Patents Assigned to Shanghai Jiaotong University
  • Publication number: 20240165037
    Abstract: The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a B-(1,4)-glucoside bond or/and a lactose with a p-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that B-(1,4)-glucoside bond provided by cellobiose or/and p-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (p-glucosidase or/and p-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.
    Type: Application
    Filed: September 26, 2023
    Publication date: May 23, 2024
    Applicant: Shanghai Jiaotong University School of Medicine
    Inventors: Zeyu Xiao, Gaoxian Chen, Kai Cui
  • Patent number: 11986575
    Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: May 21, 2024
    Assignee: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kun Sun, Jing Sun, Sun Chen, Kai Bai, Yanan Lu, Lu Wang, Fujun Wang, Fan Zhao, Jihong Huang
  • Patent number: 11973994
    Abstract: Provided is a media processing method. The method is used for uploading a function provided by a user or a third party and obtaining media processing parameters provided by the user. The method includes the following steps: receiving the description information of the media processing and determining whether a function that fulfills the requirement of the description information exists in a system; in a case where the function that fulfills the requirement of the description information exists, selecting the function that fulfills the requirement of the description information from the system; and in a case where the function that fulfills the requirement of the description information does not exist, selecting the function from the system according to the priority or selecting the function that fulfills the requirement of the description information from outside the system.
    Type: Grant
    Filed: July 4, 2020
    Date of Patent: April 30, 2024
    Assignee: Shanghai JiaoTong University
    Inventors: Yiling Xu, Qi Yang, Yunfeng Guan
  • Patent number: 11962153
    Abstract: The present invention provides an active distribution network physics-information fusion control method for a hybrid system model includes an initialization time being a starting time, predicting power output and load of a feeder intermittent distributed power supply within a control time period T, calculating a feeder exchange power deviation variation ?P(t) during the control time period, if being a fixed distribution coefficient, and establishing a hybrid system model for feeder power coordinated control; if being a rolling distribution coefficient, an exchange power P(t) of the control region at time t being obtained, generating a distribution coefficient matrix W(t), and establishing the hybrid system model of the said feeder power coordinated control; confirming a control objective function min J, converting it into a MIQP, obtaining a full period control quantity; selecting a first control quantity P of the optimized control sequence, sending the first control quantity P to the control device.
    Type: Grant
    Filed: October 4, 2021
    Date of Patent: April 16, 2024
    Assignee: Shanghai Jiaotong University
    Inventors: Dong Liu, Fei Chen, Jiaming Weng
  • Publication number: 20240115658
    Abstract: A use of an intervertebral disc fibrosis-inducing substance in preparation of medication, where the medication is used for the treatment of degenerative spinal diseases. The inventors of the present disclosure make use of the pro-fibrotic effect of the intervertebral disc fibrosis-inducing substance and the auxiliary effect of the fibroblast to achieve further treatment of intervertebral disc degeneration. The simultaneous administration of the above two drugs can reasonably control the degeneration and achieve the purpose of stepped treatment, thereby having clinical transformation value. In addition, the therapy combining the intervertebral disc fibrosis-inducing substance with the cell in the present disclosure allows the treatment regimen more personalized.
    Type: Application
    Filed: June 11, 2021
    Publication date: April 11, 2024
    Applicant: Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
    Inventors: Jie ZHAO, Chen CHEN, Xiao YANG, Tangjun ZHOU, An QIN, Zhiqian CHEN, Kai ZHANG, Yifan ZHOU
  • Patent number: 11952913
    Abstract: A turbine blade includes a blade body, a division plate, a plurality of first protruding ridges, a plurality of second protruding ridges, a first jet hole group, and a second jet hole group. The blade body includes a suction-side wall surface and a pressure-side wall surface, which are provided with multiple film cooling holes. The stagnation region at the leading edge of the blade body is provided with multiple film cooling holes. The first and second jet hole groups are provided on the division plate. The first protruding ridges are provided on a suction-side inner wall surface, and the second ridges are provided on a pressure-side inner wall surface. An engine including the turbine blade is further provided.
