Patents Assigned to South Dakota State University
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Patent number: 11896031Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.Type: GrantFiled: January 21, 2022Date of Patent: February 13, 2024Assignee: The South Dakota Board of Regent, as Governing Board for South Dakota State UniversityInventors: William Gibbons, Michael Brown
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Patent number: 11844362Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.Type: GrantFiled: April 28, 2021Date of Patent: December 19, 2023Assignee: The South Dakota of Regents, As Governing Board for South Dakota State UniversityInventors: William Gibbons, Michael Brown
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Patent number: 11800882Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.Type: GrantFiled: September 17, 2021Date of Patent: October 31, 2023Assignee: The South Dakota Board of Regents, as Governing Board for South Dakota State UniversityInventors: William Gibbons, Michael L. Brown
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Patent number: 11684661Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STatoxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.Type: GrantFiled: April 27, 2020Date of Patent: June 27, 2023Assignees: The Johns Hopkins University, South Dakota State UniversityInventors: David A. Sack, Weiping Zhang
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Patent number: 11400146Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.Type: GrantFiled: May 7, 2020Date of Patent: August 2, 2022Assignees: The Johns Hopkins University, South Dakota State UniversityInventors: David A. Sack, Weiping Zhang
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Publication number: 20220142200Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.Type: ApplicationFiled: January 21, 2022Publication date: May 12, 2022Applicant: South Dakota State UniversityInventors: William Gibbons, Michael Brown
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Patent number: 10646560Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoidLTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.Type: GrantFiled: December 17, 2014Date of Patent: May 12, 2020Assignees: The John Hopkins University, South Dakota State UniversityInventors: David A. Sack, Weiping Zhang
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Patent number: 9754733Abstract: A method for using plasma to activate biochar is disclosed where reactive gas(es) are excited by external power; biochar set on a sample holder is electrically biased or set at a floating potential so that charged particles of a certain type are attracted to the biochar, leading to intensive chemical reactions.Type: GrantFiled: April 30, 2015Date of Patent: September 5, 2017Assignee: South Dakota State UniversityInventors: Qi Hua Fan, Mukul Kumar Dubey, Zhengrong Gu
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Publication number: 20160046907Abstract: The present invention describes methods to produce vaccines and antibodies, which methods including contacting follicular dendritic cells (FDC) with naïve B-cells to mimic conditions in the germinal center (CG) in vitro, including methods of enhancing antibody production in hybridoma cells and compositions comprising product of the instant methods.Type: ApplicationFiled: February 3, 2015Publication date: February 18, 2016Applicant: SOUTH DAKOTA STATE UNIVERSITYInventor: Alan John Young
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Patent number: 9220680Abstract: The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.Type: GrantFiled: July 15, 2013Date of Patent: December 29, 2015Assignee: South Dakota State UniversityInventors: Omathanu P Perumal, Kaushalkumar Dave, Chandradhar Dwivedi, Sreevidy Santha
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Publication number: 20150307360Abstract: The present invention describes a non-aqueous organic solution for Electrophoretic Deposition (EPD) of nanoparticles onto thin films, including method of using said non-aqueous organic solution and EPD to produce films containing such nanoparticles for use in LED devices, Li ion batteries, as solar absorbers, and as thin film transistors.Type: ApplicationFiled: November 1, 2014Publication date: October 29, 2015Applicant: SOUTH DAKOTA STATE UNIVERSITYInventors: Braden Bills, Qi Hua Fan
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Publication number: 20150150822Abstract: The invention relates to an oral nanoparticle drug delivery system, including methods for preparing such a system using a hydrophobic water insoluble protein, which nanoparticles may include prolamine to generate said oral drug delivery system.Type: ApplicationFiled: June 4, 2014Publication date: June 4, 2015Applicant: SOUTH DAKOTA STATE UNIVERSITYInventors: Omathanu Perumal, Mohammed Saeed A Alqahtani
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Patent number: 8993303Abstract: The disclosed embodiments provide cyanobacteria spp. that have been genetically engineered to have increased production of carbon-based products of interest. These genetically engineered hosts efficiently convert carbon dioxide and light into carbon-based products of interest such as long chained hydrocarbons. Several constructs containing polynucleotides encoding enzymes active in the metabolic pathways of cyanobacteria are disclosed. In many instances, the cyanobacteria strains have been further genetically modified to optimize production of the carbon-based products of interest. The optimization includes both up-regulation and down-regulation of particular genes.Type: GrantFiled: February 24, 2012Date of Patent: March 31, 2015Assignee: South Dakota State UniversityInventors: Ruanbao Zhou, William Gibbons
