Abstract: A method for catalytic synthesis of ammonia under normal pressures, including: performing a reaction of hydrogen and nitrogen to synthesize ammonia under normal pressures by taking a liquid alloy as a catalyst in a reactor, where the reactor contains a molten salt, the density of the molten salt is smaller than that of the liquid alloy, and the molten salt is used for providing a reaction interface and isolating the liquid alloy from being introduced impurities. The first metal can react with the nitrogen to produce the metal nitride, and the molten salt can provide a new reaction interface for the metal nitride to react with the hydrogen to synthesize the ammonia, so that the metal nitride can continuously generate the ammonia, and the synthesis of the ammonia can be effectively catalyzed.

Abstract: Provided are chimeric polypeptides that include one or more zinc finger motifs fused to a therapeutic peptide such as botulinum neurotoxins (BoNTs). The zinc finger motif may be located at the C-terminal side of the BoNT and the chimeric polypeptide can optionally include two or more such zinc finger motifs. It said the disclosed chimeric polypeptides can be efficiently delivered to a subject transdermally.

Abstract: A compound of formula (I) and its antitumor application are disclosed. The compounds of formula (I) have degradation and inhibitory effects on ALK target proteins. They are mainly composed of four parts: the first part, ALK-TKI, being compounds with ALK tyrosine kinase inhibitory activity; the second part, LIN, being different kinds of linker (Linker); the third part, the ULM, being a small molecule ligand (ULM, ubiquitin ligase binding moiety) with ubiquitination of VHL, CRBN or other proteases; and the fourth part, the group A, being a carbonyl group or absent, which covalently bond ALK-TKI to LIN, wherein LIN and ULM are covalently bonded. A series of compounds designed and synthesized by the present disclosure have wide pharmacological activities, have functions of degrading ALK protein and inhibiting ALK activity, and can be used for related tumor treatment.

Abstract: A living engineered biofilm material comprises microbial cells embedded in a protective extracellular matrix comprising a fusion protein of an amyloid domain and a contaminant binding domain operative to bind a contaminant of a water source, and thereby facilitate decontamination of the water source.

Abstract: A preparation method for mutant cells with deletion of target genes, at least comprising the following steps: (1) transfecting a sgRNA group into same host cells, where the sgRNA group includes two sgRNAs that target different sites of a same target gene, and the number of the sgRNA group may be one or more than one. When the number of the sgRNA group is more than one, each different sgRNA group targets one different target gene. (2) Enriching the host cells expressing one or more sgRNA groups. (3) Culturing the host cells obtained from step (2) to produce mutant cells with deletion of target genes.

Abstract: A full-path circuit delay measurement device for a field-programmable gate array (FPGA) and a measurement method are provided. The measurement device includes two shadow registers and a phase-shifted clock, where the two shadow registers take an output of a measured combinational logic circuit as a clock and sample the phase-shifted clock SCLK as data; the two shadow registers are respectively triggered on rising and falling edges of the output of the measured combinational logic circuit to sample the phase-shifted clock; outputs of the two shadow registers are delivered by an OR gate as an input into a synchronization register; a clock of the synchronization register serves as a clock MCLK of the measured combinational logic circuit; an output of the synchronization register serves as that of the circuit delay measurement device; the phase-shifted clock SCLK and the clock MCLK of the measured combinational logic circuit have the same frequency.

Abstract: A high-energy-efficiency binary neural network accelerator applicable to artificial intelligence Internet of Things is provided. 0.3-0.6V sub/near threshold 10T1C multiplication bit units with series capacitors are configured for charge domain binary convolution. An anti-process deviation differential voltage amplification array between bit lines and DACs is configured for robust pre-amplification in 0.3V batch standardized operations. A lazy bit line reset scheme further reduces energy, and inference accuracy losses can be ignored. Therefore, a binary neural network accelerator chip based on in-memory computation achieves peak energy efficiency of 18.5 POPS/W and 6.06 POPS/W, which are respectively improved by 21× and 135× compared with previous macro and system work [9, 11].

Abstract: The present technology relates generally to compositions and methods of preventing or treating ischemic stroke. The present technology also relates to administering the anti-ASIC1a antibodies in effective amounts to treat a subject suffering from, or predisposed to, ischemic stroke.

Abstract: This application provides a data management system, method, terminal, and medium based on hybrid storage. The data management system includes: a first file system mount module, to mount at least one user-mode file system; a second file system mount module, to mount at least two independent back-end file systems based on the user-mode file system for storing hot data and cold data respectively; a data label module, to label the hot or cold attribute of the data in a user data request; a file system selection module, to store the data in the corresponding back-end file system and/or take the data out from the corresponding back-end file system according to the hot or cold attribute of the data.

Abstract: A method of rendering an object is provided. The method comprises: encoding a feature vector to each point in a point cloud for an object, wherein the feature vector comprises an alpha matte; projecting each point in the point cloud and the corresponding feature vector to a target view to compute a feature map; and using a neural rendering network to decode the feature map into a RGB image and the alpha matte and to update the feature vector.

Abstract: A living engineered glue system for performing autonomous mechanical repairs comprises a biofilm of microbial cells embedded in an extracellular matrix and operably linked in an environmentally-inducible, cell-cell communication genetic circuit to control gene expression.

Abstract: A pure integer quantization method for a lightweight neural network (LNN) is provided. The method includes the following steps: acquiring a maximum value of each pixel in each of the channels of the feature map of a current layer; dividing a value of each pixel in each of the channels of the feature map by a t-th power of the maximum value, t?[0,1]; multiplying a weight in each of the channels by the maximum value of each pixel in each of the channels of the corresponding feature map; and convolving the processed feature map with the processed weight to acquire the feature map of a next layer. The algorithm is verified on SkyNet and MobileNet respectively, and lossless INT8 quantization on SkyNet and maximum quantization accuracy so far on MobileNetv2 are achieved.

