Patents Assigned to Sequenom, Inc.
  • Patent number: 10964409
    Abstract: Provided herein are methods, processes, systems and machines for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: March 30, 2021
    Assignee: Sequenom, Inc.
    Inventor: Gregory Hannum
  • Patent number: 10930368
    Abstract: A method and system for analyzing circulating cell-free nucleic acids from a pregnant female with reduced bias, Counts of sequence reads mapped to portions of a reference genome are obtained. A regression model is generated that models the relationship between the counts and the GC content. The read counts are normalized according to the regression model to remove the GC bias. The normalized counts are used for further analysis, such as the detection of fetal aneuploidy.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: February 23, 2021
    Assignee: Sequenom, Inc.
    Inventors: Zeljko Dzakula, Chen Zhao, Cosmin Deciu
  • Patent number: 10892035
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragments from circulating cell free nucleic acid. Also provided herein are methods for partitioning one or more genomic regions of a reference genome into a plurality of portions according to one or more features.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: January 12, 2021
    Assignee: Sequenom, Inc.
    Inventors: Cosmin Deciu, Chen Zhao
  • Publication number: 20200392579
    Abstract: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 17, 2020
    Applicant: Sequenom, Inc.
    Inventor: Charles R. Cantor
  • Patent number: 10858645
    Abstract: Provided herein are methods and compositions to extract and enrich by, physical separation or amplification, relatively short nucleic acids from a nucleic acid composition containing a high background of longer nucleic acids (e.g., host or maternal nucleic acids; genomic nucleic acid and the like).
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: December 8, 2020
    Assignee: Sequenom, Inc.
    Inventors: Michele Elizabeth Wisniewski, William Hang Kwong, Firouz Mohsenian, Jian-Hua Ding
  • Publication number: 20200362412
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: May 27, 2020
    Publication date: November 19, 2020
    Applicant: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • Publication number: 20200362414
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 19, 2020
    Applicant: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren
  • Patent number: 10738359
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: August 11, 2020
    Assignee: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • Patent number: 10738358
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: August 11, 2020
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren
  • Patent number: 10731213
    Abstract: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: August 4, 2020
    Assignee: Sequenom, Inc.
    Inventor: Charles R. Cantor
  • Publication number: 20200232016
    Abstract: Provided herein are compositions and methods for analysis of nucleic acids, including, methods and compositions for genotyping, haplotyping, sequencing and performing other genetic and epigenetic analyses on nucleic acids, for example. In some embodiments, methods and compositions suitable for whole-genome sequencing on single molecules of nucleic acid are provided. In some embodiments, analysis of single molecules of nucleic acid are performed in conjunction with nanopores and/or nanopore devices.
    Type: Application
    Filed: December 16, 2019
    Publication date: July 23, 2020
    Applicant: Sequenom, Inc.
    Inventor: Charles R. Cantor
  • Publication number: 20200216885
    Abstract: Described herein are products and processes for nucleic acid quantification, which are in part useful for detecting and determining the nucleotide sequence of rare nucleic acids (i.e., low copy number nucleic acids) in a sample. Such products and processes are useful for reducing the dynamic range among different nucleic acid species.
    Type: Application
    Filed: December 4, 2019
    Publication date: July 9, 2020
    Applicant: Sequenom, Inc.
    Inventor: Charles R. Cantor
  • Publication number: 20200208212
    Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Application
    Filed: March 17, 2020
    Publication date: July 2, 2020
    Applicant: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren, Taylor Jacob Jensen
  • Patent number: 10699800
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: June 30, 2020
    Assignee: Sequenom, Inc.
    Inventors: Chen Zhao, Zeljko Dzakula, Cosmin Deciu, Sung Kyun Kim, Amin R. Mazloom, Gregory Hannum, Mathias Ehrich
  • Patent number: 10662421
    Abstract: Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: May 26, 2020
    Assignee: SEQUENOM, INC.
    Inventors: Carolyn R. Hoyal-Wrightson, Andreas Braun, Karsten E. Schmidt
  • Publication number: 20200160934
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: November 27, 2019
    Publication date: May 21, 2020
    Applicant: Sequenom, Inc.
    Inventors: Zeljko Dzakula, Amin R. Mazloom, Cosmin Deciu, Huiquan Wang
  • Patent number: 10622094
    Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: April 14, 2020
    Assignee: Sequenom, Inc.
    Inventors: Sung K. Kim, Gregory Hannum, Jennifer Geis, Cosmin Deciu
  • Patent number: 10612086
    Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: April 7, 2020
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren, Tyler Jacob Jensen
  • Publication number: 20200102593
    Abstract: The present invention relates to an in vitro method for detecting methylated DNA comprising (a) coating a container with a polypeptide capable of binding methylated DNA; (b) contacting said polypeptide with a sample comprising methylated and/or unmethylated DNA; and (c) detecting the binding of said polypeptide to methylated DNA. In a preferred embodiment, said method further comprises step (d) analyzing the detected methylated DNA by sequencing. Another aspect of the present invention is a kit for detecting methylated DNA according to the methods of the invention comprising (a) a polypeptide capable of binding methylated DNA; (b) a container which can be coated with said polypeptide; (c) means for coating said container; and (d) means for detecting methylated DNA.
    Type: Application
    Filed: October 10, 2019
    Publication date: April 2, 2020
    Applicant: Sequenom, Inc.
    Inventor: Michael Rehli
  • Publication number: 20200058372
    Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of chromosome alterations.
    Type: Application
    Filed: August 19, 2019
    Publication date: February 20, 2020
    Applicant: SEQUENOM, INC.
    Inventors: Sung KIM, Taylor Jacob JENSEN, Mathias EHRICH