Abstract: The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.

Abstract: A multi-valued logic (MVL) circuit includes a MVL clock generator that generates a MVL clock signal having three or more ith MVL levels, a single MVL clock signal distribution network connected to the MVL clock generator, and three or more ith MVL selection circuits connected to the single MVL clock signal distribution network where i=0 to N and N>=3. Each ith MVL selection circuit corresponds to a specified ith MVL level. The ith MVL selection circuit outputs an ith binary clock signal having: (a) a first logic level whenever the MVL clock signal is equal to the ith MVL level and the ith data input receives the first logic level, (b) a second logic level whenever the MVL clock signal is equal to the ith MVL level and the ith data input receives the second logic level, and (c) a previous logic level of the ith binary clock signal whenever the MVL clock signal is not equal to the ith MVL level.

Abstract: The present invention includes a digital controller for use with an ultrasound power amplifier circuit to increase linearity and efficiency of the ultrasound power amplifier circuit. The digital controller includes a digital signal generator and a memory unit that is coupled to the digital signal generator. The memory unit includes a processor that obtains an output signal from the ultrasound power amplifier circuit, calculates error by obtaining a difference between an ideal output signal and the output signal that is obtained from the ultrasound power amplifier circuit, and equalizes an input signal from the digital signal generator to reduce nonlinearity in the output signal of the ultrasound power amplifier circuit. The memory unit includes a look-up-table for storing values of error.

Abstract: Inhibitors of the enzyme beta-lactamase are provided. The compounds are adapted to inhibit beta-lactamase as produced by beta-lactam resistant bacterial strains. Methods of treatment of beta-lactam resistant bacterial infections in patients are provided.

Abstract: A system and method for providing multi-dimensional context-aware adaptation in vehicular networks is disclosed. The system comprises a collection module, a context resolving module, a parameter determination module and a distribution module. The collection module collects context data describing a context in a communication environment. The context resolving module resolves the context data to a matching historical context and determines one or more historical context groups associated with the matching historical context. The parameter determination module determines a subset of operating parameters from the one or more historical context groups. The distribution module distributes the subset of operating parameters to a network stack communication module.

Abstract: The present invention describes a speech enhancement method using microphone arrays and a new iterative technique for enhancing noisy speech signals under low signal-to-noise-ratio (SNR) environments. A first embodiment involves the processing of the observed noisy speech both in the spatial- and the temporal-domains to enhance the desired signal component speech and an iterative technique to compute the generalized eigenvectors of the multichannel data derived from the microphone array. The entire processing is done on the spatio-temporal correlation coefficient sequence of the observed data in order to avoid large matrix-vector multiplications. A further embodiment relates to a speech enhancement system that is composed of two stages. In the first stage, the noise component of the observed signal is whitened, and in the second stage a spatio-temporal power method is used to extract the most dominant speech component.

Abstract: According to one embodiment, a system includes at least one memory and at least one processor. The processor receives information that includes a position or motion of one or more points of a body during a movement. Based at least on the position or motion of the one or more points of the body during the movement, the processor calculates a first one or more curves indicative of a first force between a surface and at least a first portion of the body, and calculates a second one or more curves indicative of a second force between the surface and at least a second portion of the body. The processor further predicts a force applied to the surface by the body during the movement by combining the first and second one or more curves.

Abstract: Inhibitors of the enzyme beta-lactamase of formula (I): are provided. The compounds are adapted to inhibit beta-lactamase as produced by beta-lactam resistant bacterial strains. Methods of treatment of beta-lactam resistant bacterial infections in patients are provided.

Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.

Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.

Abstract: A device for automated calibration of a multiphase flowmeter comprising a tube for trapping a multiphase sample along with three ultrasound (US) transducers is described herein. The calibration device is placed vertically, using two valves the tube traps a sample of the liquid in the tube. Then, once the three phases of the liquid separate, the ultrasound transmitters are used to determine the phase fractions of each phase.

Abstract: The present invention provides a device and method for classifying a user using pattern recognition of an input device. A series of the keystroke objects are received via the user input interface. A typing signature is determined for the series of keystroke objects using the processor by analyzing the key attributes of the series of keystroke objects using a pattern recognition algorithm. The typing signature is compared to one or more user typing signatures stored in the memory using the processor. The user is classified based on whether or not the typing signature is statistically similar to one of the stored typing signatures.

