Patents Assigned to SORBONNE UNIVERSITÉ
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Patent number: 11854801Abstract: A method for depositing an object, including: —approaching, in an enclosure, a holder in the direction of a carrier substrate, then—transferring, in the enclosure, the object from the holder to an area for depositing the carrier substrate. The transfer step is preferably carried out when the inside of the enclosure is in a vacuum at a pressure below 10?6 bar.Type: GrantFiled: October 18, 2019Date of Patent: December 26, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE, SORBONNE UNIVERSITE, UNIVERSITE DE PARISInventors: Matthieu Delbecq, Tino Cubaynes, José Palomo, Matthieu Dartiailh, Takis Kontos, Matthieu Desjardins
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Patent number: 11849958Abstract: The present invention relates to a surgical kit for use in a craniectomy procedure, the surgical kit comprising: a medical device to be implanted in a cranial bone of a patient, the medical device (10) including several transducers for emitting ultrasound waves for treatment of brain tissue, a surgical accessory (20) intended to be positioned on the cranial bone of the patient, the surgical accessory (20) including a body whose outer perimeter defines the dimensions of an opening that is to be made in the cranial bone of the patient in order to receive the medical device, characterized in that the surgical accessory (20) comprises a plurality of holes (201) formed in the body, the position of each hole (201) on the body coinciding with the position of the axis of symmetry of a respective transducer, such that the accessory is able to be positioned optimally through the joint use of a neuronavigation system.Type: GrantFiled: March 13, 2019Date of Patent: December 26, 2023Assignees: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CARTHERAInventors: Alexandre Carpentier, Alexandre Vignot, Matthieu Cholvy
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Patent number: 11819492Abstract: The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.Type: GrantFiled: December 10, 2021Date of Patent: November 21, 2023Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Universite de Poitiers, Centre Hospitalier Universitaire de PoitiersInventors: Stéphane Bach, Marie-Thérèse Dimanche-Boitrel, Claire Delehouze, Thierry Hauet
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Patent number: 11808627Abstract: A photoconductive switch for generating or detecting terahertz radiation (TR) is provided. The photoconductive switch may comprise at least a first and a second pair of electrodes (EV, EH, EGR) on a surface (SS) of a photoconductive substrate, wherein the electrodes of the first pair are separated by a first gap comprising at least a plurality of first rectilinear sections (GV) extending along a first direction (x) and the electrodes of the second pairs are separated by a second gap comprising at least a plurality of second sections (GH) extending along a second direction (y), different from the first direction. The photoconductive switch may further comprise a patterned opaque layer (PML) selectively masking portions of the gaps between the electrodes. Methods and devices for generating and detecting terahertz radiation comprising such photoconductive switches are also provided.Type: GrantFiled: March 28, 2019Date of Patent: November 7, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE DE PARIS, UNIVERSITÉ PARIS CITÉInventors: Kenneth Maussang, Sukhdeep Dhillon, Jerome Tignon
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Patent number: 11803014Abstract: Optical system comprising two optical fibres which are configured to define between them a Fabry-Perot cavity, and a connecting element bonded to each of the two optical fibres, the connecting element defining a through-passage, at least one of the two optical fibres comprising an end portion arranged in the through-passage and bonded to the connecting element, the two optical fibres extending along an axis and being separated from one another by a distance Le parallel to the axis, one of the optical fibres being bonded to the connecting element at a first bonding zone, and the other optical fibre being bonded to the connecting element at a second bonding zone separated from the first bonding zone by distance parallel to the axis.Type: GrantFiled: January 29, 2021Date of Patent: October 31, 2023Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEUREInventors: Jakob Reichel, Romain Long
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Publication number: 20230330440Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.Type: ApplicationFiled: September 9, 2021Publication date: October 19, 2023Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Serge PICAUD, Sara CADONI, José-Alain SAHEL, Mickaël TANTER, Charlie DEMENE
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Patent number: 11771925Abstract: An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.Type: GrantFiled: July 18, 2022Date of Patent: October 3, 2023Assignees: SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARISInventor: Alexandre Carpentier
