Abstract: Systems and methods of the present disclosure provide a control solution for a robotic actuator. The actuator can have one or two degrees of freedom of control, and can connect with a platform using an arm. The arm can have at least two degrees of freedom of control, and the platform can have at least two degrees of freedom of control. The platform can be subjected to unpredictable forces requiring a control response. The control solution can be generated using operational space control, using the degrees of freedom of the arm, platform and actuator.
Type:
Grant
Filed:
April 23, 2021
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Methods are provided for the isolation and analysis of circular DNA from complex samples, based on the topology of the DNA molecule. A sample comprising DNA species is combined with a chaotropic dense salt solution. A fraction containing the circular DNA of interest is isolated and dialyzed to remove excess salt. In some embodiments salt gradients are generated by ultracentrifugation in the absence of intercalating dyes, e.g. ethidium bromide; and in the absence of protease digestion. The circular DNA thus isolated is substantially pure, e.g. greater than about 75%, greater than about 80%, greater than about 90%, greater than about 95% of DNA in the isolated fraction is comprised of circular DNA.
Type:
Grant
Filed:
January 18, 2023
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Massa Shoura, Stephen Levene, David Girata
Abstract: The disclosure provides NIR-II imaging probes and methods of using the NIR-II imaging probes for dynamic in vivo tracking of cells, such as stem cells, or other substances. NIR-II imaging probes can include a biocompatible NIR-II dye molecule coupled to an organic, biocompatible protein carrier complex, including a carrier protein coupled to a cell-penetrating peptide.
Type:
Grant
Filed:
February 19, 2021
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of Leland Stanford Junior University
Abstract: A supported catalyst includes: (1) a catalyst support; and (2) deposits of a catalyst covering the catalyst support, wherein the deposits have an average thickness of about 2 nm or less, and the deposits are spaced apart from one another.
Type:
Grant
Filed:
November 7, 2018
Date of Patent:
April 9, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaft
Inventors:
Friedrich B. Prinz, Thomas Jaramillo, Drew C. Higgins, Yongmin Kim, Shicheng Xu, Thomas Schladt, Tanja Graf
Abstract: Cable-actuated differential enabling N degrees of freedom provided by a plurality of pulleys and at least N+1 tensioning cables. The cable-actuated differential increases a dynamic force range by minimizing co-activation of the tensioning cables at any operating point. A cable-actuated differential having three cables provides motor based control of a 2 DOF joint that can be applied to robots or teleoperation. A cable-actuated mechanical differential having opposing bevel gears and a middle bevel gear meshed with the opposing gear allows an output connector to controllably and independently rotate about the x axis or y axis via three operational modes without backlash.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
J. Kenneth Salisbury, Jr., Alex Nathan Kahn
Abstract: Provided herein are methods for treating, reducing and/or ameliorating symptoms of autism spectrum disorder (ASD) in a subject, where at least one measure of social impairment, anxiety, or repetitive behaviors is treated and/or ameliorated. Aspects include intranasally administering arginine vasopressin (AVP), or an analog of vasopressin, to a subject (e.g., a child between 6 and 12 years of age and having endogenous pre-treatment levels between about 0.045 and about 4.028 pg/mL, where the mean was 1.324 pg/mL). In children having high pre-treatment blood levels of AVP (e.g., about 25% or more above the mean pre-treatment AVP blood levels of the treatment group; or having pre-treatment blood vasopressin levels greater than 1.324 pg/mL), the treatment was enhanced. Because no difference in pre-treatment blood AVP levels was observed between control and ASD subjects, it was surprising that AVP treatment was more effective in subjects having high pre-treatment AVP levels.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Karen J. Parker, Dean S. Carson, Antonio Y. Hardan
Abstract: The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
April 9, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A method for quantitative magnetic resonance imaging (MRI) includes [800] performing an MRI scan using a conventional pulse sequence to obtain a qualitative MR image; and [802] applying the qualitative MR image as input to a deep convolutional neural network (CNN) to produce a quantitative magnetic resonance (MR) relaxation parametric map. The qualitative MR image is the only image input to the deep neural network to produce the quantitative MR relaxation parametric map. The conventional pulse sequence may be a Spoiled Gradient Echo sequence, a Fast Spin Echo sequence, a Steady-State Free Precession sequence, or other sequence that is commonly used in current clinical practice.
