Patents Assigned to SmithKline Beecham Corporation
  • Cyclopropyl compounds as ccr5 antagonists
    Patent number: 7569579
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: August 4, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jennifer Poole Peckham, Christopher Joseph Aquino, Wieslaw Mieczyslaw Kazmierski
  • Cycloalkylidene compounds as modulators of estrogen receptor
    Patent number: 7569601
    Abstract: The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: August 4, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jing Fang, Dennis Heyer, Aaron Bayne Miller, Frank Navas, III, Terrence Lee Smalley, Jr., William J. Zuercher, Subba Reddy Katamreddy
  • TREATMENT OF CANCERS EXPRESSING P95 ERBB2
    Publication number: 20090192189
    Abstract: The truncated ErbB2 receptor (p95ErbB2) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with ErbB3, whereas full length ErbB2 heterodimerizes with either EGFR or ErbB3. Consistent with p95ErbB2 heterodimerization with ErbB3, it is shown that heregulin (an ErbB3 ligand) stimulates p95ErbB2 phosphorylation in breast cancer cell lines. Described herein are methods of identifying patients suitable for treatment with a p95ErbB2 inhibitor, and methods of treating such patients.
    Type: Application
    Filed: February 5, 2009
    Publication date: July 30, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Neil Lee Spector, Wenle Xia
  • Protease inhibitors
    Patent number: 7563784
    Abstract: The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: July 21, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Maxwell D. Cummings, Robert W. Marquis, Jr., Yu Ru, Scott K. Thompson, Daniel F. Veber, Dennis S. Yamashita
  • Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors
    Patent number: 7560467
    Abstract: The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimidine-carboxamide derivatives are useful in the treatment of diseases associated with inappropriate ROCK-1 kinase.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Brian Evans, Krista B. Goodman, Darren Victor Steven Green, David Kendall Jung, Dennis Lee, Robert A. Stavenger, Sjoerd Nocolaas Wadman
  • Cycloalkylidene compounds as modulators of estrogen receptor
    Patent number: 7560589
    Abstract: The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jonathan E. Britton, Jing Fang, Dennis Heyer, Aaron Bayne Miller, Frank Navas, III, Terrence Lee Smalley, Jr., William J. Zuercher, Subba Reddy Katamreddy
  • Thiazole compounds
    Patent number: 7560568
    Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Kyle Allen Emmitte
  • Acid and ester compounds and methods of using the same
    Patent number: 7560586
    Abstract: Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Scott K. Thompson, Lara S. Kallander, Chun Ma, Joseph Marino, Dennis Lee
  • Sialoadhesin factor-2 antibodies
    Patent number: 7557191
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: July 7, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Julie A. Abrahamson, Connie L Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer
  • IL-8 Receptor Antagonists
    Publication number: 20090170871
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: June 22, 2007
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jakob Busch-Petersen, Christopher S. Brook, Richard M. Goodman, Edward C. Webb
  • Chemical Compounds
    Publication number: 20090170907
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: June 6, 2006
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Lamont Larkin, Eugene Lee Stewart, Katherine Stetson
  • THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS
    Publication number: 20090170848
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 2, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Dahsyant Dhanak, Steven David Knight
  • Recovery of Optically Active Epoxy Alcohols
    Publication number: 20090159841
    Abstract: A process to recover optically active epoxy alcohols from asymmetric epoxidation reaction mixtures such as those produced using the Sharpless method of epoxidation of allylic alcohols. The process includes adding a reducing agent to reduce an organic hydroperoxide in the asymmetric epoxidation reaction product to a corresponding alcohol to form a reduced epoxidation reaction mixture; adding the reduced reaction product to a film evaporation unit to form a residue fraction and an optically active epoxy alcohol distillate fraction; and distilling the optically active epoxy alcohol distillate fraction to purify the optically active epoxy alcohol.
    Type: Application
    Filed: June 9, 2005
    Publication date: June 25, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Ann Marie Elderidge, Christopher Werner
  • ANILINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
    Publication number: 20090163588
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: February 25, 2009
    Publication date: June 25, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, David John Cowan, Andrew Lamont Larkin, Istvan Kaldor, Eugene Lee Stewart
  • Method of screening for drug hypersensitivity reaction
    Patent number: 7550261
    Abstract: Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNF? gene, the class 1 HLA genes, or a combination of both the TNF? and HLA genes.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 23, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Seth Hetherington, Arlene R Hughes, Eric H Lai, Michael Mosteller, Jr., Denise D Shortino
  • Compounds
    Patent number: 7550480
    Abstract: Novel substituted 1,5,7-trisubstituted-1,8-napthyridin-2(1H)-one compounds; 1,5,7 trisubstituted-1,6-napthyridine-2-(1H)-one compounds and 1,5,7-trisubstituted quinoline-2(1H)-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and pharmaceutical compositions for use in such therapy.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: June 23, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey Charles Boehm, James Francis Callahan, Ralph F. Hall, Xichen Lin, Katherine Louise Widdowson
  • Compounds
    Publication number: 20090131458
    Abstract: The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.
    Type: Application
    Filed: February 15, 2008
    Publication date: May 21, 2009
    Applicant: SmithKline Beecham Corporation
    Inventors: Linos Lazarides, Stephen Allan Smith, Richard Stocker, Colin Jack Theobald
  • Tricyclic-nucleoside prodrugs for treating viral infections
    Patent number: 7534771
    Abstract: Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: May 19, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jesse Daniel Keicher, Christopher Don Roberts
  • Indane compounds as CCR5 antagonists
    Patent number: 7531661
    Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 12, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Youngman, Wieslaw Mieczyslaw Kazmierski, Hanbiao Yang, Christopher Joseph Aquino
  • Dissolving film packaging
    Patent number: D596495
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: July 21, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Stephen Dodd