Abstract: An oral colon-targeted delivery system is described, which includes a bacterial flora sensitive layer which contains polysaccharides and covers the exterior of active ingredients, a pH sensitive layer which contains any polymer composition dissolved under the condition of pH?7 and covers the exterior of the bacterial flora sensitive layer. A preparation method and applications of the delivery system are also described. According to the oral colon-targeted delivery system combined with the pH sensitive and bacterial flora sensitive mechanisms, the selective dissolution and release of active ingredients in the colon site are effectively improved by using double-layer protection so that the therapeutic or diagnostic effect is enhanced, and the application prospect is broad.

Abstract: An apparatus used for increasing the level of CD4+T cells in a mammal. The mammal has a cancerous tissue. The apparatus comprises a cold treatment unit and a heat treatment unit. The cold treatment unit is used for cooling the cancerous tissue. The heat treatment unit is used for heating the cancerous tissue. A method for increasing the level of CD4+ T cells in the body of a cancer patient, comprising steps for cold treatment of the cancerous tissue and for heat treatment of the cancerous tissue.

Abstract: A method and apparatus for manufacturing an equiaxed crystal aluminum alloy cast ingot by using additive manufacturing and rapid solidification techniques are provided. The apparatus comprises: a metal heating mechanism and a negative pressure cooling mechanism. The metal heating mechanism is located above the negative pressure cooling mechanism and is connected thereto by a nozzle. The negative pressure cooling mechanism comprises a vacuum chamber having an air inlet hole and an air outlet hole, and a three-dimensional moving ingot mechanism disposed inside the vacuum chamber. The three-dimensional moving ingot mechanism comprises a moving ingot and a two-dimensional moving platform vertically connected to the moving ingot. A water cooling mechanism is disposed outside the moving ingot, and the moving ingot is driven by a precision motor to precisely move up and down.

Abstract: This invention relates to a double-layer fibrous annulus patch, a patch clamp, a suture needle and a fishbone suture. The inner layer foldable patch and the outer layer foldable patch are arranged and connected by a pair of crossed flexible connectors. Both ends of the two patches are connected by auxiliary connectors. A pair of auxiliary connectors are further arranged on both sides of the outer foldable patch, which can be used with the patch clamp to unfold the patch and secure it in place. With both patches in a folded state, the patch clamp is used to push the inner foldable patch through the rupture in the intervertebral disc into the annulus fibrosus and the patch unfolds within the annulus fibrosus. The outer layer foldable patch is unfolded on the outside of the annulus fibrosus and is fixed by two auxiliary connectors and fishbone sutures.

Abstract: A discrete Fourier transform spread orthogonal time frequency space modulation method comprises the steps of performing DFT preceding processing and delay-Doppler domain mapping processing on the transmit data symbols, OTFS modulator, and performing delay-Doppler domain demapping processing and IDFT decoding processing on a received signal to realize demodulation; compared with the existing waveforms, including OFDM and DFT-s-OFDM, the proposed DFT-s-OTFS can reduce the bit error rate under high Doppler spread and the peak-to-average power ratio of the transmitted signal at the same time.

Abstract: A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir.

Abstract: A robotic system includes a support structure, a motor mount assembly, first and second parallel chains, a serial translation assembly, a sensor and a control module. The motor mount assembly includes rotary motors, where the rotary motors include a first rotary motor and a second rotary motor. The first and second parallel chains are connected to the movable platform, the rotary motors and the motor mount assembly. The serial translation assembly is connected to the supporting structure and the motor mount assembly and includes a linear actuator and a third rotary motor. The sensor is connected to the movable platform and detects force applied by a human operator on the movable platform and generates a signal indicative of the force applied. The control module controls the rotary motors and the third rotary motor based on the signal to assist the human operator in moving the movable platform.

Abstract: The disclosure provides an anti-corrosion conductive film and methods of making and using thereof. The anti-corrosion conductive film is formed by sequentially forming an anti-corrosion protective layer, a stress transition layer and a conducting layer on the surface of a substrate by deposition through a high-low pulse bias alternation method. The anti-corrosion conductive film is a nano-multilayer anti-corrosion conductive film exhibiting excellent corrosion resistance and conductivity. The anti-corrosion conductive film has great application prospects in the fields of metal polar plates of fuel cells, ground grid equipment of power transmission lines, and the like.

Abstract: The invention relates to a nanosecond-scale power resource allocation method and system for microservices. In order to eliminate the macro-control delays, it uses an auto power budgeting module to distribute the limited power resource to each microservice according to its unique power-performance model. On the other side, it deploys an agile power regulation module to bypass the slow power control procedures at the server system layer. By directly invoking the voltage regulation circuit on the processor, this can remove the micro-execution delays. It also leverages a transparent mapping mechanism to coordinate the work of the auto power budgeting module and the agile power regulation module to achieve the optimal allocation of power resources. The present invention can exploit the intra-application variability brought by microservices, thus further break the energy-saving limitation of traditional data centers.

Abstract: The present disclosure provides methods and kits for diagnosing and assessing SAGE1-positive disorders, and compositions and methods for treating SAGE1-positive disorders. The present disclosure further provides SAGE1 complexes and methods and composition for inhibiting SAGE1 complexes and treating SAGE1-positive disorders.

