Abstract: A peak analyzing method for separating overlapping peaks observed in a second signal waveform representing a relationship between a second parameter and a signal intensity into a plurality of individual peaks originating from different factors based on signal patterns observed in a dimension of a first parameter, the method including at least: performing singular value decomposition on an input matrix expressing three-dimensional data to be processed; estimating characteristic orientations within a space spanned by a plurality of basis vectors by performing a geometric analysis on a trajectory defined by a plurality of weighting vectors in an SVD projection space whose number of dimensions is equal to a lowered rank given by a singular value decomposition process; and deconvoluting signal waveforms in a first matrix of a dimension of the first parameter by a transformation matrix.

Abstract: A surface analyzer is provided with a measuring unit, a scatter diagram generation unit, a cluster analysis unit, and a cluster region detection unit. The measuring unit acquires a signal reflecting a quantity of each of a plurality of components or elements that are analysis targets at a plurality of positions on a sample. The scatter diagram generation unit generates a scatter diagram based on a measurement result by the measuring unit. The cluster analysis unit performs the clustering of points in the scatter diagram. The cluster region detection unit acquires, based on clustering information given to each point in the scatter diagram by the cluster analysis unit, for each cluster, cluster region boundary information on a polygon having a predetermined number or less of vertices.

Abstract: A flow rate switching mechanism including: a first section including: a first housing with a passage internally bored through, the passage having a narrowed portion at a distance from one end of the passage, and the narrowed portion having a smaller cross-sectional area than the cross-sectional area of the passage at the one end; a capillary having an internal passage having a smaller cross-sectional area than the cross-sectional area of the narrowed portion; and a hermetic support member supporting the capillary and to provide a seal; a second section having a second housing identical in shape to the first housing, without having the capillary and the hermetic support member; and a three-way valve being alternatively switchable between a first state in which the outlet end is connected to the first inlet end and a second state in which the outlet end is connected to the second inlet end.

Abstract: A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of A?1-42 (SEQ ID NO.: 9), A?1-38 (SEQ ID NO.: 11), A?1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-A?1-42, SIL-A?1-38, SIL-A?1-40, and SIL-APP669-711.

Abstract: The gas chromatograph system 10 has the gas chromatograph 1, and a detector 2. The detector 2 has the redox unit 14. The redox unit 14 has the reaction tube 142, the oxidation zone 146 and the reduction zone 147. The reduction zone 147 is disposed on the downstream side of the oxidation zone 146. The reduction zone 147 is disposed out of a position perpendicular direction above the oxidation zone 146. Hence, even if the air heated around the oxidation zone 146 moved upward by convection, the reduction zone 147 is prevented from being exposed to such hot air.

Abstract: A mass spectrometer according to one aspect of the present invention includes an ion source (31), a mass separator (32), and a detector (33), the mass spectrometer further including: a parameter optimization unit (531, 532, 533) configured to optimize a parameter value using a Bayesian optimization method based on a result obtained by making measurements while changing values of device parameters including a plurality of parameters that affects ionization efficiency in the ion source (31), a display processor (536) configured to display a sensitivity model which is a posterior distribution indicating a relationship between a plurality of parameters in all or some of the device parameters and signal strength estimated during the optimization of the device parameters, expressing as a graph like a heat map or an array of a plurality of the graphs on a display unit (7), and to sequentially update the sensitivity model, and a file creation unit (535) configured to a user to designate a position on the displayed gr

Abstract: A liquid chromatograph is presented which enables automatic resolution of a liquid sending failure when the liquid sending failure caused by a liquid sending pump occurs, and execution of a new analysis with good reproducibility after the liquid sending failure is resolved. The liquid sending failure can be automatically resolved by a purging operation. A sample remaining in the analysis flow path is washed away by a non-injection analysis after the liquid sending failure is resolved, and a new analysis can be executed with good reproducibility.

Abstract: A time-of-flight mass spectrometry device includes an electrode to which a DC high voltage is applied in order to form an ion flight space and a high voltage power supply device that applies the high voltage to the electrode. The high voltage power supply device includes a high voltage generating circuit that generates the high voltage, and a voltage control circuit that is selectively set to a convergence responsiveness priority mode in which the high voltage generating circuit is controlled such that the high voltage has first convergence responsiveness and first stability or a stability priority mode in which the high voltage generating circuit is controlled such that the high voltage has second convergence responsiveness that is lower than the first convergence responsiveness and second stability that is higher than the first stability.

Abstract: A method for analyzing MALDI mass spectrometry data includes: calculating m/z values respectively corresponding to peaks in amass spectrum, from data corresponding to the mass spectrum acquired by MALDI mass spectrometry performed on a sample; and performing at least one of calculations (a) and (b), based on the m/z values and information on kinds of ions possibly generated from the sample in the mass spectrometry, where calculation (a) includes assuming that ions respectively corresponding to the peaks are first ions singly charged, and calculating m/z of second ions respectively corresponding to the first ions and being multiply charged, and calculation (b) includes assuming that ions respectively corresponding to the peaks are first ions that are multiply charged ions, and calculating m/z of second ions respectively corresponding to the first ions and being singly charged.

