Patents Assigned to Seno Medical Instruments, Inc.
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Method and system for managing feature reading and scoring in ultrasound and/or optoacoustice images
Patent number: 11246527Abstract: Systems, methods and computer program products are provided for reading and scoring ultrasound and/or optoacoustic (US/OA) images that include at least one of OA images or US images acquired in connection with an examination for a region of interest (ROI). The system displays a first image that has an interior ROI outline separating an internal zone from a boundary zone. In some aspects, feature scores are obtained in connection with at least the boundary zone and peripheral zone of the first image and the feature scores are applied to a classification model to obtain at least one of a prognostic result or predictive result indicative of a trait of the lesion. In accordance with some aspects, an order in which feature scores are entered is automatically managed to obtain for the at least one of the peripheral zone or the boundary zone before the feature score is obtained for the internal zone.Type: GrantFiled: June 18, 2020Date of Patent: February 15, 2022Assignee: Seno Medical Instruments, Inc.Inventors: Anthony Thomas Stavros, Bryan Clingman, Sandra G. Dykes -
Publication number: 20220031170Abstract: An optoacoustic imaging system includes an ultrasound transducer array, first and second light sources and a switching power supply that generates power for the light sources. The switching power supply includes an input for impeding its switching operation. A data acquisition unit samples the ultrasound transducer array for a first predetermined period of time after a pulse of light from the first light source and for a second predetermined period of time after a pulse of light from the second light source and stores the sampled data. A master processor utilizes the input to impede operation of the switching operation of the switching power supply during the first predetermined period of time after a pulse of light from the first light source, and during the second predetermined period of time after a pulse of light from the second light source.Type: ApplicationFiled: October 18, 2021Publication date: February 3, 2022Applicant: Seno Medical Instruments, Inc.Inventor: Gregory Schmid
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Publication number: 20220015728Abstract: Methods, devices and systems are provided that utilize one or more processors in connection with, receiving OA/US feature scores in connection with OA/US images collected from a patient examination for a volume of interest. The methods, devices and systems apply the OA/US feature scores to a feature score to molecular subtype (FSMS) model. The methods, devices and systems determine, from the FSMS model, an indication of at least one of a molecular subtype or histologic grade of a pathology experienced by the patient.Type: ApplicationFiled: September 21, 2021Publication date: January 20, 2022Applicant: Seno Medical Instruments, Inc.Inventor: Anthony Thomas Stavros
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Patent number: 11191435Abstract: An optoacoustic probe including an ultrasound transducer array, an acoustic lens and a light path separated from the transducer array by an isolator to mitigate light energy from the light path from reaching the transducer array. The isolator being formed from a mixture including a flexible carrier, a coloring and between 10% and 80% by volume micro-bubbles. The isolator mixture being adapted to both absorb light energy and the optoacoustic response to light energy. In an embodiment, an optoacoustic probe also comprises an optical window and/or a diffuser, and the isolator also separating the transducer array from these components.Type: GrantFiled: January 22, 2013Date of Patent: December 7, 2021Assignee: SENO MEDICAL INSTRUMENTS, INC.Inventors: William Ackerman, Donald G. Herzog, Justin Casas
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Patent number: 11172900Abstract: Methods, devices and systems are provided that utilize one or more processors in connection with, receiving OA/US feature scores in connection with OA/US images collected from a patient examination for a volume of interest. The methods, devices and systems apply the OA/US feature scores to a feature score to molecular subtype (FSMS) model. The methods, devices and systems determine, from the FSMS model, an indication of at least one of a molecular subtype or histologic grade of a pathology experienced by the patient.Type: GrantFiled: August 29, 2019Date of Patent: November 16, 2021Assignee: Seno Medical Instruments, Inc.Inventor: Anthony Thomas Stavros
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Patent number: 11160457Abstract: An optoacoustic imaging system includes an ultrasound transducer array, first and second light sources and a switching power supply that generates power for the light sources. The switching power supply includes an input for impeding its switching operation. A data acquisition unit samples the ultrasound transducer array for a first predetermined period of time after a pulse of light from the first light source and for a second predetermined period of time after a pulse of light from the second light source and stores the sampled data. A master processor utilizes the input to impede operation of the switching operation of the switching power supply during the first predetermined period of time after a pulse of light from the first light source, and during the second predetermined period of time after a pulse of light from the second light source.Type: GrantFiled: November 13, 2017Date of Patent: November 2, 2021Assignee: Seno Medical Instruments, Inc.Inventor: Gregory Schmid
