Patents Assigned to SORBONNE UNIVERSITÉ
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Patent number: 11414398Abstract: Disclosed are organic cation transporters (OCTs) inhibitors of Formula (A), as well as their pharmaceutically acceptable tautomers, salts or solvates. Also disclosed are pharmaceutical compositions including such OCTs inhibitor of Formula (A) and their use for treating and/or preventing mood-related disorders such as depressive disorders.Type: GrantFiled: July 13, 2018Date of Patent: August 16, 2022Assignees: SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ PARIS CITÉInventors: Sophie Gautron, Nicolas Pietrancosta, Francine Acher, Laetitia Chausset-Boissarie
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Publication number: 20220251564Abstract: A p16INK4a inhibitor, a composition that includes the p16INK4a inhibitor, or a pharmaceutical composition that includes the p16INK4a inhibitor, for use in the prevention and/or the treatment of Huntington's disease, wherein the p16INK4a inhibitor is a nucleic acid or a peptide, a small compound molecule or a marketed drug.Type: ApplicationFiled: April 17, 2020Publication date: August 11, 2022Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, BUCK INSTITUTE FOR RESEARCH ON AGINGInventors: Christian NERI, Francesca FARINA, Jessica VOISIN, Lisa ELLERBY
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Patent number: 11407741Abstract: The present invention relates to a compound of formula (I): wherein P1, P3, P4 and P5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.Type: GrantFiled: September 26, 2018Date of Patent: August 9, 2022Assignees: UNIVERSITE DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Etienne Jacotot, Elodie Bosc
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Patent number: 11407743Abstract: The present invention relates to a compound of the following formula (I): The invention also relates to uses thereof as dye or pigment, notably as a luster pigment. The invention relates also to a reflective or photonic or nanophotonic or optoelectronic device comprising a compound of the invention. The invention relates also to a metal-like reflective coating, a metal-like particle or an organic-based metal-like liquid film comprising a compound of the invention.Type: GrantFiled: July 5, 2019Date of Patent: August 9, 2022Assignees: Sorbonne Universite, Centre National De La Recherche Scientifique, Universite de ParisInventors: Philippe Laine, Laurélie Poulard, Grégory Dupeyre, Valerie Marvaud
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Patent number: 11406686Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call “fetal myeloid progenitor cells” (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.Type: GrantFiled: May 2, 2017Date of Patent: August 9, 2022Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Sorbonne Université, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (APHP)Inventors: Selim Aractingi, Mathieu Catela, Dany Nassar, Zhe Wang
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Patent number: 11399902Abstract: A medical system comprising: a robotic arm, a control unit configured to issue a control signal, a medical device intended to penetrate an anatomical structure, the medical device being configured to emit a warning signal which varies as a function of a variable electrical characteristic of the anatomical structure, said medical device comprising a body with first and second electrodes, an electric generator suitable for applying at least one measurement electric current between the first and second electrodes, and a processing device suitable for determining a measurement parameter related to the electrical characteristic, based on said at least one measurement electric current, and for emitting the warning signal corresponding to the measurement parameter, wherein the control unit is configured to issue the control signal as a function of the warning signal.Type: GrantFiled: October 24, 2018Date of Patent: August 2, 2022Assignees: SpineGuard, Sorbonne Universite, INSERM (Institute National de la Sante et de la Recherche), Centre National de la Recherche Scientifique—CNRSInventors: Maurice Bourlion, Olivier Frezal, Guillaume Morel, Stéphane Bette, Thibault Chandanson, Florian Richer, Valentin Kerspern
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Patent number: 11401390Abstract: This invention relates to a polymer membrane comprising a hydrogen bond donor polymer and a hydrogen bond acceptor polymer and to the use of such membrane as the shell of a capsule. The invention also relates to a method of manufacturing a polymer membrane comprising a step of contacting an aqueous phase comprising a first polymer, and an oil phase comprising a second different polymer; wherein one polymer is a hydrogen bond donor polymer and the other polymer is a hydrogen bond acceptor polymer. The invention also relates to a method of encapsulation comprising a step of manufacturing a polymer membrane.Type: GrantFiled: March 16, 2018Date of Patent: August 2, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE, SORBONNE UNIVERSITÉInventors: Cécile Monteux, Julien Dupré De Baubigny, Mathilde Reyssat, Patrick Perrin, Nadège Pantoustier