    Type: Grant
    Filed: April 21, 2023
    Date of Patent: April 9, 2024
    Assignee: Shanghai Jiaotong University
    Inventors: Yu Rao, Yong Luan, Yamin Xu
  • Patent number: 11931892
    Abstract: A robotic system includes a support structure, a motor mount assembly, first and second parallel chains, a serial translation assembly, a sensor and a control module. The motor mount assembly includes rotary motors, where the rotary motors include a first rotary motor and a second rotary motor. The first and second parallel chains are connected to the movable platform, the rotary motors and the motor mount assembly. The serial translation assembly is connected to the supporting structure and the motor mount assembly and includes a linear actuator and a third rotary motor. The sensor is connected to the movable platform and detects force applied by a human operator on the movable platform and generates a signal indicative of the force applied. The control module controls the rotary motors and the third rotary motor based on the signal to assist the human operator in moving the movable platform.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: March 19, 2024
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, Shanghai JiaoTong University
    Inventors: Qiao Sun, Xianbao Chen, Jing Sun, Feng Gao, Dalong Gao, Ningjian Huang
  • Publication number: 20240069027
    Abstract: A use of nitrogen-doped carbon fluorescent quantum dots in preparation of aerobic glycolysis detection products is provided. The carbon-nitrogen fluorescent quantum dots are selected from one or more of C3N4 quantum dots, C2N quantum dots, and C3N quantum dots. The aerobic glycolysis detection products are reagents, based on a final volume of the reagents, the reagents comprise the carbon-nitrogen fluorescent quantum dots with a final concentration of 1 ?g/mL-1 mg/mL. The present disclosure realizes fluorescent labeling of NAD+ in living cells using the carbon-nitrogen fluorescent quantum dots, thus achieving fluorescent labeling and imaging of cells having aerobic glycolysis, which has the advantages of low cost, high efficiency, rapidity, and high accuracy.
    Type: Application
    Filed: December 28, 2021
    Publication date: February 29, 2024
    Applicants: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE, SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: JIPENG LI, SIWEI YANG, GUQIAO DING, HUIFANG ZHOU, XIANQUN FAN
  • Patent number: 11913042
    Abstract: Methods of preparing and using a highly active blood coagulation factor XI mutant and a gene therapy/editing vector thereof and a recombinant/fusion protein thereof. The nucleotide sequence of the mutant is as shown in SEQ ID NOs: 1-6, and the amino acid sequence is as shown in SEQ ID NO: 7.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: February 27, 2024
    Assignees: RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Xuefeng Wang, Wenman Wu, Qiulan Ding
  • Publication number: 20240042109
    Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: Si: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
    Type: Application
    Filed: March 29, 2022
    Publication date: February 8, 2024
    Applicant: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kun SUN, Jing SUN, Sun CHEN, Kai BAI, Yanan LU, Lu WANG, Fujun WANG, Fan ZHAO, Jihong HUANG
  • Patent number: 11886647
    Abstract: An in-air gesture control method based on visible light signals, which transmits light signals through a display device and collects its light signals reflected by hand, and after analysis, realizes gesture recognition; the transmitted light signals are in the visible light band; which can realize the gesture recognition and control on mobile devices without modifying hardware and a visible light-based gesture recognition system on commercial mobile devices; compared with the existing gesture recognition methods on commercial mobile devices, the invention avoids special hardware modification, that is, it does not require any additional components on the mobile device, such as a depth camera, and protects the user's privacy well.
