Patents Assigned to ShanghaiTech University
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Publication number: 20250144223Abstract: The present disclosure provides compounds of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat diseases or disorders associated with NAMPT.Type: ApplicationFiled: August 25, 2022Publication date: May 8, 2025Applicants: GLUETACS THERAPEUTICS (SHANGHAI) CO., LTD., ShanghaiTech UniversityInventors: Xiaobao Yang, Gaofeng Fan, Biao Jiang, Haixia Liu, Xiaotong Zhu, Renhong Sun
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Patent number: 12270910Abstract: Described herein are systems and methods for training machine learning models to generate three-dimensional (3D) motions based on light detection and ranging (LiDAR) point clouds. In various embodiments, a computing system can encode a machine learning model representing an object in a scene. The computing system can train the machine learning model using a dataset comprising synchronous LiDAR point clouds captured by monocular LiDAR sensors and ground-truth three-dimensional motions obtained from IMU devices. The machine learning model can be configured to generate a three-dimensional motion of the object based on an input of a plurality of point cloud frames captured by a monocular LiDAR sensor.Type: GrantFiled: August 9, 2022Date of Patent: April 8, 2025Assignees: Xiamen University, ShanghaiTech UniversityInventors: Cheng Wang, Jialian Li, Lan Xu, Chenglu Wen, Jingyi Yu
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Patent number: 12240909Abstract: Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.Type: GrantFiled: June 19, 2019Date of Patent: March 4, 2025Assignees: ShanghaiTech University, The Governing Council of the University of TorontoInventors: Sachedv S. Sidhu, Donghui Wu, Guohua James Pan, Shusu Liu, Shane Miersch, Haiming Huang
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Publication number: 20250064837Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.Type: ApplicationFiled: October 22, 2024Publication date: February 27, 2025Applicant: ShanghaiTech UniversityInventors: Xiaobao Yang, Biao Jiang, Renhong Sun, Chaowei Ren, Ning Sun, Ying Kong, Yan Li, Jinju Chen, Qianqian Yin, Xiaoling Song, Quanju Zhao, Xing Qiu
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Patent number: 12226424Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.Type: GrantFiled: April 9, 2019Date of Patent: February 18, 2025Assignee: ShanghaiTech UniversityInventors: Xiaobao Yang, Biao Jiang, Renhong Sun, Chaowei Ren, Ning Sun, Ying Kong, Yan Li, Jinju Chen, Qianqian Yin, Xiaoling Song, Quanju Zhao, Xing Qiu
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Patent number: 12203077Abstract: Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.Type: GrantFiled: August 28, 2018Date of Patent: January 21, 2025Assignee: ShanghaiTech UniversityInventors: Jia Chen, Xingxu Huang, Li Yang, Bei Yang, Xiaosa Li, Ying Wang, Yajing Liu
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Patent number: 12134771Abstract: A fusion protein which may comprise a first nCas9 fragment, a chimeric insertion fragment, a second nCas9 fragment and two UGI fragments from N-terminus to C-terminus, wherein the chimeric insertion fragment is selected from APOBEC1 fragment or APOBEC3A fragment for cytosine deamination at the target site. The fusion protein may comprise a first nCas9 fragment, a chimeric insertion fragment and a second nCas9 fragment from N-terminus to C-terminus, wherein the chimeric insertion fragment is TadA-TadA* for cytosine deamination at the target site. The present disclosure provides a novel base editing tool that is compatible with insertion of various deaminases on the chimeric sites of nCas9. Compared with nCas9 terminal fusion base editor, the base editing tool of the present invention significantly reduce off-targeting on both DNA and RNA, while maintaining specific targeted base editing efficiency, with higher specificity and favorable industrialization prospects.Type: GrantFiled: January 5, 2023Date of Patent: November 5, 2024Assignee: ShanghaiTech UniversityInventors: Yajing Liu, Shisheng Huang, Xingxu Huang
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Patent number: 12129179Abstract: A method for catalytic synthesis of ammonia under normal pressures, including: performing a reaction of hydrogen and nitrogen to synthesize ammonia under normal pressures by taking a liquid alloy as a catalyst in a reactor, where the reactor contains a molten salt, the density of the molten salt is smaller than that of the liquid alloy, and the molten salt is used for providing a reaction interface and isolating the liquid alloy from being introduced impurities. The first metal reacts with the nitrogen to produce the metal nitride, and the molten salt provides a new reaction interface for the metal nitride to react with the hydrogen to synthesize ammonia, so that ammonia is produced continuously. In addition, the molten salt prevents the liquid alloy from contacting with the oxygen and the water vapor, which prevents the liquid alloy from being oxidized, thus prolonging its service life.Type: GrantFiled: November 19, 2021Date of Patent: October 29, 2024Assignee: ShanghaiTech UniversityInventors: Xiaofei Guan, Zujian Tang
