Patents Assigned to Shanghai Jiaotong University
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Publication number: 20250129457Abstract: Provided are a corrosion-resistant oxide dispersion strengthened steel and a method for preparing the corrosion-resistant oxide dispersion strengthened steel. The corrosion-resistant oxide dispersion strengthened steel includes in percentage by mass: Cr at 8.0 wt %-10.0 wt %, Al at 4.0 wt %-6.0 wt %, Ce at 0.2 wt %-0.8 wt %, Y at 0.2 wt %-0.4 wt %, O at 0.05 wt %-0.3 wt %, C less than or equal to 0.0016 wt %, and the balance of Fe.Type: ApplicationFiled: October 19, 2024Publication date: April 24, 2025Applicant: SHANGHAI JIAOTONG UNIVERSITYInventors: ZHAO SHEN, YIHENG WU, XIAOQIN ZENG, XUJIA WANG, LING LI, YIBIN TANG
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Patent number: 12280154Abstract: The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a ?-(1,4)-glucoside bond or/and a lactose with a ?-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that ?-(1,4)-glucoside bond provided by cellobiose or/and ?-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (?-glucosidase or/and ?-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.Type: GrantFiled: September 26, 2023Date of Patent: April 22, 2025Assignee: SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINEInventors: Zeyu Xiao, Gaoxian Chen, Kai Cui
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Patent number: 12276013Abstract: Provided are a corrosion-resistant oxide dispersion strengthened steel and a method for preparing the corrosion-resistant oxide dispersion strengthened steel. The corrosion-resistant oxide dispersion strengthened steel includes in percentage by mass: Cr at 8.0 wt %-10.0 wt %, Al at 4.0 wt %-6.0 wt %, Ce at 0.2 wt %-0.8 wt %, Y at 0.2 wt %-0.4 wt %, O at 0.05 wt %-0.3 wt %, C less than or equal to 0.0016 wt %, and the balance of Fe.Type: GrantFiled: October 19, 2024Date of Patent: April 15, 2025Assignee: SHANGHAI JIAOTONG UNIVERSITYInventors: Zhao Shen, Yiheng Wu, Xiaoqin Zeng, Xujia Wang, Ling Li, Yibin Tang
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Patent number: 12275924Abstract: Provided are a method for detecting a free rare tumor cell in a human biological fluid sample and assay kit. Specifically, the method of the invention determines the existence of an active tumor cell in a biological fluid sample of a cancer patient by detecting and confirming the existence of glucose absorption capability of a karyocyte and expression of a leukocyte marker (CD45).Type: GrantFiled: July 16, 2021Date of Patent: April 15, 2025Assignee: SHANGHAI JIAOTONG UNIVERSITYInventors: Qihui Shi, Shun Lu, Yuliang Deng, Yin Tang
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Publication number: 20250049992Abstract: A bone tissue regeneration product, a method for preparing the bone tissue regeneration product and, and a method for repairing a bone defect. The new use of IGSF10 of the present disclosure can reduce the effective concentration of BMP without obvious adverse reactions, thereby exploring a method to promote bone tissue regeneration and providing new ideas for the treatment of bone defects. The present disclosure is capable of promoting non-bone related cells to produce bones; the method of the present disclosure is also capable of inhibiting the bone loss in inflammatory environments.Type: ApplicationFiled: July 25, 2024Publication date: February 13, 2025Applicant: Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of MedicineInventors: Xinquan JIANG, Jin WEN, Yuwei DENG, Ruixue JIANG, Xiao WANG, Qianju WU, Ran YAN
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Patent number: 12196792Abstract: A non-destructive measurement method and apparatus for the turn-to-turn resistivity distribution (TTRD) in non-insulation (NI) superconducting coils. The method includes: during the discharging or charging process, obtaining experimental values of voltage varying over preset time at different positions of the test coil; dividing the test coil into a plurality of measurement units and obtaining basic circuit elements; then constructing a preset equivalent circuit model including the basic circuit elements; based on the constructed equivalent circuit model, obtaining the first simulated values of voltage varying over preset time at different positions of the test coil; finally, determining the TTRD of the test coil based on the fitness value between experimental values and the first simulated values. When there is high fitness value between the first simulated values and experimental values, the TTRD corresponding to the first simulated values is considered as the TTRD within the test coil.Type: GrantFiled: May 10, 2024Date of Patent: January 14, 2025Assignee: SHANGHAI JIAOTONG UNIVERSITYInventors: Wei Wu, Li Lu, Jianghong Wan
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Publication number: 20240390113Abstract: A dental braces includes at least one fixing element attached to surfaces of multiple abnormal teeth and provided with a first connector, and an orthodontic element provided with a second connector adapted to the first connector, where the second connector is engaged with the first connector to form an interference fit, such that the orthodontic element is detachably connected to the fixing element; and an elastic force of the orthodontic element acts on the abnormal teeth to control movement of the abnormal teeth.Type: ApplicationFiled: September 2, 2022Publication date: November 28, 2024Applicant: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINEInventors: Chao LIU, Bing FANG, Qingling YOU
