Patents Assigned to Simes
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Patent number: 4815687Abstract: The subject invention is directed toward a novel bracket for releasably supporting medical testing and monitoring equipment. The bracket includes a support member for supporting the medical equipment, gripping means for gripping the medical equipment and a vertical member for joining the gripping and supporting means. The gripping means are constructed so as to allow the medical equipment to be quickly removed and conversely to be quickly mounted to the bracket. Coupling means are provided for mounting the bracket to support members. The coupling means are adapted to allow the bracket to mount to support members which are vertically, horizontally or otherwise oriented.Type: GrantFiled: October 9, 1987Date of Patent: March 28, 1989Assignee: SiMed CorporationInventors: Gary J. Selke, Larry J. Morse
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Patent number: 4653548Abstract: A process for tying metal reinforcement and/or mesh structures wherein U-shaped clips having bent and generally diverging arms are placed at the crossings of the rod to be tied together and engage twice on each of the rods of the crossing, the arm ends being closed by being twisted until a portion of the ends ruptures, the twisting being performed by a substantially longitudinal tool having at the front jaws which in the open state close on the clip ends, turn and twist the same and finally break the ends leaving them twisted, the jaws returning to the same initial position.Type: GrantFiled: July 24, 1985Date of Patent: March 31, 1987Assignee: Simes-Senco, S.A.Inventor: Antonio Lucas Huerta
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Patent number: 4644004Abstract: Pyridinecarboxylic esters of dopamine and of its N-alkyl derivatives, salts thereof with pharmaceutically acceptable organic or inorganic acids, process for preparing them and pharmaceutical compositions containing them which are particularly useful in the treatment of cardiovascular and renal disorders.Type: GrantFiled: February 8, 1985Date of Patent: February 17, 1987Assignee: Simes S.p.A.Inventors: Cesare Casagrande, Emilio Mussini, Vittorio Vecchietti
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Patent number: 4528296Abstract: Derivatives of aminopyridinecarboxylic acids which inhibit the dipeptidyl carboxy peptidase (DPCP), methods for their preparation and pharmaceutical compositions containing them.The compounds have formula: ##STR1## where Z is hydrogen, alkyl having from 1 to 3 carbon atoms, halogen or alkoxy having from 1 to 3 carbon atoms;R1 is hydrogen, alkyl having from 1 to 6 carbon atoms, arylalkyl having from 7 to 12 carbon atoms, aryl having from 6 to 15 carbon atoms;m and n are an integer of from 0 to 4 each provided, however, the m+n is lower than 5;R2 is hydrogen, alkyl having from 1 to 6 carbon atoms or arylalkyl having from 7 to 12 carbon atoms;R3 is hydrogen or acyl having from 1 to 8 carbon atoms;R4 is hydrogen or alkyl having from 1 to 3 carbon atoms;and their pharmaceutically acceptable salts with organic or inorganic acids.Type: GrantFiled: December 2, 1983Date of Patent: July 9, 1985Assignee: Simes, Societa Italiana Medicinalle SinteticiInventors: Vittorio Vecchietti, Giorgio Ferrari, Cesare Casagrande
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Patent number: 4507307Abstract: N.sub.1 -acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation of the new tetrahydroquinoline compounds.Process for preparing the new tetrahydroquinoline compounds and some intermediates useful in the preparation thereof.Type: GrantFiled: July 28, 1982Date of Patent: March 26, 1985Assignee: SimesInventors: Vittorio Vecchietti, Emilio Mussini, Giorgio Ferrari
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Patent number: 4467094Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.Type: GrantFiled: December 3, 1982Date of Patent: August 21, 1984Assignee: Simes S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4381305Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.Type: GrantFiled: June 5, 1981Date of Patent: April 26, 1983Assignee: Simes S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4376117Abstract: The magnesium salt of creatinol-O-phosphate, having the formula: ##STR1## is useful in the treatment and in the prevention of the myocardiac infarction.The preparation of the above magnesium salt takes place by reacting creatinol-O-phosphate, as a water solution, with a reactive magnesium compound.The magnesium salt according to the invention may be obtained in either anhydrous or hydrated form and is useful for the preparation of the normal pharmaceutical formulations for the administration by oral and parenteral route.Type: GrantFiled: October 17, 1980Date of Patent: March 8, 1983Assignee: Simes S.p.A.Inventors: Theophile Godfraind, Paolo Ghirardi, Giorgio Ferrari, Cesare Casagrande
