Abstract: This application relates to the production and characterization of a mutant strain of Aspergillus fumigatus. The application also relates to a method for inhibiting siderophore biosynthesis in Aspergillus fumigatus and an assay for identifying drug candidates or other agents having potential inhibitory activity. The method may comprise, for example, the step of inhibiting an enzyme catalyzing siderophore biosynthesis, such as L-ornithine N5-oxygenase. In one embodiment the siderophore is a hydroxamate siderophore, such as N?N?N??-triacetylfusarinine C (TAF) or ferricrocin. A method of preventing or treating fungal infections in a patient is also described comprising administering to the patient an agent suitable for inhibiting fungal secretion of siderophores. The method is particularly useful for immunocompromised patients susceptible to fungal infections caused by Aspergillus fumigatus, such as pulmonary aspergillosis.

Abstract: Procedures for decorrelating the branch signals of a signal adjuster of an amplifier linearizer are presented herein. The decorrelation procedures can be performed with or without self-calibration.

Abstract: A method and apparatus for a spherical parallel mechanism are disclosed. The invention involves a platform and at least three kinetic chains. The kinetic chains each comprise a link with one end pivotally coupled to the platform about a first axis and a second end pivotally coupled to an arm about a second axis. The arms in all of the kinetic chains share a common third axis. All of the first, second and third axes for all of the kinetic chains pass through a stationary point in space. Movement of the arms to selected angular positions about the common third axis adjusts an orientation and position of the platform about a spherical surface centered at the stationary point. The parallel mechanism has particular advantages for manipulating implements, such as cameras used in laparoscopic surgery, when the implements are mounted to the mobile platform.

Abstract: A high efficiency, low distortion switching mode power amplifier for telecommunication applications includes an analog to binary digital converter and a class S amplifier terminated by an output filter/matching network capable of operation over one or more frequency bands. The modulator may be connected to the class S amplifier with a fiber optic link. This construction can provide a low-distortion connection to remote antennas. Multiple modulators and amplifiers can be multiplexed over the fiber link to support a multiple sector antenna on a cell site or multiple transmitter elements on a phased array antenna.

Abstract: A monitoring system for a valuable item, such as a digital device, has a base unit affixed to the valuable and a remote unit carried by a person responsible for the valuable. Signals are exchanged between the base and remote units. The base continuously monitors for signals from the remote unit and can arm or disarm automatically in response to such signals. When armed, the base communicates with a program running on the valuable to lock peripherals. The base alerts the owner upon movement of the valuable, allowing the owner to screen for false alarms or be notified of an occurring theft attempt. A digital connection between the base and the valuable may be used to encrypt any data stored on the valuable and charge the internal batteries of the security device. A soft switch enables the base to be powered off by the corresponding remote unit.

Abstract: A thermal pressure sensor monitors pressure by measuring effects caused by variations of thermal conductivity between a member and a substrate to which the member is adhered by stiction. The interface between the member and the substrate behaves as an extremely narrow gap. In a preferred embodiment the member is a bridge extending between a pair of cantilever arms. Two pressure sensors may be combined in a Wheatstone bridge configuration. A method for fabricating a pressure sensor according to the invention comprises forming a layer of oxide on a substrate, depositing a layer of material on the oxide layer, forming the member from the layer of material, removing the oxide layer and then bringing the member into contact with the substrate. The portion of the substrate under the member may be patterned with plateaus and valleys.

Abstract: An amplifier linearizer includes a signal adjuster having an internal signal, and an adaptation controller for monitoring the signal adjuster. The internal signal at an input to the adaptation controller is deemed a monitor signal. The adaptation controller generates a control signal for the signal adjuster by accounting for a difference between the internal and monitor signals.

Abstract: An amplifier linearizer includes a signal adjuster having an internal signal, and an adaptation controller for monitoring the signal adjuster. The internal signal at an input to the adaptation controller is deemed a monitor signal. The adaptation controller generates a control signal for the signal adjuster by accounting for a difference between the internal and monitor signals.

Abstract: Procedures for decorrelating the branch signals of a signal adjuster of an amplifier linearizer are presented herein. The decorrelation procedures can be performed with or without self-calibration.

Abstract: A photoresist-free method for making patterned films of metal oxides, metals, or other metal containing compounds is described. The method involves applying a thin film coating of a metal complex, resulting in the formation of a liquid crystal film. This film can be photolyzed resulting in a chemical reaction which deposits a metal or metal oxide film. The metal complex used is photoreactive and undergoes a chemical reaction in the presence of light of a suitable wavelength. The end product of the reactions depends upon the atmosphere in which the reactions take place. Metal oxide films may be made in air. Patterned films may be made by exposing only selected portions of the film to light. Patterns of two or more materials may be laid down from the same film by exposing different parts of the film to light in different atmospheres.