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Patent number: 12142752Abstract: Monodisperse microspheres are arranged in macropores of a substrate to form a photonic crystal structure; with the photonic crystal as a template, ordered microporous carbon is synthesized in gaps of the template, and then the photonic crystal template is removed to obtain a three-dimensional ordered hierarchical porous carbon photonic crystal, and thus a large-area thick-film controllable textured photonic crystal is formed and is composited with element sulphur to obtain a sulphur cathode, and the sulphur cathode and metal lithium serving as a counter electrode are assembled into a lithium-sulphur battery. According to the invention, the controllable thick film with an electrode thickness of 10 ?m to 650 ?m can be achieved by changing the thickness of the substrate and the concentration of a suspension liquid. In the meanwhile, large-area preparation with an electrode area of 0.1 cm sup.2 to 400 cm sup.2 can be achieved by changing the area of the substrate.Type: GrantFiled: December 13, 2019Date of Patent: November 12, 2024Assignee: SHANGHAI JIAOTONG UNIVERSITYInventors: Xiaobin Hu, Shengxuan Lin, Zihe Cai, Jlajia Xiao, Yuhang Chen, Yifan Wang
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Patent number: 12138683Abstract: The present invention relates to a substrate-triggered single crystal superalloy directional solidification process, including: (1) preparing a single crystal substrate material having crystallographic characteristics that match crystallographic characteristics of the single crystal superalloy; (2) fabricating a single crystal substrate chilling plate using the obtained single crystal substrate material; and (3) applying the obtained single crystal substrate chilling plate in a directional solidification apparatus, and then preparing a single crystal alloy product by performing superalloy melting and directional solidification.Type: GrantFiled: December 9, 2020Date of Patent: November 12, 2024Assignee: Shanghai Jiaotong UniversityInventors: Long Zeng, Mingxu Xia, Jun Li, Binqiang Wang, Jianguo Li
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Patent number: 12116345Abstract: A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.Type: GrantFiled: May 21, 2024Date of Patent: October 15, 2024Assignees: SHANGHAI JIAOTONG UNIVERSITY, SPH NO.1 BIOCHEMICAL & PHARMACEUTICAL CO., LTD.Inventors: Wanbin Zhang, Yaohua Zhang, Feng Gao, Wei Yu, Jing Li, Ximing Jiang, Zhenfeng Zhang, Liang Wu, Yuanlin Wang, Yujia Fu
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Patent number: 12067728Abstract: A heterogeneous image registration method includes: performing edge detection on collected images, in combination with a curvature scale space strategy to extract contour curved segments in an edge image. Implementing a feature point detection strategy based on global and local curvature detecting feature points in the contour curved segments, and obtaining the nearest minimum local curvature of the feature points pointing to starting and end points of the contour, respectively. Calculating the number of neighborhood sampling points and neighborhood auxiliary feature points of neighborhoods on both edges of each of the feature points according to the nearest minimum local curvature. Using neighborhood auxiliary feature points and feature points to form a feature triangle, calculating an angle bisector vector and a main direction corresponding to the feature point in the feature triangle.Type: GrantFiled: June 8, 2020Date of Patent: August 20, 2024Assignee: Shanghai Jiaotong UniversityInventors: Yadong Liu, Yingjie Yan, Qian Jiang, Ling Pei, Zhe Li, Peng Xu, Lei Su, Xiaofei Fu, Xiuchen Jiang
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Publication number: 20240165037Abstract: The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a B-(1,4)-glucoside bond or/and a lactose with a p-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that B-(1,4)-glucoside bond provided by cellobiose or/and p-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (p-glucosidase or/and p-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.Type: ApplicationFiled: September 26, 2023Publication date: May 23, 2024Applicant: Shanghai Jiaotong University School of MedicineInventors: Zeyu Xiao, Gaoxian Chen, Kai Cui
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Patent number: 11986575Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.Type: GrantFiled: March 29, 2022Date of Patent: May 21, 2024Assignee: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINEInventors: Kun Sun, Jing Sun, Sun Chen, Kai Bai, Yanan Lu, Lu Wang, Fujun Wang, Fan Zhao, Jihong Huang
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Patent number: 11973994Abstract: Provided is a media processing method. The method is used for uploading a function provided by a user or a third party and obtaining media processing parameters provided by the user. The method includes the following steps: receiving the description information of the media processing and determining whether a function that fulfills the requirement of the description information exists in a system; in a case where the function that fulfills the requirement of the description information exists, selecting the function that fulfills the requirement of the description information from the system; and in a case where the function that fulfills the requirement of the description information does not exist, selecting the function from the system according to the priority or selecting the function that fulfills the requirement of the description information from outside the system.Type: GrantFiled: July 4, 2020Date of Patent: April 30, 2024Assignee: Shanghai JiaoTong UniversityInventors: Yiling Xu, Qi Yang, Yunfeng Guan
