Abstract: A compound midazolam-D3 and its preparation method as it's synthesized from 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Compound II), by ring closure reaction with ethyl isocyanoacetate, hydrolysis with base, ring-opening with acid, ring closure under high temperature, and reacted with trideuteromethyl reagent; the synthetic route has advantage of short synthetic route appropriate, accessible and affordable. The prepared midazolam-D3 has characteristic with high purity, high deuterium content and very good stability.

Abstract: A pilot assembly having a shaped portion and a shaped fastener relief for attachment to a die. The pilot assembly includes a fastener with a shaped washer that engages the shaped fastener relief to permit installation and removal of the pilot from the die. The shaped portion of the pilot assembly helps to locate and center the stock down the pilot assembly toward the die.

Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).

Abstract: A method for identifying and tracking an inventory item is provided. The method includes using two or more sensors to produce two or more outputs associated with an inventory item, including at least one of a possible identifier for the inventory item and a possible event type indicating whether the inventory item has been taken from a shelf or placed onto a shelf. The method further includes generating confidence levels for the inventory item, wherein each respective confidence level is based on a subset of one or more outputs, and identifying, based on the confidence levels, a prediction for the inventory item including at least one of a predicted identifier for the inventory item and a predicted event type for the inventory item. The method further includes modifying a planogram of a shopping store based on the prediction for the inventory item.

Abstract: Described herein are methods, kits and systems for sample enrichment, multi-step library preparation, sample normalization, detection of sample biomolecules and combinations thereof. Enrichment and multi-step library preparation is described in the context of microfluidic workflows. Sample barcoding methods and kits are described for increasing sample throughput while reducing background in negative samples. Integrated microfluidic devices comprising sample processing unit cells coupled to an array of reaction sites are provided for integrated workflows.

Abstract: A pump assembly and method is disclosed comprising, a pump including a pump housing having a fluid inlet and at least one fluid outlet extending from the pump housing. A magnetic body of a brushless DC motor is submerged in the fluid and drives an impeller that moves the fluid from the fluid inlet to the at least one fluid outlet. A valve rotatably mounted between the impeller and the at least one fluid outlet selectively directs the flow of fluid through the at least one fluid outlet.

Abstract: A push-on fastener for engagement on a cylindrical stud includes a body having oppositely facing first and second exterior surfaces and an outer marginal periphery. A central opening extends axially through the body between the oppositely facing exterior surfaces defining an inner periphery. A first resilient tab includes a first engagement edge and a second resilient tab includes a second engagement edge. The first engagement edge defining an inner periphery of the central opening and the second engagement edge defining a periphery that is outwardly of the inner periphery of the central opening.

Abstract: The present disclosure relates to a method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, belonging to the field of functional emulsions. The method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, includes the following steps: (1) WPI, Tween 80 and water were mixed evenly according to the amount ratio of 0.5 g:0.5-0.7 g:50 mL to obtain the aqueous phase; (2) Mixing a saponin extract containing the minor ginsenosides Rg3 and CK with edible oil evenly to obtain the oil phase; (3) Mixing the aqueous phase with the oil phase, carrying out shearing dispersion to obtain coarse emulsion, and then allowing the coarse emulsion to be subjected to microfluidization homogenization to obtain an oil-in-water nano-emulsion containing the minor ginsenosides Rg3 and CK.

Abstract: An assembly comprising a housing having a first and a second fluid inlet for directing fluid to a pump cavity. A valve switch located in the housing is arranged to selectively switch the flow of the fluid between the second fluid inlet and the pump cavity. A fluid outlet is fluidically connected to the pump cavity and an impeller contained in the pump cavity is arranged to be rotated on demand by an electrical motor that accelerates the fluid in the pump cavity out of the fluid outlet.

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.

Abstract: Automated techniques provide for recalibrating cameras in a real space in which puts and takes of items are tracked. The method includes first processing one or more selected images selected from a plurality of sequences of images received from a plurality of cameras calibrated using a set of calibration images that were used to calibrate the cameras previously. The first processing includes a process step to match one or more features from the selected images with features extracted from the set of calibration images using a trained neural network classifier. The features correspond to points located at displays or structures that remain substantially immobile. Camera calibrations can be updated when transform information between features matched meets or exceeds a threshold.