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Publication number: 20230293490Abstract: Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer.Type: ApplicationFiled: August 12, 2021Publication date: September 21, 2023Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Sorbonne Université, Centre National de la Recherche Scientifique, INSERM (Institut de la Sante er de la Recherche Medicale)Inventors: Partha Roy, Lee McDermott, Abigail E. Allen, David Koes, David M. Gau, Paul G. Francoeur, Xavier Guillonneau
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Patent number: 11757168Abstract: A method for manufacturing a superconducting LC-type resonator of the type including at least one high-resistivity substrate on which are printed an inductive meander, a first so-called lower electrode and a second so-called upper electrode arranged opposite the first so as to form together a capacitor connected in parallel with the inductive meander, as well as inductive coupling means dedicated to the resonator, in which a sacrificial aluminium layer is deposited between the first and second electrodes. Also disclosed is the superconducting LC-type resonator thus obtained and the use of such a resonator for detecting the noise of a millimetre photon.Type: GrantFiled: December 4, 2019Date of Patent: September 12, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, OBSERVATOIRE DE PARIS, CY CERGY PARIS UNIVERSITÉ, SORBONNE UNIVERSITE, UNIVERSITÉ DE PARISInventors: Faouzi Boussaha, Samir Beldi, Christine Chaumont, Thibaut Vacelet
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Publication number: 20230279422Abstract: The use of recombinant AAV vectors expressing a molecule of interest in a method for treating diseases or conditions affecting the nervous system in a subject in need thereof, or in a method for increasing or inducing expression of the molecule of interest in the nervous system of a subject.Type: ApplicationFiled: May 20, 2022Publication date: September 7, 2023Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCH MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITEInventors: Françoise PIGUET, Caroline SEVIN
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Patent number: 11738214Abstract: An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.Type: GrantFiled: April 20, 2020Date of Patent: August 29, 2023Assignees: SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, CARTHERAInventors: Alexandre Carpentier, Michael Canney, Matthieu Cholvy
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Patent number: 11731127Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.Type: GrantFiled: March 15, 2016Date of Patent: August 22, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITEInventors: Michaël Aymeric Baudoin, Olivier Khalil Bou Matar-Lacaze, Antoine Jean-Pierre Riaud, Jean-Louis Pierre Thomas
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Patent number: 11723988Abstract: Several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea are provided. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector comprising a VP1 capsid protein as set forth in SEQ ID NO: 11 and the polynucleotide of interest under the control of the pR1.7 promoter as set forth in SEQ ID NO: 12 are also provided.Type: GrantFiled: October 22, 2018Date of Patent: August 15, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), SORBONNE UNIVERSITEInventors: Deniz Dalkara, Hanen Khabou, José-Alain Sahel, Thierry Leveillard, Jens Duebel
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Publication number: 20230253118Abstract: An in vitro method of classifying a subject suspected to suffer from an acute event including the steps of: determining neopterin concentration in a biological sample obtained from the subject, comparing the concentration with a predetermined reference neopterin concentration, and assigning the subject to a risk group based on the comparison of the neopterin concentration with the predetermined reference neopterin concentration.Type: ApplicationFiled: July 12, 2021Publication date: August 10, 2023Applicants: SORBONNE UNIVERSITÉ, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Delphine SAUCE, Martin LARSEN
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Patent number: 11717513Abstract: Disclosed is a method utilizing (R)-2-(2-aminothiazol-4-yl)-4?-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or an analogue, pharmaceutically acceptable salt or solvate thereof for the treatment of a retinal disease, more specifically using mirabegron for the treatment of age-related macular degeneration. Also Disclosed is a pharmaceutical composition, a medicament and a kit for the treatment of age-related macular degeneration.Type: GrantFiled: November 17, 2016Date of Patent: August 8, 2023Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Valérie Fontaine, Cécile Vidal, José-Alain Sahel
