Abstract: The present invention relates to the use of at least one thermal spring water from the Vichy basin as substance P antagonist in a cosmetic composition or for the preparation of a pharmaceutical composition. The invention also relates to the use of at least one thermal spring water from the Vichy basin in a cosmetic composition or for the preparation of a pharmaceutical composition, more especially a dermatological composition, intended for treating disorders associated with excessive synthesis and/or release of substance P.
Type:
Grant
Filed:
September 19, 1996
Date of Patent:
August 22, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Lionel Breton, Jacques Leclaire, Olivier de Lacharriere
Abstract: Methods for determining the sensitizing, irritant and/or allergenic potential of a candidate substrate are provided. These methods involve simultaneously cultivating keratinocytes and Langerhans cell precursors in a nutrient medium in order to effect differentiation of the Langerhans cell precursors, and contacting the candidate substrate with the cultured cells to determine the effect if any on markers associated with sensitizing, irritant or allergenic potential.
Abstract: Topically applicable cosmetic/dermatological sunscreen compositions well suited for the UV-photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a UV-photoprotecting effective amount of at least one solubilized organolipophilic silicon compound, whether silane or organopolysiloxane, bearing a benzotriazole function substituent and (ii) an amount of at least one benzoic triacid triester effective to (substantially) dissolve said at least one organolipophilic silicon compound.
Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective amount of 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) at least one homomenthyl and/or octyl salicylate solvent for the triazine sunscreen compound (i), in a cosmetically acceptable vehicle, diluent or carrier therefor.
Type:
Grant
Filed:
January 2, 1997
Date of Patent:
August 1, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Isabelle Hansenne, Victoria Van Leeuwen
Abstract: Topically applicable dermocosmetic compositions for combating the clinical signs of skin aging and/or for improving the appearance of the skin, the scalp or the hair, comprise an anti-free-radical effective amount of at least one novel melatonin derivative having the structural formula (I): ##STR1## in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, with the proviso that the hydroxyl radical is in the 4-, 6- or 7-position on the indole ring system, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.
Type:
Grant
Filed:
July 25, 1997
Date of Patent:
July 25, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Jean-Fran.cedilla.ois Nadaud, Christian Colin
Abstract: Novel silicone-substituted cinnamamide/malonamide/malonate compounds having the structural formulae (1) and (2): ##STR1## in which A is a radical of formula (3): ##STR2## are well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, and are also useful for photoprotecting such UV-sensitive substrates as plastics.
Abstract: Cosmetic/pharmaceutical/hygienic compositions (e.g., lipcolors) are formulated as homogeneous and stable, supple dough extrudates, said supple dough extrudates having at least one thermally-unmodified but normally heat-sensitive compound (for example a volatile compound and/or a compound having a low flash point) and at least one elevated melting temperature T compound (for example a wax) homogeneously distributed therethrough.
Abstract: A process for evaluating the type A ultraviolet radiation induced damage to the skin and/or the dermis. The invention also relates to a method of evaluating substances capable of modulating the damage induced in the skin and/or dermis by type A ultraviolet radiation.
Type:
Grant
Filed:
December 23, 1997
Date of Patent:
June 27, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Fran.cedilla.oise Bernerd, Daniel Asselineau
Abstract: Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise (1) a UV-photoprotecting effective amount of at least one dibenzoylmethane sunscreen compound and (2) a photostabilizing effective amount of at least one silane or organosiloxane bearing a 2-hydroxybenzophenone substituent.
Abstract: The subject of the present invention is an extract of at least one plant of the Labiatae family, the said plant being cultured in vitro.Its subject is also a cosmetic or pharmaceutical composition comprising, as active ingredient, at least an effective quantity of the said extract. The invention finally relates to the use of such an extract in a cosmetic composition or for the preparation of a pharmaceutical composition for controlling disorders involving an inflammatory process or an allergic process, and a process of cosmetic treatment involving such an extract.
Type:
Grant
Filed:
March 9, 1998
Date of Patent:
May 9, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Lionel Breton, Richard Martin, Nathalie Pineau
Abstract: Novel compounds of the aryl 2,4 dioxo oxazolidine family, a method for synthesizing same, compositions containing said compounds, and the use of an effective amount of at least one of said compounds as an active principle in a physiologically acceptable medium in a cosmetic composition or for preparing a pharmaceutical composition, are disclosed. Said compound or said compositions are useful for inducing and/or stimulating hair growth and/or controlling hair loss and/or treating hyperseborrhea and/or acne.
