Patents Assigned to South Dakota State University
  • Immunogenic composition containing inactivated swine infertility and respiratory Syndrome virus
    Patent number: 6241990
    Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: June 5, 2001
    Assignees: Regents of the University of Minnesota, South Dakota State University, Boehringer Ingelheim Vetmedica, Inc.
    Inventors: James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
  • Vaccine for swine infertility and respiratory syndrome and method of use thereof
    Patent number: 6110468
    Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: August 29, 2000
    Assignees: Regents of the University of Minnesota, South Dakota State University, Boechringer Ingelheim Vetmedica, Inc.
    Inventors: James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
  • Culture of swine infertility and respiratory syndrome virus in simian cells
    Patent number: 5846805
    Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: December 8, 1998
    Assignees: Boehringer Ingelheim Animal Health, Inc., South Dakota State University, Regents of University of Minnesota
    Inventors: James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
  • Method for diagnosis of mystery swine disease
    Patent number: 5683865
    Abstract: The method of diagnosis of Mystery Swine Disease (MSD) is carried out with polyclonal or monoclonal antibody sera. Either the antibody sera or the biopsied tissue homogenate may be immobilized by contact by contact with a polystyrene surface or with a surface of another polymer for immobilizing protein. Preferably the monoclonal antibody is produced by a murine derived hybrid cell line wherein the antibody is an IgG or IgM type immunoglobulin. Example monoclonal antibodies to the infectious agent for SIRS are monoclonal antibody SDOW 12 and SDOW 17.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: November 4, 1997
    Assignees: South Dakota State University, Regents of the University of Minnesota
    Inventors: James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
  • Monoclonal antibodies to the Mystery Swine Disease virus
    Patent number: 5677429
    Abstract: Monoclonal antibody sera can be produced by hybridoma technique. After immunization of a mouse, pig, rat, rabbit or other appropriate species with Mystery Swine Disease (MSD) containing cell culture lysate, the spleen of the animal can be removed and converted into a whole cell preparation. Preferably the monoclonal antibody is produced by a murine derived hybrid cell line wherein the antibody is an IgG or IgM type immunoglobulin. Example monoclonal antibodies to the infectious agent for SIRS are monoclonal antibody SDOW 12 and SDOW 17.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: South Dakota State University
    Inventor: David A. Benfield