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Patent number: 11400311Abstract: The invention concerns a device 10 for illuminating an object 12 with a controlled light intensity, the light intensity being controlled when the light intensity fulfills a plurality of conditions to be fulfilled, the plurality of conditions comprising a condition relative to the intensity at a given time and a condition relative to the dose during a period of time.Type: GrantFiled: June 16, 2017Date of Patent: August 2, 2022Assignees: GENSIGHT BIOLOGICS, SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Joël Chavas, Guillaume Chenegros, Benjamin R. Benosman
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Publication number: 20220236301Abstract: The present invention relates to an atomic force microscope for evaluating a surface of a sample, comprising a sample holder, having a first zone suitable for receiving the sample mounted in a stationary manner, a probe having a tip able to be positioned facing the surface of the sample, the microscope being configured to allow an adjustment of a position of the tip relative to the surface, and a support, the sample holder having at least one second zone, separate from the first zone and stationary relative to the support, the sample holder being deformable so as to allow a relative movement of the first zone with respect to the second zone, and the microscope comprising a detector able to detect a movement of the first zone relative to the second zone.Type: ApplicationFiled: July 16, 2020Publication date: July 28, 2022Applicants: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Université de ParisInventors: Antoine Niguès, Alessandro Siria
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Publication number: 20220228167Abstract: The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a peptide-modified hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins comprising at least one copy of a peptide comprising the RGD motif, wherein said recombinant peptide-modified hybrid AAV capsid protein has a further reduced liver tropism and an increased muscle transduction compared to the recombinant hybrid AAV capsid protein not having said peptide. The invention relates also to the derived peptide-modified hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases, in particular muscular genetic diseases.Type: ApplicationFiled: October 4, 2019Publication date: July 21, 2022Applicants: Genethon, Institut National de la Sante et de la Recherche Medicale, Universite d'Evry Val d'Essonne, Sorbonne Universite, Association Institut de MyologieInventors: Giuseppe RONZITTI, Patrice VIDAL, Federico MINGOZZI
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Patent number: 11390866Abstract: The present invention relates to a nucleic acid sequence derived from the regulatory region of the human gamma-synuclein gene and having a promoter activity in retinal ganglion cells. The present invention also relates to expression cassettes or vectors comprising said promoter operably linked to a nucleic acid sequence encoding a polypeptide of interest as well as viral particles or host cells comprising said expression cassette or vector. The present invention also relates to the use of said expression cassettes, vectors, viral particles or cells in the treatment of ocular disease, in particular ocular disease associated with retinal ganglion cell or photoreceptor cell degeneration.Type: GrantFiled: December 5, 2016Date of Patent: July 19, 2022Assignees: SORBONNE UNIVERSITÉ, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Deniz Dalkara, Serge Picaud, Melissa Desrosiers, Jose-Alain Sahel, Jens Duebel, Alexis Bemelmans, Botond Roska
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Patent number: 11385231Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a lung cancer.Type: GrantFiled: August 26, 2016Date of Patent: July 12, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE), UNIVERSITE DE PARIS, SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)Inventors: Marie-Caroline Dieu-Nosjean, Wolf Herdman Fridman, Catherine Sautes-Fridman, Priyanka Devi
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Patent number: 11383004Abstract: The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.Type: GrantFiled: April 1, 2019Date of Patent: July 12, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PARIS XIII PARIS-NORD, ÉCOLE SUPÉRIEUR DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE PARIS, SORBONNE UNIVERSITEInventors: Ludwik Leibler, Anne Meddahi-Pellé, Didier Letourneur, Alba Marcellan-Parisot