Abstract: A novel micro-optical electric field sensor exploits morphology-dependent shifts of the optical modes of dielectric cavities to measure temporally- and spatially-resolved of electric field with extremely high sensitivity. The measurement principle is based on the electrostriction effect on the optical modes of dielectric micro-resonators (or micro-cavities) and exploits recent developments in optical fiber and switching technologies. The optical modes are commonly referred to as “whispering gallery modes” (WGM) or “morphology dependent resonances” (MDR). By monitoring the WGM shifts, the electric field causing the electrostriction effect can be determined. Different sensitivities and measurement ranges (maximum measured electric field) can be obtained by using different cavity geometries (for example solid or hollow spheres), polymeric materials (PMMA, PDMS, etc) as well as poling the dielectric material.

Abstract: Transforming an integer comprises receiving the integer, where the integer can be expressed as a modular factorization. The modular factorization comprises one or more factors, where each factor has an exponent. The integer is expressed as a product of residues. A discrete logarithm of the integer is established from a sum corresponding to the product of residues. A value for an exponent of a factor is determined from the discrete logarithm. The integer is represented as the modular factorization comprising the one or more factors, where each factor has a value for the exponent.

Abstract: Systems and methods for processing medical image data with increased sensitivity to facilitate comparisons among groups of subjects are disclosed herein. In one embodiment, a method comprises receiving a first three-dimensional image comprising a plurality of voxels, reducing a regional trend within the three-dimensional image, computing a semivariogram for a region of interest, defining at least one block of spatially correlated voxels, calculating voxel weights for each voxel within the at least one block, and determining a block average count and variance for the at least one block.

Abstract: Determining a table output of a table representing a hierarchical tree for an integer valued function includes determining an address from a table input. A subset of a memory is selected according to the address, where the memory represents the hierarchical tree and the subset represents a subtree of the hierarchical tree. Bit fields are selected from the subset, and bits are extracted from the bit fields. A table output is determined from the extracted bits.

Abstract: Measuring mechanical propulsive power includes establishing a first power and a second power. The first power is associated with a first rate of energy conversion by a device in a fluid, where the device is in the wake of a self-propelled conveyance moving with respect to the fluid. The average distance between the device and self-propelled conveyance may remain substantially unchanged. The second power is associated with a second rate of energy conversion by the device in the fluid without the self-propelled conveyance, where the other physical factors are substantially similar to that associated with the first power. The difference between the first power and the second power is calculated. The mechanical propulsive power for the self-propelled conveyance is determined using mappings, where a mapping associates the difference with the mechanical propulsive power.

Abstract: The present invention provides compositions and methods of synthesizing optionally substituted 3-substituted indolin-2-ones and methods to employ the resultant compounds to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke.

Abstract: An apparatus and method to determine fractions of various phases in a multiphase fluid. The apparatus includes main body including an interior configured receive a multiphase fluid and an exterior. The apparatus senses fluid pressure of multiphase fluid received in the interior and senses a fluid temperature of the multiphase fluid. The apparatus transmits an ultrasonic wave into the fluid and detects the transmitted wave to determine its velocity and attenuation. The apparatus may adjust the determined velocity and attenuation based on the temperature and pressure of the fluid to compensate for a difference between the sensed temperature and pressure and a standard temperature and pressure. The apparatus determines a gas fraction, water fraction, and a non-water fluid fraction of the multiphase fluid based on the sensed fluid pressure, the sensed fluid temperature, and the velocity and attenuation of the ultrasonic wave in the multiphase fluid.

Abstract: An apparatus and method to determine fractions of various phases in a multiphase fluid. The apparatus includes main body including an interior configured receive a multiphase fluid and an exterior. The apparatus senses fluid pressure of multiphase fluid received in the interior and senses a fluid temperature of the multiphase fluid. The apparatus transmits an ultrasonic wave into the fluid and detects the transmitted wave to determine its velocity and attenuation. The apparatus may adjust the determined velocity and attenuation based on the temperature and pressure of the fluid to compensate for a difference between the sensed temperature and pressure and a standard temperature and pressure. The apparatus determines a gas fraction, water fraction, and a non-water fluid fraction of the multiphase fluid based on the sensed fluid pressure, the sensed fluid temperature, and the velocity and attenuation of the ultrasonic wave in the multiphase fluid.