Abstract: A crowdsourced energy system includes a plurality of distributed energy resources managed by crowdsourcees of the system, a power network to which the distributed energy resources are connected, and a system operator that manages energy trading transactions and energy delivery within the system, the system operator operating at least one computing device configured to: obtain day-ahead peer-to-peer energy trading transaction requests from crowdsourcees for energy to be delivered from the distributed energy resources, estimate day-ahead energy load and solar forecasts, determine optimal power flow for the delivery of energy, and schedule delivery of energy from the distributed energy resources across the power network based upon the energy trading transaction requests, the estimated forecasts, and the determined optimal power flow.

Abstract: The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine and citric acid for a time sufficient to form a co-amorphous solid, which co-amorphous solid can be converted into a co-crystal, and nutritional supplements that include the same.

Abstract: Systems and methods for computing interactions of charge sources embedded in three dimensional (3D) layered media. At least one of the methods includes decomposing the Green's function representing the potential caused by a charge source into a free space component and a plurality of reaction components; generating, for each reaction component of the plurality of reaction components, a multipole expansion (ME) operator and a multipole to local (M2L) translation operator; performing, for each reaction component of the plurality of reaction components, a convergence analysis of an ME of that reaction component; defining, for each reaction component, polarization charge sources based on the convergence analysis and combining the polarization charges sources with the charge sources; and computing, using a fast multipole method (FMM), interactions of the charge sources based on the polarization charge sources, the ME operators, and the M2L translation operators.

Abstract: The present invention includes a system, apparatus and method for generating a three-dimensional image and/or printing a three-dimensional structures, the system comprising: a medium comprising an acid-sensitive photoinitiator, a photoacid, monomers, donors, and acceptors, wherein the acceptor has a non-fluorescent state and a fluorescent state, wherein at one wavelength of optical excitation an optical molecular switch molecule has a first state, and at a second state the optical molecular switch molecule fluoresces at a second wavelength of excitation; and at least a first light source and a second light source into the medium, wherein light emitted by the at least first and second light sources are directed to contact the acid-sensitive photoinitiator, wherein a first wavelength activates the photo acid, and the second wavelength triggers polymerization of the monomers.

Abstract: Provided herein is a method for determining a soil classification comprising: obtaining a soil sample; conducting two or more field tests on the soil sample to obtain raw data for each field test; and calculating the soil classification from the raw data by applying a previously obtained validation dataset obtained from a training and validation soil classification calculation using samples of known soil classification, wherein the validation dataset is obtained using a feed-forward backpropagation neural network.

Abstract: The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both.

Abstract: An apparatus and method for detecting one or more target molecules includes a hydrophobic substrate, and a sensor. The sensor includes two or more electrodes disposed on the hydrophobic substrate and separated from one another by a gap, a plurality of nanostructures formed on or within an upper surface of each electrode, a plurality of binding molecules attached to the plurality of nanostructures, wherein the plurality of binding molecules are configured to bind with the one or more target molecules, and wherein the upper surface of each electrode and the plurality of nanostructures are hydrophilic, and may further detect two or more analytes with two or more sensors that detect two or more different modalities, such as, electrical, optical fluorescence, optical resonance, magnetic detection, or acoustic waves.

Abstract: An optical motion sensor includes a substrate, a whispering-gallery-mode-based optical resonator disposed on the substrate, a mass-spring-damper system disposed on the substrate proximate to a first side of the whispering-gallery-mode-based optical resonator, and a waveguide or optical fiber. The whispering-gallery-mode-based optical resonator has a substantially circular cross-section. A gap separates an end of the mass-spring-damper system from the whispering-gallery-mode-based optical resonator. The waveguide or optical fiber abuts a second side of the whispering-gallery-mode-based optical resonator that is substantially opposite to the first side.

Abstract: A method for classifying a response signal of acceleration data of a structure includes obtaining at least one signal feature of a response signal, inputting the at least one signal feature into an artificial neural network, and classifying, using the artificial neural network, the response signal as an impact event or a non-impact event. One or more signal features may be used, including a response length feature, a number of peaks feature, a spectral energy feature, a dominant frequency feature, a maximum response feature, a center of mass feature, a slope feature, an average peak power feature, a response symmetry feature, or combinations thereof. One or more artificial neural networks may be used. The artificial neural networks may be trained using different combinations of signal features.

