Patents Assigned to Shimadzu Corporation
  • Publication number: 20180052184
    Abstract: An autosampler includes: a sample cooling unit that is brought into thermally contact with a bottom surface of a sample rack so as to cool a sample accommodated in the sample rack; a condensed water receiver that has at least one hole on a bottom surface thereof, and is provided below the sample rack for receiving water condensed around the sample rack; a discharging passage configured in such a manner that a droplet falling from the at least one hole flows therein.
    Type: Application
    Filed: March 11, 2015
    Publication date: February 22, 2018
    Applicant: SHIMADZU CORPORATION
    Inventor: Masami TOMITA
  • Publication number: 20180052172
    Abstract: A sample preparation kit related to the present invention provides a significantly versatile analytical technique that is not affected by the diversity of antibodies, difference in species, matrix and the like. For preparing a sample to be used for detection of a monoclonal antibody through high-performance liquid chromatography-mass spectrometry (LC-MS), the kit includes a porous body for immobilizing a monoclonal antibody to be detected; nanoparticles with an immobilized protease; a reaction vessel for selectively digesting the monoclonal antibody by bringing the porous body and nanoparticles into contact; a buffer to be introduced into the reaction vessel along with the nanoparticles and porous body so that a protease reaction is carried out; and a filtration membrane to remove the porous body and nanoparticles after the proteolysis so as to extract the reaction product and the buffer.
    Type: Application
    Filed: December 18, 2015
    Publication date: February 22, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Takashi SHIMADA, Noriko IWAMOTO
  • Publication number: 20180052240
    Abstract: A X-ray detector having enhanced X-ray sensitivity, which enables dual energy imaging having high diagnostic performance. This X-ray detector includes: scintillator elements which are partitioned by light blocking walls and which convert low-energy X-rays to light; and scintillator elements which are partitioned by light blocking walls and which convert high-energy X-rays to light. When seen from the direction of incidence of the X-rays, the positional pattern of the light blocking walls and that of the light blocking walls are configured so as not to be in alignment with each other. Accordingly, the X-rays incident on the X-ray detector are converted to light by at least either one of the scintillator elements and are finally outputted as X-ray detection signals.
    Type: Application
    Filed: January 26, 2016
    Publication date: February 22, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Koichi Tanabe, Shingo Furui, Toshinori Yoshimuta, Kenji Kimura, Akihiro Nishimura, Taro Shirai, Takahiro Doki, Satoshi Sano, Akira Horiba, Toshiyuki Sato
  • Publication number: 20180051272
    Abstract: The present invention provides a highly active protease that can be used in sample preparation for mass spectrometry of a protein and has excellent stability against a change in an external environment. The present invention provides an immobilized protease characterized in that a crudely purified protease or a protease that has not been subjected to a self-digestion resistance treatment is immobilized on surfaces of nanoparticles, and provides a method for producing the immobilized protease. The immobilized protease of the present invention can maintain high activity without being subjected to a change in an external environment, and thus is effective, for example, in preparing a sample to be supplied for mass spectrometry of a protein in a clinical specimen.
    Type: Application
    Filed: December 18, 2015
    Publication date: February 22, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Takashi SHIMADA, Noriko IWAMOTO
  • Publication number: 20180051053
    Abstract: The present invention provides: a method for increasing a yield, from a target monoclonal antibody, of a peptide fragment that comprises an Fab region or a variable region of the antibody or a portion of the region, the method being characterized by including a process in which digestion of the target monoclonal body is performed by bringing the target monoclonal antibody, which is immobilized on inner surfaces of pores of a porous body, and a protease, which is immobilized on surfaces of nanoparticles having an average particle size larger than an average pore diameter of the porous body, into contact with each other in a liquid by stirring or tapping rotation stirring at a low speed of less than 100 rpm so as to maintain a uniform dispersion, the average pore diameter of the porous body being in a range of 10 nm-200 nm and the average particle size of the nanoparticles being in a range of 50 nm-500 nm; and a kit for use in the method.
    Type: Application
    Filed: December 18, 2015
    Publication date: February 22, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Takashi SHIMADA, Noriko IWAMOTO
  • Patent number: 9897576
    Abstract: A gas chromatography device includes a sample injection part, a detector, a separation column, and a transfer line connecting between the sample injection part and the separation column and between the sample injection part and the detector. Furthermore, a column temperature adjustment part for adjusting the temperature of the separation column, and a line temperature adjustment part for adjusting the temperature of the transfer line are provided. The line temperature adjustment part is structured to include a heat block which includes a heating element and which is in contact with the transfer line from one side, and a holding member which presses the transfer line toward the heat block side by being in contact from the other side, and to sandwich the transfer line by the heat block and the holding member.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: February 20, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Satoshi Matsuoka, Takahiro Nishimoto, Masaki Kanai, Masanori Nishino
  • Patent number: 9895098
    Abstract: An optical biometric system (1) is characterized by being provided with: a first received light amount information acquisition unit (25) which acquires skin blood flow data relating to a skin blood flow in a wide range of the scalp of a subject by controlling the transmission/reception of light to/from a light transmission/reception unit (30) using a wide-range control table; and a selection control table creation unit (24) which causes a storage unit (23) to store a selection control table for acquiring X pieces of first received light amount information (?A1) selected from among N pieces of first received light amount information (?A1), and in that when acquiring multiple pieces of measurement data relating to the brain activity in a predetermined range of the brain of the subject by controlling the transmission/reception of light to/from the light transmission/reception unit (30) using a control table, a light transmission/reception control unit (21) acquires skin blood flow data relating to a skin blood f
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: February 20, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Akihiro Ishikawa, Yoshihiro Inoue, Takashi Amita, Satoru Kohno, Haruhide Udagawa, Yoshinori Masuda
  • Patent number: 9897580
    Abstract: In a two-dimensional LC system configured to introduce components trapped in a trap column during a fractionation period T into a second-dimension column, separate components, and then detect the components using a mass spectrometer, a data collection unit receives a signal which indicates timing to delimit the fractionation period T, determines the first data item in the fractionation period T, adds measurement start point identification information to the first data item, and stores all the data in a data storage unit. A two-dimensional chromatogram creation unit recognizes the first data item in each fractionation period T from the read data, and create a two-dimensional chromatogram by aligning data so that the first data items will be aligned at the top along an abscissa.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: February 20, 2018
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 9899203
    Abstract: The present invention is a mass spectrometer (1) for sequentially performing a measurement for a plurality of target ions, characterized by a storage section (41) for holding ion time-of-flight information concerning the time required for each of target ions to fly through each of the sections constituting the mass spectrometer, and a voltage controller (42) for changing, based on the ion time-of-flight information, the voltage applied to each of those sections to a voltage suited for each target ion, with a time lag corresponding to the difference in the timing of the arrival of the target ion at the section concerned.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: February 20, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Shiro Mizutani, Shigenobu Nakano
  • Publication number: 20180042571
    Abstract: Provided is a radiation phase difference imaging apparatus in which a separation distance between a phase grating and a radiation detector is optimized. The separation distance between the phase grating and a detection surface of an FPD is determined based on the magnitude of noise corruption in a self-image projected onto the detection surface. The magnitude of the effect of the noise is used as a basis for assessing the separation distance. It is determined whether a distance Zd is appropriate for imaging, based on the magnitude of noise corruption in the self-image in a self-image picture which is obtained when the distance Zd is the distance between the phase grating and the detection surface of the FPD. The separation distance can thus be optimized based on actual conditions of an actual X-ray source that emits a plurality of types of X-rays.
    Type: Application
    Filed: March 6, 2015
    Publication date: February 15, 2018
    Applicant: Shimadzu Corporation
    Inventors: Satoshi SANO, Toshiyuki SATO, Koichi TANABE, Shingo FURUI, Toshinori YOSHIMUTA, Hiroyuki KISHIHARA, Takahiro DOKI, Akira HORIBA
  • Publication number: 20180045564
    Abstract: In an exterior fixing mechanism, an elastic body (7) having a groove (72) is provided in a first exterior member (1). A plate-like member (9) having a concave part (92) is provided in a second exterior member (2). When the first exterior member and the second exterior member are moved toward each other in a state in which the first exterior member and the second exterior member face each other, a circumferential edge of the concave part of the plate-like member is fitted into the groove of the elastic body and thus the first exterior member and the second exterior member are fixed. For this reason, the first exterior member and the second exterior member can be fixed in which the first exterior member and the second exterior member are merely moved toward each other and the elastic body is merely inserted into the concave part of the plate-like member.
    Type: Application
    Filed: July 6, 2017
    Publication date: February 15, 2018
    Applicant: SHIMADZU CORPORATION
    Inventor: TAKESHI MAJI
  • Patent number: 9892897
    Abstract: A method of controlling a DC power supply to change a DC offset voltage applied to a component for manipulating charged particles. The method includes, whilst an AC voltage waveform is being applied to the component: controlling the DC power supply to produce an initial DC offset voltage that is applied to the component via a link that causes the DC offset voltage at the component to lag behind the DC offset voltage produced by the DC power supply when the DC offset voltage produced by the DC power supply is changed; then controlling the DC power supply to produce an overdrive DC offset voltage that is applied to the component via the link for a predetermined period of time; then controlling the DC power supply to produce a target DC offset voltage that is applied to the component via the link, wherein the target DC offset voltage is between the initial DC offset voltage and the overdrive DC offset voltage.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: February 13, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Matthew Gill, Stuart Harley, Jeff Chadbourne
  • Patent number: 9890796
    Abstract: A vacuum pump device comprises: a power supply device including a dew condensation detector configured to detect dew condensation, a regenerative braking resistance, and a controller configured to energize the regenerative braking resistance; a cooling system using coolant; and a pump main body including a motor rotatably driven by the power supply device. When the dew condensation detector detects the dew condensation, the controller energizes the regenerative braking resistance to heat an inside of the power supply device.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: February 13, 2018
    Assignee: Shimadzu Corporation
    Inventor: Nobuhiko Moriyama
  • Patent number: 9892899
    Abstract: An ion manipulation device for guiding or confining ions in an ion processing apparatus. The device has a first circuit board, wherein at least one first electrode for manipulating the path of ions is mounted on a mounting surface of the first circuit board; a second circuit board, wherein at least one second electrode for manipulating the path of ions is mounted on a mounting surface of the second circuit board; at least one bridging electrode for manipulating the path of ions, wherein the at least one bridging electrode is mounted to both the mounting surface of the first circuit board and the mounting surface of the second circuit board, wherein the bridging electrode is configured to hold the first circuit board and the second circuit board apart from each other in a fixed spatial relationship in which the mounting surface of the second circuit board faces towards the mounting surface of the first circuit board.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: February 13, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Matthew Clive Gill, Roger Giles
  • Patent number: 9892902
    Abstract: Used as an ion beam guiding unit for introducing primary ions to the surface of the sample is an ion optical system of reflectron TOFMS for achieving time focusing including an orthogonal acceleration unit for accelerating the ions in the orthogonal direction, a flight space of a non-electric field, and an ion reflector for forming a reflecting electric field. A dual stage type is used as the ion reflector to superimpose the correction potential showing a predetermined non-linear potential distribution on the potential having a linear gradient of a uniform electric field at the side deeper than the second order focusing position that fulfills the Mamyrin solution, thereby correcting the temporal spread of ion packets emitted from the orthogonal acceleration unit until the deviation of third or higher order in energy, achieving high time focusing.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: February 13, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Osamu Furuhashi, Hideaki Izumi
  • Patent number: 9891104
    Abstract: Provided is a spectroscopic detector including: a light source for generating polychromatic light 11; a single diffraction grating 13; an excitation optical system for guiding the light from the light source 11 onto the diffraction grating 13, for selecting one wavelength from the light diffracted by the diffraction grating 13, and for casting the selected wavelength of light into a sample as excitation light; a detection optical system for guiding observation light emitted from the sample irradiated with the excitation light onto the diffraction grating 13 to disperse the observation light; and a photodetector 15 for detecting the observation light dispersed by the detection optical system. By using one diffraction grating 13 in both the excitation optical system and the detection optical system, the number of diffraction gratings is reduced, whereby both the cost reduction and the downsizing of the device are achieved.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: February 13, 2018
    Assignee: SHIMADZU CORPORATION
    Inventor: Hiroyuki Minato
  • Publication number: 20180038828
    Abstract: There are provided an electrophoresis measurement method which can easily and accurately judge degree of similarity between reference data and measurement target data, a data processing device, and a data processing program. Detected data obtained by subjecting a reference sample to electrophoresis is standardized with reference to peaks of a lower limit marker substance and an upper limit marker substance, and thus reference data is acquired. Detected data obtained by subjecting a measurement target sample to electrophoresis is standardized with reference to peaks of the lower limit marker substance and the upper limit marker substance, and thus measurement target data is acquired. The measurement target data is warped or shifted in a time axis direction with reference to the reference data, and corrected measurement target data is obtained.
    Type: Application
    Filed: June 30, 2017
    Publication date: February 8, 2018
    Applicant: SHIMADZU CORPORATION
    Inventor: Akira HARADA
  • Patent number: 9884267
    Abstract: An eluate-collecting mechanism is constructed, including: a collection passage and having an inlet to be inserted into and removed from the upper end of a trap column and an outlet to be inserted into and removed from a collection container; a support member for supporting the collection passage in such a manner that the inlet is fixed while the outlet is vertically movable; a contact part provided at the outlet to come in contact with the collection container when the outlet is inserted into this container; and an elastic member for pressing the outlet downward so that a tip of the outlet is lower than the tip of the inlet, the elastic member being compressed when the support member and the collection container are brought closer to each other while keeping the contact part in contact with the container.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: February 6, 2018
    Assignee: Shimadzu Corporation
    Inventors: Tomoyuki Yamazaki, Stasica Przemyslaw, Bob Boughtflower
  • Patent number: 9885725
    Abstract: The present invention provides a mass spectrometry method that can achieve analysis with high sensitivity using a matrix additive capable of improving ionization efficiency in mass spectrometry. A mass spectrometry method comprising the steps of: forming a mixed crystal for mass spectrometry on a target plate for mass spectrometry, the mixed crystal comprising a sample to be analyzed, a matrix, and a matrix additive selected from the group consisting of a 2,5-dihydroxybenzoate and a 3,5-dihydroxybenzoate that are represented by the following formula (I): where R represents an alkyl group having 4 to 14 carbon atoms; and irradiating the mixed crystal with laser to detect the sample to be analyzed.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: February 6, 2018
    Assignees: SHIMADZU CORPORATION, HIROSHIMA UNIVERSITY
    Inventors: Yuko Fukuyama, Shunsuke Izumi
  • Patent number: 9887061
    Abstract: This X-ray tube device includes an anode and a cathode including an emitter emitting an electron to the anode. The emitter includes an electron emission portion in a flat plate shape, a pair of terminal portions extending from the electron emission portion, connected to an electrode, and a supporting portion provided separately from the terminal portions, insulated from the electrode, supporting the electron emission portion.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: February 6, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Takumi Kobayashi, Masaaki Ukita