Abstract: A fluidic system for producing extracellular vesicles from producer cells, including at least one container, a liquid medium contained by the container and producer cells, characterised in that it also includes microcarriers suspended in the liquid medium, the majority of producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being adapted to control a turbulent flow of the liquid medium in the container.
Type:
Application
Filed:
June 29, 2018
Publication date:
December 10, 2020
Applicants:
UNIVERSITE PARIS DIDEROT PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHON
Abstract: Disclosed is a piezoelectric transducer of the type including a stack of a contact piece, a piezoelectric pellet and a support of very great stiffness. Specifically, the contact piece forms tips, the respective apex of which constitutes contact points that are spatially isolated from one another. Also disclosed is a process for the manufacture of such a contact piece as well as a resonant ultrasound spectroscopy device including one or more of such piezoelectric transducers.
Type:
Grant
Filed:
September 21, 2017
Date of Patent:
December 8, 2020
Assignees:
SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Abstract: The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such Alzheimer's disease in a patient, comprising the step of detecting the level of HNRNPC in a biological sample obtained from said patient.
Type:
Grant
Filed:
June 10, 2016
Date of Patent:
December 8, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
Inventors:
Thierry Leveillard, Jose-Alain Sahel, Hawa Camara
Abstract: The present invention relates to highly soluble, non-fluorescent and photostable myosin inhibitors; especially, for in vivo inhibition of the ATPase activity of neuronal non-muscle myosin 2 of formula (II): wherein Q1, Q2, Q3, Q4, R1, R2, R4 and R5 are as defined in claim 1. The invention also relates to pharmaceutical compositions or medicaments comprising the compounds of the invention and processes for manufacturing these compounds and their intermediates.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
December 8, 2020
Assignees:
PARIS SCIENCES ET LETTRES-QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), PRINTNET LTD.
Inventors:
Zsolt Lenkei, András Málnási Csizmadia, Miklós Képiró, Boglárka Várkuti
Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.
Type:
Grant
Filed:
April 9, 2020
Date of Patent:
December 8, 2020
Assignees:
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, UNIVERSITE D'ANGERS, THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors:
François Guerard, Jean-François Gestin, Martin W. Brechbiel, Yong-Sok Lee
Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.
Type:
Application
Filed:
June 9, 2020
Publication date:
December 3, 2020
Applicants:
Institut National de la Santé et de la Recherche Médicale (INSERM), UNIVERSITE D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE NANTES
Inventors:
Daniel OLIVE, Marc BONNEVILLE, Emmanuel SCOTET, Christelle HARLY, Yves GUILLAUME
Abstract: Method for the preparation, by means of a heating technique, of a composite material composed of a matrix of at least a first oxide of at least one metal and/or at least one metalloid reinforced by reinforcements in at least a second oxide of at least one metal and/or at least one metalloid, characterised in that the following successive steps are carried out: the reinforcements are placed in at least one liquid precursor of the first oxide of at least one metal and/or at least one metalloid; said reinforcements and the liquid precursor are heated so as to form the first oxide by means of the thermal decomposition of said liquid precursor, and to deposit the first oxide thus formed around the reinforcements and between the reinforcements thus forming the matrix.
Type:
Application
Filed:
February 21, 2018
Publication date:
December 3, 2020
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX
Inventors:
Alexandre ALLEMAND, Patrick DAVID, Pierre BROISSON, Clemence BESNARD, Laurence MAILLE
Abstract: The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
Type:
Grant
Filed:
January 25, 2019
Date of Patent:
December 1, 2020
Assignees:
BIOKINESIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The object of the present invention is to produce a metal part equipped with a protection system, particularly for turbine blades for aircraft engines, having a thermal barrier that is improved in terms of thermal properties, adhesion to the part and resistance to oxidation/corrosion. In order to achieve this, the method according to the invention produces in a single step, from specific ceramics, coating layers using SPS technology. According to one embodiment, a metal part is produced according to an SPS flash sintering method and comprises a superalloy substrate (22), a metal sub-layer (21), a TGO oxide layer (25) and the thermal barrier (23) formed by said method from at least two chemically and thermally compatible ceramic layers (2a, 2b). A first ceramic (2a), referred to as the inner ceramic, is designed to have a substantially higher expansion coefficient.
Type:
Grant
Filed:
November 13, 2018
Date of Patent:
December 1, 2020
Assignees:
SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, UNIVERSITE PAUL SABATIER DE TOULOUSE
Inventors:
Juliette Hugot, Mathieu Boidot, Daniel Monceau, Djar Oquab, Claude Estournes
Abstract: The invention relates to a method for the transportation and/or storage of at least one semiconductor plate, in which the plate is disposed in a hermetic container (1) filled with hydrogen at a pressure of between 10?1 and 4*103 Pa and, optionally, at least one inert gas, the total pressure in the casing being between 10?1 and 5*104 Pa.
