Abstract: Disclosed is a technique for identifying a mutation of a particular gene as a new case of a FOP-like phenotype, in addition to the existing ACVR1-R206H mutation known as a cause of FOP and utilizing the identified mutation in the bone disease treatment through osteogenic differentiation. There is provided a bone morphogenetic protein type 2 receptor (BMPR2)-E376K mutant in which the 376th amino acid glutamic acid (E) is mutated into lysine (K) in the BMPR2 gene encoding BMPR2.

Abstract: A clearing pretreatment method of a biological sample having a size of at most 1 mm, that is, a spheroid or organoid, according to the present invention uses a phosphate-buffered saline (PBS) rather than a conventional sucrose solution as a pretreatment solution, thus solving the problem in which the spheroid or organoid floats above the surface of water due to the density difference such that the structure of the sample is damaged. Therefore, there is an effect in that the spheroid or organoid can be transparentized while maintaining the original shape thereof, thus making it possible to image deep parts.

Abstract: A method and device for predicting Alzheimer's disease based on voice characteristics are provided. The device for predicting Alzheimer's disease according to an embodiment includes: a voice input unit configured to generate a voice sample by recording a voice of a subject; a data input unit configured to receive demographic information of the subject; a voice characteristic extraction unit configured to extract voice characteristics from the generated voice sample; and a prediction model that is pre-trained to predict presence or absence of Alzheimer's disease in the subject, based on the voice characteristics and the demographic information.

Abstract: A composition suitable for diagnosing a musculoskeletal disease and a composition suitable for preventing or treating a musculoskeletal disease are disclosed. The composition contains zinc finger protein with KRAB and SCAN domains 8 (Zkscan8) protein, which can be effectively used as an excellent biomarker for obtaining accurate information about the occurrence and progression stages of a musculoskeletal disease, specifically a tendon disease or a ligament disease. The compositions containing Zkscan8 can be effectively used for preventing or treating a musculoskeletal disease through Zkscan8 overexpression.

Abstract: Provided is a composition for treating coronavirus disease-19 (Corona19, COVID-19), including a phenanthroindolizidine and phenanthroquinolizidine alkaloid derivative compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. According to the presently claimed subject matter, the phenanthroindolizidine and phenanthroquinolizidine alkaloid derivative compound has excellent antiviral activity against COVID-19, and therefore can be effectively used as a composition for treating SARS coronavirus infection including COVID-19.

Abstract: Embodiments relate to a motor driving system comprising a power network between an inverter and a motor and a method for designing such motor drive system, the motor drive system comprising: an AC motor; an inverter unit for applying a voltage to the AC motor; a controller configured for controlling an output voltage of the inverter unit; and a power network circuit disposed between the inverter unit and the AC motor, wherein the power network circuit is configured with passive element.

Abstract: The present invention relates to a polymer, an organic solar cell comprising the polymer, and a perovskite solar cell comprising the polymer. The polymer according to the present invention has excellent absorption ability for visible light and an energy level suitable for the use as an electron donor compound in a photo-active layer of the organic solar cell, thereby increasing the light conversion efficiency of the organic solar cell. In addition, the polymer according to the present invention has high hole mobility, and is used as a compound for a hole transport layer, and thus can improve efficiency and service life of the perovskite solar cell without an additive.

Abstract: Disclosed are a natural killer (NK) cell expressing an anti-cotinine chimeric antigen receptor (CAR) specifically binding to cotinine, and a cell therapeutic agent containing the NK cell. The CAR-expressing NK cell which specifically binds cotinine, can effectively move to tumor tissue, regardless of the kind of cancer, depending on the binding substance bound to cotinine. Therefore, the natural killer cell can be usefully employed as a gene therapy exhibiting a highly efficient anticancer effect.

Abstract: A processor-implemented method of a neural network includes obtaining intermediate pooling results, respectively corresponding to sub-pooling kernels obtained by decomposing an original pooling kernel, by performing a pooling operation on input pixels included in a current window in an input feature map with the sub-pooling kernels, obtaining a final pooling result corresponding to the current window by post-processing the intermediate pooling results, and determining an output pixel value of an output feature map, based on the final pooling result, wherein the current window is determined according to the original pooling kernel having been slid, according to a raster scan order, in the input feature map.

Abstract: The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food.