Abstract: Methods, systems, and computer readable media for analyzing an image using machine learning and human computation. A method for analyzing an image includes providing, via multiple instances of an interactive application for analysis of the image, multiple instances, respectively, of the image and receiving, via the interactive application, data from results of analyses of the image including multiple sets of user inputs from the analyses of the multiple instances of the image, respectively. The multiple sets of user inputs are from multiple users, respectively and the multiple users are associated with the multiple instances of the interactive application, respectively. The method further includes processing the received data to identify areas of interest within the image based on the multiple sets of user inputs and analyzing the image using a machine learning algorithm to identify structures in the image based on the identified areas of interest within the image.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The present invention includes a composition, method of making and method of using a novel C5-substituted carbapenem antibiotic of formula 1: R1 is H or CH3 R2 is not H, and is CH3, or C1-C6 straight chain, or branched alkyl, or C3-C6 cycloalkyl group, or unsaturated alkenyl, including C?CH2; R3 is H, CH3, or a C1-C6 alkyl or cycloalkyl group, a heteroatom-substituted alkyl; and R4 is a C1 to C6 alkyl, or substituted alkyl group, especially including substituents which possess positive charge, or a hydroxyl group; or R4 is an SRa, where Ra is an unsubstituted C1 to C6 alkyl group, a substituted C1 to C6 alkyl group, or a functional group that is positively charged, or which bears a positive charge when in aqueous solution at pH 7; or R4 is a CH2ORb, where Rb=C1 to C6 alkyl or substituted alkyl groups, substituted or unsubstituted aryl, or a heteroaryl groups.

Abstract: A system configured to generate images includes one or more narrowband electromagnetic sources configured to emit a first radiation and a second radiation. The system also includes a detector configured to detect first reflected radiation off of an object and second reflected radiation off of the object, where the first reflected radiation results from the first radiation and the second reflected radiation results from the second radiation. The system further includes a processor operatively coupled to the detector and configured to generate an image of the object based at least in part on a first amplitude of the first reflected radiation and a second amplitude of the second reflected radiation. The processor is also configured to determine a depth profile of the object based at least in part on the first reflected radiation and the second reflected radiation detected by the detector.

Abstract: In some implementations, a method includes retrieving data from multiple sensors in a computing device, and the multiple sensors comprise different types of sensors. The sensor data is analyzed based on a predictive model, and the predictive model is trained to detect malware. Initiation of malware is determined based on the analysis. In response to the determination, the malware is terminated.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The present invention is a Distally Assembled Steerable Cannula (DASC), a robotically-manipulated device that can be deployed and extended within a patient's body by growing from its distal end, or can be used in non-medical applications. In some embodiments, growth occurs by sequentially assembling segments that interlock to form a rigid tube with a complex 3-D shape. The segments are individually transported through the growing cannula, and then assembled at the distal end. A segment can be wedge-shaped in profile, allowing adjustment of the local radius and plane of curvature of the cannula to be controlled by relative segment orientation.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The present invention provides a method for the rapid monitoring of biological analytes in a point-of-care setting by providing a smart phone; providing a sample chamber; providing a sample; providing a dark box with a smartphone holder attached to the dark box top with the camera opening positioned about the aperture, adding a biological specimen suspected of containing a biological analyte in the sample chamber; adding a bis(2,4,6-trichlorophenyl) oxalate, an imidazole and a fluorophore to the sample chamber to react with the biological analyte; placing the sample chamber into the dark box; generating an emission from the fluorophore in response to the reaction with the biological analyte; and recording a set of time-lapse images of the emission with the smartphone.

Abstract: The present invention includes a process, system and apparatus for multi-material additive manufacturing process comprising: extruding an extrudable material through a nozzle capable of moving along one or more axis and concurrently extruding one or more filaments, wherein the filament is embedded in, on or about the extrudable material from the nozzle.

Abstract: A electrical switch has a first substrate, a first conducting layer disposed on the first substrate, a first dielectric layer disposed on the first conducting layer and a second conducting layer disposed on the first dielectric layer, and the second conducting layer disposed on the second substrate, and a conductive via connected to the first conducting layer and extending through the first dielectric layer. Active dielectric has a first conductor, a first dielectric layer disposed on the first conducting layer, one or more electrical switches disposed on the first dielectric layer, a dielectric layer disposed between neighboring electrical switches, the second dielectric layer disposed on the last electrical switch, and the second conducting layer disposed on the second dielectric layer.