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Patent number: 11962153Abstract: The present invention provides an active distribution network physics-information fusion control method for a hybrid system model includes an initialization time being a starting time, predicting power output and load of a feeder intermittent distributed power supply within a control time period T, calculating a feeder exchange power deviation variation ?P(t) during the control time period, if being a fixed distribution coefficient, and establishing a hybrid system model for feeder power coordinated control; if being a rolling distribution coefficient, an exchange power P(t) of the control region at time t being obtained, generating a distribution coefficient matrix W(t), and establishing the hybrid system model of the said feeder power coordinated control; confirming a control objective function min J, converting it into a MIQP, obtaining a full period control quantity; selecting a first control quantity P of the optimized control sequence, sending the first control quantity P to the control device.Type: GrantFiled: October 4, 2021Date of Patent: April 16, 2024Assignee: Shanghai Jiaotong UniversityInventors: Dong Liu, Fei Chen, Jiaming Weng
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Publication number: 20240115658Abstract: A use of an intervertebral disc fibrosis-inducing substance in preparation of medication, where the medication is used for the treatment of degenerative spinal diseases. The inventors of the present disclosure make use of the pro-fibrotic effect of the intervertebral disc fibrosis-inducing substance and the auxiliary effect of the fibroblast to achieve further treatment of intervertebral disc degeneration. The simultaneous administration of the above two drugs can reasonably control the degeneration and achieve the purpose of stepped treatment, thereby having clinical transformation value. In addition, the therapy combining the intervertebral disc fibrosis-inducing substance with the cell in the present disclosure allows the treatment regimen more personalized.Type: ApplicationFiled: June 11, 2021Publication date: April 11, 2024Applicant: Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of MedicineInventors: Jie ZHAO, Chen CHEN, Xiao YANG, Tangjun ZHOU, An QIN, Zhiqian CHEN, Kai ZHANG, Yifan ZHOU
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Patent number: 11952913Abstract: A turbine blade includes a blade body, a division plate, a plurality of first protruding ridges, a plurality of second protruding ridges, a first jet hole group, and a second jet hole group. The blade body includes a suction-side wall surface and a pressure-side wall surface, which are provided with multiple film cooling holes. The stagnation region at the leading edge of the blade body is provided with multiple film cooling holes. The first and second jet hole groups are provided on the division plate. The first protruding ridges are provided on a suction-side inner wall surface, and the second ridges are provided on a pressure-side inner wall surface. An engine including the turbine blade is further provided.Type: GrantFiled: April 21, 2023Date of Patent: April 9, 2024Assignee: Shanghai Jiaotong UniversityInventors: Yu Rao, Yong Luan, Yamin Xu
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Patent number: 11931892Abstract: A robotic system includes a support structure, a motor mount assembly, first and second parallel chains, a serial translation assembly, a sensor and a control module. The motor mount assembly includes rotary motors, where the rotary motors include a first rotary motor and a second rotary motor. The first and second parallel chains are connected to the movable platform, the rotary motors and the motor mount assembly. The serial translation assembly is connected to the supporting structure and the motor mount assembly and includes a linear actuator and a third rotary motor. The sensor is connected to the movable platform and detects force applied by a human operator on the movable platform and generates a signal indicative of the force applied. The control module controls the rotary motors and the third rotary motor based on the signal to assist the human operator in moving the movable platform.Type: GrantFiled: December 17, 2021Date of Patent: March 19, 2024Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, Shanghai JiaoTong UniversityInventors: Qiao Sun, Xianbao Chen, Jing Sun, Feng Gao, Dalong Gao, Ningjian Huang
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Publication number: 20240069027Abstract: A use of nitrogen-doped carbon fluorescent quantum dots in preparation of aerobic glycolysis detection products is provided. The carbon-nitrogen fluorescent quantum dots are selected from one or more of C3N4 quantum dots, C2N quantum dots, and C3N quantum dots. The aerobic glycolysis detection products are reagents, based on a final volume of the reagents, the reagents comprise the carbon-nitrogen fluorescent quantum dots with a final concentration of 1 ?g/mL-1 mg/mL. The present disclosure realizes fluorescent labeling of NAD+ in living cells using the carbon-nitrogen fluorescent quantum dots, thus achieving fluorescent labeling and imaging of cells having aerobic glycolysis, which has the advantages of low cost, high efficiency, rapidity, and high accuracy.Type: ApplicationFiled: December 28, 2021Publication date: February 29, 2024Applicants: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE, SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: JIPENG LI, SIWEI YANG, GUQIAO DING, HUIFANG ZHOU, XIANQUN FAN
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Patent number: 11913042Abstract: Methods of preparing and using a highly active blood coagulation factor XI mutant and a gene therapy/editing vector thereof and a recombinant/fusion protein thereof. The nucleotide sequence of the mutant is as shown in SEQ ID NOs: 1-6, and the amino acid sequence is as shown in SEQ ID NO: 7.Type: GrantFiled: August 30, 2018Date of Patent: February 27, 2024Assignees: RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINEInventors: Xuefeng Wang, Wenman Wu, Qiulan Ding