Patents Assigned to SmithKline Beecham Corporation
  • CHEMICAL COMPOUNDS
    Publication number: 20090264482
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 22, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Tricyclic-Nucleoside Compounds for Treating Viral Infections
    Publication number: 20090253648
    Abstract: Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 8, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jesse Daniel Keicher, Christopher Don Roberts, Sebastian Johannes Reinhard Liehr, Xiaoling Zheng, Marija Prhavc, Vivek Kumar Rajwanshi, Ronald Conrad Griffith, Choung U. Kim
  • Aminopyrazine derivatives and compositions
    Patent number: 7598251
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 6, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • N-(5-membered aromatic ring)-amido anti-viral compounds
    Patent number: 7595398
    Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers, Irina Slobodov, Roopa Rai
  • Benzimidazole thiophene compounds
    Patent number: 7595330
    Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Mui Cheung, Kyle Allen Emmitte, James M. Salovich
  • Methods of healing wounds by administering human IL-18
    Patent number: 7595039
    Abstract: The present invention relates generally to the use of human IL-18, also known as interferon-?-inducing factor (IGIF), in the treatment of skin wounds, surgical wounds, leg ulcers, diabetic ulcers, gastrointestinal mucositis, oral mucositis, and lung injury.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Kimberly A. Dede, Judithann M. Lee
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20090239866
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 24, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Jesus R. Medina
  • Substituted thieno and furo-pyridines
    Patent number: 7592352
    Abstract: This invention relates to newly identified compounds for treating and preventing tumors and cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: September 22, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Yasushi Miyazaki
  • Quinoxaline derivatives as PI3 kinase inhibitors
    Patent number: 7592342
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: September 22, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Yanhong Feng, Cynthia A. Parrish, Martha A Sarpong, Domingos J Silva
  • Compounds
    Patent number: 7592357
    Abstract: Novel Inhibitors of Rho-kinases are disclosed.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: September 22, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Lee, Krista B. Goodman
  • Indane compounds as CCR5 antagonists
    Patent number: 7589204
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: September 15, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Youngman, Wieslaw Mieczyslaw Kazmierski, Hanbiao Yang, Christopher Joseph Aquino
  • Cyclohexyl compounds as CCR5 antagonists
    Patent number: 7589207
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 15, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Maosheng Duan, Wieslaw Mieczyslaw Kazmierski, Christopher Joseph Aquino
  • Imidazoyl-benzamide anti-cancer agents
    Patent number: 7582668
    Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: September 1, 2009
    Assignees: Cytokinetics, Incorporated, SmithKline Beecham Corporation
    Inventors: Xiangping Qian, Luke W. Ashcraft, Jianchao Wang, Bing Yao, Hong Jiang, Gustave Bergnes, Bradley P. Morgan, David J. Morgans, Jr., Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin J. Duffy, Duke Fitch, Rosanna Tedesco
  • Pyradazine compounds as GSK-3 inhibitors
    Patent number: 7582630
    Abstract: The present invention relates to pyrazaolpyradazine derivatives that inhibit GSK3 (glycogen synthase kinase), pharmaceutical compositions containing these derivatives, and methods for their use in the treatment of disorder characterized by misregulation of GSK3.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: September 1, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Scott Howard Dickerson, Francis Xavier Tavares, Huiqiang Zhou
  • THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20090215818
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using thiozolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiozolidinedione derivatives.
    Type: Application
    Filed: July 24, 2007
    Publication date: August 27, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: Nicholas D. Adams, Dashyant Dhanak, Steven David Knight, Lee Schaller, Jun Tang
  • Tricyclic-Nucleoside Prodrugs for Treating Viral Infections
    Publication number: 20090208457
    Abstract: Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
    Type: Application
    Filed: March 31, 2009
    Publication date: August 20, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jesse Daniel Keicher, Christopher Don Roberts
  • Metabolic Syndrome Genetics
    Publication number: 20090203012
    Abstract: A gene (and polymorphisms within it) was associated with multiple components of the metabolic syndrome. Methods of screening subjects to identify risk of metabolic syndrome and related conditions are described, as are methods of screening compounds to identify those that act on the gene product as a target for the treatment of these conditions.
    Type: Application
    Filed: December 17, 2008
    Publication date: August 13, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Vincent Mooser, Dawn Waterworth, KiJoung Song, Xin Yuan, Christopher W. Knouff
  • Chemical compounds
    Patent number: 7572820
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Biphenyl carboxylic amide p38 kinase inhibitors
    Patent number: 7572790
    Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Katherine Louise Jones, Vipulkumar Kantibhai Patel, Stephen Swanson, Ann Louise Walker
  • Container
    Patent number: D598738
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: August 25, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Ronald Supranowicz