    Type: Grant
    Filed: September 21, 2022
    Date of Patent: January 30, 2024
    Assignee: SHANGHAI JIAOTONG UNIVERSITY
    Inventors: Fan Wu, Zimo Liao, Guihai Chen
  • Patent number: 11881015
    Abstract: The present invention provides a high-precision identification method and system for substations, including building a Mask RCNN objection recognition network model based on convolutional neural networks; inputting acquired image information of a object into the Mask RCNN object recognition network model for preliminary recognition and outputting a recognition result of the object; using an information entropy to create a semantic decision tree and correcting the recognition result of the object according to a principle of relative correlation between different objects and outputting a final recognition decision result; reading the recognition decision result to obtain a true type of the object to be recognized. The present invention greatly improves the accuracy of image recognition of substations, and has a positive role in the research and development of automatic inspection equipment for inspection robots.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: January 23, 2024
    Assignee: Shanghai Jiaotong University
    Inventors: Yadong Liu, Yingjie Yan, Siheng Xiong, Ling Pei, Zhe Li, Peng Xu, Lei Su, Xiaofei Fu, Xiuchen Jiang
  • Publication number: 20230404763
    Abstract: A muscle function preservation type total temporomandibular joint prosthesis includes an articular fossa member (1) and an articular head member (2) abutting against the articular fossa member (1). The articular head member (2) includes a mandibular trailing edge fixing plate (21), a sigmoid notch fixing plate (22) and an articular head portion (23). The mandibular trailing edge fixing plate (21) is connected to a bottom end of the articular head portion (23) and extends downwards, and has a plate-shaped structure and includes a mandibular-trailing-edge-surface attaching surface. The sigmoid notch fixing plate (22) protrudes from one side of the mandibular trailing edge fixing plate (21) and extends in a direction away from the mandibular trailing edge fixing plate (21), and has a plate-shaped structure and includes a mandibular-ramus-proximal-sigmoid-notch-portion attaching surface.
    Type: Application
    Filed: November 18, 2020
    Publication date: December 21, 2023
    Applicant: SHANGHAI NINTH PEOPLE'S HOSPITAL, SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: CHI YANG, JISI ZHENG, ZIXIAN JIAO, MINJIE CHEN, WENBO JIANG
  • Publication number: 20230398071
    Abstract: The present invention relates to the field of hemodialysis and peritoneal dialysis, in particular to a fat emulsion dialysate, and preparation method and the use thereof. Provided in the present invention is a fat emulsion dialysate, comprising a long-chain fat emulsion oil, a medium-chain triglyceride, an anti-oxidant, sodium oleate, glycerin, phospholipid, and a solvent. Compared with traditional dialysis, the fat emulsion dialysate provided by the present invention has a better advantage for protein-bound toxin removal. In addition, the fat emulsion dialysate not only has a simple preparation method and a low cost, but also has good stability and safety, and remains stable at room temperature for 14 days without obvious precipitation. Thus, the fat emulsion dialysate can become a hemodialysis dialysate or peritoneal dialysate with broad application prospects, and has good industrialization prospects.
    Type: Application
    Filed: July 5, 2023
    Publication date: December 14, 2023
    Applicant: Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
    Inventors: Feng DING, Yifeng WANG, Yuqi SHEN, Jiaolun LI
  • Patent number: 11844289
    Abstract: A method for fabricating a second generation high-temperature superconductor (2G-HTS) tape, including: (S1) depositing a superconducting thin film on a surface of a ductile metal substrate with a buffer layer; (S2) forming a micro-holes array pattern on a surface of the superconducting thin film by etching using a reel-to-reel dynamic femtosecond infrared laser etching system, where the micro-holes array pattern covers the superconducting thin film; (S3) depositing a superconducting thick film on the surface of the superconducting thin film; and (S4) depositing a silver protective layer and a copper stabilization layer on a surface of the superconducting thick film.