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Publication number: 20210158518Abstract: The diagnostic vector classification support system and method disclosed herein may both reduce the time and effort required to train radiologists to interpret medical images, and provide a decision support system for trained radiologists who, regardless of training, have the potential to miss relevant findings. In an embodiment, a morphological image is used to identify a zone of interest in a co-registered functional image. An operator's grading of a feature at least partially contained within the zone of interest is compared to one or more computer-generated grades for the feature. Where the operator and computer-generated grades differ, diagnostic support can be provided such as displaying additional images, revising the zone of interest, annotating one or more displayed images, displaying a computer-generated feature grade, among other possibilities disclosed herein.Type: ApplicationFiled: February 3, 2021Publication date: May 27, 2021Applicant: Seno Medical Instruments, Inc.Inventors: Anthony Thomas Stavros, Reni S. Butler, Philip T. Lavin, Jason Zalev, Thomas G. Miller
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Patent number: 10949967Abstract: The diagnostic vector classification support system and method disclosed herein may both reduce the time and effort required to train radiologists to interpret medical images, and provide a decision support system for trained radiologists who, regardless of training, have the potential to miss relevant findings. In an embodiment, a morphological image is used to identify a zone of interest in a co-registered functional image. An operator's grading of a feature at least partially contained within the zone of interest is compared to one or more computer-generated grades for the feature. Where the operator and computer-generated grades differ, diagnostic support can be provided such as displaying additional images, revising the zone of interest, annotating one or more displayed images, displaying a computer-generated feature grade, among other possibilities disclosed herein.Type: GrantFiled: June 28, 2018Date of Patent: March 16, 2021Assignee: Seno Medical Instruments, Inc.Inventors: Anthony Thomas Stavros, Reni S. Butler, Philip T. Lavin, Jason Zalev, Thomas G. Miller
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Publication number: 20210022680Abstract: An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.Type: ApplicationFiled: July 22, 2019Publication date: January 28, 2021Applicant: Seno Medical Instruments, Inc.Inventors: Jeffrey Nelson Harris, Tam Thien Do, Xavier Rey Saenz, Lisa Michelle Richards Cook
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METHOD AND SYSTEM FOR MANAGING FEATURE READING AND SCORING IN ULTRASOUND AND/OR OPTOACOUSTICE IMAGES
Publication number: 20200345292Abstract: Systems, methods and computer program products are provided for reading and scoring ultrasound and/or optoacoustic (US/OA) images that include at least one of OA images or US images acquired in connection with an examination for a region of interest (ROI). The system displays a first image that has an interior ROI outline separating an internal zone from a boundary zone. In some aspects, feature scores are obtained in connection with at least the boundary zone and peripheral zone of the first image and the feature scores are applied to a classification model to obtain at least one of a prognostic result or predictive result indicative of a trait of the lesion. In accordance with some aspects, an order in which feature scores are entered is automatically managed to obtain for the at least one of the peripheral zone or the boundary zone before the feature score is obtained for the internal zone.Type: ApplicationFiled: June 18, 2020Publication date: November 5, 2020Applicant: Seno Medical Instruments, Inc.Inventors: Anthony Thomas Stavros, Bryan Clingman, Sandra G. Dykes -
METHOD AND SYSTEM FOR MANAGING FEATURE READING AND SCORING IN ULTRASOUND AND/OR OPTOACOUSTICE IMAGES
Publication number: 20200315589Abstract: Systems, methods and computer program products are provided for reading and scoring ultrasound and/or optoacoustic (US/OA) images that include at least one of OA images or US images acquired in connection with an examination for a region of interest (ROI). The system displays a first image that has an interior ROI outline separating an internal zone from a boundary zone. In some aspects, feature scores are obtained in connection with at least the boundary zone and peripheral zone of the first image and the feature scores are applied to a classification model to obtain at least one of a prognostic result or predictive result indicative of a trait of the lesion. In accordance with some aspects, an order in which feature scores are entered is automatically managed to obtain for the at least one of the peripheral zone or the boundary zone before the feature score is obtained for the internal zone.Type: ApplicationFiled: June 18, 2020Publication date: October 8, 2020Applicant: Seno Medical Instruments, Inc.Inventors: Anthony Thomas Stavros, Bryan Clingman, Sandra G. Dykes -
Patent number: 10762628Abstract: Electromagnetic energy is deposited into a volume, an acoustic return signal from energy deposited in the volume is measured, and a parametric map that estimates values of at least one parameter as spatially represented in the volume is computed. A reference level of a region of interest is determined, and upper and lower color map limits are specified, with at least one of them being determined in relation to the reference level. The parametric map is then rendered in the palette of a color map by mapping the estimated values of the parametric map onto the color map according to the color map limits. Two wavelengths of energy can be applied to the volume, and the parametric map computation can be adapted by applying an implicit or explicit model of, or theoretical basis for, distribution of electromagnetic energy fluence within the volume pertaining to the two wavelengths.Type: GrantFiled: May 15, 2019Date of Patent: September 1, 2020Assignee: Seno Medical Instruments, Inc.Inventors: Jason Zalev, Bryan Clingman
