Abstract: Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the heterologous antigenic insert is positioned within the rubella structural protein ORF. In some examples, the heterologous antigenic insert is positioned in the rubella structural protein ORF in between a gene encoding structural protein E2 and a gene encoding structural protein E1. Exemplary antigenic inserts include HIV, SIV, RSV or hepatitis B surface antigens. In some examples, the HIV antigenic insert is a Gag antigenic insert, a gp41 antigenic insert or a gp120 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to a particular virus, such as HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors).
Type:
Grant
Filed:
April 8, 2013
Date of Patent:
February 14, 2017
Assignee:
The United States of America, as Represented by the Secretary, Department of Health and Human Services
Abstract: A sand control completion system comprises: (A) a first flow rate regulator, wherein the first flow rate regulator is positioned in a first interval of a wellbore, wherein the first flow rate regulator is part of a first sand control assembly; and (B) a second flow rate regulator, wherein the second flow rate regulator is positioned in a second interval of the wellbore, wherein the second flow rate regulator is part of a second sand control assembly, wherein a reservoir fluid is caused or allowed to simultaneously flow through the first and second flow rate regulators into a tubing string, wherein the reservoir fluid is commingled into a single fluid stream within the tubing string. A method of using the sand control completion system to simultaneously produce a reservoir fluid from more than one zone of a subterranean formation is also provided.
Type:
Grant
Filed:
August 20, 2013
Date of Patent:
February 14, 2017
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Richard C. Jannise, Gregory W. Garrison, John C. Gano
Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
Type:
Grant
Filed:
November 9, 2011
Date of Patent:
February 14, 2017
Assignee:
Zoetis Services LLC
Inventors:
Jay Gregory Calvert, David Ewell Slade, Siao-Kun W. Welch
Abstract: Methods and systems are disclosed for configuring a plurality of tiles displayed in a graphical user interface. In some embodiments, the method comprises receiving an initial state of the tiles, wherein the initial state includes two overlapping tiles; deriving, via the one or more computer processors, one or more secondary states from the initial state by rearranging the tiles in the initial state; calculating one or more scores for the initial state and the secondary states; and determining, based on the scores, a selected state from among the initial state and the one or more secondary states as a display state to be displayed on the user interface.
Abstract: A well system and associated method can include an acoustic generator which can be used to excite a formation with acoustic waves transmitted from the acoustic generator. Another well system and associated method can include an acoustic generator which can transmit acoustic waves into cement surrounding a casing. Another well system and associated method can include an acoustic generator which can be used to transmit acoustic waves into an annulus surrounding a well screen during or after a gravel packing operation. Another well system and associated method can include an acoustic generator which can be connected in a drill string in close proximity to a drill bit, with the acoustic generator transmitting acoustic waves into a formation ahead of the bit.
Type:
Grant
Filed:
July 13, 2010
Date of Patent:
February 14, 2017
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Travis W. Cavender, Roger L. Schultz, Daniel D. Gleitman
Abstract: Various embodiments include apparatus and methods of determining the viscosity of a fluid downhole in a well. A parameter of a response signal, obtained from driving a tube containing a fluid with an excitation signal for vibrating the tube, can be collected while maintaining the tube in a vibrating mode. The parameter can be evaluated to measure the viscosity of the fluid. In various embodiments, the fluid viscosity may be measured in-situ downhole in the well.
Type:
Grant
Filed:
March 29, 2010
Date of Patent:
February 14, 2017
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Li Gao, Michael T. Pelletier, Bob Engelman
Abstract: An image of a check that is in the field of view of a camera is monitored prior to the image of the check being captured. When the image of the check in the field of view passes monitoring criteria, an image may be taken by the camera and provided from the mobile device to a financial institution. The image capture may be performed automatically as soon as the image of the check is determined to pass the monitoring criteria. The check may be deposited in a user's bank account based on the image. Any technique for sending the image to the financial institution may be used. Feedback may be provided to the user of the camera regarding the image of the check in the field of view.
Type:
Grant
Filed:
June 20, 2013
Date of Patent:
February 14, 2017
Assignee:
United Services Automobile Association (USAA)
Inventors:
Michael Patrick Bueche, Jr., Bharat Prasad, Minya Liang, Reynaldo Medina, Charles Lee Oakes, III
Abstract: Apparatus, systems, and methods may operate to communicate, by an information-bearing signal across a mechanical interface, between a pair of electromechanical transducer elements when the pair is compressively loaded. Compressive loading may occur after coupling a male portion of a pipe joint to a female portion of the pipe joint to form the pipe joint. A first one of the pair of electromechanical transducer elements may be included in the male portion, and a second one of the pair may be included in the female portion. Additional apparatus, systems, and methods are disclosed.
Abstract: CO2 scavenging additives having one or more cyanamide functionalities for the reduction of corrosion in subterranean formations are disclosed. The additives are also suitable for the simultaneous scavenging of CO2 and H2S. The additives can be introduced by way of a treatment fluid for the subterranean formation to interact with and reduce the concentration of CO2 and/or H2S in the formation.
