Patents Assigned to SCIENTIFIQUE (CNRS)
  • Patent number: 11274160
    Abstract: The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 15, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale, INSTITUT JEAN PAOLI & IRENE CALETTES, CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE
    Inventor: Marc Lopez
  • Patent number: 11274127
    Abstract: An engineered adenovirus penton base protomer, wherein the penton base protomer comprises a first RGD-loop, a second RGD-loop, a variable loop (V loop), an Adenovirus fiber protein binding cleft, and an N-terminal domain; wherein at least one of the first RGD-loop, the second RGD-loop, and the V loop comprises at least one inserted non-adenoviral antigenic polypeptide; and wherein the engineered adenovirus penton base protomer is capable of assembling into virus-like particles (VLPs).
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: March 15, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), THE EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Imre Berger, Frédéric Garzoni, Pascal Fender
  • Publication number: 20220073663
    Abstract: A copolymer including fluorinated units of formula (I): —CX1X2—CX3X4—??(I) in which each of the X1, X2, X3 and X4 is independently chosen from H, F and alkyl groups including from 1 to 3 carbon atoms which are optionally partially or totally fluorinated; and units of formula (III): —CXAXB—CXCZ—??(III) in which each of the XA, XB and XC is independently chosen from H, F and alkyl groups including from 1 to 3 carbon atoms which are optionally partially or totally fluorinated, and Z being a polarizable group of formula —Y—Ar—R; Y representing an O atom or an S atom or an NH group, Ar representing an aryl group, and R being a monodentate or bidentate group including from 1 to 30 carbon atoms; and the copolymer having a heat of fusion of greater than or equal to 5 J/g. Also a process, a composition, an ink and a film.
    Type: Application
    Filed: December 16, 2019
    Publication date: March 10, 2022
    Applicants: ARKEMA FRANCE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Fabrice DOMINGUES DOS SANTOS, Thibaut SOULESTIN, Georges HADZIIOANNOU, Eric CLOUTET, Cyril BROCHON, Konstantinos KALLITSIS
  • Publication number: 20220071985
    Abstract: A compound of formula (Ib?) or anyone of its metabolites or a pharmaceutically acceptable salt thereof for use for treating and/or preventing cancer and/or dysplasia wherein R is independently hydrogen, halogen, —CN, hydroxyl, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, (C3-C6)cycloalkyl, —NO2, —NR1R2, (C1-C4)alkoxy, phenoxy, —NR1—SO2—NR1R2, —NR1—SO2—R1, —NR1—C(?O)—R1, —NR1—C(?O)—NR1R2, —SO2—NR1 R2, —SO3H, —O— SO2—OR3, —O—P(?O)(OR3)(OR4), —O—CH2—COOR3, (C1-C3)alkyl, said alkyl being optionally mono- or di-substituted by a hydroxyl group, a -A-(CH2)m—B—NRaRb group, or a —(O—CH2—CH2)p—O—Ra group. The present disclosure also relates to a compound of formula (IVb?) or a pharmaceutically acceptable salt thereof for use for treating and/or preventing cancer and/or dysplasia.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 10, 2022
    Applicants: ABIVAX, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Philippe POULETTY, Hartmut EHRLICH, Didier SCHERRER, Jamal TAZI
  • Publication number: 20220077379
    Abstract: The piezoelectric device includes a first electrode, a second electrode, piezoelectric elongate nano-objects in contact with the first electrode, and extending between the first electrode and the second electrode, a first layer of an electrically-insulating first material, the first layer surrounding a first longitudinal portion of each of the piezoelectric elongate nano-objects, a second layer of an electrically-insulating second material, the second layer surrounding a second longitudinal portion of each of the piezoelectric elongate nano-objects. The first layer is arranged between the first electrode and the second layer. The thickness of the first layer is strictly smaller than the thickness of the second layer. The first material has a Young's modulus strictly higher than the Young's modulus of the second material.
