Abstract: A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

Abstract: Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.

Abstract: An implant and a process for preparing such an implant are disclosed. The implant includes a porous layer including collagen, a non-porous layer including a collagenic constituent, and a reinforcement component. The non-porous layer is joined to the porous layer and the reinforcement member is embedded into the non-porous layer. The porous layer has a three dimensional density ranging from about 20 mg collagen/cm3 to about 200 mg collagen/cm3.

Abstract: The present invention relates to a reinforcing element (200) for a circular mesh, comprising a plurality of fingers (201) which, at rest, form a conical structure (202) that can open out when the reinforcing element is placed under axial stress, each finger comprising a vertex segment (201a) and a peripheral segment (201b) defining a vertex part (202a) and a peripheral part (202b) of the said conical structure, the said reinforcing element comprising, for each finger, means (201c, 205; 402; 502) of misaligning the said vertex segment and the said peripheral segment, at least when the said reinforcing element is under axial stress, the said misalignment means making it possible, in the said position under axial stress, firstly for the peripheral part of the said conical structure to adopt a planar configuration, and secondly, for the said vertex part of the said structure to maintain a conical shape.

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract: A prosthetic knit for medical or surgical use which has a structure made of monofilament and/or multifilament yarn which is biocompatible and optionally partially bioabsorbable. According to the invention, this knit comprises a monofilament sheet forming, on one face of the knit, spiked naps which protrude perpendicularly with respect to said sheet, that is to say naps each having a substantially rectlinear body and, at the free end of this body, a head of greater width than that of this body.

Abstract: The present invention relates to a knit with outwardly protruding barbs on each of its faces, said knit being obtained by: i) knitting yarns on at least four guide bars, one bar forming a chain leaving one needle free in two; two bars threaded with monofilament yarn generating loops protruding outwards from the faces of said knit; the fourth bar producing the connection between the yarns of the three other bars, ii) thermosetting the knit obtained at i), iii) forming the barbs by melting the loops. The invention also relates to a prosthesis comprising such a knit.

Abstract: The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.

Abstract: The present invention relates to an implant comprising: a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof. The invention also relates to a method for making such an implant.

Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

Abstract: The present invention relates to a prosthesis (200) comprising:—at least one layer of a flexible mesh (1) delimited by a peripheral outer edge (1a), said mesh having a first colour, and—at least one layer (2) of porous material fixed to said mesh substantially along the perimeter of said peripheral outer edge, said layer of porous material being recessed at its central part (4), said layer of porous material having a second colour, different from said first colour.

Abstract: The present invention relates to a prosthesis comprising at least two pieces of knitted fabric and to the method of manufacturing it using a sonotrode to perform ultrasonic welding. The prosthesis comprises at least one first piece of knitted fabric and at least one second piece of knitted fabric, which are welded together by means of a plurality of welds situated in a joining region in which at least a portion of the said first and second pieces of knitted fabric are superposed, the said first and second pieces of knitted fabric each comprising a group of yarns extending respectively in first and second directions A and B, characterized in that the said directions A and B are substantially aligned with one another in the said joining region, and each said weld in the joining region is of elongate shape with its longitudinal axis being aligned with the said directions A and B.

Abstract: The present disclosure provides mono- and multi-layered implants which include at least one porous layer made from a freeze-dried aqueous solution containing chitosan, the solution having a pH of less than about 5.

Abstract: A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract: The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of the fabric. The invention further relates to a method of making such an implant.

Abstract: The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.

Abstract: The invention relates to a device (1) and method for selecting the size and shape of a prosthesis and/or for determining the location of marks to be made on the external face of the skin of a patient intended to receive such a prosthesis, for example for repairing a hernia, comprising a sheet (2) of transparent material, the said sheet comprising:—a plurality of graphical representations (3a, 3b, 4a, 4b, 5a, 5b, 5c, 5d) concentrically embodying the respective outlines of various shapes and sizes of prosthesis,—a plurality of first holes (6a, 6b, 6c, 6d, 6e, 7a, 7b, 7c, 7d, 7e) arranged along the transverse line passing through the centre of the said sheet, and—a plurality of second holes (8a, 8b, 8c, 8d, 8e, 8f, 8g, 9a, 9b, 9c, 9d, 9e, 9f, 9g) arranged along the longitudinal line passing through the centre (C) of the said sheet.

Abstract: Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.

Abstract: A mesh implant is disclosed which may be utilized for treating urinary incontinence, hernias, uterovaginal prolapses and other related injuries.