Type:
Grant
Filed:
September 5, 2017
Date of Patent:
December 1, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPES
Abstract: A coolant mixture including water and at least one of the compounds chosen from 1-methoxy-2-propanol and 1-ethoxy-2-propanol in the proportions of the corresponding azeotrope or in near-azeotropic proportions. Such a mixture can be used as a heat-transfer fluid in a heat-exchange device, which can be incorporated into an aircraft or spacecraft. A method for obtaining a mixture by fractional distillation is also disclosed.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
December 1, 2020
Assignees:
Safran Electrical & Power, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE
Inventors:
Nicolas Delalandre, Benjamin Roland Stanislas Joossen, Jean-Marie Aubry, Vincent Gerbaud, Ivonne Rodriguez-Donis
Abstract: The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. The inventors have introduced mutations at very specific positions that abrogate the N-glycosylation site on the E protein of the epidemic strain which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have also produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein E of the epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.
Type:
Grant
Filed:
June 22, 2017
Date of Patent:
December 1, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE LA REUNION SAINT DENIS, INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
Inventors:
Philippe Despres, Gilles Gadea, Patrick Mavingui, Wildriss Viranaicken
Abstract: Disclosed is a floating wind turbine including a floating platform and a turbomachine resting on the platform, the turbomachine including: —first and second transverse flow turbines disposed symmetrically with respect to a first plane, each turbine including blades including central parts that are extended at the ends by arms, connected to shaft elements by pivoting connections, each turbine also including upper and lower fairings; and—a structure for holding the turbines including a vertical median pylon between the turbines and upstream of a second plane containing the axes of rotation of the blades of the turbines.
Type:
Grant
Filed:
March 7, 2017
Date of Patent:
November 24, 2020
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: A method for extracting the tantalum from an acid aqueous phase A1 comprising at least one step comprising the bringing of the aqueous phase A1 into contact with a phase A2 not miscible with water, and then the separation of the aqueous phase A1 from the phase A2, the phase A2 consisting of one ionic liquid or a mixture of ionic liquids as an extractant. A method for recovering the tantalum that implements this extraction method and to a use of an ionic liquid or of a mixture of ionic liquids as an extractant, in order to extract the tantalum from such an aqueous phase A1.
Type:
Grant
Filed:
August 10, 2016
Date of Patent:
November 24, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, UNIVERSITE DE CHAMBERY, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, TND, UNIVERSITE DE LORRAINE
Inventors:
Raphael Turgis, Guilhem Arrachart, Stéphane Pellet-Rostaing, Micheline Draye, Sophie Legeai, David Virieux, Christian Thomas
Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques.
Type:
Grant
Filed:
November 29, 2013
Date of Patent:
November 24, 2020
Assignees:
INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE NICE SOPHIA ANTIPOLIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Abstract: The application relates to a method for preparing magnetite, comprising steps of: a) reaction at a temperature of 100° to 500° C. of a material containing wüstite with water, in order to obtain a solid comprising magnetite, and then b) recovery of the magnetite in the form of particles wherein more than 25% by weight are of nanometric size.
Type:
Grant
Filed:
June 6, 2017
Date of Patent:
November 24, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLE
Inventors:
Fabrice Brunet, Camille Crouzet, Bruno Goffe
Abstract: Some embodiments are directed to an optoelectronic device for converting an electrical signal into electromagnetic radiation or vice-versa, including an active zone sandwiched between first and second electrodes, the optoelectronic device having a stack of layers with a lateral edge and first and second opposite faces, the layers of the stack forming at least the active zone and the first and second electrodes, the stack being intended to receive or emit the electromagnetic radiation through the lateral edge perpendicularly to the direction of stacking of the layers.
Type:
Grant
Filed:
July 21, 2017
Date of Patent:
November 24, 2020
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT POLYTECHNIQUE DE GRENOBLE
Inventors:
David Munoz Rojas, Maria del Carmen Jimenez Arevalo, Daniel Bellet, Stéphane Brochen
Abstract: Polypeptides having the ability to specifically form connections of glucosyl units in alpha 1,3 on an acceptor having at least one hydroxyl moiety are presented. The polypeptides include i) the pattern I of sequence SEQ ID NO: 1, ii) the pattern II of sequence SEQ ID NO: 2, iii) the pattern III of sequence SEQ ID NO: 3, and iv) the pattern IV of sequence SEQ ID NO: 4, or derivates from one or several of said patterns, wherein the polypeptide furthermore has an aspartic residue (D) at position 5 of the pattern II (SEQ ID NO: 2), a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3) and an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4). Methods for producing acceptors connected to glucosyl units in alpha 1,3 using the polypeptides are also provided.
Type:
Grant
Filed:
September 22, 2017
Date of Patent:
November 24, 2020
Assignees:
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)