    Type: Application
    Filed: September 7, 2021
    Publication date: March 10, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Clément LAUSECKER, Xavier BAILLIN, Vincent CONSONNI, Bassem SALEM
  • Patent number: 11270808
    Abstract: A spectral selection component for XUV radiation comprises a first multilayer mirror for receiving an XUV radiation beam along an input axis located in a first plane of incidence. The spectral selection component comprises a second multilayer mirror for receiving, in a second plane of incidence, an XUV radiation beam reflected by the first mirror in order to transmit the radiation to an output axis of the spectral selection component. One of the first and second mirrors has a first, high-pass energy spectral response, with a flank on the low-energy side with a steepness that is greater than 0.1 eV?1, whereas the other mirror has a second, low-pass energy spectral response, with a flank on the high-energy side with a steepness that is greater than 0.1 eV?1. The first and second mirrors may have an only partial overlap in their spectral energy responses.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: March 8, 2022
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Franck Delmotte, Maël Dehlinger
  • Patent number: 11267947
    Abstract: A method for modifying a cellular polymer foam with apparent porosity, which includes providing a cellular polymer foam with apparent porosity, placing the cellular polymer foam in contact with at least one compound in order to obtain a cellular polymer foam including on the surface thereof an intermediate phase formed from the compound having at least one catechol unit. The foam may be used as a catalyst substrate.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: March 8, 2022
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: David Edouard, Vincent Ritleng, Loïc Jierry, Nguyet Trang Thanh Chau Dalencon
  • Patent number: 11266754
    Abstract: Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1?, R2, R2?, R3, R3?, L1, L1?, L2 and L2? are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: March 8, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉDE BRETAGNE OCCIDENTALE
    Inventors: Fatima Oukhatar, Maryline Beyler, Raphaël Tripier
  • Patent number: 11266705
    Abstract: The invention concerns a nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, comprising: at least 1% of catechins and epicatechins, the percentage being given by weight in relation to the total weight of the mix, preferably at least 5%, at least 5 ppm (parts per million in the mix) of ferulic acid, preferably at least 10 ppm. The invention also relates to the use of this agent due to its effects on cognitive functions in particular.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 8, 2022
    Assignees: SPECIALITES PET FOOD, ACTIV'INSIDE, INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE LAVAL
    Inventors: David Gaudout, Stephane Rey, Benoit Lemaire, Julien Bensalem, Anne Lepoudere, Delphine Lethuillier, Marie-Eve Paradis, Stephanie Dudonne, Yves Desjardins, Frederic Calon, Alexandre Dal-Pan, Charles Ramassamy
  • Patent number: 11271230
    Abstract: Disclosed is a method for electrical supply of an apparatus by a system including an intermittent electrical source, electrical storage unit, a fuel cell, and an electrochemical unit for generating the fuel. The method includes steps of: determining a power balance of the system depending on the power consumed by the apparatus and supplied by the intermittent electrical source; receiving data representative of the stability of the power balance during a safety period; controlling the fuel cell and the electrochemical unit: to activate the electrochemical unit if the power balance is greater than a first threshold and the data are not characteristic of a subsequent decrease in the power balance; activating the fuel cell if the power balance is less than a second threshold, which is less than the first threshold, and the data are not characteristic of a subsequent increase in the power balance.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 8, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'OrlÉANS
    Inventors: Pascal Brault, Cédric Grolleau, Samuel Rouxel, Serge Gasnier, Amael Caillard, Thomas Lecas
  • Publication number: 20220069306
    Abstract: A negative electrode active material for a lithium-ion battery has the following formula (I): Li1-xOHFe1+xS (I). x varies from 0.00 to 0.25, preferably from 0.05 to 0.20.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 3, 2022
    Applicants: RENAULT s.a.s, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Nationale Superieure de Chimie de Paris
    Inventors: Philippe BARBOUX, Mohamed CHAKIR, Domitille GIAUME, Caroline MIR
  • Publication number: 20220068664
    Abstract: Method for interconnecting components of an electronic system comprising the steps of: a) depositing a sintering solution onto a first component in order to form an interconnection layer, the sintering solution comprising a solvent, metal nanoparticles dispersed in the solvent, and a stabilizing agent adsorbed onto the metal nanoparticles, more than 95.0%, preferably more than 99.0% of the mass of the metal nanoparticles comprising a metal selected from silver, gold, copper and alloys thereof and having a polyhedral shape with an aspect ratio of more than 0.
