Patents Assigned to SCIENTIFIQUE (CNRS)
  • Patent number: 11236132
    Abstract: The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: February 1, 2022
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lorène Belval, Gérard Demangeat, Caroline Hemmer, Christophe Ritzenthaler
  • Publication number: 20220023324
    Abstract: A compound of Formula (I): or anyone of its metabolites or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein each R is independently hydrogen, halogen, —CN, hydroxyl, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, (C3-C6)cycloalkyl, —NO2, —NR1R2, (C1-C4)alkoxy, phenoxy, —NR1—SO2—NR1R2, —NR1—SO2—R1, —NR1—C(?O)—R1, —NR1—C(?O)—NR1R2, —SO2—NR1R2, —SO3H, —O—SO2—OR3, —O—P(?O)—(OR3)(OR4), —O—CH2—COOR3, (C1-C3)alkyl; each R? is independently hydrogen, (C1-C3)alkyl, hydroxyl, halogen, —NO2, —NR1R2, morpholinyl, morpholino, N-methylpiperazinyl, (C1-C3)fluoroalkyl, (C1-C4)alkoxy, —O—P(?O)—(OR3)(OR4), —CN, a —NH—SO2—N(CH3)2 group, or other groups and further relates to A compound of formula (IV): or a pharmaceutically acceptable salt thereof, for use for treating and/or preventing an inflammatory disease, disorder or condition, wherein V, Z, R, R?, n, and n? are as described above.
    Type: Application
    Filed: December 19, 2019
    Publication date: January 27, 2022
    Applicants: ABIVAX, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Philippe POULETTY, Hartmut EHRLICH, Didier SCHERRER, Jamal TAZI
  • Publication number: 20220028574
    Abstract: The invention relates to an electrically insulating composite material (1) comprising a polyepoxide matrix (2) of cycloaliphatic type or of diglycidyl ether type in a content of less than 40% by mass, from 20 to 75% by mass of one or several micrometric and/or mesometric filler(s) (3), and from 0.1 to 20% by mass of at least one ionic liquid (4), the masses being expressed relative to the total mass of the electrically insulating composite material (1). The invention also relates to a method for manufacturing such an electrically insulating composite material (1), as well as its use for an electrically insulating support (9) in a metal-enclosed substation (5).
    Type: Application
    Filed: December 27, 2019
    Publication date: January 27, 2022
    Applicants: SUPERGRID INSTITUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE JEAN MONNET SAINT ETIENNE
    Inventors: Thibaut LEFORT, Damien BACHELLERIE, Sébastien PRUVOST, Jannick DUCHET, Sébastien LIVI
  • Patent number: 11229356
    Abstract: Evaluation of the perception of colors by mammals with a view to obtaining a characteristic biomarker of each tested subject takes advantage of the slow pupillary oscillatory response to generate an objective neurological signature of this perception of colors. A method based on pupil frequency tagging is used at a tagging frequency Ftag adapted to the pupil response speed. A dynamic two-color stimulus is displayed, this stimulus comprising a two-color pattern the colors of which are inverted at the frequency Ftag, one of the colors gradually varying in a range of possible values. From the pupillary response, a signal representative of the oscillation power of the pupil is generated. The minimum of this signal corresponds to the relative iso-luminance of the tested pair of colors.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: January 25, 2022
    Assignees: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM), CENTRE NATIONAL DE LA RACHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP), SORBONNE UNIVERSITE
    Inventors: Pierre Pouget, Pierre Daye, Jean Lorenceau
  • Patent number: 11229691
    Abstract: The invention relates to vaccine compositions for treating and/or preventing infections by a bacterium of the Chlamydiaceae family, said compositions comprising bacteria of the Chlamydiaceae family, which have been previously treated by at least one peptidoglycan inhibitor, or extracts of said treated bacteria.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: January 25, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DIDEROT PARIS 7, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Philippe Verbeke, Colette Kanellopoulos
  • Patent number: 11229597
    Abstract: The present invention relates to a novel pharmaceutical composition comprising doxycycline for topical application, in particular to the eye and eyelids. The invention also relates to this topical composition for use in the treatment of bacterial infections of the skin and mucous membranes.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 25, 2022
    Assignees: HORUS PHARMA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marion Dubald, Sandrine Bourgeois, Hatem Fessi, Martine Claret
  • Patent number: 11232894
    Abstract: Disclosed is a method for generating, from a first electric current having a first frequency, a plurality of second currents each having a second respective frequency component, the method including the following steps: supplying a frequency distributor including a first set of pillars including a layer made from a first magnetic material and having a resonance frequency; exciting each pillar of the first set with an electromagnetic field having the first frequency, the ratio between twice the resonance frequency of each pillar of the first set and the first frequency being equal, to within ten percent, to a first natural integer; and generating, by each pillar of the first set, a second frequency component in the second respective current.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: January 25, 2022
    Assignees: THALES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Paolo Bortolotti, Julien Kermorvant, Vincent Cros, Bruno Marcilhac, Romain Lebrun
  • Publication number: 20220016068
    Abstract: Compounds of general formula: wherein R0A and R0B are independently selected from hydrogen and pharmaceutically acceptable cations; and RA and RB are identical and selected from amide, carbamate, sulphonamide, azido, cyano and halide. Also, a pharmaceutical composition including one of the compounds. The composition may also include another active ingredient, especially an antineoplastic agent. Further a compound or a composition for use as a medicament, especially a compound or a composition for use in the treatment of a proliferative disease such as for example cancer.