Abstract: Disclosed are embodiments of an apparatus and system for performing a sleeve gastrectomy. The apparatus can include a bougie for insertion into an interior of a stomach, the bougie having a proximal bougie end and a distal bougie end, an inflation lumen having a proximal lumen end and a distal lumen end, the inflation lumen extending from the proximal bougie end through the distal bougie end, a fluid delivery system coupled with the proximal lumen end, the fluid delivery system being operably configured to deliver positive pressure in a predetermined positive pressure range into the stomach, and a monitor coupled with the proximal lumen end operably configured for the monitoring of pressure or volume within the stomach. The bougie can be operably configured to define a resection line for the sleeve gastrectomy when the predetermined positive pressure range is achieved within the stomach.

Abstract: Systems and methods for reducing insufflation loss due to gas leakage during a laparoscopic surgical procedure are provided. The surgical procedure includes the use of a surgical instrument having an end effector and a trocar through which the surgical instrument is inserted for access to the abdominal cavity of a patient receiving laparoscopic surgery. The trocar includes a lip, a lip seal disposed within the lip, and a cannula located beneath the lip. The systems and methods reduce or prevent a loss of insufflation when using conventional systems and methods to insert the surgical instrument through a conventional trocar.

Abstract: Provided herein is an asphalt membrane emulsion for reducing voids in an asphalt joint that includes asphalt, an asphalt modifier, mineral filler, an emulsifier, and water. Provided herein is a method of making an asphalt membrane emulsion, the method including: forming a first phase; forming a second phase; pumping the first phase and the second phase into a colloid mill; and mixing the first phase and second phase into the colloid mill to form the asphalt membrane emulsion. The first phase includes asphalt, asphalt modifier, and mineral filler. The second phase includes water and an emulsifier. A method of applying an asphalt membrane emulsion to fill a crack is also provided.

Abstract: A surgical system and device for use with a computerized surgical manipulation system, wherein the computerized surgical manipulation system includes a robotic arm and a support coupled to the robotic arm for receiving various instruments, comprising a surgical device, wherein the surgical device includes an elongated shaft; and a control housing coupled to the elongated shaft, wherein the control housing is configured to attach to a motor housing having a notch, wherein the motor housing is coupled to the support; and a trocar pivotally coupled to the support such that the trocar can pivot away from axial alignment with the support, wherein the elongated shaft extends into the pivoted trocar, wherein the trocar containing the surgical device is pivoted into axial alignment with the support such that the notch receives the elongated shaft of the surgical device, and wherein the control housing engages the motor housing.

Abstract: The disclosed technology generally relates to energy storage devices, and more particularly to redox batteries. In one aspect, a redox battery comprises a first half cell and a second half cell. The first half cell comprises a positive electrolyte reservoir comprising a first electrolyte contacting a positive electrode and has dissolved therein a first redox couple configured to undergo a first redox half reaction. The second half cell comprises a negative electrolyte reservoir comprising a second electrolyte contacting a negative electrode and has dissolved therein a second redox couple configured to undergo a second redox half reaction. The redox battery additionally comprises an ion exchange membrane separating the positive electrolyte reservoir and the negative electrolyte reservoir. The first half cell, the second half cell and the ion exchange membrane define a redox battery cell that is sealed in a casing.

Abstract: A pump assembly is disclosed comprising, a pump including a pump housing having a fluid inlet. At least one fluid outlet extends from the pump housing. An impeller driven by a motor is mounted in the pump housing arranged to move a fluid from the fluid inlet to the at least one fluid outlet. A valve rotatably mounted between the impeller and the at least one fluid outlet selectively controls the flow of fluid through the at least one fluid outlet.

Abstract: A system for sensing a physical property of a fluid flowing inside a composite hose includes a radio frequency identification (RFID) reader arranged to transmit radio frequency signals. An RFID tag receives the radio frequency signals and exchanges the received radio frequency to electrical energy powering the RFID tag. An included sensor electrically connected to the RFID tag receives the electrical energy from the RFID tag and powers the sensor to obtain measurement data of at least one physical property of the fluid and transmit the measurement data to the RFID tag. The RFID tag transmits the measurement data to the RFID reader using the radio frequency.