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Publication number: 20240217168Abstract: An additive manufacturing method for fabricating 3D nanostructures is provided, charged species dispersed in a fluid are precisely arranged at nanoscale in each dimension with a configured electric field, so that the charged species are printed on a substrate to form an array of 3D nanostructures as desired. The additive manufacturing method of the present disclosure can be carried out at room temperature and atmospheric pressure without the aid of chemical reaction, laser sources, ion/electron beams, or photosensitive materials, and enables low-cost, ultra-fast printing speed, large-area, high-purity, multi-material, ultra-high-resolution and solves problems encountered in other nanofabrication techniques in making 3D nanostructures, such as a limited range of available printing materials, low resolution, slow printing speed, and one by one serial printing.Type: ApplicationFiled: June 15, 2022Publication date: July 4, 2024Applicant: ShanghaiTech UniversityInventors: Jicheng FENG, Shirong LIU, Bingyan LIU
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Patent number: 12012519Abstract: Liquid-liquid phase separation (LLPS) driven protein-based underwater adhesive coatings are made from a dimeric protein comprising a marine adhesive protein (MAP) domain and a liquid-liquid phase separation-mediating low complexity (LC) domain.Type: GrantFiled: February 8, 2021Date of Patent: June 18, 2024Assignee: ShanghaiTech UniversityInventors: Chao Zhong, Mengkui Cui
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Patent number: 11970621Abstract: A material fabrication method comprises (a) fabricating a structure from a programmable amyloid material (PAM) ink comprising an amyloid monomer stabilized in a liquid solvent; and (b) contacting the structure with an agent which triggers polymerization of the amyloid monomer and stabilization of the structure.Type: GrantFiled: November 7, 2020Date of Patent: April 30, 2024Assignee: ShanghaiTech UniversityInventors: Chao Zhong, Yingfeng Li, Ke Li
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Patent number: 11884947Abstract: Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.Type: GrantFiled: February 22, 2019Date of Patent: January 30, 2024Assignee: ShanghaiTech UniversityInventors: Jia Chen, Li Yang, Xingxu Huang, Bei Yang, Xiao Wang, Jianan Li
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Patent number: 11875523Abstract: The present disclosure provides an adaptive stereo matching optimization method, apparatus, and device, and a storage medium. The method includes: acquiring images of at least two perspectives of the same target scene, accordingly obtaining, through calculation, disparity value ranges corresponding to pixels in the target scene; and obtaining optimized depth value ranges by adjusting the disparity value ranges of the pixels in the target scene in real time through an adaptive stereo matching model; adjusting an execution cycle in the adaptive stereo matching model in real time through a DVFS algorithm according to a resource constraint condition of the processing system; and/or training on a plurality of scene image data sets through a convolutional neural network, so that the specific function parameters in the adaptive stereo matching model are correspondingly adjusted in real time according to the acquired different scene images.Type: GrantFiled: September 20, 2019Date of Patent: January 16, 2024Assignee: ShanghaiTech UniversityInventors: Fupeng Chen, Heng Yu, Yajun Ha
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Patent number: 11840685Abstract: Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.Type: GrantFiled: July 11, 2022Date of Patent: December 12, 2023Assignee: ShanghaiTech UniversityInventors: Jia Chen, Bei Yang, Li Yang, Xingxu Huang, Lijie Wang
