Patents Assigned to SORBONNE UNIVERSITÉ
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Publication number: 20230192772Abstract: Peptides endowed with an anti-inflammatory, anti-angiogenic and/or antimicrobial activity, a medicament or a pharmaceutical composition including such peptides, and the use thereof in the prevention or treatment of inflammatory diseases, and more particularly inflammatory diseases due to or associated with microbial infections, or in the prevention or treatment of angiogenesis-related diseases.Type: ApplicationFiled: December 22, 2017Publication date: June 22, 2023Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS-SUD 11, UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOInventors: Claire LACOMBE, Constance AUVYNET, Yvonne ROSENSTEIN, Emmanuelle SACHON
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Patent number: 11679140Abstract: The present invention relates to the use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin for modulating cellular redox homeostasis. A particularly preferred use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin in the context of the present invention is as an antioxidant. The present invention also concerns a virally-mediated gene therapy for restoring genetically-impaired auditory and vestibular functions in subjects suffering from an Usher syndrome. More precisely, this gene therapy takes advantage of an AAV2/8 vector expressing at least one USH1 gene product, preferably SANS.Type: GrantFiled: July 27, 2020Date of Patent: June 20, 2023Assignees: INSTITUT PASTEUR, Centre National de la Recherche Scientifique (CNRS), Universite Clermont Auvergne, Sorbonne UniversiteInventors: Christine Petit, Paul Avan, Sedigheh Delmaghani, Jean Defourny, Asadollah Aghaie, Saaid Safieddine, Alice Emptoz
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Publication number: 20230172919Abstract: An insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment, and in particular for preventing or treating the loss of vision induced by retinal detachment. Also, a composition including the insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment and a device including the composition.Type: ApplicationFiled: March 26, 2021Publication date: June 8, 2023Applicants: SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Florian SENNLAUB, Jean-Baptiste CONART, José-Alain SAHEL
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Patent number: 11666584Abstract: The invention relates to a new method for the prevention and treatment of wave burst arrhythmia by administering a gestagen having an androgenic effect.Type: GrantFiled: April 18, 2017Date of Patent: June 6, 2023Assignees: ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITÉInventors: Joe-Elie Salem, Christian Funck-Brentano, Anne Bachelot, Xavier Waintraub
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Patent number: 11661662Abstract: The present invention relates to an electrode comprising an electrically conductive substrate of which at least one portion of the surface is covered with a metal deposit of copper, the surface of said deposit being in an oxidised, sulphurised, selenised and/or tellurised form and the deposit having a specific surface area of more than 1 m2/g; a method for preparing such an electrode; and a method for oxygenising water with dioxygen involving such an electrode.Type: GrantFiled: March 31, 2017Date of Patent: May 30, 2023Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne UniversiteInventors: Marc Fontecave, Victor Mougel, Ngoc Huan Tran
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Patent number: 11654055Abstract: The sensory substitution system includes a portable matrix of exciters that can be worn by a user in such a way that the exciters are placed against the skin of a user, as well as a control circuit for the exciters of the matrix. An asynchronous signal source provides the control circuit with an asynchronous signal representative of visual information organised according to a matrix of pixels. This asynchronous signal includes, for each pixel, successive events associated in an asynchronous manner with the pixel.Type: GrantFiled: December 7, 2017Date of Patent: May 23, 2023Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Guillaume Chenegros, Ryad Benosman, Kevin Arth, Sio-Hoi Ieng
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Publication number: 20230149512Abstract: The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.Type: ApplicationFiled: January 6, 2023Publication date: May 18, 2023Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Assistance Publique - Hopitaux De Paris, SORBONNE UNIVERSITEInventors: David KLATZMANN, David SAADOUN, Patrice CACOUB, Michèle ROSENZWAJG, Eliane PIAGGIO, Gilbert BENSIMON, Claude BERNARD
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Publication number: 20230142905Abstract: A method for predicting the return to functional autonomy in a subject suffering from an acute event, including the steps of i) determining neopterin level in a biological sample obtained from the subject; ii) comparing the level with its predetermined reference neopterin level and iii) predicting that the subject will have a long time to return to functional autonomy when the level of neopterin is higher than its predetermined reference neopterin level or predicting that the subject will have a short time to return to functional autonomy when the level of neopterin is lower than its predetermined reference neopterin level.Type: ApplicationFiled: April 23, 2021Publication date: May 11, 2023Applicants: SORBONNE UNIVERSITE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Delphine SAUCE, Martin LARSEN, Jacques BODDAERT, Hélène VALLET
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Patent number: 11642073Abstract: A system for calculating an indicator associated to a brain activity of a subject, the system including an acquisition module configured to acquire at least an epoch of electroencephalographic signal of a subject from a plurality of electrodes and a data processing module configured to carry out the steps of: calculating an average vector (VA) using as input of an autoencoder neural network (aNN) an electroencephalographic signals (ES) of a subject acquired from a plurality of electrodes; detecting (DET) the presence of at least a predefined pattern in the consecutive average values of the average vector (VA); and generating an indicator of brain activity (Idx) of the subject when detecting the predefined pattern.Type: GrantFiled: December 21, 2018Date of Patent: May 9, 2023Assignees: BIOSERENTIY, ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÈPINIÈRE, APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTTIFIQUE, INSERM (INSTITUT CENTRE NATIONAL DE LA RECHERCHE SCIENTTIFIQUE NATIONAI DF TA SANTÉ ET DF TA RECHERCHE MÉDICALEInventors: Mohcine Heddi, Michel Le Van Quyen, Jean-Eudes Le Douget