    Type: Grant
    Filed: January 14, 2023
    Date of Patent: December 12, 2023
    Assignee: Shanghai Jiaotong University
    Inventors: Yue Zhao, Chunjiang Guo, Yue Wu, Sikan Chen, Jiamin Zhu, Wei Wu, Zhijian Jin
  • Patent number: 11813743
    Abstract: A robotic system includes a support structure, a platform, a center serial chain, outer serial chains, motors, a sensor, and a control module. The center serial chain connects a center of the platform to the support structure and includes first joints connected to a linear sliding shaft. The outer serial chains are disposed radially outward of the center serial chain. Each of the outer serial chains includes second joints connecting a bar to the platform and the supporting structure. The motors are connected to the outer serial chains. The sensor is connected to the platform and detects at least one of force or torque applied by a human operator on the platform and generates a signal indicative thereof. The control module controls the motors based on the signal to assist the human operator in at least one of moving or rotating the platform.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 14, 2023
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, Shanghai JiaoTong University
    Inventors: Qiao Sun, Xianbao Chen, Jing Sun, Dalong Gao, Feng Gao, Ningjian Huang
  • Patent number: 11810348
    Abstract: The present disclosure provide a method for identifying power equipment targets based on human-level concept learning, including: creating a dataset of power equipment images, and annotating power equipment in power equipment images; training neural network and Bayesian network with the annotated dataset and respectively acquire identification results and conditional probabilities; calculating probabilities of unions with the conditional probabilities; and filtering the identification result corresponding to the highest probability of the union as identification result of the dataset of the power equipment images and complete the identification of the power equipment. The present disclosure combines Mask R-CNN and probabilistic graphical model. The bottom layer uses Mask R-CNN, and the top layer uses Bayesian network to train in identifying power equipment images, so that a small amount of data samples can achieve good recognition, which improved the performance of Mask R-CNN model.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: November 7, 2023
    Assignee: Shanghai Jiaotong University
    Inventors: Yadong Liu, Yingjie Yan, Siheng Xiong, Ling Pei, Zhe Li, Peng Xu, Lei Su, Xiaofei Fu, Xiuchen Jiang
  • Patent number: 11808980
    Abstract: A compact silicon waveguide mode converter, a dielectric meta-surface structure based on periodical oblique subwavelength perturbations, including a top silicon structure with oblique subwavelength perturbations etched in certain periods with period length of ?, a duty cycle and an oblique angle ? on the SOI substrate. The invention adopts an all-dielectric meta-surface structure with oblique subwavelength perturbation, which can achieve a compact mode conversion from fundamental mode to arbitrary high-order mode of silicon waveguide, and can improve the optical communication capacity greatly.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: November 7, 2023
    Assignee: SHANGHAI JIAOTONG UNIVERSITY
    Inventors: Hongwei Wang, Yong Zhang, Yu He, Lu Sun, Yikai Su
  • Publication number: 20230338219
    Abstract: An intelligent mouth opening rehabilitation device is provided, including: a body, an end of the body is provided with an upper bite pad and a lower bite pad; a pressure sensor, for detecting pressure data on the upper bite pad and/or the lower bite pad; a stepping motor, for driving the upper bite pad and/or the lower bite pad to swing longitudinally; and a processor, for controlling the stepping motor to operate or stop according to the pressure data and/or a preset training instruction, thereby driving the upper bite pad and/or the lower bite pad to swing longitudinally or to stop. Compared with traditional mouth opening rehabilitation devices, the intelligent mouth opening rehabilitation device controls automatically the upper bite pad and/or the lower bite pad to swing longitudinally, so that a mouth opening training is more accurate, and more controllable. Therefore, a rehabilitation effect is greatly improved.
    Type: Application
    Filed: July 27, 2021
    Publication date: October 26, 2023
    Applicant: Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
    Inventors: Jiannan LIU, Guangtao ZHAI, Chenping ZHANG, Zhiyuan ZHANG
  • Publication number: 20230338479
    Abstract: A high-activity blood coagulation factor XI mutant Ala570Thr (A570T), having nucleotide sequences as shown in SEQ ID NOs: 1-4 and an amino acid sequence as shown in SEQ ID NO: 5, is provided. The mutant is resistant to a physiological inhibitor thereof after being activated from a zymogen state to an active enzyme. Therefore, the mutant has a very high blood coagulation activity and a stronger catalytic ability for a non-physiological substrate; and the mutant is applied to the treatment of hemorrhagic diseases, and has good prospects in terms of gene therapy, gene editing and recombinant protein replacement treatments.
    Type: Application
    Filed: April 13, 2021
    Publication date: October 26, 2023
    Applicants: RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Wenman WU, Xuefeng WANG, Qiulan DING