    Type: Application
    Filed: November 22, 2019
    Publication date: January 20, 2022
    Applicants: UNIVERSITÉ DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DU MANS
    Inventors: Fabrice FLEURY, Alexandre DEMEYER, Pierre WEIGEL, Benoit CHENAIS, Monique MATHÉ, Jacques LEBRETON
  • Patent number: 11224386
    Abstract: A method for determining a configuration setting of a source of ionizing radiation reducing a radiation dose absorbed by a patient and a practitioner in a medical operating room during a procedure. Prior to the procedure a database of maps of simulated propagation and scattering of ionizing radiation in a model of the medical operating room is obtained for different configuration settings. During the procedure, a position of the practitioner is determined. After determining a set of configuration settings of the source enabling the production of an image of a target anatomical structure a radiation dose absorbed by the patient and the practitioner is determined using the maps from the database. A recommended configuration setting for which a combined radiation dose is reduced is then outputted.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: January 18, 2022
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS-
    Inventors: Nicolas Padoy, Nicolas Loy Rodas, Michel de Mathelin, Julien Bert, Dimitris Visvikis
  • Patent number: 11226424
    Abstract: The invention is a method applicable to oil and gas exploration and exploitation for automatically detecting geological objects belonging to a given type of geological object in a seismic image, on a basis of a priori probabilities of belonging to a type of geological object assigned to each of samples of the image to be interpreted. The image is transformed into seismic attributes applied beforehand, followed by a classification method. For each of the classes, an a posteriori probability of belonging to a type of geological object is determined for each of the samples of the class according to the a priori probabilities, of the class, of belonging, and according to a parameter ? describing a confidence in the a priori probabilities of belonging. Based on the class of the sample, the determined a posteriori probability of belonging to a type of geological object is assigned for the samples of the class.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: January 18, 2022
    Assignees: IFP ENERGIES NOUVELLES, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITY
    Inventors: Pauline Le Bouteiller, Jean Charlety
  • Patent number: 11225601
    Abstract: For applications in the fields of organic electronics and photonics, disclosed are fluorescent charge-transfer compounds emitting in the visible spectral range from blue to red, including a triarylamine moiety, an electron-withdrawing group and at least two photopolymerizable groups. Also disclosed is a method for manufacturing a film-forming and photo-crosslinkable composition including at least one compound of the invention and its use as a precursor of a photocrosslinked emissive layer.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: January 18, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (CEA), UNIVERSITE DE NANTES
    Inventors: Elena Ishow, Simon Olivier, Tony Maindron, Bernard Geffroy
  • Patent number: 11226343
    Abstract: The present invention relates to methods and kits for diagnosing a postoperative pulmonary infection in a patient who underwent surgery. More particularly, the present invention relates to a method for diagnosing a postoperative pulmonary infection in a patient who underwent surgery, comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said patient, at a time point comprised between 3 h and 30 h after surgery.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: January 18, 2022
    Assignees: BIOTHELIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LE RECHERCHE MEDICAL), INSTITUT PASTEUR DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE DE LILLE
    Inventors: Philippe Lasalle, Sidney Chocron, Nathalie De Freitas Caires
  • Patent number: 11226288
    Abstract: A device for measuring a matter flux, including: at least one first light source to emit a first light beam having a measurement wavelength corresponding to the absorption wavelength of an element of interest of the matter flux; an optical connector; and a light sensor to receive, via the optical connector: an attenuated beam resulting from a transmission of the first light beam through the matter flux; and a non-attenuated beam resulting from a transmission of the first light beam without passing through the matter flux. The light sensor is one-dimensional and the optical connector is positioned relative to the light sensor so that the center of the optical connector is aligned with the center of the light sensor, the non-attenuated beam is spectrally directed towards a first part of the light sensor and the attenuated beam is spectrally directed towards a second part of the light sensor.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: January 18, 2022
