Abstract: Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-? (G6Pase-?) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-?. The disclosed AAV vectors and rAAV can be used for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia), and complications thereof.

Abstract: An apparatus configured to provide portioned instances of a compressible material includes a channel assembly, a gas source, a cutting assembly, and a discharge assembly. The channel assembly holds a bulk instance of the material extending through upper and lower channels of a continuous channel. The gas source supplies gas to compress the bulk instance. The cutting assembly moves in relation to the channel assembly to isolate the upper and lower channels, severing upper and lower material portions of the bulk instance. The discharge assembly directs gas to impinge on a lower face of the cutting assembly to discharge the lower material portion as a portioned instance. The channel assembly may be moveable, where operation of the gas source, cutting assembly, and/or discharge assembly are based on moving the channel assembly between various positions. The gas supply may be controlled based on a determined property of the portioned instance.

Abstract: An aviation gasoline composition comprising an impure iso-octane fraction, at least one xylene and at least one C4 or C5 alkane, wherein the impure iso-octane fraction in said composition is a fraction comprising at least 90 mol % iso-octane and having a final boiling point of at least 180° C. and is present in the composition in an amount in the range of from 30 to 80 vol. % based on the composition, the composition is substantially free of any lead compounds, the composition has a motor octane number of at least 94 and the composition has a final boiling point of at most 170° C. The composition of the present invention may be made by blending together an impure iso-octane fraction, xylene, at least one C4 or C5 alkane, optionally ethyl tertiary butyl ether, and optionally methylcyclopentadienyl manganese tricarbonyl and may he used in a spark ignition aviation engine, either alone or in combination with methanol or a methanol and water mixture.

Abstract: System and methods of controlling fluid diversion during stimulation treatments are provided. Real-time measurements are obtained from a plurality of fiber-optic data sources at a well site during a stimulation treatment being performed along a portion of a wellbore within a subsurface formation. Fracture growth and stress within the subsurface formation surrounding the portion of the wellbore are determined as the stimulation treatment is performed, based on the real-time measurements and a fully-coupled diversion model. An amount of diverter for a diversion phase of the stimulation treatment to be performed along the portion of the wellbore is determined, based on the fracture growth and the stress within the subsurface formation. The diversion phase of the stimulation treatment is performed by injecting the amount of diverter into the subsurface formation via at least one injection point located along the portion of the wellbore.

Abstract: Improved steamblow commissioning of a steam plant with continuous filtration of particle laden condensate through dual strainer filters with backflush means operatable in parallel to enable isolation of one and backflushing while the other is backflushed and venting backflushed particles to waste to enable an uninterrupted commissioning process recycling steam with significant particulate burden relived by continuous cycling in alteration through the dual filers and removal of particles to waste with backflush.

Abstract: Systems and methods are provided for managing a cash advance service associated with a payment account of a user. An exemplary method may include providing, to a device of the user, instructions to display an application interface, the application interface receiving user requests to enable and disable the cash advance service. The method may also include receiving, through the application interface, a request to enable the cash advance service. The method may further include associating a transaction rule with the payment account, the transaction rule defining a condition upon which approval of a cash advance transaction is permitted. The method may further include receiving a cash advance transaction authorization request associated with the payment account. The method may further include approving the cash advance transaction authorization request when the condition is met and declining the cash advance transaction authorization request when the condition is not met.

Abstract: Methods for producing proppants with a nanocomposite proppant coating are provided. The methods include coating the proppant particles with a nano-reinforcing agent, a surface modifier, and a resin to produce proppants with nanocomposite proppant coating. Additionally, a proppant comprising a proppant particle and a nanocomposite proppant coating is provided. The nanocomposite proppant coating includes a nano-reinforcing agent, a surface modifier, and a resin. The nanocomposite proppant coating coats the proppant particle. Additionally, a method for increasing a rate of hydrocarbon production from a subsurface formation through the use of the proppants is provided.

Abstract: A method of operations in a subterranean formation, including driving a pump with an electrically powered motor to pressurize fluid, inserting a tool into a wellbore that intersects the formation, and directing the pressurized fluid into the wellbore above the tool to push the tool into the wellbore.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: A method and system for an electromagnetic sensor. A method may comprise introducing an electromagnetic induction tool into a wellbore. The electromagnetic induction tool may comprise an insulated section and an electromagnetic device. The method may further comprise performing a first measurement with the electromagnetic induction tool; adjusting an impedance parameter of the insulated section; performing a second measurement with the electromagnetic induction tool; including the first measurement and the second measurement in an inversion process, wherein the inversion process calculates the downhole electromagnetic parameters; and adjusting at least one operational parameter of a well operation based at least in part on the downhole electromagnetic parameters. An electromagnetic sensor system may comprise a conductive body, an electromagnetic device, and a microcontroller configured to adjust an impedance parameter of the insulated section.