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Patent number: 11718661Abstract: The invention is in the field of therapy of antibody deficiencies. Inventors demonstrate for the first time in both controls and IgA-deficient patients, systemic anti-microbiota IgG responses correlate with reduced inflammation suggesting that systemic IgG responses contribute to the gut microbiota confinement. Furthermore, SIgAd-associated inflammation is inversely correlated with systemic anti-commensal IgG responses, which may thus serve as a second line of defense. Altogether, these data suggest that systemic IgG and intestinal IgA cooperate in different body compartments to limit systemic pro-inflammatory pathways. As selective IgA deficient patients harbour elevated seric anti-commensal IgG levels, these findings suggest that in selective IgA deficiency, microbiota confinement is obtained at the price of a strong inflammatory response.Type: GrantFiled: October 29, 2019Date of Patent: August 8, 2023Assignees: INSERM (Instut National de la Santé et de la Recherche Médicale), Sorbonne Université, Assistance Publique-Hôpitaux de Paris (APHP)Inventors: Guy Gorochov, Martin Larsen, Delphine Sterlin, Jehane Fadlallah
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Patent number: 11713481Abstract: A process for pre-concentration and detection of at least one single-stranded nucleic acid target molecule, the process comprising the steps of generating a flow of liquid comprising at least one magnetic nanoparticle in a micro-channel and a plurality of single-stranded nucleic acid probe molecules attached to the nanoparticle, generating an alternating magnetic field in the part of the micro-channel using an electromagnet, the magnetic field having an intensity and frequency that are suitable for causing magnetic hyperthermia of the nanoparticles so as to cause denaturing of the duplex formed by the single-stranded nucleic acid target molecule and the single-stranded nucleic acid probe molecule, and detecting the single-stranded target molecule dispersed in the liquid.Type: GrantFiled: October 5, 2018Date of Patent: August 1, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Institut National de La Sante et de la Recherche Medicale (INSERM), Sorbonne UniversiteInventors: Marie-Charlotte Horny, Jean-Michel Siaugue, Vincent Dupuis, Mathieu Lazerges, Jean Gamby
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Patent number: 11707052Abstract: An animal feed dispenser includes a control module and a feed dispensing module. The control module includes a detection member and an electronic control card. The detection member is suitable for generating a detection signal when the feed dispenser is located close to an enclosure containing animals. The feed dispensing module includes a feed dispensing orifice and an actuator. The electronic control card is configured to receive the detection signal and, as a function of the detection signal, to transmit an activation signal to the actuator and the actuator is configured to trigger a flow of feed through the dispensing orifice when the activation signal is received.Type: GrantFiled: November 9, 2018Date of Patent: July 25, 2023Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS)Inventors: Raphael Candelier, Abdelkrim Mannioui, Alex Bois, Stephane Tronche, Jeremy Mahieu
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Patent number: 11704128Abstract: An execution method includes supplying of a machine code, the machine code being formed by a succession of base blocks and each base block being associated with a signature and comprising instructions to be protected. Each instruction to be protected is immediately preceded or followed by an instruction for constructing the value of the signature associated with the base block. Each construction instruction is coded on strictly less than N bits, and each word of the machine code which comprises at least one portion of one of said instructions to be protected also comprises one of the construction instructions so that A is not possible to load an instruction to be protected into an execution file, without at the same time loading a construction instruction which modifies the value of the signature associated with the base block when it is executed.Type: GrantFiled: March 20, 2018Date of Patent: July 18, 2023Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Damien Courousse, Karine Heydemann, Thierno Barry
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Patent number: 11684303Abstract: A computer-implemented method for detecting pathological brain activity patterns from a scalp electroencephalographic signal, the method including the steps of obtaining (A) an electroencephalographic signal as a function of multiple channels and time; identifying (C), for each channel, the zero-crossings of the electroencephalographic signal over a fixed threshold; generating a zero-crossing representation of at least a segment of the obtained electroencephalographic signal with the identified zero-crossings; obtaining (D) a reference family of real functions of time and channels from a zero-crossing statistical analysis of zero-crossing representation of pre-recorded electroencephalographic signals; calculating (E) a matching score by comparing the zero-crossing representation of a segment of the electroencephalographic signal with at least one reference function from the reference family of functions; and computing the matching score as a function of time by sliding the at least one reference function fromType: GrantFiled: March 30, 2018Date of Patent: June 27, 2023Assignees: Bioserenity, ICM (Institut Du Cerveau Et De La Moellle Épiniére), APHP (Assistance Publique—Hôpitaux De Paris), Centre National De La Recherche Scientifique, INSERM (Institut National De La Santé Et De La Recherche Médicale), Sorbonne UniversiteInventors: Jan Pyrzowski, Michel Le Van Quyen, Jean-Eudes Le Douget