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Publication number: 20230140419Abstract: A system for automatic evaluation of cognition and consciousness of a subject, the system including a micro-controller, a digital-to-analog converter and at least one sensory stimulation element, wherein the system is configured to receive as input an information concerning a stimulation paradigm and to generate as output a sensory stimulation according to the stimulation paradigm and transmit at least one synchronization signal determined by the stimulation paradigm to a device for the acquisition of a physiological signal so as to synchronize the system for stimulation with the device for the acquisition of a physiological signal during an acquisition.Type: ApplicationFiled: October 2, 2020Publication date: May 4, 2023Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITEInventors: Federico RAIMONDO, Jacobo SITT, Lionel NACCACHE
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Patent number: 11639440Abstract: The present invention relates to bituminous compositions comprising molecules of formula (I), (II) and/or (III). The invention also relates to the use of said bitumen compositions in the fields of road applications, particularly in the production of road binders and roadways in general, as well as in the fields of industrial applications. The invention also relates to a method for producing said bituminous compositions. The invention further relates to novel molecules that can be used in particular in the formulation of bituminous compositions.Type: GrantFiled: August 19, 2019Date of Patent: May 2, 2023Assignees: TOTAL MARKETING SERVICES, SORBONNE UNIVERSITEInventors: Manuel Merce, Laurent Bouteiller, Sandrine Pensec, Thomas Coustham
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Patent number: 11628438Abstract: A method is provided for manipulating objects in a cavity including a liquid, the method including providing in at least one region of the cavity objects capable of absorbing light in a given wavelength range, forming an aggregate of the objects by submitting them to an acoustic field, and disrupting the aggregate by submitting the aggregate to a light beam emitting at the given wavelength range. Also provided is a device for manipulating objects.Type: GrantFiled: June 29, 2018Date of Patent: April 18, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITEInventors: Jean-Luc Aider, Mauricio Hoyos, Gabriel Dumy
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Patent number: 11617560Abstract: The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (10), the sample (10) comprising blood (14) comprising diffusors and solid tissue (16), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.Type: GrantFiled: September 15, 2017Date of Patent: April 4, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉInventors: Zsolt Lenkei, Mathieu Pernot, Mickael Tanter, Thomas Deffieux
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Patent number: 11612743Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.Type: GrantFiled: January 24, 2020Date of Patent: March 28, 2023Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA ECHERCHE MEDICALE), SORBONNE UNIVERSITEInventors: Michel Le Van Quyen, Stéphane Charpier, Séverine Mahon
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Patent number: 11609124Abstract: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation ??ij defined by ??ij=arccos, where “·” stands for the inner product between and .Type: GrantFiled: September 28, 2021Date of Patent: March 21, 2023Assignees: UNIVERSITE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITEInventors: Marc Guillon, Gilles Tessier, Tengfei Wu, Pascal Berto
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Patent number: 11596657Abstract: The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.Type: GrantFiled: July 11, 2017Date of Patent: March 7, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, SORBONNE UNIVERSITÉ, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Harry Sokol, Jane Mea Natividad, Bruno Lamas, Henri Duboc, Mathias Lavie-Richard, Marie-Laure Michel, Philippe Langella
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Patent number: 11576371Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.Type: GrantFiled: June 12, 2018Date of Patent: February 14, 2023Assignees: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE - HOPITAUX DE PARISInventors: Cécile Legallais, Patrick Paullier, Olivier Scatton, Eric Savier
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Patent number: 11559566Abstract: The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.Type: GrantFiled: July 10, 2020Date of Patent: January 24, 2023Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, SORBONNE UNIVERSITEInventors: David Klatzmann, David Saadoun, Patrice Cacoub, Michèle Rosenzwajg, Eliane Piaggio, Gilbert Bensimon, Claude Bernard
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Patent number: 11559244Abstract: Disclosed is a method for the generation of a consciousness indicator for a non-communicating subject, including the steps of generating an auditory stimulation, receiving an electrocardiographic signal of the subject obtained from a recording during the generation of the auditory stimulation, extracting at least one feature from the electrocardiographic signal and deducing a consciousness indicator from an analysis of the electrocardiographic feature.Type: GrantFiled: September 11, 2018Date of Patent: January 24, 2023Assignees: ICM—INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE), APHP, SORBONNE UNIVERSITÉInventors: Federico Raimondo, Jacobo D Sitt, Lionel Naccache, Diego Fernandez Slezak
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Patent number: 11542295Abstract: The invention relates to 20-hydroxyecdysone and the derivatives thereof, for use in the treatment of genetic myopathies.Type: GrantFiled: April 27, 2018Date of Patent: January 3, 2023Assignees: BIOPHYTIS, SORBONNE UNIVERSITÉInventors: Pierre Dilda, René Lafont, Mathilde Latil, Maria Serova, Onnik Agbulut, Stanislas Veillet