    Type: Application
    Filed: September 2, 2021
    Publication date: March 3, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX
    Inventors: Maxime BRONCHY, Etienne DUGUET, Céline FEAUTRIER, Mona TREGUER-DELAPIERRE
  • Patent number: 11264688
    Abstract: An interposer (16) and a substrate (10) incorporating the interposer (16) are provided. The interposer (16) includes one or more layers (18) and a cavity (20) defined in the one or more layers (18), the cavity (20) being configured as a waveguide for propagation of electromagnetic waves.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: March 1, 2022
    Assignees: THALES SOLUTIONS ASIA PTE LTD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLES ALPES, L'INSTITUT POLYTECHNIQUE DE GRENOBLE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE 1, UNIVERSITÉ DE LIMOGES, NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Philippe Coquet, Beng Kang Tay, Mathieu Cometto, Dominique Baillargeat, Stéphane Bila, Kamel Frigui, Philippe Ferrari, Emmanuel Pistono, Florence Podevin
  • Patent number: 11262333
    Abstract: A method for concentrating electrically charged objects in a non-Newtonian liquid medium comprises: feeding a sample containing electrically charged objects into a channel having a flow axis, a first transverse cross-section orthogonal to the flow axis, and at least one second transverse cross-section orthogonal to the flow axis, one dimension of the second cross-section being less than the corresponding dimension of the first cross-section; and applying a hydrodynamic flow in a direction of the channel together with the application, in the opposite direction, of an electric field in the channel, thus making it possible to move the electrically charged objects in the channel along the flow axis from the first cross-section to the second cross-section, stop the objects, and concentrate the objects in at least one area upstream from the second transverse cross-section.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: March 1, 2022
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Aurélien Bancaud, Hubert Ranchon, Thierry Leichle, Pattamon Teerapanich
  • Patent number: 11261093
    Abstract: A process for the nitrogen doping of a material includes a set of carbon atoms in the sp2 hybridization state. The process further includes the material not being oxidized beforehand, then placing the material in contact with dinitrogen. Irradiating the material and the dinitrogen placed in contact with a beam of electrons or of light ions whose energy is greater than or equal to 0.1 MeV, to obtain a material wherein some of the carbon atoms in the sp2 hybridization state is nitrogen-doped.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: March 1, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE POLYTECHNIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Catherine Corbel, Irina Shchedrina, Jean-Philippe Renault
  • Publication number: 20220059261
    Abstract: A method for producing a permanent or soft magnet including the following steps: a) providing: a solution containing a solvent in which are dispersed a set of objects which possess a permanent magnetic moment; a substrate on which are fixed to the surface or within a cavity that it may have, a 1st pad and a 2nd pad, said 1st pad includes a face facing and parallel to a face that the 2nd pad includes; b) the solution is deposited on the surface of the substrate or, as the case may be, within its cavity; c) the substrate is placed in a magnetic field so that the set of objects are grouped together between the face of the 1st pad and the face of the 2nd pad so as to form a permanent magnet.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 24, 2022
    Applicants: INSTITUT NATIONAL DES SCIENCES APPLIQUÉES, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lise-Marie LACROIX, Guillaume VIAU, Thierry LEICHLE, Pierre MORITZ
  • Publication number: 20220054424
    Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.
    Type: Application
    Filed: September 16, 2019
    Publication date: February 24, 2022
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
    Inventors: Giovanna LOLLO, Jean-Pierre BENOIT, Marie BRACHET - BOTINEAU
  • Publication number: 20220053766
    Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.
    Type: Application
    Filed: December 19, 2019
    Publication date: February 24, 2022
    Applicants: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS).
    Inventors: Thomas BERTHELOT, Céline GOULARD-HUET, Fanny HAUQUIER
  • Patent number: 11258227
    Abstract: Some embodiments relate to a generation device that includes: a pulsed laser source generating primary photons having at least one wavelength within pulses having time dissymmetry, a forming device(s) controlling the primary photons so as to generate a selective-polarization, focused input beam, and an optical fiber wherein the primary photons induce secondary photons having different wavelengths resulting from a raman conversion cascade and forming a wide-spectrum output beam having substantially constant energy.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: February 22, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LIMOGES
    Inventors: Christophe Louot, Dominique Pagnoux, Katarzyna Krupa, Badr Shalaby, Alexis Labruyère, Alessandro Tonello, Vincent Couderc
  • Patent number: 11253535
    Abstract: A method of treating Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), a cardiomyopathy or a muscular traumatism in a subject includes administering to the subject certain ADP ribosylcyclase antagonist compounds, certain cyclic ADP ribose (cADPR) antagonist compounds, certain nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist compounds or a mixture of these compounds.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: February 22, 2022
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: José-Manuel Cancela, Sabine De La Porte, Antoine De Zelicourt