Patents Assigned to South Dakota State University
  • Patent number: 11896031
    Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: February 13, 2024
    Assignee: The South Dakota Board of Regent, as Governing Board for South Dakota State University
    Inventors: William Gibbons, Michael Brown
  • Patent number: 11844362
    Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: December 19, 2023
    Assignee: The South Dakota of Regents, As Governing Board for South Dakota State University
    Inventors: William Gibbons, Michael Brown
  • Patent number: 11800882
    Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: October 31, 2023
    Assignee: The South Dakota Board of Regents, as Governing Board for South Dakota State University
    Inventors: William Gibbons, Michael L. Brown
  • Patent number: 11684661
    Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STatoxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: June 27, 2023
    Assignees: The Johns Hopkins University, South Dakota State University
    Inventors: David A. Sack, Weiping Zhang
  • Patent number: 11400146
    Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: August 2, 2022
    Assignees: The Johns Hopkins University, South Dakota State University
    Inventors: David A. Sack, Weiping Zhang
  • Publication number: 20220142200
    Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 12, 2022
    Applicant: South Dakota State University
    Inventors: William Gibbons, Michael Brown
  • Patent number: 10646560
    Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoidLTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 12, 2020
    Assignees: The John Hopkins University, South Dakota State University
    Inventors: David A. Sack, Weiping Zhang
  • Patent number: 9754733
    Abstract: A method for using plasma to activate biochar is disclosed where reactive gas(es) are excited by external power; biochar set on a sample holder is electrically biased or set at a floating potential so that charged particles of a certain type are attracted to the biochar, leading to intensive chemical reactions.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: September 5, 2017
    Assignee: South Dakota State University
    Inventors: Qi Hua Fan, Mukul Kumar Dubey, Zhengrong Gu
  • Publication number: 20160046907
    Abstract: The present invention describes methods to produce vaccines and antibodies, which methods including contacting follicular dendritic cells (FDC) with naïve B-cells to mimic conditions in the germinal center (CG) in vitro, including methods of enhancing antibody production in hybridoma cells and compositions comprising product of the instant methods.
    Type: Application
    Filed: February 3, 2015
    Publication date: February 18, 2016
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventor: Alan John Young
  • Patent number: 9220680
    Abstract: The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: December 29, 2015
    Assignee: South Dakota State University
    Inventors: Omathanu P Perumal, Kaushalkumar Dave, Chandradhar Dwivedi, Sreevidy Santha
  • Publication number: 20150307360
    Abstract: The present invention describes a non-aqueous organic solution for Electrophoretic Deposition (EPD) of nanoparticles onto thin films, including method of using said non-aqueous organic solution and EPD to produce films containing such nanoparticles for use in LED devices, Li ion batteries, as solar absorbers, and as thin film transistors.
    Type: Application
    Filed: November 1, 2014
    Publication date: October 29, 2015
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventors: Braden Bills, Qi Hua Fan
  • Publication number: 20150150822
    Abstract: The invention relates to an oral nanoparticle drug delivery system, including methods for preparing such a system using a hydrophobic water insoluble protein, which nanoparticles may include prolamine to generate said oral drug delivery system.
    Type: Application
    Filed: June 4, 2014
    Publication date: June 4, 2015
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventors: Omathanu Perumal, Mohammed Saeed A Alqahtani
  • Patent number: 8993303
    Abstract: The disclosed embodiments provide cyanobacteria spp. that have been genetically engineered to have increased production of carbon-based products of interest. These genetically engineered hosts efficiently convert carbon dioxide and light into carbon-based products of interest such as long chained hydrocarbons. Several constructs containing polynucleotides encoding enzymes active in the metabolic pathways of cyanobacteria are disclosed. In many instances, the cyanobacteria strains have been further genetically modified to optimize production of the carbon-based products of interest. The optimization includes both up-regulation and down-regulation of particular genes.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 31, 2015
    Assignee: South Dakota State University
    Inventors: Ruanbao Zhou, William Gibbons
  • Publication number: 20140370110
    Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer, such as a polyethylene glycol (PEG) chain, which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of an encapsulated agent in vivo, protecting an encapsulated agent against degradation, and enhancing the water solubility of a drug or other agent.
