Abstract: Three-dimensional, living, self-regenerative structures of predetermined geometry comprising solidified print material comprising a biofilm of Bacillus subtilis comprise a TasA-R protein, wherein R is a recombinant, heterologous functional group, wherein the TasA-R provides a preferably tunable physiochemical property like viscosity, reactivity, affinity as a function of the R group.

Abstract: Liquid-liquid phase separation (LLPS) driven protein-based underwater adhesive coatings are made from a dimeric protein comprising a marine adhesive protein (MAP) domain and a liquid-liquid phase separation-mediating low complexity (LC) domain.

Abstract: Engineered living glues made by bacteria biofilms integrate natural marine adhesive proteins and electrostatic interactions into bacterial biofilm components such as amyloid protein TasA, surface layer protein BslA, and exopolysaccharides.

Abstract: A material fabrication method comprises (a) fabricating a structure from a programmable amyloid material (PAM) ink comprising an amyloid monomer stabilized in a liquid solvent; and (b) contacting the structure with an agent which triggers polymerization of the amyloid monomer and stabilization of the structure.

Abstract: The present disclosure provides a compound of formula (I) targeting and degrading BCR-ABL protein and its use in the field of antitumor. The compound of formula (I) shows degradation and inhibitory effects on BCR-ABL target protein, which is mainly comprised of four moieties, wherein the first moiety (BCR-ABL-TKIs) is compound moiety with BCR-ABL tyrosine kinase inhibited activity; the second moiety (the LIN) is link units; the third moiety (the ULM) is a small molecule ligand for VHL or CRBN proteases with ubiquitination; and the four moiety (the group A) is carbonyl group that covalently binds to BCR-ABL-TKIs and LIN, and the LIN is further covalently bonded to ULM. A series of compounds designed and synthesized by the present disclosure shows extensive pharmacological effective, which function to degrade BCR-ABL protein and inhibit BCR-ABL effective, and can be utilized for treating relevant tumor.

Abstract: A compound of formula (I) and its antitumor application are disclosed. The compounds of formula (I) have degradation and inhibitory effects on ALK target proteins. They are mainly composed of four parts: the first part, ALK-TKI, being compounds with ALK tyrosine kinase inhibitory activity; the second part, LIN, being different kinds of linker (Linker); the third part, the ULM, being a small molecule ligand (ULM, ubiquitin ligase binding moiety) with ubiquitination of VHL, CRBN or other proteases; and the fourth part, the group A, being a carbonyl group or absent, which covalently bond ALK-TKI to LIN, wherein LIN and ULM are covalently bonded. A series of compounds designed and synthesized by the present disclosure have wide pharmacological activities, have functions of degrading ALK protein and inhibiting ALK activity, and can be used for related tumor treatment.

Abstract: Provided methods for diagnosing and treating cancer by reducing the biological activity and/or expression of P-element induced wimpy testis-like protein 4 (PIWIL4), and related compositions and methods.

Abstract: A method for generating high resolution multi-spectral light fields is disclosed. The method may include capturing a multi-perspective spectral image which includes a plurality of sub-view images; aligning and warping the sub-view images to obtain low resolution multi-spectral light fields; obtaining a high resolution dictionary and a low resolution dictionary; obtaining a sparse representation based on the low resolution multi-spectral light fields and the low resolution dictionary; and generating high resolution multi-spectral light fields with the sparse representation and the high resolution directory. Each sub-view image is captured with a different perspective and a different spectral range. The multi-perspective spectral image is obtain with one exposure.

Abstract: A method for generating hyperspectral data-cubes based on a plurality of hyperspectral light field (H-LF) images is disclosed. Each H-LF image may have a different view and a different spectral band. The method may include calculating a magnitude histogram, a direction histogram, and an overlapping histogram of oriented gradient for a plurality of pixels; developing a spectral-invariant feature descriptor by combining the magnitude histogram, the direction histogram, and the overlapping histogram of oriented gradient; obtaining a correspondence cost of the H-LF images based on the spectral-invariable feature descriptor; performing H-LF stereo matching on the H-LF images to obtain a disparity map of a reference view; and generating hyperspectral data-cubes by using the disparity map of the reference view. A bin in the overlapping histogram of oriented gradient may comprise overlapping ranges of directions.

Abstract: A method of generating a stereoscopic panorama is provided, the method comprising: processing a first right image, a second right image, a first left image, and a second left image to derive a right homography between the first right image and the second right image and a left homography between the first left image and the second left image; stitching the first right image with the second right image to generate a right panorama, the first left image with the second left image to generate a left panorama wherein the right homography is consistent with the left homography; and generating a stereo panorama using the right panorama and the left panorama.