Abstract: An amplifier linearizer circuit has a signal cancellation circuit including a signal adjuster having M branch signals (M≧1), and a distortion cancellation circuit including a signal adjuster having N branch signals (N≧1). The linearizer has a controller for adaptively controlling the M-branch and N-branch signal adjusters. The controller has only one monitor receiver to monitor the M branch signals and only one monitor receiver to monitor the N branch signals.

Abstract: An amplifier linearizer includes a signal adjuster having an internal signal, and an adaptation controller for monitoring the signal adjuster. The internal signal at an input to the adaptation controller is deemed a monitor signal. The adaptation controller generates a control signal for the signal adjuster by accounting for a difference between the internal and monitor signals.

Abstract: An amplifier linearizer circuit has a signal cancellation circuit including a signal adjuster having M branch signals (M≧1), and a distortion cancellation circuit including a signal adjuster having N branch signals (N≧1). The linearizer has a controller for adaptively controlling the M-branch and N-branch signal adjusters. The controller has only one monitor receiver to monitor the M branch signals and only one monitor receiver to monitor the N branch signals.

Abstract: An accelerometer has a substrate with a cavity therein, a heater extending over the cavity, and a pair of temperature sensitive elements each spaced apart from the heater a distance of 75-400 microns also extending over the cavity. On passing an electrical current through the heater a symmetrical temperature distribution is set up on both sides of the heater. On acceleration, this distribution moves and by measuring the temperature as sensed by the pair of temperature sensitive elements the acceleration that caused the shift can be calculated.

Abstract: The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds have the general formula (I) Preferably the compounds have a carboxyethyl or a substituted carboxymethyl substituent at the 2-position and a hydroxyl group at the 5-position and have a molecular shape suitable for binding to and reacting with the active site of a pencillin-recognizing enzyme. The compounds are synthesized by condensing a carboxyl-protected N-hydroxy amino acid with a 3-hydroxyprotected-4-bromobutanoic acid to form a a doubly protected N-hydroxy N-acylamino acid, which is cyclized with an organic base to yield a: doubly protected 1,2-oxazin-3-one. The protecting groups are then removed to provide an antibacterial agent.

Abstract: A process for fabricating an accelerometer, which includes providing a substrate with a layer of electrically conductive material on the substrate, micromachining the substrate to form a central electrical heater, a pair of temperature sensitive elements, and a cavity beneath the heater and the temperature sensing elements. Each temperature sensing element is spaced apart from said heater a distance in the range of 75 to 400 microns. The temperature sensing elements are located on opposite sides of the heater, thereby forming an accelerometer.

Abstract: The invention presents an approach that uses plural separated foils to shape an ion beam so that the intensity density of hot spots in the ion beam is lowered. More particularly, plural foils are placed in close proximity to each other, wherein at least one foil intercepts a portion of the beam to strip a charge from ions in different portions of the beam at different times, and thus, shape the ion beam. At a basic level, the inventive approach places plural foils so that the distance between planes of successive foils is a fraction of the radius of curvature of the beam's cyclotron orbit.

Abstract: A method for synthesizing Salacinol, its stereoisomers, and non-naturally occurring selenium and nitrogen analogues thereof having the general formula (I): The compounds are potentially useful as glycosidase inhibitors. The synthetic schemes comprise reacting a cyclic sulfate with a 5-membered ring sugar containing a heteroatom (X). The heteroatom preferably comprises sulfur, selenium, or nitrogen. The cyclic sulfate and ring sugar reagents may be readily prepared from carbohydrate precursors, such as D-glucose, L-glucose, D-xylose and L-xylose. The target compounds are prepared by opening of the cyclic sulfates by nucleophilic attack of the heteroatoms on the 5-membered ring sugars. The resulting heterocyclic compounds have a stable, inner salt structure comprising a heteroatom cation and a sulfate anion. The synthetic schemes yield various stereoisomers of the target compounds in moderate to good yields with limited side-reactions.

Abstract: A feedforward amplifier is disclosed in which either the main amplifier or the auxiliary amplifier includes at least three parallel signal paths. Each of the signal paths includes a complex gain adjuster. In addition, a feedforward amplifier is disclosed in which a plurality of control linearizers compensate for nonlinearities in the response of signal adjusters to control inputs.

Abstract: The invention is directed to a photoresist-free method for depositing films composed of metals, such as copper, or its oxides from metal complexes. More specifically, the method involves applying an amorphous film of a metal complex to a substrate. The metal complexes have the formula MfLgXh, wherein M is selected from the group consisting of Ti, V, Cr, Au, Mn, Fe, Co, Ni, Cu, Zn, Si, Sn, Li, Na, K, Ba, Sr, Mo, Ru, Pd, Pt, Re, Ir, and Os, L is a ligand of the formula (R2NCR2′CO) wherein R and R′ are independently selected from H, CnHm and CnHmAxBy wherein A and B are independently selected from main group elements and f, g, h, n, m, x and y represent integers and wherein X is an anion independently selected from N3, NCO, NO3, NO2, Cl, Br, I, CN, OH, H and CH3. These films, upon, for example, thermal, photochemical or electron beam irradiation may be converted to the metal or its oxides.