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Patent number: 11388808Abstract: The present invention relates to a plasma reactor and more specifically to an plasma microreactor comprising a support, made at least partially of a dielectric material, the support comprising a gas inlet, a liquid inlet, at least a fluid outlet, a liquid microchannel in the support, a gas channel, at least a ground electrode, at least a high voltage electrode, separated from the gas channel by the dielectric material of the support, wherein said ground electrode and said high voltage electrode are arranged on opposite sides of the gas channel so as to be able to create an electric field inside the gas channel, wherein the liquid microchannel and the gas channel are contiguous and at least an opening is arranged between the liquid microchannel and the gas channel so as to form a fluid channel and to cause the liquid flow contact the gas flow and wherein the liquid flow is retained within the liquid microchannel by capillarity action.Type: GrantFiled: February 28, 2019Date of Patent: July 12, 2022Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Ecole Nationale Supérieure de Chimie de ParisInventors: Julien Wengler, Stéphanie Ognier, Safwan Al Ayoubi, Michael Tatoulian
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Patent number: 11377590Abstract: A method of preparation of mercury chalcogenide nanoparticles that includes the steps of providing a precursor of mercury and mixing the precursor of mercury with a precursor of chalcogenide, wherein the precursor of mercury is a mercury thiolate. Also, mercury telluride nanoparticles and their use in an IR photodetector, an IR photoconversion device, an IR filter or an IR photodiode.Type: GrantFiled: September 18, 2020Date of Patent: July 5, 2022Assignees: NEXDOT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITEInventors: Emmanuel Lhuillier, Nicolas Goubet
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Patent number: 11376321Abstract: The present invention relates to a method for removing undesired anti-AAV antibodies from a blood-derived composition.Type: GrantFiled: March 1, 2018Date of Patent: July 5, 2022Assignees: GENETHON, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), SORBONNE UNIVERSITÉ, ASSOCIATION INSTITUT DE MYOLOGIEInventors: Bérangére Bertin, Carole Masurier, Otto-Wilhelm Merten, Federico Mingozzi
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Patent number: 11369341Abstract: The invention relates to a method for characterising bone, the method comprising the steps of receiving (102) ultrasonic wave echo signals transmitted into a body, determining (104) a speed of sound in the body's non-bone biological tissue, locating (106) a first demarcation curve between non-bone biological tissue and bone in an image of the body constructed during said determining step, and determining (108) a speed of sound in bone. The steps of determining speed include constructing images from the signals, and a metric calculation indicative of a focus quality in the constructed images.Type: GrantFiled: July 19, 2018Date of Patent: June 28, 2022Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Guillaume Renaud, Didier Cassereau
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Publication number: 20220198959Abstract: A device for simulating a behavior of a mammal in an environment by a virtual mammal includes a mobile head and at least one mobile eye including a first input for successive data representative of eye poses, a second input for mobility action instructions, a memory for storing information on the environment and on stabilization constraints, at least one processor assessing a current part of the environment and recording information on said current part, triggering successive movements of the head and of the eye(s) in function of said mobility action, controlling a dynamic adjustment of the successive movements of the eye(s) with respect to the successive movements of the head in function of the successive data and by using the stabilization constraints. The device further comprises a third input for training data representative of a training movement sequence of the head and the eye(s) associated with a training environment.Type: ApplicationFiled: March 20, 2020Publication date: June 23, 2022Applicants: Essilor International, Sorbonne UniversitéInventors: Denis SHEYNIKHOVICH, Richard CARRILLO, Luca Leonardo BOLOGNA, Youssouf CHERIFI, Tiany LI, Angelo ARLEO, Konogan BARANTON, Anne-Catherine SCHERLEN, Delphine TRANVOUEZ-BERNARDIN
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Patent number: 11357816Abstract: The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.Type: GrantFiled: June 17, 2019Date of Patent: June 14, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITE, ECOLE NORMALE SUPERIEURE, COLLEGE DE FRANCEInventors: Jean-Maurice Mallet, Solange Lavielle, Rodrigue Marquant, Alain Prochiantz, Ariel Di Nardo, Damien Testa
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Patent number: 11359027Abstract: The present disclosure relates to the in vivo prevention or treatment of hematologic malignancy relapse using a TNFR2 antagonist (an anti TNFR2 antagonist antibody) (i) for use in the prevention or treatment of hematologic malignancy relapse after allogeneic hematopoietic stem cell transplantation (AHCT) or after a treatment with lymphocytes and (ii) for use in enhancing the graft-versus-leukemia-activity (GVL activity) of a hematopoietic stem cell transplantation (HCT) or a treatment with lymphocytes.Type: GrantFiled: June 22, 2017Date of Patent: June 14, 2022Assignees: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sébastien Maury, José Cohen, Benoît Salomon, Sina Naserian, Mathieu Leclerc