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Alexandre Arnoult
  • Patent number: 11225481
    Abstract: This invention relates to xanthine derivative compounds that are inhibitors of BET bromodomains proteins, the method of preparation thereof and applications thereof.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 18, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES
    Inventors: Xavier Morelli, Sébastien Combes, Jean-Claude Guillemot, Stéphanie Betzi, Yves Collette, Philippe Roche, Adrien Lugari, Sabine Milhas, Brigitt Raux, Iuliia Voitovich
  • Publication number: 20220013772
    Abstract: A positive electrode active material for a sodium-ion battery has the following formula: NaxNi0.5-yCuyMn0.5-zTizO2, in which: -x varies from 0.9 to 1; -y varies from 0.05 to 0.1; -z varies from 0.1 to 0.3. When z is equal to 0.1 and x is equal to 1, then y is not equal to 0.05.
    Type: Application
    Filed: October 10, 2019
    Publication date: January 13, 2022
    Applicants: RENAULT s.a.s., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), COLLEGE DE FRANCE, SORBONNE UNIVERSITE
    Inventors: Mohamed CHAKIR, Sathiya MARIYAPPAN, Jean-Marie TARASCON, Qing WANG
  • Patent number: 11220527
    Abstract: Disclosed are new peptides derived from the neurotensin receptor 3 (NTSR3), and to their use, particularly in the treatment of various diseases, especially depression.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: January 11, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS
    Inventors: Jean Mazella, Marc Borsotto, Catherine Heurteaux, Alaeddine Djillani, Sébastien Moreno, Mariel Pietri
  • Patent number: 11219901
    Abstract: The invention concerns a robotic method for coating the bottom surface of at least one well of a multiwell plate by a polyelectrolyte multilayer film, the multiwell plate obtainable according to the method and the use thereof for cell culture.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 11, 2022
    Assignees: INSTITUT POLYTECHNIQUE DE GRENOBLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Catherine Cécile Picart, Jie Liu, Fabien Dalonneau, Paul Machillot
  • Patent number: 11220482
    Abstract: The present invention is directed to novel compounds of Formula (I): pharmaceutically acceptable salts or solvates thereof, and their use, in particular in the treatment or prevention of malaria.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: January 11, 2022
    Assignees: UNIVERSITE AMIENS PICARDIE JULES VERNE, CENTRE HOSPITALIER UNIVERSITAIRE D'AMIENS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
    Inventors: Pascal Sonnet, Alexandra Dassonville-Klimpt, Guillaume Bentzinger, Catherine Mullie-Demailly, Patrice Agnamey
  • Publication number: 20220000967
    Abstract: The disclosure relates to TSP-1-derived peptides capable of inducing immunogenic cell death, in particular immunogenic cancer cell death. It further relates to uses of such peptides, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 6, 2022
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Philippe KAROYAN, Ana Carolina MARTINEZ TORRES, Maria Cristina RODRIGUEZ PADILLA
  • Publication number: 20220000454
    Abstract: This system for real-time localization of a millimetric or submillimetric object, such as a microrobot, in a viscoelastic medium, in particular in an organ of a subject such as a brain, a liver or a pancreas, includes: at least one bubble configured to be attached to said object, the or each bubble having a hermetic envelope filled with a gas; at least one ultrasound transducer configured to emit initial ultrasound signals and to detect deflected ultrasound signals deflected at the surface of the bubble(s); a processing unit in communication with the ultrasound transducers and configured to generate localization data of the object from localization data of the bubble(s) based on the deflected ultrasound signals detected by the ultrasound transducers.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 6, 2022
    Applicants: ROBEAUTE, SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Bertrand DUPLAT, Quentin FRANCOIS, Sinan HALIYO, Régis MARCHIANO, Stéphane REGNIER