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Patent number: 4362721Abstract: There are disclosed penicillanic and cephalosporanic derivatives of the formula: ##STR1## wherein R is H or --OH; R.sub.1 is a carbohydrate hexose radical of 3-O-glucose, 6-O-galactose, 3-O-glucose acetals, 3-O-glucose ketals, 6-O-galactose acetals, and 6-O-galactose ketals, and R.sub.2 is: ##STR2## where R.sub.3 is H or an alkali or alkaline-earth metal. The preparation of the derivatives and pharmaceutical compositions containing same are also disclosed.A process according to the invention comprises reacting a compound of the formula ##STR3## with a hexose carbohydrate, in --OH protected form, in an aqueous medium, in the presence of a water-miscible organic solvent, in the presence of a base, the reaction product being optionally transformed into the derivative wherein R.sub.1 is a carbohydrate in the unprotected form by treatment with Lewis' acid or a hydrogen halide acid.Type: GrantFiled: December 3, 1981Date of Patent: December 7, 1982Assignee: Simes S.p.A.Inventors: Giorgio Ferrari, Vittorio Vecchietti
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Patent number: 4358087Abstract: A lifting jack has its upward and downward traveling distance controlled by means of a limit switch. The lifting jack has a base, an upright outer member rigidly connected to the base and an upright inner member movable coaxially within the outer member. An up stop and an adjustable down stop are rigidly attached to and move with the inner member. An adjustable mount is mounted in a fixed position on the outer member, and the limit switch is mounted in fixed position on the mount. A guide shoe assembly is pivotally connected to the mount and is oriented generally perpendicular to the direction of travel of the inner member. A stop engaging member at one end of the guide is positioned to engage the up stop and the down stop, and an arm guiding portion at the opposite end engages and guides an actuating arm of the limit switch.Type: GrantFiled: November 6, 1980Date of Patent: November 9, 1982Assignee: Simes, Inc.Inventor: Sylvan H. Sime
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Patent number: 4302471Abstract: The present invention relates to a method of inducing a response dopamine-like in an animal having impaired cardiovascular and renal functions, comprising administering to said animal an effective amount of a compound having the general formula: ##STR1## wherein R is a secondary or tertiary alkyl radical having from 3 to 7 carbon atoms, and their salts with nontoxic organic and inorganic acids.In particular, the present invention relates to a method of treating cardiac and renal failures comprising administering to a patient suffering therefrom an effective amount of a compound having the above-identified general formula, in suitable pharmaceutical preparations.Type: GrantFiled: May 20, 1980Date of Patent: November 24, 1981Assignee: Simes Societa Italian Medicinali e Sintetici S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4287211Abstract: Novel derivatives of phenylethylamine, having general formula: ##STR1## wherein R is hydrogen or a lower alkyl, are disclosed, to be used in the therapy of diseases of the digestive apparatus, particularly gastric and/or duodenal ulcers. The novel derivatives of phenylethylamine are prepared(a) from a compound of formula (II) ##STR2## by reaction with potassium cyanate, in the presence of an organic acid; (b) from the compound of formula (II) which is converted to the corresponding phenylcarbonic derivative by reacting with phenylchloroformiate and then with ammonia(c) from a compound of formula (IV) ##STR3## which is converted to a compound of formula (V), the latter being converted to the desired derivatives (I) by treatment with aqueous alkali.Type: GrantFiled: December 28, 1979Date of Patent: September 1, 1981Assignee: Simes, S.p.A.Inventors: Giorgio Ferrari, Vittorio Vecchietti
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Patent number: 4277656Abstract: A lifting jack has its upward and downward traveling distance controlled by means of a limit switch. The lifting jack has a base, an upright outer member rigidly connected to the base and an upright inner member movable coaxially within the outer member. An up stop and an adjustable down stop are rigidly attached to and move with the inner member. An adjustable mount is mounted in a fixed position on the outer member, and the limit switch is mounted in fixed position on the mount. A guide shoe assembly is pivotally connected to the mount and is oriented generally perpendicular to the direction of travel of the inner member. A stop engaging member at one end of the guide is positioned to engage the up stop and the down stop, and an arm guiding portion at the opposite end engages and guides an actuating arm of the limit switch.Type: GrantFiled: September 14, 1979Date of Patent: July 7, 1981Assignee: Simes Inc.Inventor: Sylvan H. Sime
