean-Jacques Simon, Christine Videlot-Ackermann