Abstract: A pressure sensor includes: a first substrate; a second substrate having an inner surface and a touch surface that is opposite to the inner surface, wherein the inner surface faces the first substrate with a resistance sensing space therebetween; a first electrode and a second electrode, which are arranged spaced apart from each other in the resistance sensing space; and a piezoresistive pattern arranged between the first electrode and the second electrode and disposed in the resistance sensing space, wherein the piezoresistive pattern includes a porous elastic support and a plurality of conductive carbon structures dispersed in the porous elastic support.

Abstract: A processor-implemented data processing method includes encoding a plurality of weights of a filter of a neural network using an inverted two's complement fixed-point format; generating weight data based on values of the encoded weights corresponding to same filter positions of a plurality of filters; and performing an operation on the weight data and input activation data using a bit-serial scheme to control when to perform an activation function with respect to the weight data and input activation data.

Abstract: A spiking neural network device comprises at least one NAND cell string including a first NAND cell string that includes a string select transistor and a plurality of nonvolatile memory cells between a bit line and a ground select line, a string control circuit configured to generate a string selection signal to turn on the string select transistor in response to an input spike, a word line decoder configured to generate a word line selection signal for selecting a word line of a plurality of word lines for each of the plurality of nonvolatile memory cells in response to the input spike, a plurality of sensing circuits connected to the bit line, respectively corresponding to the plurality of word lines, each sensing circuit configured to generate an output spike according to a current transmitted through the bit line when a corresponding word line is selected, a plurality of switch transistors, each configured to connect one of the plurality of sensing circuits to the bit line according to a switch selection

Abstract: The present invention relates to a technique for genomic library screening and provides a method for separating, capturing, analyzing, and retrieving cells and cell products by using a microstructure that can be preferentially applied to the field of antibody engineering for the development of new therapeutic antibodies and can be extensively applied to multiple genetic/phenotypic analysis of various biochemical molecules, for example, in the field of protein engineering and metabolic engineering.

Abstract: A method and apparatus for generating a speaker identification neural network include generating a first neural network that is trained to identify a first speaker with respect to a first voice signal in a first environment, generating a second neural network for identifying a second speaker with respect to a second voice signal in a second environment, and generating the speaker identification neural network by training the second neural network based on a teacher-student training model in which the first neural network is set to a teacher neural network and the second neural network is set to a student neural network.

Abstract: A hepatitis B virus-derived polypeptide exhibits anti-viral effects not only on HIV-1 and HBV but also on all viruses by increasing the expression of type I interferon. The hepatitis B virus-derived polypeptide has a synergistic effect when co-administered with a conventional anti-viral agent. The hepatitis B virus-derived polypeptide is effectively usable in the treatment of virus-related diseases such as AIDS or liver diseases.

Abstract: Disclosed is an electronic apparatus. The electronic apparatus includes a memory storing a composite function in which at least two polynomials are composed and a processor configured to, based on a comparison operation command being received for a plurality of homomorphic ciphertexts, perform operation by reflecting the plurality of homomorphic ciphertexts to the composite function, and obtain a comparison result of the plurality of homomorphic ciphertexts based on the operation result, each of the at least two polynomials may output a value in a preset range for a value in a preset domain, and a domain of one of the at least two polynomials may be determined based on a range of a previous polynomial.

Abstract: A cell genetically engineered for activating natural killer (NK) cells. The genetically engineered cell for activating NK cells synergistically induces the proliferation and activation of NK cells in a sample, thereby producing effects that can be usefully utilized in a method of proliferating NK cells, a method of measuring NK cells proliferated by the method, or an activation degree of NK cells, or a method of diagnosing an NK cell activity-related disease. A feeder cell for culturing a natural killer (NK) cell, genetically engineered to express membrane bound interleukin-18 (mbIL-18) and membrane bound interleukin-21 (mbIL-21).

Abstract: Uses and a composition including a peptidylarginine deiminase 2 (PADI2) as an active ingredient are disclosed. A peptidylarginine deiminase 2 (PADI2) is useful for preventing or alleviating cellular senescence.

Abstract: A feeder cell for culturing natural killer (NK) cells, genetically engineered to express membrane bound interleukin-18 (mbIL-18), membrane bound interleukin-21 (mbIL-21), and/or OX40L. A method of proliferating NK cells, including: obtaining a blood sample containing a population of NK cells; and contacting at least a part of the population of NK cells with a genetically engineered cell, where the genetically engineered cell is genetically engineered to express mbIL-18, mbIL-21, and/or OX40L.