Patents Assigned to Snow Brand Milk Products Co., Ltd.
  • Agent accelerating collagen decomposition
    Patent number: 5840311
    Abstract: The present invention relates to an agent accelerating collagen decomposition and a therapeutic agent for fibrosis disorder containing HGFs (Hepatocyte Growth Factors) as an active ingredient. The active ingredients HGFs accelerate the decomposition of collagen (increase of collagenase activity), and can effectively treat fibrosis disorder by the acceleration of collagen decomposition. Therefore, according to the present invention, the prevention and treatment of a disease due to reduced collagenase activity and fibrosis disorders characterized by excessive production of fibroblast-derived connective tissue matrix are possible.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: November 24, 1998
    Assignees: Toshikazu Nakamura, Snow Brand Milk Products Co., Ltd., Sumitomo Pharmaceuticals Co., Ltd.
    Inventors: Toshikazu Nakamura, Akira Shiota, Nobuaki Fujise, Mitsuo Namiki
  • Method of preparing ganglioside
    Patent number: 5795980
    Abstract: A method of preparing Ganglioside G.sub.M3 which comprises thermally treating a lipid containing material which includes Ganglioside G.sub.D3 at a temperature of from 60.degree. to 140.degree. C., for a period of from 2 to 180 minutes at a pH ranging from 6-8. The lipid containing material contains at least 10 wt % liquid and is cream or a milk product prepared from cream.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: August 18, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Goro Hanagata, Susumu Miura, Kiyoshi Tatsumi
  • Process and apparatus for preparing precut solid water-in-oil emulsion
    Patent number: 5776533
    Abstract: Precut, solid water-in-oil emulsion compositions are prepared by providing a mold having an outer frame and a plurality of configured partitioning plates disposed within the outer frame. The mold is at least partially filled with a fluid form of the emulsion so as to form precuts in the emulsion corresponding to the partitioning plates. The emulsion is then allowed to set. An extrusion die is advanced into the mold. The extrusion die has grooves configured complimentary to the configuration of the partitioning plates so as to receive the partitioning plates therein. The set emulsion is then discharged from the mold by at least partially passing the extrusion die through the mold so as to discharge the set emulsion with the precuts therein.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: July 7, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Kiyotaka Okamoto, Yoshihiko Honda, Mototake Murakami, Shigeru Oniki, Koji Suzuki
  • Continuous process for producing high protein foodstuff and an apparatus useful therein
    Patent number: 5776525
    Abstract: A process and an apparatus for continuously and efficiently producing high protein foodstuff such as cheese curd, by continuously sprinkling and pouring a protein solution such as cow's milk or soybean milk from above onto the water surface of a warm water bath through a nozzle having multiple holes. A constant amount of warm water kept at a fixed temperature is supplied to the water bath. This process converts the protein solution into curd useful in producing various types of cheese.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: July 7, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Takeo Ide, Yasunobu Hiraoka, Shoichi Koizumi, Minoru Morita, Kunio Ueda
  • Method of preparing a synthetic butter flavor
    Patent number: 5753281
    Abstract: A method of preparing a synthetic butter flavor having enriched milk flavor and butter flavor, containing the steps of hydrolysing a milk fat with a lipolytic enzyme and then oxidizing the hydrolysate of the milk fat by ultraviolet irradiation. The hydrolysate of the milk fat is preferably oxidized by ultraviolet irradiation to have a POV of 1.5 to 9.0, in particular 4.0 to 7.5.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: May 19, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Katsutoshi Tanno, Kenji Ganmyo, Nobuyuki Kawai, Tetsuo Nakamura
  • Composition for suppressing infection and growth of human immunodeficiency virus
    Patent number: 5725864
    Abstract: The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an iron-binding protein (e.g., lactoferrin, transferrin, ovotransferrin), a chemically modified compound of the iron-binding protein, or a hydrolyzed compound of the iron-binding protein. The effective components are safe and can be easily prepared from inexpensive raw materials. The composition can be orally administered, injected or applied to the skin, eye, ear, nose or used as a preparation for vagina affusion, mouth washing or suppositories, and can effectively inhibit infection or suppress growth of human immunodeficiency virus.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: March 10, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Naoki Yamamoto, Hideki Nakashima, Wataru Motsuchi, Shigeaki Tanaka, Shunichi Dosako, Hiroshi Shinmoto
  • Medicinal compositions for the improvement of blood coagulation comprising TCF-II
    Patent number: 5714461
