Abstract: The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method.

Abstract: The disclosure herein addresses estimating WTP distributions from bundled and unbundled sales data using GMDN model. The input samples are passed through the GMDN model to learn the plurality gamma mixture parameters. The learnt gamma mixture parameters are then used to evaluate the weighted CDF value at the offered price of the bundle and the bundle composition. The weighted CDF value is then used to predict the customer's choice based on the predefined threshold and estimates the revenue optimal price of the bundle composition. The disclosed GMDN model models the WTP distributions as the mixture of gamma distributions and learns the WTP distributions from the bundled and the unbundled sales with greater accuracy and excels in estimating the revenue optimal prices and the revenues of the products and the bundles.

Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.

Abstract: A device may receive a VCN generation request comprising a primary account number (PAN) and an approved URL. A device may generate a VCN based on the PAN, the VCN being associated with the approved URL. A device may receive a VCN use request from an external entity, the VCN use request comprising the VCN. A device may receive a use request URL associated with the VCN use request. A device may compare the use request URL to the approved URL. A device may provide a VCN use decision based on the comparing the use request URL to the approved URL, the VCN use decision including a VCN use authorization or a VCN use denial.

Abstract: Enrollment data packet including device information of a user and resource provider information is received by a processing computer from an authorizing entity computer. The processing computer generates a token request push data packet including user information and the device information and transmits, to user device, the token request push data packet. The user device then transmits a request to initiate token provisioning to a resource provider computer associated with the resource provider information. Provisioning request generated based on the request to initiate the token provisioning is received by the processing computer from the resource provider computer and transmitted to a token service computer. The provisioning request includes the token request push data packet. Upon receiving the provisioning request, the token service computer determines token data using the device information and the user information and provides the token data to the resource provider computer.

Abstract: This disclosure relates generally to method and system to generate persona-based commentary data for machine learning model card document. Existing techniques on model card are designed mainly for personas and understanding section of the model card document requires a certain level of expertise in machine learning. The method of the present disclosure receives a model card document comprising a plurality of sections and the model card document corresponds to a persona. Each section of the model card document obtains a metadata for the persona. The data curator machine learning model automatically generates a persona-based report trajectory for a plurality of sections of the metadata and a plurality of schema rules to generate a prompt template. The commentary generator ML model generates one or more commentary data for each section associated with the prompt template corresponding to the persona.

Abstract: The method includes applying a first current at a pair of connectors, the first current passing through a bypass line while circumventing an activation of an internal circuitry, a first end of the bypass line being connected to one of the pair of connectors and a first line of the internal circuitry, a second end of the bypass line being connected to a first terminal of a first battery and a second line of the internal circuitry, the first terminal and a second terminal of the first battery each being respectively electrically connected to one of the pair of connectors, and measuring a first measured voltage at the pair of connectors during the applying of the first current.

Abstract: A method may include: providing one or more inputs to a hybrid data generator, wherein one of the one or more inputs is based at least in part on a wellsite location, wherein the hybrid data generator comprises a large language model, and wherein the large language model is based at least in part on a machine learning algorithm; utilizing an information handling system to generate a cement job design based at least in part on the one or more inputs and the hybrid data generator; performing at least a portion of a cementing operation based at least in part on the cement job design; and collecting at least one measurement from at least one sensor during the cementing operation.

Abstract: A method for locating a fault in an electric utility system includes retrieving fault data, with a computing system and analyzing relay history to find a pattern of events and locations, with the computing system. The method further includes analyzing the fault data to determine an approximate location with the computing system and determining, with a short circuit and load flow module, a pre-fault load. The method further includes running a short circuit study at a plurality of locations until a location is found that corresponds to the fault data and determining that the location is where a fault occurred.

Abstract: End of line packaging automation is an automated technology that is operated at end of production line to pack products. Existing packaging machines occupy greater footprints, with huge material wastage and loss of material. Embodiments herein provide an autonomous packaging machine for packaging objects. Autonomous packaging machine includes centering unit with two centering actuators moving in opposing directions to align objects symmetrically about central line of a tensioned package material. Web guide roller moves in predefined arc carrying a tail of package material roll to align between the web guide roller and nip roller. Forming rods create a hollow brick type cavity for the package. Centre sealing with hot sealing jaws and fluted jaws to press package material and seal at centre with object placed inside. Outfeeder carries centre sealed packed objects from infeeder to exit conveyor. Set of four hot sealers for sealing on both sides of formed pack.