    Type: Application
    Filed: April 8, 2014
    Publication date: December 18, 2014
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventors: Omathanu P. Perumal, Satheesh K. Podaralla, Ranjith Kumar Averineni
  • Publication number: 20140313574
    Abstract: Disclosed are methods for forming nanoparticle films using electrophoretic deposition. The methods comprise exposing a substrate to a solution, the solution comprising substantially dispersed nanoparticles, an organic solvent, and a polymer characterized by a backbone comprising Si—O groups. The methods further comprise applying an electric field to the solution, whereby a nanoparticle film is deposited on the substrate. Suitable polymers include polysiloxanes, polysilsesquioxanes and polysilicates. Coated glass windows and methods of forming the coated glass windows using the solutions are also disclosed.
    Type: Application
    Filed: January 14, 2014
    Publication date: October 23, 2014
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventors: Braden Bills, Nathan Morris, Qi Hua Fan, Mukul Dubey, David Galipeau
  • Publication number: 20140308351
    Abstract: Methods are described for producing non-immunogenic nanoparticles from protein sources by controlling the pH in a nanoprecipitation process. The nanoparticles that are produced by the disclosed methods range in diameter size from about 100 ran to about 400 nm, with a preferred diameter size of from approximately 100 nm to approximately 300 nm, thereby rendering them non-immunogenic. The invention further discloses methods for producing nanoconjugates that are suitable for a variety of therapeutic, diagnostic and other uses.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 16, 2014
    Applicant: South Dakota State University
    Inventors: Omathanu P. Perumal, Satheesh K. Podaralla, Radhey S Kaushik
  • Patent number: 8771779
    Abstract: A method of reversing the formation of an oxidized off-flavor in milk that includes providing milk, and heating the milk to a temperature between approximately 70° C. and approximately 90° C. for a period of between approximately 25 seconds and approximately 60 seconds.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: July 8, 2014
    Assignee: South Dakota State University
    Inventors: Robert J. Baer, Howard H. Bonnemann
  • Publication number: 20140162873
    Abstract: The invention is directed to improved methods for producing high-quality activated carbons from biochar. The invention also provides materials and methods for creation of activated carbons useful for purification of water, adsorption of gases or vapors, and catalyst supports. The methods include ash modification, physical activation, the addition of a catalyst, chemical activation, and removal and/or recycling of the catalyst. The usefulness of the present method is that it results in the production of a high-quality activated carbon from a waste product of the biofuel manufacturing process, thereby increasing the economic sustainability and viability of the biofuel production process itself.
    Type: Application
    Filed: July 11, 2013
    Publication date: June 12, 2014
    Applicant: SOUTH DAKOTA STATE UNIVERSITY
    Inventor: Zhengrong Gu
  • Patent number: 8697098
    Abstract: The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. The invention also encompasses a prolamine protein conjugated to a polymer, such as a polyethylene glycol (PEG) chain, which conjugates can be used to prepare micelle assemblies. The invention further encompasses methods of encapsulating molecules using the conjugates of the invention. The micelle assemblies can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of an encapsulated agent in vivo, protecting an encapsulated agent against degradation, and enhancing the water solubility of a drug or other agent.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: April 15, 2014
    Assignee: South Dakota State University
    Inventors: Omathanu P. Perumal, Satheesh K. Podaralla, Ranjith Kumar Averineni
  • Publication number: 20140073822
    Abstract: Reactors for the pyrolysis of pyrolyzable matter, pyrolysis systems incorporating the reactors and methods of using the reactors are provided. Also provided are systems and methods for integrating the pyrolysis and hydrodeoxygenation of pyrolyzable matter. The pyrolysis reactors create a horizontally rotating, fluidized-bed to which pyrolyzable matter, such as biomass, may be converted via pyrolysis into liquid fuels and/or value-added chemicals.
    Type: Application
    Filed: July 7, 2013
    Publication date: March 13, 2014
    Applicant: South Dakota State University
    Inventors: Lin Wei, James Julson