Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.
Type:
Application
Filed:
August 23, 2016
Publication date:
December 22, 2016
Applicant:
FloDesign Sonics, Inc.
Inventors:
Thomas J. Kennedy, III, Bart Lipkens, Louis Masi, Stanley Kowalski, Chris Leidel
Abstract: A flow chamber is provided through which is flowed a mixture of a fluid and a particulate. The flow chamber comprises at least one multi-phase water inlet through which multi-phase water enters the flow chamber, a water outlet through which water exits the flow chamber, a solids outlet through which particles having a density at or above a pre-defined threshold exit the flow chamber, and a low density outlet through which particles having a density below the pre-defined threshold exit the flow chamber. Also provided are one or more ultrasonic transducers and one or more reflectors corresponding to each transducer to acoustically filter the fluid and cause particles/fluid to be selectively diverted to one of the outlets. Related apparatus, systems, techniques and articles are also described.
Type:
Application
Filed:
August 23, 2016
Publication date:
December 22, 2016
Applicant:
FloDesign Sonics, Inc.
Inventors:
Jason Dionne, Bart Lipkens, Edward Rietman
Abstract: A method includes receiving flits forwarded from an upstream router into a first input virtual channel (VC) associated with an input port. The flits are associated with packets originated from a first Intellectual Property (IP) core and forwarded to a second IP core. The flits are stored in a VC storage associated with the first input VC. The method further includes performing link width conversion based on a width of the flits being different from a width of an output port. Link width conversion includes accumulation of the flits when the width of the output port is wider and unpacking of the flits when the width of the output port is narrower. Credits are generated based on the flits being forwarded from the first input VC to the output port. The credits are sent to the upstream router to enable receiving more flits from the upstream router.
Type:
Grant
Filed:
April 29, 2014
Date of Patent:
December 6, 2016
Assignee:
Sonics, Inc.
Inventors:
Liping Guo, Doddaballapur N. Jayasimha, Jeremy Chan
Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
Type:
Grant
Filed:
November 5, 2014
Date of Patent:
December 6, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Jason Barnes, Dane Mealey, Walter M. Presz, Jr., Stanley Kowalski, III, Louis Masi, Thomas J. Kennedy, III, Brian McCarthy, Ben Ross-Johnsrud
Abstract: A method, apparatus, and system are described, which generally relate to an integrated circuit having an interconnect that implements internal controls. The interconnect in an integrated circuit communicates transactions between initiator Intellectual Property (IP) cores and target IP cores coupled to the interconnect. The interconnect implements logic configured to support multiple transactions issued from a first initiator IP core to the multiple target IP cores while maintaining an expected execution order within the transactions. The logic supports a second transaction to be issued from the first initiator IP core to a second target IP core before a first transaction issued from the same first initiator IP core to a first target IP core has completed while ensuring that the first transaction completes before the second transaction and while ensuring an expected execution order within the first transaction and second transaction are maintained. The logic does not include any reorder buffering.
Type:
Grant
Filed:
June 24, 2008
Date of Patent:
November 15, 2016
Assignee:
Sonics, Inc.
Inventors:
Drew E. Wingard, Chien-Chun Chou, Stephen W. Hamilton, Ian Andrew Swarbrick, Vida Vakilotojar
Abstract: An apparatus for separating particles from a fluid stream includes a flow chamber that has at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber. The transducer includes a piezoelectric array with at least two piezoelectric elements. The piezoelectric array includes a piezoelectric material to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer.
Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
Type:
Grant
Filed:
September 13, 2013
Date of Patent:
October 4, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Jason Dionne, Walter M. Presz, Jr., Thomas J. Kennedy, III
Abstract: A flow chamber is provided through which is flowed a mixture of a fluid and a particulate. The flow chamber comprises at least one multi-phase water inlet through which multi-phase water enters the flow chamber, a water outlet through which water exits the flow chamber, a solids outlet through which particles having a density at or above a pre-defined threshold exit the flow chamber, and a low density outlet through which particles having a density below the pre-defined threshold exit the flow chamber. Also provided are one or more ultrasonic transducers and one or more reflectors corresponding to each transducer to acoustically filter the fluid and cause particles/fluid to be selectively diverted to one of the outlets. Related apparatus, systems, techniques and articles are also described.