Abstract: A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.

Abstract: An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.

Abstract: An absorbance detector includes a sample cell, a light source for irradiating the sample cell, a photo sensor, an optical system for guiding light emitted from the light source to the sample cell and guiding light that has been transmitted through the sample cell to the photo sensor, a reference signal acquirer configured to acquire a detection signal of the photo sensor when the sample solution is not flowing through the sample cell as a reference signal for each analysis of the sample, a calculator configured to find absorbance of the sample based on a measurement signal obtained by the photo sensor in the analysis and the reference signal acquired for the analysis when an analysis of the sample is carried out, and an analysis data storage configured to associate data of the absorbance found by the calculator and data of the reference signal to each other for storage.

Abstract: An injection valve switches between a first state in which a sample loop is connected to a separation flow path through which a mobile phase from a liquid sender flows and a second state in which the sample loop is disconnected from the separation flow path. A pump speed determiner, in a case where a sample intake operation by a syringe pump is started immediately after the injection valve is switched from the second state to the first state, and a filling operation of filling the sample loop with the sample by the syringe pump is started after the intake operation is completed, determines an intake operation speed of the syringe pump that is required in order for the filling operation to complete immediately before the injection valve is switched from the second state to the first state next time using a set injection interval time. The syringe pump operates at the intake operation speed determined by the pump speed determiner while performing the intake operation.

Abstract: A circulation device causes gas to circulate between a sample storage space and a temperature adjustment space through the first and second opening regions in a separating member. A temperature of gas flowing in the temperature adjustment space is adjusted by a heat exchanger, so that the temperature of gas surrounding a sample in the sample storage space is adjusted. The separating member further has first and second unit regions. The second opening region includes a first portion located in the first unit region and a second portion located in the second unit region. The shortest distance between the first portion and the first opening region is larger than the shortest distance between the second portion and the first opening region, and an aperture ratio of the first portion in the first unit region is larger than an aperture ratio of the second portion in the second unit region.

Abstract: The present invention relates to a fiber branch structure for spatial optical communication for transmitting information by emitting communication light. The fiber branch structure is provided with: a light emitter configured to emit communication light; a light emission controller configured to control the light emitter; an optical fiber configured to transmit the light emitted from the light emitter; a distributor configured to distribute the light, the distributer being optically coupled to an output terminal of the optical fiber; and an optical fiber group optically coupled to a plurality of output terminals of the distributor. According to the present invention, a communication area can be established without blind spots. That is, the fiber branch structure for spatial optical communication according to the present invention includes an optical fiber group optically coupled to a plurality of output terminals of the distributor.

Abstract: A calibrant for use in correction of machine difference of mass spectrometers and a method for producing the calibrant are provided. A calibrant for use in a mass spectrometer, the calibrant comprising not less than two calibration substances, wherein a ratio of, relative to a concentration of one calibration substance of the not less than two calibration substances, a concentration of another calibration substance of the not less than two calibration substances is a predetermined value, and a method for producing the calibrant.

Abstract: A power supply device applies a voltage to a quadrupole mass filter. The power supply device has a main substrate and a wave-detection substrate. The main substrate includes a detector. The wave-detection substrate includes a wave detector and an identifier. The wave detector detects an AC component of a voltage to be applied to the quadrupole mass filter as a wave-detection voltage. The identifier outputs identification information of the wave detector defined in correspondence with the configuration of a rectifying device of the wave detector. The detector detects identification information output by the identifier, and supplies the detected identification information to a corrector that corrects a deviation of voltage caused by a leakage current of the rectifying device.

Abstract: A polymer not including a fluorescent dye is introduced into an electrophoresis flow channel and electrophoresis is performed (Steps S101, S103), so that a fluorescent dye in the electrophoresis flow channel is removed from the inside of the electrophoresis flow channel by the polymer. The fluorescent dye accumulated in the electrophoresis flow channel can be adhered to the polymer having a certain viscosity and removed from the electrophoresis flow channel. Accordingly, separation performance of a flow channel member can be recovered effectively.

Abstract: A bioinert piping (1) that has a flow path (2) provided inside and a main body portion (10) between end portions (8, 8) includes a resin tube (4) that forms an inner wall of the flow path (2) over an entire length of the flow path (2), and a metal tube (6) that accommodates the resin tube (4) inside so as to cover the outer peripheral surface of the resin tube (4) over at least an entire length of the main body portion (10). The metal tube (6) is plastically deformed toward an inner side so that the outer peripheral surface of the resin tube (4) and an inner peripheral surface of the metal tube (6) are in liquid-tight contact with each other.