Abstract: The present application provides an automatic knife stop device and a system for fibula cutting, a computer equipment, and a medium. The device includes: an acquisition module; a threshold module; and a judgment module. The present application can avoid the destruction of blood vessels during shaping and greatly improve the success rate of surgery, while greatly improve the robustness of the control system by increasing the strength of the force feedback signal.

Abstract: The present application provides an automatic knife stop device and a system for fibula cutting, a computer equipment, and a medium. The device includes: an acquisition module; a threshold module; and a judgment module. The present application can avoid the destruction of blood vessels during shaping and greatly improve the success rate of surgery, while greatly improve the robustness of the control system by increasing the strength of the force feedback signal.

Abstract: Use of glycerol in preparing an adipose tissue cryopreservation protective agent and the adipose tissue cryopreservation protective agent. Based on the total volume of the adipose tissue cryopreservation protective agent, the adipose tissue cryopreservation protective agent includes: glycerol with a volume fraction of 60-80%; 0.090-0.200 g/ml trehalose; and a PBS buffer serving as the solvent. The adipose tissue cryopreservation protective agent is free of DMSO and other protective agents having biological toxicity, poses no toxicity to cells and tissues, and causes no safety problem during clinical use even in a case of incomplete elution. The adipose tissue cryopreservation protective agent is free of xenoantigen and has low cost. With glycerol and trehalose being clinically approved medicinal ingredients and inexpensive products, the agent of the present disclosure contains no costly products such as human albumin, thus providing increased possibility for clinical use and promotion.

Abstract: The present disclosure provides the use of a recombinant human secretory DDRGK1. Experiments demonstrate that the recombinant human secretory DDRGK1 prepared by the present disclosure can be used in the preparation of biological medicines for treating intervertebral disc degeneration, fractures or bone defects. The recombinant human secretory DDRGK1 of the present disclosure provides a promising direction for the treatment of bone related diseases and has obtained firm scientific evidence, thereby expanding the further application of recombinant human secretory DDRGK1 in clinical practice.

Abstract: An MA-M2T spinel solid solution-reinforced magnesium oxide-based ceramic foam filter and a preparation therefor. The preparation method comprising: 1) preparing a ceramic slurry having a solid content of 60%-70% by dosing 15%-25% by mass of a nanometer alumina sol, 0.8%-1.5% by mass of a rheological agent, and the balance magnesium oxide ceramic powder comprising a nanometer titanium oxide sintering aid, and then adding deionized water and ball milling to mix until uniform, and then vacuum degassing the mixture; 2) soaking a polyurethane foam plastic template into the ceramic slurry, squeezing by a roller press the polyurethane foam plastic template to remove redundant slurry therein to make a biscuit, and drying the biscuit by heating it to 80° C.-120° C.; 3) putting the dried biscuit into a sintering furnace, elevating the temperature to 1400° C.-1600° C. and performing a high temperature sintering, cooling to the room temperature with the furnace to obtain the magnesium oxide-based ceramic foam filter.

Abstract: The present invention relates to a substrate-triggered single crystal superalloy directional solidification process, including: (1) preparing a single crystal substrate material having crystallographic characteristics that match crystallographic characteristics of the single crystal superalloy; (2) fabricating a single crystal substrate chilling plate using the obtained single crystal substrate material; and (3) applying the obtained single crystal substrate chilling plate in a directional solidification apparatus, and then preparing a single crystal alloy product by performing superalloy melting and directional solidification.

Abstract: An array-spraying additive manufacturing apparatus and method for manufacturing a large-sized equiaxed crystal aluminum alloy ingot, comprising: a liquid aluminum spraying mechanism having array nozzles disposed in an atmospheric pressure chamber, a movable condensing mechanism disposed in the atmospheric pressure chamber below the liquid aluminum spraying mechanism, and a control mechanism. The control mechanism sends an upward guiding command to a release mechanism and issues a three-dimensional movement command to the movable condensing mechanism, such that liquid aluminum in the liquid aluminum spraying mechanism is sprayed at the surface of the movable condensing mechanism in a continuous array of liquid flows according to a preset path and is rapidly condensed to form an ingot. Also disclosed is an additive manufacturing method employing the apparatus.

Abstract: An injectable in situ pore-forming hydrogel system and its preparation method and use are provided. The injectable in situ pore-forming hydrogel system uses an injectable hydrogel as a continuous base phase, and isolated live cells and magnesium particles are distributed in the continuous base phase, where the injectable hydrogel is a precursor or prepolymer of hydrogel, which can form hydrogel by cross-linking. The injectable in situ pore-forming hydrogel system can be used to create pores while the gel encapsulates live cells, which makes use of both the injectability and porous structures of hydrogel, which is important for the repair of cavitary, surgically difficult and irregularly defective tissues; meanwhile, magnesium particles generate magnesium ions after the former undergoes gas production and degradation, which can improve the bioactivity of the gel and aid in tissue repair.

Abstract: The present disclosure provides a detection system, comprising a client for unloading malicious HTTP traffic and a server for receiving and detecting the malicious HTTP traffic, wherein the server comprises an active label corrector for correcting noisy labels of the malicious HTTP traffic and a multi-field feature extractor for automatically discovering underlying features of the malicious HTTP traffic.

Abstract: The present disclosure provides a large-scale malware classification system, comprising a client for unloading malware and a server for receiving and classifying the malware, wherein the server comprises a deep learning module for classifying the malware.