Abstract: Apparatus and methods are described, such as for obtaining information indicative of a formation resistivity using an electromagnetic formation evaluation tool apparatus. For example, the electromagnetic formation evaluation tool apparatus includes exciter electrodes configured to transmit and receive a formation current. A first exciter electrode may be insulated from a conductive apparatus housing and a second exciter electrode may be coupled to the conductive apparatus housing. Monitor electrodes may be insulated from the conductive apparatus housing. A receiver circuit may be coupled to the monitor electrodes and configured to measure a voltage differential between the monitor electrodes. A power amplifier circuit may be coupled to the first exciter electrode and the conductive apparatus housing and configured to generate the formation current wherein the conductive apparatus housing provides a return path to the power amplifier circuit for the formation current.
Abstract: Rheological quantities, such as shear stress, can sometimes be difficult to determine under extreme temperature and pressure conditions. In contrast, the relative rheology of a fluid can often be readily determined over a range of temperature and pressure conditions. The relative rheology can then be used to scale a rheological quantity of the fluid to a given temperature and pressure condition. Methods for scaling a rheological quantity can comprise: measuring an apparent viscosity of a drilling fluid at first, second and third reference temperature and pressure conditions; determining a rate of change in apparent viscosity with respect to temperature at a substantially equal pressure; determining a rate of change in apparent viscosity with respect to pressure at a substantially equal temperature; and scaling a rheological quantity from an initial set of temperature and pressure conditions to a final set of temperature and pressure conditions using the rates of change.
Abstract: A drilling method includes assigning values to behaviors of drilling parameters during a drilling operation; forming multiple parameter signatures, each of the parameter signatures comprising a respective combination of the values; comparing the parameter signatures to multiple event signatures, each of the event signatures being indicative of a respective drilling event; and controlling the drilling operation in response to at least a partial match resulting from comparing the parameter signatures to the event signatures.
Type:
Grant
Filed:
July 7, 2010
Date of Patent:
February 14, 2017
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Saad Saeed, Charles M. Pool, Frank Urias, James R. Lovorn, Emad Bakri
Abstract: A method for controlling a sensor may be performed by a mobile device including a processor and a memory. The method may include receiving raw data from the sensor, classifying the raw data into a context value, interpreting the context value into a higher-level context, receiving a predicted context based on the higher-level context, and controlling the sensor based on the predicted context. Controlling the sensor may include controlling a frequency at which raw data is received from the sensor, or an on/off state of the sensor. Control of the sensor may also be based on both the higher-level context and the predicted context.
Abstract: The present invention relates to chimeric pestiviruses having utility as immunogenic compositions and vaccines. Also described herein are methods and kits for treating or preventing the spread of bovine viral diarrhea virus infection, as well as methods and kits for differentiating between vaccinated and wild-type infected animals.
Type:
Grant
Filed:
November 24, 2009
Date of Patent:
February 14, 2017
Assignee:
Zoetis Services LLC
Inventors:
Yugang Luo, Siao-Kun Wan Welch, Ying Yuan, Robert Gerard Ankenbauer
Abstract: Configurable user interface systems for a patient support structure are disclosed. As described a control interface comprises the capability to allow limited impact on processes deemed important when other applications and programs are run. The configurable user interface systems described herein allow for customized display of information and display options available to a user in various environments.
Abstract: Systems and methods for optimizing drilling results may be based on, inter alia, (1) real-time data collected during drilling, (2) a transiently modeled cuttings distribution along the wellbore, and optionally (3) a theoretical change to one or more operational parameters. In some instances, methods may include drilling a wellbore penetrating a subterranean formation while circulating a drilling fluid; gathering real-time data about the drilling; calculating a cuttings distribution along the wellbore based on the real-time data using a transient model; calculating an equivalent circulating density profile along the wellbore based on (1) real-time data collected during drilling, (2) a transiently modeled cuttings distribution along the wellbore, and optionally (3) a theoretical change; and changing at least one operational parameter based on a comparison of the equivalent circulating density profile to a fracture gradient of the subterranean formation.
Abstract: A tool sensor calibration system and tool calibration method are disclosed herein. A tool sensor calibration system (200) comprises a flow pipe (206), an isolation cell (214) in fluid communication with the flow pipe, a sensor (210) positioned proximate to the isolation cell, a fluid chamber (213) containing a reference fluid (212) with a known property value, and a first valve (222a) coupled to the fluid chamber that provides selective fluid communication between the fluid chamber and the flow pipe. A tool calibration method comprises introducing a first fluid (208) into a flow pipe, introducing a reference fluid into the flow pipe from a fluid chamber in fluid communication with the flow pipe through a valve, wherein the first fluid and the reference fluid mix to form a composite fluid, and detecting a property of the composite fluid at an isolation cell in fluid communication with the flow pipe.
Abstract: The present invention relates to nucleic acids encoding flavonoid biosynthetic enzymes, flavonoid-regulating transcription factors and a flavonoid-specific membrane transporter in plants, and the use thereof for the modification of flavonoid biosynthesis in plants. The present invention also relates to constructs and vectors including such nucleic acids, and related polypeptides. More particularly, the protein involved in flavonoid biosynthesis is selected from the group consisting of TRANSPARENT TESTA 12 (TT12), TRANSPARENT TESTA GLABRA 1 (TTG1), TRANSPARENT TESTA 2 (TT2), TRANSPARENT TESTA 8 (TT8), Ieucoanthocyanidin dioxygenase (LDOX), cinnamate-4-hydroxylase (C4H), 4-coumaroyl:CoA-ligase (4CL); and functionally active fragments and variants thereof.