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Patent number: 4272529Abstract: The N-m-trifluoromethylphenylanthranilates of O-alcoxycarbonylphenyl, having the formula ##STR1## wherein R is an alkyl group, preferably comprising 1 to 4 carbon atoms, besides being of low toxicity, are endowed with anti-inflammatory properties and are adapted for the treatment of inflammatory and thrombotic diseases. The method for the preparation of the above compounds comprises reacting the N-m-trifluoromethylphenylisatoic anhydride with an alkyl salicylate.Type: GrantFiled: April 3, 1980Date of Patent: June 9, 1981Assignee: Simes S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4229450Abstract: Novel ergoline derivatives are disclosed having the general formula (I) ##STR1## wherein R.sub.1 is hydrogen, and alkyl radical (C.sub.1 to C.sub.4) either straight of branched chain,Z is hydrogen, bromine, S-R.sub.IV (in which R.sub.IV is an alkyl of from C.sub.1 to C.sub.4,R.sub.II is equal to R.sub.III and is an alkyl of from C.sub.1 to C.sub.6, orR.sub.II united with R.sub.III by-(CH.sub.2).sub.n, with n from 0 to 7, to form simple heterocyclic compounds such as pyrrolidine, piperidine, hexamethyleneimine, or united with --(CH.sub.2).sub.n --A--(CH.sub.2).sub.n, with n equal to a number from 2 to 5 to form heterocyclic compounds such as A=0 and n=2 to give morpholine, A is N-R.sub.V and N=2 for piperazine, either substituted or unsubstituted, with R.sub.V being hydrogen, an alkyl of from C.sub.1 to C.sub.4, or a phenyl radical, the x--y bridge being a ##STR2## bond. A method for the preparation of such compounds and pharmaceutical compositions thereof are also disclosed.Type: GrantFiled: January 16, 1979Date of Patent: October 21, 1980Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.Inventors: Giorgio Ferrari, Vittorio Vecchietti
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Patent number: 4218470Abstract: Novel cardiocirculatory analeptics are prepared, which are epinine esters as obtained by reacting epinine (N-methyldopamine) with branched-chain aliphatic carboxylic acids. Exemplary members are 3,4-di-O-butyrylepinine and 3,4-di-O-pivaloylepinine. These medicaments are effective also by the oral route of administration, contrary to the hitherto commonly used dopamine derivatives which are rapidly destroyed by metabolization when administered orally.Type: GrantFiled: July 28, 1977Date of Patent: August 19, 1980Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4198344Abstract: A method is disclosed for extracting lysergol and ergolinic alkaloids from seeds of plants belonging to the Convulvulaceae family, Ipomoeae section, petaloidea genus (Choisy). The process applies to ground and defatted seeds and, after an orderly sequence of extraction, filtrations and crystallization, a first insoluble fraction is obtained, which contains the expected ergoline alkaloids and lysergol, whereafter a second sequence of extractive operations is carried out in order to separate as discrete fractions, the ergolinic alkaloids on the one hand, and the lysergol on the other hand.Type: GrantFiled: August 4, 1978Date of Patent: April 15, 1980Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.Inventor: Giorgio Ferrari
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Patent number: 4197299Abstract: A method for preparing ergoline derivatives in which the ergoline structure is variously substituted by morpholino-piperazino- and other active radicals to obtain novel compounds useful in cardiology as alpha-blocking, vasodilating, antihypertensive active ingredients of pharmaceutical preparations.Type: GrantFiled: June 20, 1978Date of Patent: April 8, 1980Assignee: Simes Societa Italiana Medicinali e SinteticiInventors: Giorgio Ferrari, Vittorio Vecchietti
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Patent number: 4190654Abstract: A pharmaceutical composition for the therapeutical treatment of anxiety and neurodystonic states characterized by combining an anxiolytic belonging to the class of the benzodiazepines and a beta-adrenergic receptor blocking agent, in which said benzodiazepinic anxiolytic is 3-N,N-dimethylcarbamoyloxy-1-methyl, 5-phenyl, 7-chloro, 1,3-dihydro-2H-1,4-benzodiazepin-2-one- and said beta-adrenergic receptor blocking agent is 1-(0-methoxyphenoxy)-3-isopropylamino-propan-2-olo.Type: GrantFiled: August 21, 1978Date of Patent: February 26, 1980Assignee: Simes Societa Italiana Medicinali e Sintatici S.p.A.Inventors: Paolo Gherardi, Giorgio Ferrari
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Patent number: 4057635Abstract: Ergoline carbamates are disclosed, which have proven to be effective spasmolytic and vasodilatory drugs. They are derivatives of D-6-methyl-8.beta.-(methanol)-9,10-didehydroergoline (also called lysergol). Three convenient methods for their preparation are also disclosed. The toxicity of these compounds is extremely low.Type: GrantFiled: August 19, 1975Date of Patent: November 8, 1977Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.Inventors: Giorgio Ferrari, Jiri Jan Krepinsky