Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.

Abstract: The present invention provides apparatuses, systems and methods for the controllable oxidation of bromide into bromine either directly through electrochemical (EC) anodes or indirectly through electrochemically generated oxidants.

Abstract: The present invention includes an apparatus and method for determining cell coverage in a region with reduced in-field propagation measurements comprising: obtaining geographical features of the region; predicting the number of measurements required to accurately characterize its path loss; determining the path loss prediction accuracy of wardriving and crowdsourcing by oversampling a suburban and a downtown region from cell measurements that comprise signal strength and global positioning system coordinates; and using statistical learning to build a relationship between these geographical features and the measurements required, thereby reducing the number of measurements needed to determine path loss accuracy.

Abstract: The present invention describes a speech enhancement method using microphone arrays and a new iterative technique for enhancing noisy speech signals under low signal-to-noise-ratio (SNR) environments. A first embodiment involves the processing of the observed noisy speech both in the spatial- and the temporal-domains to enhance the desired signal component speech and an iterative technique to compute the generalized eigenvectors of the multichannel data derived from the microphone array. The entire processing is done on the spatio-temporal correlation coefficient sequence of the observed data in order to avoid large matrix-vector multiplications. A further embodiment relates to a speech enhancement system that is composed of two stages. In the first stage, the noise component of the observed signal is whitened, and in the second stage a spatio-temporal power method is used to extract the most dominant speech component.

Abstract: An integrated circuit has a first scan cell segment, a second scan cell segment connected to one or more hidden content, and a scan cell circuit connected to the first scan cell segment and the second scan cell segment. The scan cell circuit alternatively provides access to the first scan cell segment and the second scan cell segment based on a state of the scan cell circuit.

Abstract: Various integrated circuits protect hidden content e.g., embedded instruments, keys, data, etc.) using scan cell circuit(s). For example, a first scan cell circuit is connected to the hidden content, and a second scan cell circuit is connected to the first scan cell circuit forming all or part of a serial data path. The first scan cell circuit provides access to the hidden content whenever the first scan cell circuit is in a first specified state and prevents access whenever the first scan cell circuit is in a different state. The first scan cell circuit does not interrupt the serial data path when the first scan cell circuit is in the different state. The second scan cell circuit changes an operational characteristic of the first scan cell circuit whenever the second scan cell circuit is in a second specified state. In some cases, the second scan cell circuit can be eliminated.

Abstract: Methods, apparatuses, and computer program products for squaring an operand include identifying a fixed-point value with a fixed word size and a substring size for substrings of the fixed-point value, wherein the fixed-point value comprises a binary bit string. A square of the fixed-point value can be determined using the fixed point value, the substring size, and least significant bits of the fixed-point value equal to the substring size.

Abstract: The present invention describes a speech enhancement method using microphone arrays and a new iterative technique for enhancing noisy speech signals under low signal-to-noise-ratio (SNR) environments. A first embodiment involves the processing of the observed noisy speech both in the spatial- and the temporal-domains to enhance the desired signal component speech and an iterative technique to compute the generalized eigenvectors of the multichannel data derived from the microphone array. The entire processing is done on the spatio-temporal correlation coefficient sequence of the observed data in order to avoid large matrix-vector multiplications. A further embodiment relates to a speech enhancement system that is composed of two stages. In the first stage, the noise component of the observed signal is whitened, and in the second stage a spatio-temporal power method is used to extract the most dominant speech component.

Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: The present invention provides pharmaceutical compound of formula: wherein A and B are individually an C or N and R1 is an alkyl and R2 is a substituted phenyl, wherein the substituted phenyl comprises 1 to 3 functional groups and R3-R6 are individually a hydrogen, an amine or a halogen disposed in a pharmaceutical carrier.

Abstract: An automated calibration device that comprises a tube for trapping a multiphase sample between three ultrasound (US) transducer pairs wherein each of the three transducer pairs is positioned to measure a different fraction of the multiphase sample.

Abstract: The present invention provides multi-thiol mercaptoalkoxysilane compositions and methods of making multi-thiol mercaptoalkoxysilane compositions having the formula: wherein the R3 group, and the R4 group are independently an alkoxy, a halogen, an alkyl, an aryl, a heteroaryl, a heterocycle or derivatives thereof and n is an integer between 1 and 30.

Abstract: The present invention includes a digital controller for use with an ultrasound power amplifier circuit to increase linearity and efficiency of the ultrasound power amplifier circuit. The digital controller includes a digital signal generator and a memory unit that is coupled to the digital signal generator. The memory unit includes a processor that obtains an output signal from the ultrasound power amplifier circuit, calculates error by obtaining a difference between an ideal output signal and the output signal that is obtained from the ultrasound power amplifier circuit, and equalizes an input signal from the digital signal generator to reduce nonlinearity in the output signal of the ultrasound power amplifier circuit. The memory unit includes a look-up-table for storing values of error.

Abstract: The present invention provides a device and method for classifying a user using pattern recognition of an input device. A series of the keystroke objects are received via the user input interface. A typing signature is determined for the series of keystroke objects using the processor by analyzing the key attributes of the series of keystroke objects using a pattern recognition algorithm. The typing signature is compared to one or more user typing signatures stored in the memory using the processor. The user is classified based on whether or not the typing signature is statistically similar to one of the stored typing signatures.

Abstract: The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.

Abstract: A system includes a camera and a projector for capturing spatial detail having resolution exceeding that afforded by the imaging optics, and recovering topographic information lost to the projective nature of imaging. The projector projects a spatial pattern onto the scene to be captured. The spatial patterns may include any pattern or combination of patterns that result in complex sinusoidal modulation. Spatial detail such as texture on the objects in the scene modulate the amplitude of the spatial pattern, and produce Moiré fringes that shifts previously unresolved spatial frequencies into the camera's optical passband. The images may be demodulated, and the demodulated components may be combined with the un-modulated components. The resulting image has spatial detail previously inaccessible to the camera owing to the band-limited nature of the camera optics. A spatial pattern may also be projected and received by the camera to estimate topographic information about the scene.

Abstract: The present invention is a Distally Assembled Steerable Cannula (DASC), a robotically-manipulated device that can be deployed and extended within a patient's body by growing from its distal end, or can be used in non-medical applications. In one embodiment, growth occurs by sequentially assembling segments that interlock to form a rigid tube with a complex 3-D shape. The segments are individually transported through the growing cannula, and then assembled at the distal end. A segment can be wedge-shaped in profile, allowing adjustment of the local radius of curvature and direction of the cannula to be controlled by relative segment orientation.

Abstract: The present invention provides multi-thiol mercaptoalkoxysilane compositions and methods of making multi-thiol mercaptoalkoxysilane compositions having the formula: wherein the R3 group, and the R4 group are independently an alkoxy, a halogen, an alkyl, an aryl, a heteroaryl, a heterocycle or derivatives thereof and n is an integer between 1 and 30.