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Publication number: 20140370110Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer, such as a polyethylene glycol (PEG) chain, which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of an encapsulated agent in vivo, protecting an encapsulated agent against degradation, and enhancing the water solubility of a drug or other agent.Type: ApplicationFiled: April 8, 2014Publication date: December 18, 2014Applicant: SOUTH DAKOTA STATE UNIVERSITYInventors: Omathanu P. Perumal, Satheesh K. Podaralla, Ranjith Kumar Averineni
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Publication number: 20140313574Abstract: Disclosed are methods for forming nanoparticle films using electrophoretic deposition. The methods comprise exposing a substrate to a solution, the solution comprising substantially dispersed nanoparticles, an organic solvent, and a polymer characterized by a backbone comprising Si—O groups. The methods further comprise applying an electric field to the solution, whereby a nanoparticle film is deposited on the substrate. Suitable polymers include polysiloxanes, polysilsesquioxanes and polysilicates. Coated glass windows and methods of forming the coated glass windows using the solutions are also disclosed.Type: ApplicationFiled: January 14, 2014Publication date: October 23, 2014Applicant: SOUTH DAKOTA STATE UNIVERSITYInventors: Braden Bills, Nathan Morris, Qi Hua Fan, Mukul Dubey, David Galipeau
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Publication number: 20140308351Abstract: Methods are described for producing non-immunogenic nanoparticles from protein sources by controlling the pH in a nanoprecipitation process. The nanoparticles that are produced by the disclosed methods range in diameter size from about 100 ran to about 400 nm, with a preferred diameter size of from approximately 100 nm to approximately 300 nm, thereby rendering them non-immunogenic. The invention further discloses methods for producing nanoconjugates that are suitable for a variety of therapeutic, diagnostic and other uses.Type: ApplicationFiled: March 10, 2014Publication date: October 16, 2014Applicant: South Dakota State UniversityInventors: Omathanu P. Perumal, Satheesh K. Podaralla, Radhey S Kaushik
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Patent number: 8771779Abstract: A method of reversing the formation of an oxidized off-flavor in milk that includes providing milk, and heating the milk to a temperature between approximately 70° C. and approximately 90° C. for a period of between approximately 25 seconds and approximately 60 seconds.Type: GrantFiled: August 12, 2010Date of Patent: July 8, 2014Assignee: South Dakota State UniversityInventors: Robert J. Baer, Howard H. Bonnemann
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Publication number: 20140162873Abstract: The invention is directed to improved methods for producing high-quality activated carbons from biochar. The invention also provides materials and methods for creation of activated carbons useful for purification of water, adsorption of gases or vapors, and catalyst supports. The methods include ash modification, physical activation, the addition of a catalyst, chemical activation, and removal and/or recycling of the catalyst. The usefulness of the present method is that it results in the production of a high-quality activated carbon from a waste product of the biofuel manufacturing process, thereby increasing the economic sustainability and viability of the biofuel production process itself.Type: ApplicationFiled: July 11, 2013Publication date: June 12, 2014Applicant: SOUTH DAKOTA STATE UNIVERSITYInventor: Zhengrong Gu
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Patent number: 8697098Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer, such as a polyethylene glycol (PEG) chain, which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of an encapsulated agent in vivo, protecting an encapsulated agent against degradation, and enhancing the water solubility of a drug or other agent.Type: GrantFiled: February 24, 2012Date of Patent: April 15, 2014Assignee: South Dakota State UniversityInventors: Omathanu P. Perumal, Satheesh K. Podaralla, Ranjith Kumar Averineni
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Publication number: 20140073822Abstract: Reactors for the pyrolysis of pyrolyzable matter, pyrolysis systems incorporating the reactors and methods of using the reactors are provided. Also provided are systems and methods for integrating the pyrolysis and hydrodeoxygenation of pyrolyzable matter. The pyrolysis reactors create a horizontally rotating, fluidized-bed to which pyrolyzable matter, such as biomass, may be converted via pyrolysis into liquid fuels and/or value-added chemicals.Type: ApplicationFiled: July 7, 2013Publication date: March 13, 2014Applicant: South Dakota State UniversityInventors: Lin Wei, James Julson