Abstract: A predictive network service provisioning method uses personal schedule information of a user [120] to predict the geographic/network location of the user, the operational context of a user, and/or the computation and communication needs of a user. These predicted user attributes may be used to reduce network latency by prepositioning user data [122] at a location [126] closer to the user, allocating services and/or resources for the user at the predicted location, and/or providing the user with access to the prepositioned personal data files [138] and services when requested by the user.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: Devices and methods for preventing tracheal aspiration as described, where a cuff assembly having an inflatable member with an inflation tube fluidly coupled may be placed over a proximal end of an endotracheal tube or laryngeal mask and inserted into the patient trachea with the endotracheal tube or separately after the endotracheal tube has already been positioned. In either case, the inflatable member may be positioned distal (or inferior) to the vocal cords and proximal to the endotracheal balloon via a delivery instrument which automatically positions the balloon in proximity to the vocal cords.

Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

Abstract: Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

Abstract: Example embodiments relate to a solar cell including organic nanowires. The solar cell may include a photoelectric conversion layer formed of a p-type material including an organic material and an n-type material including organic nanowires.

Abstract: A method of real-time radiotherapy beam visualization is provided that includes disposing a free-form flexible scintillating sheet on a subject of interest, irradiating the subject of interest with a source of ionizing radiation, where the free-forming flexible scintillating sheet emits light when irradiated by the therapeutic photon beam, collecting the emitted light and collecting ambient light reflected from the subject of interest and surrounding objects using a camera, where the collected light is converted to image data by the camera, where the image data is communicated to an appropriately programmed computer, and processing the image data to determine beam characteristics and the characteristics of the subject of interest, using the appropriately programmed computer, where the beam characteristics and the characteristics of the subject of interest are displayed in real-time to a machine operator enabling real-time verification of treatment delivery.

Abstract: Predictive biomarkers identify those patients suffering from immunoglobulin positive (Ig+) B lineage malignancies that are responsive to active immunotherapy, where the active immunotherapy comprises vaccination with a tumor-specific idiotype-immunogen. It is shown herein that patient responsiveness to the idiotype-immunogen is dependent upon the sequence of the immunogen, where an immunogen having a low number of tyrosine residues in the CDR1 (herein termed CDR1-Y10) regions of one or both of the immunogen heavy and light chains is predictive of a positive anti-tumor response, while a high number of CDR1 tyrosine residues (herein termed CDR1-Yhi) is predictive of a low anti tumor response.

Abstract: Improved thermionic energy converters are provided by electrodes that include a silicon carbide support structure, a tungsten adhesion layer disposed on the silicon carbide support structure, and an activation layer disposed on the tungsten adhesion layer. The activation layer is a material that lowers the electrode work function, such as BaO, SrO and/or CaO.

Abstract: Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity are disclosed. In particular, the invention relates to engineered protein voltage sensors that comprise a voltage-sensing domain comprising four transmembrane domains linked to a circularly permuted fluorescent protein, which is inserted into the extracellular loop between the third (S3) and fourth (S4) transmembrane segments of the voltage-sensing domain. Such fluorescent protein voltage sensors can be used for measuring the electrical activity of neurons, including single action potentials, trains of action potentials, and subthreshold potential changes and, in particular, for imaging high-frequency neuronal electrical activity.

Abstract: A method for measuring ammonia in a blood sample may involve positioning the blood sample in proximity with an ammonia gas sensor, generating a current with the ammonia gas sensor in response to ammonia gas released from the blood sample, and measuring the current generated by the ammonia gas sensor, using a current measurement member coupled with the ammonia gas sensor. A device for measuring an ammonia level in a blood sample may include a blood sample containment member, an ammonia gas sensor coupled with the blood sample containment member, and a current measurement member coupled with the ammonia gas sensor. The method and device may be used to measure an ammonia level in a blood sample as small as one drop of blood, or approximately 0.05 mL of blood.

Abstract: A thermally-conductive and mechanically-robust bonding method for attaching a metal nanowire (MNW) array to an adjacent surface includes the steps of: removing a template membrane from the MNW; infiltrating the MNW with a bonding material; placing the bonding material on the adjacent surface; bringing an adjacent surface into contact with a top surface of the MNW while the bonding material is bondable; and allowing the bonding material to cool and form a solid bond between the MNW and the adjacent surface. A thermally-conductive and mechanically-robust bonding method for attaching a metal nanowire (MNW) array to an adjacent surface includes the steps of: choosing a bonding material based on a desired bonding process; and without removing the MNW from a template membrane that fills an interstitial volume of the MNW, depositing the bonding material onto a tip of the MNW.

Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a first gateway circuit in an optical access network connecting a plurality of end-of-network users to a central node, the first gateway circuit connecting one of the plurality of end-of-network users to the central node via fiber optic data lines. Further, the first gateway circuit is configured and arranged to: relay a first set of data between the end-of-network user and the central node using a packet-switching communication protocol, and relay a second set of data between the end-of-network user and the central node using an optical flow switching communication protocol.

Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitDynaivity to antigens.

Abstract: Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.

Abstract: According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.

Abstract: A crossed nanobeam structure for strain engineering in semiconductor devices is provided. For example, such a structure can be used for a low-threshold germanium laser. While the photonic crystal nanobeam enables light confinement in a subwavelength volume with small optical loss, another crossing nanobeam induces high tensile strain in the small region where the optical mode is tightly confined. As maintaining a small optical loss and a high tensile strain reduces the required pumping for achieving net optical gain beyond cavity losses, this technique can be used to develop an extremely low-threshold Ge laser source. Moreover, the structure can be easily integrated into electronic and photonic circuits.

Abstract: A method of conductively coupling a carbon nanostructure and a metal electrode is provided that includes disposing a carbon nanostructure on a substrate, depositing a carbon-containing layer on the carbon nanostructure, according to one embodiment, and depositing a metal electrode on the carbon-containing layer. Further provided is a conductively coupled carbon nanostructure device that includes a carbon nanostructure disposed on a substrate, a carbon-containing layer disposed on the carbon nanostructure and a metal electrode disposed on the carbon-containing layer, where a low resistance coupling between the carbon nanostructure and metal elements is provided.

Abstract: Described here is a solid-state lithium-ion battery, comprising a cathode, an anode, and a solid-state electrolyte disposed between the cathode and the anode, wherein the electrolyte comprises a hexacyanometallate represented by AxPy[R(CN)6-wLw]z, wherein: A is at least one alkali metal cation, P is at least one transition metal cation, at least one post-transition metal cation, and/or at least one alkaline earth metal cation, R is at least one transition metal cation, L is an anion, x, y, and z are related based on electrical neutrality, x>0, y>0, z>0, and 0?w?6.

Abstract: A capacitive micromachined ultrasonic transducer (CMUT) is provided that includes a substrate, a bottom conductive layer disposed on a bottom surface of the substrate, a cavity disposed into a top surface of the substrate, a nonconductive layer disposed on the substrate top surface and on the cavity, a CMUT plate disposed on the nonconductive layer and across the cavity, a top conductive layer disposed on a top surface of the CMUT plate, a pressure control via that spans from the cavity to an ambient environment, and an active pressure controller connected to the pressure control via, wherein the active pressure controller is capable of actively varying a pressure differential across the CMUT plate.