Abstract: The subject-matter of the invention is a cosmetic composition comprising, in a cosmetically acceptable medium, at least phloroglucinol or one of its derivatives. Another subject-matter of the invention is the use of phloroglucinol or of its derivatives in a cosmetic composition intended to promote epidermal renewal.
Type:
Grant
Filed:
December 21, 1998
Date of Patent:
April 25, 2000
Assignee:
Societe L'Oreal S.A.
Inventors:
Lionel Breton, Florence Girerd, Beatrice Renault
Abstract: Stable, water-resistant photoprotective water-in-oil cosmetic emulsions, well suited for the photoprotection of human skin and/or hair against the deleterious effects of UV irradiation, comprise an effective stabilizing/emulsifying amount of a pair of active emulsifying agents, said emulsifying agent pair comprising (i) at least one polyalkylpolyethersiloxane emulsifier substituted by polyoxyethylene and polyoxypropylene moieties grafted onto the backbone polymer thereof, and (ii) at least one water-in-oil emulsifying polyoxyalkylenated glycol fatty acid ester polymer.
Abstract: A topical composition containing capsazepine and particularly suitable for treating neurogenic skin disorders and diseases, especially painful and/or pruriginous diseases, as well as for treating sensitive skin and eyes. In particular, the composition is useful for preventing and/or controlling skin and/or eye irritation, itching, erythema and dysaesthesia and heating of the skin, eyes and mucosa, as well as for reducing the irritancy of an active substance having an irritant side-effect.
Abstract: The invention relates to novel cyclodextrin derivatives of formula (I)CD(OH).sub.l (OR.sub.1).sub.m (OR.sub.2).sub.n (I)in which:OR.sub.1 represents a screening or antioxidant group or a mixture thereof,OR.sub.2 represents an alkyl or hydroxyalkyl radical, l, m and n are statistical values.The invention also relates to a process for the preparation of these compounds and to the use of these compounds in cosmetics.
Abstract: The subject-matter of the present invention is the use of octoxyglycerol in a cosmetic or dermatological composition for treating seborrhoea and/or cutaneous disorders which are associated with it, in particular acne and/or greasy skin with a tendency towards acne and/or hyperseborrhoea.
Abstract: Topically applicable cosmetic/dermatological compositions well suited for the persistent and water-resistant artificial tanning and/or darkening of human skin, comprise an effective artificial tanning/darkening amount of particulates of at least one iron oxide nanopigment, the mean size of the primary particles of which nanopigment particulates being less than 100 nm, the particulates of the at least one iron oxide nanopigment being formulated into a vehicle, diluent or carrier therefor which comprises a water-in-oil emulsion, advantageously a water-in-silicone emulsion, and the particulates comprising greater than 2% by weight of the total weight of such cosmetic/dermatological compositions.
Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced SPF photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise synergistically effective amounts of (i) particular benzotriazole-substituted silicon compounds and (ii) particular sulfonic/benzimidazole compounds, formulated into appropriate vehicles, diluents or carriers therefor, advantageously formulated as oil-in-water emulsions.
Abstract: The invention relates to an antisun composition with a high degree of protection, containing water-soluble and liposoluble screening agents, combined with a solid elastomeric organopolysiloxane, which has noteworthy cosmetic properties. It is in the form of a water-in-oil or oil-in-water emulsion. The invention also relates to a process for protecting the skin or the lips against solar radiation, containing this composition.
Abstract: Transfer-resistant cosmetic/dermatological compositions (e.g., lipcolors) formulated as supple and homogeneous doughs, advantageously via extrusion, include a fatty phase which comprises at least one volatile oil, at least one phenylated silicone oil and at least 12% by weight of at least one wax.
Type:
Grant
Filed:
July 29, 1996
Date of Patent:
February 15, 2000
Assignee:
Societe l'Oreal S.A.
Inventors:
Isabelle Agostini, Dolores Miguel-Colombel, Fran.cedilla.ois Pradier, Alex Junino, Veronique le Bras-Roulier