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Publication number: 20230313205Abstract: A fusion protein which may comprise a first nCas9 fragment, a chimeric insertion fragment, a second nCas9 fragment and two UGI fragments from N-terminus to C-terminus, wherein the chimeric insertion fragment is selected from APOBEC1 fragment or APOBEC3A fragment for cytosine deamination at the target site. The fusion protein may comprise a first nCas9 fragment, a chimeric insertion fragment and a second nCas9 fragment from N-terminus to C-terminus, wherein the chimeric insertion fragment is TadA-TadA* for cytosine deamination at the target site. The present disclosure provides a novel base editing tool that is compatible with insertion of various deaminases on the chimeric sites of nCas9. Compared with nCas9 terminal fusion base editor, the base editing tool of the present invention significantly reduce off-targeting on both DNA and RNA, while maintaining specific targeted base editing efficiency, with higher specificity and favorable industrialization prospects.Type: ApplicationFiled: January 5, 2023Publication date: October 5, 2023Applicant: ShanghaiTech UniversityInventors: Yajing LIU, Shisheng HUANG, Xingxu HUANG
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Publication number: 20230312358Abstract: A method for catalytic synthesis of ammonia under normal pressures, including: performing a reaction of hydrogen and nitrogen to synthesize ammonia under normal pressures by taking a liquid alloy as a catalyst in a reactor, where the reactor contains a molten salt, the density of the molten salt is smaller than that of the liquid alloy, and the molten salt is used for providing a reaction interface and isolating the liquid alloy from being introduced impurities. The first metal can react with the nitrogen to produce the metal nitride, and the molten salt can provide a new reaction interface for the metal nitride to react with the hydrogen to synthesize the ammonia, so that the metal nitride can continuously generate the ammonia, and the synthesis of the ammonia can be effectively catalyzed.Type: ApplicationFiled: November 19, 2021Publication date: October 5, 2023Applicant: ShanghaiTech UniversityInventors: Xiaofei GUAN, Zujian TANG
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Patent number: 11773145Abstract: Provided are chimeric polypeptides that include one or more zinc finger motifs fused to a therapeutic peptide such as botulinum neurotoxins (BoNTs). The zinc finger motif may be located at the C-terminal side of the BoNT and the chimeric polypeptide can optionally include two or more such zinc finger motifs. It said the disclosed chimeric polypeptides can be efficiently delivered to a subject transdermally.Type: GrantFiled: July 20, 2018Date of Patent: October 3, 2023Assignee: ShanghaiTech UniversityInventors: Jia Liu, Biao Jiang
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Patent number: 11771709Abstract: A compound of formula (I) and its antitumor application are disclosed. The compounds of formula (I) have degradation and inhibitory effects on ALK target proteins. They are mainly composed of four parts: the first part, ALK-TKI, being compounds with ALK tyrosine kinase inhibitory activity; the second part, LIN, being different kinds of linker (Linker); the third part, the ULM, being a small molecule ligand (ULM, ubiquitin ligase binding moiety) with ubiquitination of VHL, CRBN or other proteases; and the fourth part, the group A, being a carbonyl group or absent, which covalently bond ALK-TKI to LIN, wherein LIN and ULM are covalently bonded. A series of compounds designed and synthesized by the present disclosure have wide pharmacological activities, have functions of degrading ALK protein and inhibiting ALK activity, and can be used for related tumor treatment.Type: GrantFiled: June 15, 2020Date of Patent: October 3, 2023Assignee: ShanghaiTech UniversityInventors: Xiaobao Yang, Biao Jiang, Xiaoling Song, Haifan Lin, Ning Sun, Jinju Chen, Xing Qiu, Chaowei Ren, Ying Kong
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Publication number: 20230295618Abstract: A preparation method for mutant cells with deletion of target genes, at least comprising the following steps: (1) transfecting a sgRNA group into same host cells, where the sgRNA group includes two sgRNAs that target different sites of a same target gene, and the number of the sgRNA group may be one or more than one. When the number of the sgRNA group is more than one, each different sgRNA group targets one different target gene. (2) Enriching the host cells expressing one or more sgRNA groups. (3) Culturing the host cells obtained from step (2) to produce mutant cells with deletion of target genes.Type: ApplicationFiled: March 10, 2023Publication date: September 21, 2023Applicant: ShanghaiTech UniversityInventor: Xiajun LI
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Publication number: 20230295023Abstract: A living engineered biofilm material comprises microbial cells embedded in a protective extracellular matrix comprising a fusion protein of an amyloid domain and a contaminant binding domain operative to bind a contaminant of a water source, and thereby facilitate decontamination of the water source.Type: ApplicationFiled: December 19, 2022Publication date: September 21, 2023Applicant: ShanghaiTech UniversityInventors: Chao Zhong, Jiahua Pu, Yi Liu