Patents Assigned to Scinopharm Taiwan, Ltd.
  • Patent number: 8461347
    Abstract: A process of making Form A of atazanavir sulfate comprises: a) mixing atazanavir free base with a solvent selected from the group consisting of methanol (MeOH), ethanol (EtOH), isopropanol (IPA), N-methylprrolidone (NMP) and combinations thereof; b) reacting sulfuric acid with the atazanavir free base in the mixture formed in step a) to form a reaction solution comprising atazanavir sulfate; c) mixing an antisolvent with the reaction solution; d) seeding the mixture formed in step c) with an effective amount of Form A of atazanavir sulfate to form a seeded mixture comprising Form A of atazanavir sulfate; and e) isolating Form A of atazanavir sulfate in solid form from the seeded mixture; wherein the antisolvent is selected from the group consisting of methyl tert-butyl ether (MTBE), ethyl acetate (EtOAc), acetonitrile (MeCN), isopropyl acetate (IPAc), cyclohexane, and combinations thereof. In one alternative, step c) may be performed before step b).
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: June 11, 2013
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Ai-Hua Kao, Chia-Ying Lee
  • Publication number: 20130116444
    Abstract: The present invention relates to processes for making cabazitaxel, cabazitaxel analogues and intermediates thereof. The invention provides novel compounds useful in the synthesis of cabazitaxel.
    Type: Application
    Filed: October 30, 2012
    Publication date: May 9, 2013
    Applicant: Scinopharm Taiwan, LTD.
    Inventor: Scinopharm Taiwan, LTD.
  • Patent number: 8436194
    Abstract: The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6): R1 represents H, C1-C5-alkyl, or benzyl, in particular isopropyl.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 7, 2013
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Julian P. Henschke, Yuanlian Liu, Yung-Fa Chen, Dechao Meng, Ting Sun
  • Patent number: 8420672
    Abstract: The present invention provides for new crystalline and amorphous forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, and methods of making the same.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: April 16, 2013
    Assignee: ScinoPharm Taiwan Ltd.
    Inventors: Chen-Tung Chen, Inze Lin
  • Publication number: 20130065955
    Abstract: The present invention provides crystalline forms, including an anhydrate form, of cabazitaxel and processes for the preparation of these forms, designated as Forms C1, C2, C3, C4, C5, C6, C7, C8, C8b, C9 and C9p.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 14, 2013
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Julian Paul Henschke, TsungYu Hsiao, MengFen Ho, YuanChang Huang
  • Publication number: 20130005971
    Abstract: The present invention provides a process for making lapatinib and its pharmaceutically acceptable salt by use of new intermediates. A new process for obtaining a pharmaceutical form of lapatinib ditosylate monohydrate is also provided.
    Type: Application
    Filed: March 23, 2011
    Publication date: January 3, 2013
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Yung-Fa Chen, Julian Paul Henschke, Yuanlian Liu, Guodong Chu, Xiaoheng Zhang
  • Publication number: 20120296068
    Abstract: A method of purifying a compound from a mixture through a chromatographic column loaded with a column adsorbent. The method comprises: applying the mixture to the chromatographic column; eluting the mixture with an elution solvent composition; and collecting the compound; wherein at least one of the column adsorbent and elution solvent is selected based on one of solubility parameters of the compound, column adsorbent, elution solvent, and conformation energy of the compound.