Abstract: A full-path circuit delay measurement device for a field-programmable gate array (FPGA) and a measurement method are provided. The measurement device includes two shadow registers and a phase-shifted clock, where the two shadow registers take an output of a measured combinational logic circuit as a clock and sample the phase-shifted clock SCLK as data; the two shadow registers are respectively triggered on rising and falling edges of the output of the measured combinational logic circuit to sample the phase-shifted clock; outputs of the two shadow registers are delivered by an OR gate as an input into a synchronization register; a clock of the synchronization register serves as a clock MCLK of the measured combinational logic circuit; an output of the synchronization register serves as that of the circuit delay measurement device; the phase-shifted clock SCLK and the clock MCLK of the measured combinational logic circuit have the same frequency.

Abstract: A normal distributions transform (NDT) method for LiDAR point cloud localization in unmanned driving is provided. The method proposes a non-recursive, memory-efficient data structure occupation-aware-voxel-structure (OAVS), which speeds up each search operation. Compared with a tree-based structure, the proposed data structure OAVS is easy to parallelize and consumes only about 1/10 of memory. Based on the data structure OAVS, the method proposes a semantic-assisted OAVS-based (SEO)-NDT algorithm, which significantly reduces the number of search operations, redefines a parameter affecting the number of search operations, and removes a redundant search operation. In addition, the method proposes a streaming field-programmable gate array (FPGA) accelerator architecture, which further improves the real-time and energy-saving performance of the SEO-NDT algorithm. The method meets the real-time and high-precision requirements of smart vehicles for three-dimensional (3D) lidar localization.

Abstract: A ripple push method for a graph cut includes: obtaining an excess flow ef(v) of a current node v; traversing four edges connecting the current node v in top, bottom, left and right directions, and determining whether each of the four edges is a pushable edge; calculating, according to different weight functions, a maximum push value of each of the four edges by efw=ef(v)*W, where W denotes a weight function; and traversing the four edges, recording a pushable flow of each of the four edges, and pushing out a calculated flow. The ripple push method explores different push weight functions, and significantly improves the actual parallelism of the push-relabel algorithm.

Abstract: A static random-access memory (SRAM) cell for high-speed content-addressable memory (CAM) and in-memory Boolean logic operations includes a standard 6T-SRAM and two additional PMOS access transistors, where read word lines of the two positive-channel metal oxide semiconductor (PMOS) access transistors P1 and P2 are RWLR and RWLL respectively, and under the control thereof, a differential read port RBL/RBL is formed. The SRAM cell is suitable for multi-row address selection, and typically applied to in-memory high-speed CAM and in-memory Boolean logic operations. Due to PMOS device characteristics, the structure design of the SRAM cell can avoid read disturbance generated by an in-memory SRAM, and ensure that the SRAM can perform in-memory CAM and in-memory Boolean logic operations stably at a high speed. In addition, this SRAM-based IMC solution supports commercial CMOS technology, and has an opportunity to leverage a large number of existing on-chip SRAM caches.

Abstract: An enhanced dynamic random access memory (eDRAM)-based computing-in-memory (CIM) convolutional neural network (CNN) accelerator comprises four P2ARAM blocks, where each of the P2ARAM blocks includes a 5T1C ping-pong eDRAM bit cell array composed of 64×16 5T1C ping-pong eDRAM bit cells. In each of the P2ARAM blocks, 64×2 digital time converters convert a 4-bit activation value into different pulse widths from a row direction and input the pulse widths into the 5T1C ping-pong eDRAM bit cell array for calculation. A total of 16×2 convolution results are output in a column direction of the 5T1C ping-pong eDRAM bit cell array. The CNN accelerator uses the 5T1C ping-pong eDRAM bit cells to perform multi-bit storage and convolution in parallel. An S2M-ADC scheme is proposed to allot an area of an input sampling capacitor of an ABL to sign-numerical SAR ADC units of a C-DAC array without adding area overhead.

Abstract: Provided are immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that specifically bind acid-sensing ion channel 1a (ASIC1a) protein and uses of the same. Also provided is a method of administering an effective amount of the anti-ASIC1a antibodies to treat a subject suffering from, or predisposed to, acidosis, or to treat a subject suffering from a disease caused by or related to altered ASIC1a activity and/or signaling, including ischemic stroke and related conditions.

Abstract: The present disclosure relates generally to inhibitors of mycobacterial membrane protein MmpL3, compositions comprising the inhibitors, and methods of preparation and use thereof.

Abstract: The present disclosure provides a compound of formula (I) targeting and degrading BCR-ABL protein and its use in the field of antitumor. The compound of formula (I) shows degradation and inhibitory effects on BCR-ABL target protein, which is mainly comprised of four moieties, wherein the first moiety (BCR-ABL-TKIs) is compound moiety with BCR-ABL tyrosine kinase inhibited activity; the second moiety (the LIN) is link units; the third moiety (the ULM) is a small molecule ligand for VHL or CRBN proteases with ubiquitination; and the four moiety (the group A) is carbonyl group that covalently binds to BCR-ABL-TKIs and LIN, and the LIN is further covalently bonded to ULM. A series of compounds designed and synthesized by the present disclosure shows extensive pharmacological effective, which function to degrade BCR-ABL protein and inhibit BCR-ABL effective, and can be utilized for treating relevant tumor.