Type:
Grant
Filed:
August 23, 2011
Date of Patent:
August 23, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Jason Dionne, Bart Lipkens, Edward A. Rietman
Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
Type:
Grant
Filed:
July 11, 2014
Date of Patent:
August 23, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Thomas J. Kennedy, III, Bart Lipkens, Louis Masi, Stanley Kowalski, III, Chris Leidel
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
Type:
Grant
Filed:
February 7, 2014
Date of Patent:
August 16, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Louis Masi, Stanley Kowalski, III, Walter M. Presz, Jr., Jason Dionne, Brian Dutra, Ari Mercado, Thomas J. Kennedy, III, Arthur Martin
Abstract: Various methods and apparatus are described for communicating transactions between one or more initiator IP cores and one or more target IP cores coupled to an interconnect. A centralized Memory Management logic Unit (MMU) is located in the interconnect for virtualization and sharing of integrated circuit resources including target cores between the one or more initiator IP cores. A master translation look aside buffer (TLB) stores virtualization and sharing information in the entries of the master TLB. A set of two or more translation look aside buffers (TLBs) locally store virtualization and sharing information replicated from the master TLB. Logic in the MMU or other software updates the virtualization and sharing information replicated from the master TLB in the entries of one or more of the set of local TLBs.
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
Type:
Grant
Filed:
May 13, 2015
Date of Patent:
May 17, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Jason Dionne, Ari Mercado, Brian Dutra, Walter M. Presz, Jr., Thomas J. Kennedy, III, Louis Masi
Abstract: A method, apparatus, and system in which an interconnect for an integrated circuit communicates transactions between one or more initiator Intellectual Property (IP) cores and one or more target IP cores coupled to the interconnect, including a power manager having a hierarchy of two or more layers including a hardware logic portion to control a power consumption of two or more domains in the integrated circuit, where each layer of the power manager performs its own function; wherein the power manager has its own dedicated CPU or dedicated state machine to execute power management instructions; and wherein the power manager controls the power consumption of two or more domains without using a CPU IP core utilized by other IP cores on the integrated circuit to execute power management instructions.
Type:
Grant
Filed:
July 29, 2013
Date of Patent:
April 12, 2016
Assignee:
Sonics, Inc.
Inventors:
Raymond G. Brinks, Benoit de Lescure, Stephen W. Hamilton
Abstract: A method, apparatus, and system are described, which generally relate to an interconnect routing transactions to target IP cores, including two or more channels making up a first aggregate target. The two or more channels populate an address space assigned to the first aggregate target and appear as a single target to the initiator IP cores. The interconnect implements chopping logic to chop an individual transaction from a first initiator IP core whose address sequence crosses a channel address boundary from a first channel to a second channel within the first aggregate target into two or more burst transactions. A first chopped burst transaction is chopped to fit within the address boundaries of the first channel and a second chopped burst transaction is chopped to fit within the address boundaries of the second channel.
Type:
Grant
Filed:
June 24, 2008
Date of Patent:
March 22, 2016
Assignee:
Sonics, Inc.
Inventors:
Drew E. Wingard, Chien-Chun Chou, Stephen W. Hamilton, Ian Andrew Swarbrick, Vida Vakilotojar
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
Type:
Grant
Filed:
July 16, 2013
Date of Patent:
March 1, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Jason Dionne, Ari Mercado, Brian Dutra, Walter M. Presz, Jr., Thomas J. Kennedy, III, Louis Masi
Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
Type:
Grant
Filed:
December 1, 2014
Date of Patent:
January 5, 2016
Assignee:
FloDesign Sonics, Inc.
Inventors:
Bart Lipkens, Jason Dionne, Walter M. Presz, Jr., Thomas J. Kennedy, III
Abstract: A method and apparatus for transaction level modeling where communications occur between modules in the system that contain time annotations is described. An apparatus includes an initiator module, a target module, and a communications channel with each being modeled as an executable behavioral model. The communications channel transports burst information between the initiator module and the target module. The communications channel has a timing variable function to store timing variables and derive timing information associated with each individual transfer within a burst transaction during a simulation.
Abstract: There is provided a sound absorbing member lamination structure in which the functions by the sound field adjustment can effectively be achieved by preventing the sound reflection against an intension of design in a boundary between the sound absorbing member and the other layer, when the sound absorbing member and the other layer are laminated into a united body. When the sound absorbing member and the other layer are placed in a stacked state, they are bonded with the use of a pressure-sensitive adhesive, so that the sound absorbing member and the other layer are combined together, with the pressure-sensitive adhesive kept uncured in a stacked state of the sound absorbing member and the other layer. Thus, such an uncured pressure-sensitive adhesive does not become a reflection portion of a sound. It is therefore possible to cause the sound to pass through appropriately the boundary between the respective layers.
Abstract: Systems are provided with varying flow chamber configurations which acoustically agglomerate microorganisms such as algae for separation from a host fluid such as water. Related apparatus, systems, techniques and articles are also described.
Type:
Grant
Filed:
August 23, 2011
Date of Patent:
April 21, 2015
Assignee:
FloDesign Sonics, Inc.
Inventors:
Jason Dionne, Jeff King, Bart Lipkens, Edward A. Rietman