Abstract: A procedure for modifying a user interface may include causing a first application on a user device to monitor an electronic session of a second application on the user device. The first application may determine a characteristic of the electronic session, query an API using the determined characteristic for a relevant single-application code, and receive a response back from the API. The first application may detect an activation of a user interface element associated with completing an interaction on the electronic session. In response to the detection, the first application may interrupt a response of the second application to the activation. During the interruption, the first application may modify the interaction, e.g., by injecting execution of the single-application code into the second application, and then cause the response of the second application to resume with the modified interaction.

Abstract: MST calibration is required to ensure that all examinees are assessed on a common scale. State of the art approaches have the disadvantages that they become computationally unstable and demanding or may have standard errors of estimated item parameters. Method and system in the embodiments disclosed herein provide a module-wise calibration approach in which a shift parameter value is estimated as difference in the average difficulty level between each two modules from among the plurality of modules. Further, based on the estimated value of the shift parameter, the estimated average difficulty level of each of the plurality of modules is aligned to a common scale. By aligning each of the plurality of modules to the common scale users who took different combinations of the plurality of modules are assessed on the common scale.

Abstract: A computer-implemented method for debiasing vectorized language representations can include identifying two (or more) pairs of concepts for which debiasing is desired, computing a mean vector for each concept, determining a center point for a rotation operation to orthogonalize based on the mean vectors, and shifting the vectors to the center point before performing a rectification operation (which can be a graded rotation), after which the vectors can be shifted back from the center point. If desired, the process can be performed iteratively.

Abstract: Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Disclosed herein are methods and systems for capturing a large collection of downhole fluid samples and, more particularly, disclosed are methods and systems for using at least two hydraulic pressure lines to alternatingly actuate hydraulic valves disposed in an interlinked series to obtain any large collection of hydraulically actuated components to be energized in sequence. A large collection of downhole fluid samples may be defined as any number of downhole fluid samples wherein the number of downhole fluid samples is larger than the number of actuators.

Abstract: A computer-implemented method to estimate a boundary of a downhole formation data includes obtaining an inversion model of a downhole formation. The method also includes defining a boundary of the downhole formation. The method further includes determining the boundary based on values associated with the inversion model. The method further includes organizing the boundary into one or more clusters. The method further includes determining uncertainties associated with the one or more clusters.

Abstract: A method includes receiving, from an exchange rate computer, a rate for exchange between a first value type and a second value type, providing, to a clearing and settlement system, the rate or a derivative thereof, and receiving a trade sum from the clearing and settlement system. The trade sum corresponds to an expected settlement amount for a plurality of transactions in which receivers in the transactions receive values of the second value type. At least some of the transactions utilize the rate or a derivative thereof. The method also includes transmitting, to a correspondent entity computer, an exchange request to exchange an amount of value from the first value type to the second value type. The amount of value is based on the trade sum. The clearing and settlement system initiates a transfer message to the correspondent entity computer to transfer the value of the second value type.

Abstract: Methods, systems, and apparatuses are described herein for improving the accuracy of synthetic authentication questions by analyzing third party account data. A request for access to a first account associated with a user may be received. The first account may be managed by a first organization. A transactions database might be queried for first account data. Second account data corresponding to a second account associated with the user might be received. That second account may be managed by a second organization different from the first organization. One or more second transactions, unique to the second account, may be identified. A synthetic transaction, configured to be different from transactions in the first account and the one or more second transactions, may be generated. An authentication question may be generated based on the synthetic transaction. Access to the first account might be provided based on a response to the authentication question.

Abstract: Systems and methods to process overhead imagery received from overhead image sources are described herein. Examples include accessing an aerial image of properties, determining damage estimates, and reserving resources to repair the properties based on the damage estimates. Examples include receiving information describing property damage, determining a cause, and based on the cause, conditionally deploying a unmanned aerial vehicle to perform insurance adjustment activities.

Abstract: Systems and methods for authentication may include an authentication server. The authentication server may include a processor and a memory. The processor may be configured to transmit an authentication request. The processor may be configured to receive a first response that is responsive to the authentication request, the first response comprising a first cryptogram. The processor may be configured to generate a first challenge based on the first response. The processor may be configured to encrypt the first challenge with a symmetric key. The processor may be configured to transmit the first challenge receive a second response that is responsive to the first challenge, the second response comprising a second cryptogram. The processor may be configured to authenticate the second response.