    Abstract: Blood coagulation normalizing agents comprising effective ingredient of TCF-II.The blood coagulation normalizing agents of the present invention comprised of glycoprotein TCF-II produced by human fibroblast cells and accelerates the production of blood coagulation factor and increases platelet count to treat abnormal blood coagulation such as disseminated intravascular coagulation (DIC) and decreased platelet count caused by administration of cisplatin.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: February 3, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Hiroaki Masunaga, Nobuaki Fujise
  • Column packings for liquid chromatography
    Patent number: 5707516
    Abstract: Column packings for liquid chromatography comprising porous granules which have hydrophilic surfaces prepared by calcining a crystalline clay mineral having a fibrous structure. Median pore diameter of the porous ceramic granules is in the range of from 0.001 .mu.m to 0.01 .mu.m. The crystalline clay mineral can be sepiolite or attapulgite. The column packings for liquid chromatography have high mechanical strength, are presssure resistant and very stable to elutants having a high pH value and/or a high polarity so that the separating characteristics thereof are not changed even after long use.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: January 13, 1998
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Akira Tomizawa, Akinori Shigematsu, Hisashi Matsuda, Naoki Koga, Keisuke Hisada
  • Method of fractionating an edible oil containing 2-palmitoyl-1,3-dioleylglycerol
    Patent number: 5700509
    Abstract: The present invention provides a well-digestible and well-absorbable edible oil and fat composition containing 20% by weight or more 2-palmitoyl-1,3-dioleylglycerol. Also a process for production of the above edible oil and fat composition which comprises fractionating the edible oil and fat composition to increase the content of 2-palmitoyl-1,3-dioleylglycerol to 20% by weight or more is disclosed. The edible oil and fat composition of the present invention is useful as a fat material used in diets for infants or for the sick.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: December 23, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Mototake Murakami, Seiichiro Aoe, Kiyoshi Tatsumi
  • Whitening cosmetic preparation and method of using same
    Patent number: 5698185
    Abstract: A whitening cosmetic preparation containing angiogenin as an effective component is disclosed. Angiogenin used in the present invention may be derived from milk, especially bovine milk. The whitening cosmetic preparation contains at least 0.001% by weight, preferably from 0.01 to 20% by weight angiogenin based on the total amount of said preparation. A method for whitening skin comprising administration of angiogenin to skin is also disclosed. The whitening cosmetic preparation inhibits melanin production and prevents the developments of blotches and freckles of skin.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: December 16, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Yasuharu Itagaki, Hidetoshi Ishikawa, Seiji Kurosawa
  • Fish oil having decreased fish odor and a method for preparing the same
    Patent number: 5693835
    Abstract: A method for preparing fish oil having decreased fish odor, which comprises slightly hydrogenating fish oil to have decrease rate of iodine value of 15% or less and decrease rate of highly unsaturated fatty acid of 33% or less. A method for preparing fish oil having decreased fish odor, which comprises slightly hydrogenating fish oil under the following non-selective conditions: (1) an amount of catalyst used in the hydrogenation is 0.05% by weight or more to an amount of the fish oil; (2) hydrogen pressure in gaseous phase at the beginning of the hydrogenation is 3 kg/cm.sup.2 or more; (3) reaction temperature of the hydrogenation is in the range from 90.degree. to 150.degree. C.; (4) reaction time of the hydrogenation is in the range from 5 to 30 minutes. The fish oil is preferably sardine oil, mackerel oil, skipjack oil, tuna oil, skipjack orbital fat or tuna orbital fat.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: December 2, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Hiroaki Konishi, Kiyoshi Tatsumi, Norifumi Sato
  • Edible oil or fat and edible oil or fat mixture
    Patent number: 5686131
    Abstract: An edible oil or fat improved in oxidative stability and suppressed in the development of off flavor is obtained without impairment of high physiological functions inherent to highly-unsaturated fatty acids. To obtain the edible oil or fat, a specific polyunsaturated fatty acid-base oil or a particular fat and saturated fatty acid-base oil or fat are mixed and subjected to an interesterification reaction so that fatty acids are caused to bond at random on glycerol skeletons of the oil or fat to achieve the following properties:(a) the content of polyunsaturated fatty acids of at least three unsaturated bonds per molecule in fatty acid residual groups: 5 to 30%,(b) the content of saturated fatty acids free of any unsaturated bond: 50 to 80%,(c) iodine value: at least 35, and(d) melting point: 35.degree. C. or higher.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 11, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Norifumi Sato, Yuzi Murakami, Tadashi Idota, Hiroaki Konishi, Kiyoshi Tatsumi, Mototake Murakami
  • Sialic acid powder and process for the preparation thereof
    Patent number: 5679645