    Type: Application
    Filed: May 15, 2012
    Publication date: November 22, 2012
    Applicants: ScinoPharm Taiwan Ltd., National Central University
    Inventors: Wen-Yih CHEN, Li-Chiao Chang, Ruoh-Chyu Ruaan, Ching-Wei Tsai
  • Patent number: 8232387
    Abstract: A process for the preparation of cladribine of API grade is provided by direct coupling of O-protected 2-deoxy-ribofuranose with silylated 2-chloroadenine followed by deprotection of the resultant protected nucleoside in a separate step and then a purification step. Following the coupling, the desired N-9-glycosylated ?-anomer of the nucleoside is directly isolated as a solid from the coupling reaction mixture by filtration in relatively high purity and yield, and it does not require purification.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: July 31, 2012
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Julian Paul Henschke, Xiaoheng Zhang, Guodong Chu, Lijun Mei, Yung Fa Chen
  • Patent number: 8212002
    Abstract: A process of making a polylpeptide or a pharmaceutically acceptable salt thereof comprises reacting a L-lysine protected polypeptide, which comprises L-alanine, L-tyrosine, L-glutamate, and L-lysine that is protected with a protecting group, with a tetraalkylammonium hydroxide in water to remove the protecting group.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: July 3, 2012
    Assignee: Scinopharm Taiwan Ltd
    Inventors: Tsung-Yu Hsiao, Meng-Fen Ho
  • Patent number: 8212021
    Abstract: A process of synthesizing a 5-azacytosine nucleoside, such as azacitidine and decitabine, comprises coupling a silylated 5-azacytosine with a protected D-ribofuranose of formula in the presence of a sulfonic acid catalyst.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: July 3, 2012
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Julian Paul Henschke, Xiaoheng Zhang, Lunghu Wang, Yung Fa Chen
  • Patent number: 8193217
    Abstract: Crystalline granisetron hydrochloride characterized by a powder x-ray diffraction pattern with peaks at about 14.3, 20.4, and 23.0±0.2 degrees two-theta and process of making the same are disclosed.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: June 5, 2012
    Assignee: ScinoPharm Taiwan Ltd.
    Inventors: Shu-Ping Chen, Hsiao-Ping Fang
  • Publication number: 20120107941
    Abstract: Provided are systems, apparatus, materials and methods for directly monitoring products and intermediates of solid phase chemical synthesis such as solid phase peptide synthesis.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 3, 2012
    Applicants: SCINOPHARM TAIWAN, LTD., SCINOPHARM SINGAPORE PTE, LTD., NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: Li-Chiao Chang, Jentaie Shiea, Yi-Tzu Cho
  • Patent number: 8138343
    Abstract: A crystalline polymorph of 7-ethyl-10-hydroxycamptothecin exhibiting an X-ray diffraction pattern having peaks at 10.9±0.2, 13.2±0.2, 23.9±0.2, and 26.1±0.2 2-theta degree.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: March 20, 2012
    Assignee: ScinoPharm Taiwan Ltd.
    Inventors: Shu-Ping Chen, Piin-Jye Harn
  • Patent number: 8080582
    Abstract: The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as hypertension, cancer, atherosclerosis, and myocardial infarction.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: December 20, 2011
    Assignee: ScinoPharm Taiwan Ltd.
    Inventors: Hardy Chan, Chung Faye Chao, Vallapa Soong
  • Publication number: 20110287550
    Abstract: The present invention provides a system and method for real-time continuously monitoring of oligonucleotide synthesis in solution phase.
    Type: Application
    Filed: May 24, 2011
    Publication date: November 24, 2011
    Applicants: National Sun Yat-Sen University, ScinoPharm Taiwan, Ltd.
    Inventors: Jentaie Shiea, Chu-Nian Cheng
  • Publication number: 20110288235
    Abstract: The present invention provides for an efficient process for making pramlinitide, as well as novel intermediates for the making of the same.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 24, 2011
    Applicant: ScinoPharm Taiwan Ltd.
    Inventors: Tsung Yu Hsiao, Jin Guo Ding
  • Patent number: 8013158
    Abstract: Novel crystalline forms of topotecan hydrochloride and processes of making the same are disclosed.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: September 6, 2011
    Assignee: Scinopharm Taiwan Ltd.
    Inventors: Tsung-Cheng Hu, Shu-Ping Chen, Piin-Jye Harn, Chia-Lin Charlene Shieh
  • Publication number: 20110183426
    Abstract: The present invention provides for a method of characterizing and classifying a sample containing a complex molecule, such as a peptide or polypeptide mixture, protein, protein mixture, biologic and biosimilar by using physical analysis, such as mass spectrometry, and statistic methods.
    Type: Application
    Filed: January 26, 2011
    Publication date: July 28, 2011
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Hardy Chan, Jentaie Shiea
  • Patent number: 7985879
    Abstract: A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (?)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl) amine.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: July 26, 2011
    Assignee: Scinopharm Taiwan Ltd.
    Inventors: Lunghu Wang, Yung Fa Chen, Julian Paul Henschke
  • Patent number: 7977483
    Abstract: A process of making topotecan or a pharmaceutically acceptable salt thereof comprising reacting an iminium salt with 10-hydroxy-camptothecin.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: July 12, 2011
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Tsung-Cheng Hu, Piin-Jye Harn