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Patent number: 10709419Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: GrantFiled: September 27, 2016Date of Patent: July 14, 2020Assignee: SENO MEDICAL INSTRUMENTS, INC.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Patent number: 10638935Abstract: An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored.Type: GrantFiled: March 20, 2019Date of Patent: May 5, 2020Assignee: Seno Medical Instruments, Inc.Inventors: Jason Zalev, Bryan Clingman, Donald G. Herzog
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Publication number: 20200113505Abstract: A system and method for performing optoacoustic classification prediction is provided. The method utilizes one or more processors in connection with receiving OA feature scores in connection with OA images collected from a patient examination for a volume of interest. The volume of interest includes a lesion. The method applies the OA feature scores to a classification model to obtain a predictive result indicative of a trait of the lesion.Type: ApplicationFiled: June 19, 2019Publication date: April 16, 2020Applicant: Seno Medical Instruments, Inc.Inventors: Bryan Clingman, Sandra G. Dykes
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Publication number: 20200069275Abstract: Methods, devices and systems are provided that utilize one or more processors in connection with, receiving OA/US feature scores in connection with OA/US images collected from a patient examination for a volume of interest. The methods, devices and systems apply the OA/US feature scores to a feature score to molecular subtype (FSMS) model. The methods, devices and systems determine, from the FSMS model, an indication of at least one of a molecular subtype or histologic grade of a pathology experienced by the patient.Type: ApplicationFiled: August 29, 2019Publication date: March 5, 2020Applicant: Seno Medical Instruments, Inc.Inventor: Anthony Thomas Stavros
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Patent number: 10542892Abstract: A testing apparatus for an optoacoustic device includes a light pulse sensor operatively connected to a light output port of the optoacoustic device, the light pulse sensor being adapted to sense a pulse of light capable of generating an optoacoustic response in a subject and to distinguish between the light pulse and the at least one other light pulse on the basis of the predominant wavelength. The light pulse sensor outputs a trigger signal associated with the distinguished light pulse when such light pulse is sensed. A transducer signal simulator outputs a first plurality of electrical signals simulating those produced by a transducer array and reflective of an optoacoustic response in a subject to a light pulse at a first wavelength in response to a trigger signal from the light pulse sensor associated with a light pulse having a first wavelength.Type: GrantFiled: July 27, 2017Date of Patent: January 28, 2020Assignee: Seno Medical Instruments, Inc.Inventors: Donald G. Herzog, William Ackerman
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Patent number: 10539675Abstract: In an embodiment, a system and method are provided for determining position and orientation of an optical delivery unit relative to an acoustic receiving unit, in the field of opto-acoustic imaging, wherein the optical delivery unit comprises a first fiducial marker site configured to emit acoustic responses and a second fiducial marker site configured to emit acoustic responses. A plurality of acoustic signals from a volume of a subject are sampled and recorded, each of the plurality of acoustic signals being collected at a different data collection position relative to a coordinate reference frame. The system is configured to identify in each of the plurality of acoustic signals a response of a first fiducial marker and a response of a second fiducial marker. Each identified response indicates a separation between a fiducial marker site and a data collection position of an acoustic signal.Type: GrantFiled: October 30, 2015Date of Patent: January 21, 2020Assignee: Seno Medical Instruments, Inc.Inventor: Jason Zalev
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Patent number: 10517481Abstract: A method for controlling an optoacoustic imaging system includes the steps of analyzing sinogram data values to identify variations, storing information concerning the variations, generating first and second sinograms, and processing the sinograms to mitigate the effect of the variations. In the analyzing step, sinogram data values are analyzed to identify one or more variations that are related to performance of one or more of the discrete components of the optoacoustic imaging system. The identified variations are then stored. A first sinogram is generated by sampling transducer elements acoustically coupled with a surface of a volume for a predetermined period of time after delivery of a pulse of light having a first wavelength, the first sinogram containing one channel for each of the transducer elements.Type: GrantFiled: July 11, 2016Date of Patent: December 31, 2019Assignee: Seno Medical Instruments, Inc.Inventors: Jason Zalev, Bryan Clingman, Gregory Schmid
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Patent number: 10433732Abstract: An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicone rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection coated plates with acoustic impedance matching that of tissues to be imaged.Type: GrantFiled: January 22, 2013Date of Patent: October 8, 2019Assignee: SENO MEDICAL INSTRUMENTS, INC.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev