Abstract: A co-culture apparatus includes: a first airtight container; a co-culture device disposed outside of the first airtight container; a first culture medium source disposed in the first airtight container and storing a first culture medium; a second culture medium source storing a second culture medium having a lower dissolved oxygen concentration than that of the first culture medium; and a first conduit connected to the co-culture device and the first culture medium source. The co-culture device includes: a membrane having a first main surface, and a second main surface opposite to the first main surface for culturing cells; a first flow path partially defined by the first main surface and disposed such that the first culture medium flows therethrough; and a second flow path partially defined by the second main surface and disposed such that the second culture medium flows therethrough. The first flow path has an inlet connected to the first conduit.

Abstract: In order to improve the ionization efficiency and ion collection efficiency in an ESI ion source to achieve a higher level of analysis sensitivity while improving the throughput of the analysis, one mode of the present invention provides an ion analyzer equipped with an ion source employing an electrospray ionization method, where the ion source (2) includes: a plurality of capillaries (211-218) configured to spray a supplied liquid sample in the same direction; one or more auxiliary electrodes (23, 231-328) arranged so as to be surrounded by the plurality of capillaries; and a voltage supplier (24) configured to apply, to the plurality of capillaries, a DC high voltage for which the potential of the one or more auxiliary electrodes is used as a reference.

Abstract: Provided is a method by which the disaccharides derived from glycosaminoglycans can be analyzed in a stable and highly reproducible manner. A method for analyzing a glycosaminoglycan according to the present invention includes: a first process for producing a plurality of kinds of disaccharides derived from a glycosaminoglycan in a biological sample by adding a plurality of kinds of glycosaminoglycan-specific enzymes to the biological sample; and a second process for separating and analyzing the plurality of kinds of disaccharides by a liquid chromatography-mass spectrometry method, where a column used for liquid chromatography in the liquid chromatography-mass spectrometry method is a column packed with a stationary-phase support to which an amide group as a functional group is bound, or a column packed with a stationary-phase support to which an adamantyl group as a functional group is bound.

Abstract: A method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota, Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota, Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella ba

Abstract: A conductivity meter includes a measurement unit including an electrode arranged as being in contact with sample water and a substrate on which a circuit that processes information outputted from the measurement unit is mounted. The measurement unit and the substrate are connected to each other, with a wall portion being interposed, the wall portion partitioning a space in a housing into a water section and an electric section. The measurement unit is arranged on a first surface of the wall portion on a side of the water section such that the electrode is located in an opening provided in the wall portion. The substrate is arranged on a second surface of the wall portion on a side of the electric section such that an electrode contact that electrically connects a power supply and a circuit to each other is located in the opening.

Abstract: A heavy solution is stored in a heavy solution reservoir. A sample is separated in a container based on a specific gravity difference with the use of the heavy solution supplied from the heavy solution reservoir. A waste solution from the container is discharged through a first pipe. The heavy solution from the first pipe is sent through a second pipe to the heavy solution reservoir. A filter unit is provided in the second pipe to remove a contaminant from the heavy solution discharged through the first pipe.

Abstract: ICP-MS includes: an ion source to ionize a sample component; a vacuum chamber (4-into which generated ions are introduced; a cell inside the vacuum chamber to bring the ions into contact with a predetermined gas; a mass spectrometer unit at a later stage of the vacuum chamber to perform mass spectrometry of ions having passed through the cell or ions derived from the ions; a first gas introduction unit to introduce a predetermined gas into the cell; a second gas introduction unit to introduce a predetermined gas into the vacuum chamber and outside the cell; and controllers to control gas introduction such that a gas is introduced by the first gas introduction unit when analysis is performed while bringing a gas into contact with ions, whereas a gas is introduced by the second gas introduction unit when analysis is performed without bringing a gas into contact with ions.

Abstract: In a jig mounting step (Step S1), a laser module having an optical axis adjustment mechanism is mounted on an optical axis adjustment jig in a state where the laser module is detached from a Raman spectrometer. In an optical axis adjusting step (Step S2), an optical axis of a laser module mounted on the optical axis adjustment jig is adjusted using the optical axis adjustment mechanism of the laser module. In a device attaching step (Step S4), a laser module whose optical axis has been adjusted by the optical axis adjusting step is attached to an attachment position of a Raman spectrometer.

Abstract: An electronic balance includes a balance unit having a measuring pan surrounded by a space enclosed within a windshield having a door, and a rear-section casing formed by plates and containing a motor unit which includes a motor and a driving element connected with the rotation shaft of the motor. When the motor unit is fixed within the rear-section casing, the driving element protrudes through a driving-element hole in one of the plates to the outside of the rear-section casing and engages with a driven element fixed to the door so that the door can be opened and closed by the motor. When the motor must be replaced, the motor unit including the motor and the driving element in an integrated form can be entirely and easily replaced with a new motor unit.

Abstract: The present invention provides a detection method for a monoclonal antibody in a sample, comprising: (a) a step of capturing the monoclonal antibody in the sample and immobilizing the monoclonal antibody in pores of a porous body; (b) a step of bringing the porous body in which the monoclonal antibody is immobilized with nanoparticles on which protease is immobilized to conduct selective protease digestion of the monoclonal antibody; (c) a step of detecting, by a liquid chromatography mass spectrometry (LC-MS), peptide fragments obtained by the selective protease digestion; and (a?) a step of conducting a reduction reaction under an acidic condition after the step (a). By the present invention, further applicability of the detection method for the monoclonal antibodies using mass spectrometry is expected.

Abstract: A defect inspection device (100) includes an excitation unit that excites an elastic wave, an irradiation unit (2) that applies laser lights, a measurement unit (3) that measures the interfered laser lights, and a control unit that acquires vibration state information which is information about a state of the elastic wave excited in an inspection target (P) for a plurality of frequencies by changing a frequency of excitation vibration caused by the excitation unit in order to excite the elastic wave in the inspection target (P), and extracts recommended frequencies (F) recommended for inspecting a defect of the inspection target (P) from among the plurality of frequencies based on the acquired vibration state information for the plurality of frequencies.

Abstract: A high-voltage power supply device includes a voltage generation unit for outputting a DC high-voltage, a switching unit using a semiconductor switching element, the switching unit being configured to output an output voltage by the voltage generation unit to a voltage output terminal in a conduction state, a driver for driving a control terminal of the semiconductor switching element, and a controller for controlling the switching unit via the driver. The driver includes a high-frequency transformer provided with primary and secondary windings, a distribution of a stray capacitance per number of unit turns of the primary winding between the primary and secondary windings in an extension direction of the primary winding being symmetrical to a midpoint of the primary winding, a rectifier for rectifying an AC current induced in the secondary winding, and a balanced output type high-frequency excitation unit for exciting the primary winding differentially.

Abstract: An imaging analysis device according to the present invention includes: an analysis execution unit (1) configured to perform analysis by a predetermined analysis method for each of a plurality of measurement points set in a measurement area on a sample and collect imaging data; a reference image acquiring unit (2) configured to acquire a reference image for the measurement area; a regression analysis executer (36) configured to, with respect to the imaging data and the reference image obtained for the same sample, perform predetermined regression analysis calculation with the imaging data as an explanatory variable and data constituting the reference image as a target variable and acquire a regression model; and a predicted image creator (37) configured to apply, to the regression model, imaging data obtained by the analysis execution unit using a sample different from the sample used in the regression analysis executer, and create a predicted image based on a pseudo regression analysis result.

Abstract: An ion detector includes a conversion dynode having a conversion region, an electron multiplier including a first-stage dynode, a box electrode including a first opening through which the ions traveling to the conversion region pass and a second opening through which the electrons traveling to the first-stage dynode pass, a conductive shielding portion disposed in the first opening and including a gap through which the ions traveling to the conversion region pass, and a potential application unit which applies a first potential to the conversion dynode, applies a second potential to the first-stage dynode, applies a third potential to the box electrode, and applies a fourth potential to the shielding portion. The first potential and the third potential have polarities opposite to a polarity of the ions, the second potential is higher than the first potential, and the third potential and the fourth potential are substantially the same potential.

Abstract: A method of estimating a structure of a target compound containing a linear acyl group, the method comprising: analyzing a sample containing the target compound on a chromatograph to determine a retention time; and estimating a combination of a total number of carbon atoms and a total number of carbon-carbon double bond(s) in the acyl group in the target compound from the retention time, based on the following equations 1 and 2: N=f(T)??(Equation 1) T=t/Dm??(Equation 2).

Abstract: First and second MRM transitions for a target substance, a first reference value concerning a measured intensity of the first MRM transition, and a second reference value concerning the measured-intensity ratio between the first and second MRM transitions are set. MRM measurements of an analyte sample using the first and second MRM transitions are performed to obtain a first intensity of the first MRM transition and a second intensity of the second MRM transition (Steps 11 and 12). The value of the first intensity is compared with the first reference value to determine whether the target substance is possibly contained (first determination; Step 14). For a target substance considered to be possibly contained in the analyte sample, the ratio between the first and second intensities is compared with the second reference value to determine whether the target substance is contained (second determination; Step 18).

Abstract: A Ramsey spectrometer is provided with an optical path, an optical path length stabilization circuit configured to stabilize a length of the optical path, a modulator optically connected to the optical path, the modulator being configured to generate resonant laser light of a first frequency f1 that causes a resonance of an atom, a molecule, or an ion as a spectroscopic target in pulses a plurality of times and generates non-resonant laser light of a second frequency f2 that does not cause the resonance, and a spectroscopic unit configured to spectroscope the spectroscopic target. The spectroscopic unit detects a state change of the spectroscopic target corresponding to the first frequency f1, the state change being caused by irradiating the resonant laser light to the spectroscopic target.

Abstract: A light-scattering detection device includes a transparent sample cell, a light source for emitting coherent light onto the sample cell, an imaging optics for collecting scattered light from the sample cell to the periphery thereof at different scattering angles, a slit plate for limiting the scattering angle range, a detector for receiving collected light from the imaging optics, and an aperture plate for limiting, by the aperture width thereof, the width of the light received by the detector, the aperture plate being arranged in the detector with respect to the focal length of the imaging optics. A plurality of detection optics is arranged around the sample cell at equal intervals from the central axis of the sample cell. The aperture width of each aperture plate differs in accordance with the arrangement angle ? of each detector with respect to the sample cell.

Abstract: A resin tube connection device includes a resin tube, a resin expanding portion and a metal sleeve. The resin expanding portion has a sealing surface being able to come into contact with a contact surface. Further, the resin expanding portion has a second flow path that communicates with a first flow path of the resin tube and opens in the sealing surface. The sealing surface projects farther than an end surface of the metal sleeve in an axial direction. The maximum length of a contact region where the resin expanding portion and the metal sleeve come into contact with each other in the axial direction in an outer surface is larger than the thickness of a resin layer in a radial direction.

Abstract: A liquid chromatograph includes a plurality of units that execute each function of the liquid chromatograph, and a system controller connected to the plurality of units, wherein the system controller includes a status provider that acquires a status from any unit and provides the acquired status to a computer connected to the system controller, a data accumulator that accumulates the status to be provided to the computer in a database, and a data provider that provides the status accumulated in the database to any unit.