    Abstract: An amorphous sialic acid powder is disclosed. It is prepared by rapidly freezing an aqueous solution of sialic acids and freeze-drying the frozen product. It has a melting point of 131.degree.-136.degree. C. (decomposed) and exhibits no peaks inherent to crystals in differential scanning thermal analysis (at 165.degree.-200.degree. C.) and X-ray diffractiometric pattern (in the range of 5.degree..ltoreq.2.theta..ltoreq.40.degree.). The amorphous sialic acid powder is highly reactive and can be used as a raw material for drugs and the like.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: October 21, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Yoshihiro Ikeuchi, Takafumi Yakabe
  • Monoclonal antibody
    Patent number: 5658742
    Abstract: This invention relates to a monoclonal antibody having affinity to human TCF-II without any affinity to HGF and determination or purification methods of TCF-II using the antibody. The monoclonal antibody can be obtained by adding a blocking solution containing a surface active agent to the culture medium containing monoclonal antibody to block antibodies other than said monoclonal antibody, followed by reaction with a solid phase antigen, TCF-II. Human TCF-II can be selectively and effectively purified or determined without any influence of the presence of HGF by using the antibody.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: August 19, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Kanji Higashio, Nobuyuki Shima, Fumiko Oogaki
  • Bone enhancing factors from whey and compositions containing the same
    Patent number: 5654019
    Abstract: The invention relates to an osteoblast growth and bone enhancing factor or factors having a molecular weight of about 5,000 to 28,000 daltons and an isoelectric point of 4 to 9, which is isolated from whey or whey protein. The invention includes various methods for obtaining the factor or factors from whey and whey protein. The factor or factors from whey and whey protein may be incorporated in foods, medicines and feeds for preventing or treating osteoporosis and other maladies in joints of bones.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: August 5, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Naomichi Kobayashi, Yukihiro Takada, Masatoshi Yahiro
  • Modified tumor cytotoxic factor (TCF) and DNA encoding such
    Patent number: 5648233
    Abstract: Modified TCF in which one or more amino-acid residues of the wild type TCF responsible for glycosylation are substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCFs have a longer biological half-lives without loss of their biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: July 15, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Kyoji Yamaguchi, Nobuyuki Shima, Akihiko Murakami, Masaaki Goto, Eisuke Tsuda, Hiroaki Masunaga, Reiko Takahira, Fumiko Oogaki, Masatsugu Ueda, Kanji Higashio
  • Anti-human IgE monoclonal antibodies
    Patent number: 5625039
    Abstract: Monoclonal antibodies are provided which specifically bind to human immunoglobulin e (IgE) and has a molecular weight of approximately 150,000 determined by SDS-polyacrylamide gel electrophoresis (non-reduced state), the ability to bind to human IgE-producing B cells, the ability to recognize IgE bound to human or canine cell having Fc.epsilon. receptor and further characterized by specific sequences.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: April 29, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Naohiro Washida, Toshiko Yoshida
  • Iron lactoferrin complexes and preparation thereof
    Patent number: 5606086
    Abstract: Heat resistant carbonate- and/or hydrogencarbonate-iron-Lf complexes in which one molecule of lactoferrin is bound with 15 molecules or over of iron via carbonic acid and/or hydrogencarbonic acid.Process for the production of above mentioned complexes prepared by adjusting pH.ltoreq.7 by adding alkali salts of carbonic acid and/or hydrogencarbonic acid to an aqueous solution containing an iron salt exhibiting pH.ltoreq.4 when dissolved in water and lactoferrins, or adding an iron salt and lactoferrin solution to carbonic acid and/or hydrogencarbonic acid solution, or adding the iron salt or its solution to a solution containing carbonic acid and/or hydrogencarbonic acid and lactoferrins.The resultant lactoferrin complexes are highly heat resistant and useful as raw materials of foods, medicines, feeds, cosmetics and so forth.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: February 25, 1997
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Shunichi Dosako, Toshio Sakurai, Naomichi Kobayashi
  • Human derived glycoprotein, biologically active factor which includes glycoprotein and pharmaceutical product
    Patent number: 5587359
    Abstract: The new glycoprotein, which possesses an anti-tumor activity, a leukemia cell differentiation inducing activity, a cellular immunology enhancing activity, a vascular endothelial cell growth stimulating activity and a hepatocyte growth stimulating activity, can be obtained.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: December 24, 1996
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Kanji Higashio, Shinjiro Mitsuda, Nobuyuki Shima, Yasuharu Itagaki, Masaya Nagao
  • Method for the treatment of xerostomia
    Patent number: 5580880
    Abstract: A method for the treatment of xerostomia not caused by Sjogren's syndrome comprising administering to an affected individual an effective amount of a derivative of spirooxathiolane-quinuclidine.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 3, 1996
    Assignee: Snow Brand Milk Products Co., Ltd.
    Inventors: Harumi Handa, Yasuyoshi Takeshita