Type:
Grant
Filed:
December 12, 2019
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Aspects of various embodiments are directed to sensor apparatuses and methods thereof. An example sensor apparatus includes a capacitor and sensor circuitry. The capacitor includes a first substrate having a first electrode, a second substrate having a second electrode, and a dielectric layer. The dielectric layer has a plurality of apertures arranged in a pattern, the first and second electrode being separated by the dielectric layer and arranged with an overlapping area with respect to one another. The sensor circuitry is coupled to the capacitor and configured and arranged to detect normal and shear forces applied to the sensor apparatus based on changes in capacitance derived from changes in at least one of a distance between the first and second electrodes and the overlapping area of the first and second electrodes.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Zhenan Bao, Mark R. Cutkosky, Jooyeun Ham
Abstract: Simulated motion of the papillary muscles in a heart simulator is provided that simulates natural motion of the papillary muscles. This improves heart valve simulation. This can be done with a six degree of freedom robotic actuator (e.g., a Stewart platform or the like) appropriately driven by a controller. This can also be done with a robotic actuator that provides constrained motion of its effector by including a mechanical linkage, as long as the resulting simulated papillary muscle motion includes time-varying position and orientation of the papillary muscle.
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
April 2, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Y. Joseph Woo, Michael John Paulsen, Annabel M. Imbrie-Moore, Matthew Park, Rohun Kulkarni
Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.
Type:
Application
Filed:
November 17, 2023
Publication date:
March 28, 2024
Applicants:
CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Elizabeth Yang Chen, Felicia Reinitz, Jane Antony, Michael F. Clarke, Robert C. Jones
Abstract: Compositions comprising an iboga alkaloid and a cardioprotective agent are provided. Use of the compositions in treating neuropsychiatric disorders are described, where the cardioprotective agent is administered before, during and/or after the iboga alkaloid.
Type:
Application
Filed:
September 14, 2023
Publication date:
March 28, 2024
Applicants:
The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
Inventors:
Nolan R. Williams, Ian Kratter, AnnaMarie Daniels, Gregory Bird
Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
Type:
Application
Filed:
September 6, 2023
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
Abstract: The present disclosure provides methods of improving the structure and/or function of a joint tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating joint dysfunction and/or degeneration associated with aging, injury, disease, disorder, and/or condition.
Type:
Application
Filed:
December 9, 2021
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Helen M. BLAU, Nidhi BHUTANI, Mamta SINGLA, Adelaida Rosa PALLA
Abstract: Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.
Type:
Application
Filed:
August 18, 2023
Publication date:
March 28, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jacob J. Chabon, David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.
Type:
Application
Filed:
September 14, 2023
Publication date:
March 28, 2024
Applicants:
The Board of Trustees of the Leland Stanford Junior University, Soneira Inc., P.B.C.
Inventors:
Nolan R. Williams, John Philip Coetzee, Andrew Dedinas Geoly, AnnaMarie Daniels, Gregory Bird
Abstract: Compositions and methods for targeted treatment of cancer are disclosed. In particular, the invention relates to methods of targeting anti-cancer therapy to cells exhibiting aberrant signaling associated with cancer pathogenesis by administering synthetic signaling proteins that couple detection of an oncogenic signal to release of therapeutic agents into cancerous cells.
Type:
Grant
Filed:
May 1, 2019
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images captured by at least one camera and provide this information to the wearer via one or more outputs such as (but not limited to) displaying an image, displaying a holographic overlay, generating an audible signal, and/or generating a vibration.
Type:
Grant
Filed:
August 9, 2021
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Catalin Voss, Nicholas Joseph Haber, Dennis Paul Wall, Aaron Scott Kline, Terry Allen Winograd
Abstract: This disclosure relates to ultrasound imaging with reduced speckle. Ultrasound imaging with frequency compounding and angle compounding is disclosed. Techniques are disclosed to make ultrasound imaging with frequency and angle compounding more robust. One such technique is non-rigid image registration to align ultrasound images for angle compounding. Another disclosed technique includes selecting a subset of ultrasound images for non-rigid ultrasound image registration.
Type:
Grant
Filed:
June 18, 2019
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Noah Yuzo Toyonaga, Yilei Li, Steven Chu
Abstract: We use the AC Hall effect to characterize a magnetic field at an unknown frequency (or frequencies). The current to the Hall sensor is driven at a known frequency f. The output Hall voltage is characterized in a frequency range from f1 to f2 (with f<f1<f2 and f2?f1<2f). This provides a measurement of the magnetic field in a frequency range from f1?f to f2?f. The resulting measurement of magnetic field spectral components is phase-independent and requires no prior knowledge of exact magnetic field frequency.
Type:
Grant
Filed:
May 27, 2022
Date of Patent:
March 26, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University