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.

Abstract: Object recognition based estimation of planogram compliance provides an expected arrangement of products in shelves. Identifying whether a product is placed in an appropriate location of a shelf is a challenging task due to various real-time parameters associated with image capturing. In the present disclosure, an input image associated with shelf of a retail store is received and a product images are cropped. Further, a set of reference images stored in a database are scaled corresponding to the input image. Further, one or more composite matching scores are calculated based on normalized cross-correlation and shape based feature matching to obtain one or more probable product images associated with a location. Further, a Directed Acyclic Graph (DAG) is constructed based on the one or more composite scores and the one or more probable products. Finally, an optimal matching product image for a particular location is obtained from the DAG.

Abstract: The present disclosure provides the identification of tobacco Nic1 locus. Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Also provided are compositions and methods for producing tobacco plants having novel Nic1 mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or nicotine free while maintaining tobacco leaf grade and tobacco product quality.

Abstract: Disclosed are systems and method of securing and pro-tecting control lines during run-in into a wellbore with wellbore tape. The wellbore tape includes a substrate having a front surface and a back surface, a wear-resistant coating disposed on at least a portion of the front surface, and an adhesive layer disposed on the back surface, the adhesive layer being configured to affix the substrate to an outer surface of a conveyance.

Abstract: The present disclosure addresses the technical problem related to the identification of microbial basis of a disease in microbiome. A system and method for identification of key driver responsible for bringing a change in a microbial population has been disclosed. A subset of common taxa between the ‘control’ and ‘case’ dataset is chosen and corresponding microbial association network is created. The method involves the characterization of the important community level changes between two association networks (‘control’ and ‘case’) that are obtained for a particular disease or condition. A taxon in the diseased state with an altered set of associations (identified by a high network shift score), while still being increasingly important (identified with a positive increase in betweenness) for the whole network, necessarily holds a key significance in the identification of key driver.

Abstract: Systems and methods are provided for managing foreign transactions. An exemplary method may include providing, to a device of the user, instructions to display an application interface. The application interface may receive user requests to specify a foreign geographical area and to enable and disable the foreign transaction service in the foreign geographical area. The method may also include receiving, through the application interface, a request to enable the foreign transaction service. The method may include associating a transaction rule with the payment account. The transaction rule may define a condition upon which approval of a foreign transaction is permitted. The method may also include receiving a foreign transaction authorization request associated with the payment account. The method may also include approving the foreign transaction authorization request when the condition is met and declining the foreign transaction authorization request when the condition is not met.

Abstract: The disclosure generally relates to vehicle maintenance and more particularly to methods and systems for automatic vehicle maintenance scheduling. The method comprises obtaining acceleration data at a fixed sampling rate of a moving vehicle when the moving vehicle attains at least a pre-determined speed for a pre-determined time from start of the moving vehicle. The obtained acceleration data is processed to generate jerk energy values at predetermined intervals. Speed normalized jerk energy is computed based on an average of the generated jerk energy values and average speed of the moving vehicle. A relationship between journey number and the computed speed normalized jerk energy is computed. A vehicle maintenance indicator based on the computed relationship between the journey number and the computed speed normalized jerk energy is finally computed.

Abstract: A communication assembly including at least one sensor assembly made up of interrogation circuitry and one or more antennae is described. The interrogation circuitry comprises at least one inductor comprising at least two sensing coils for reception of signals from the MEMS data sensors.

Abstract: Various embodiments are directed to systems and methods for monitoring and compiling weather information/data for a plurality of identified locations along a route. A central computing entity 100 may store and retrieve a weather information/data inquiry template from memory, and may populate the weather information/data inquiry template with relevant information/data identifying locations for which weather information/data is requested. The central computing entity 100 may utilize the populated inquiry template to retrieve weather information/data from one or more weather information/data sources by transmitting the populated weather information/data inquiry to the one or more weather information/data sources to cause the weather information/data sources to provide weather information/data to the one or more computer processors; and to compile the retrieved weather information/data from the one or more weather information/data sources.

Abstract: A device receives, from a transaction device, transaction data associated with a transaction performed by a user, and receives first location data indicating a location of a mobile user device. The device receives, from a stationary user device, browser data associated with online activity of the user, and determines, based on the browser data, second location data indicating a location of the stationary user device. The device determines, based on the transaction data, third location data indicating a location of the transaction device, and assigns weights and time stamps to the first, second, and third location data. The device aggregates the first, second, and third location data, based on the weights and the time stamps, to generate aggregated location data. The device processes the aggregated location data, with a model, to predict a particular location of the user, and performs actions based on the particular location.