Patents Assigned to Stanford Junior University
  • Nanotextured metal powders for 3D printing of metals
    Patent number: 11938536
    Abstract: Metal powder particles for use in additive manufacturing are made by removing material from the surface of the particles using wet chemical etching to create a nanoscale texturing of the surface, increasing absorptivity by the metal powder particles of incident laser light and maintaining flowability. The nanoscale texturing has sub-wavelength features at laser wavelengths in the range 800-1100 nm. The particles are substantially spherical and have mean diameters in the range 10-70 ?m.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ottman A. Tertuliano, Philip J. DePond, Andrew Curtis Lee, Xun Gu, Wei Cai, Adrian J. Lew
  • Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
    Patent number: 11938153
    Abstract: The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention fmd use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 26, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rachel Lynn, Crystal Mackall, Tom J. Wandless, Evan Weber
  • BLOCKCHAIN SYSTEM FOR CONFIDENTIAL AND ANONYMOUS SMART CONTRACTS
    Publication number: 20240095728
    Abstract: Blockchain-based, smart contract platforms have great promise to remove trust and add transparency to distributed applications. However, this benefit often comes at the cost of greatly reduced privacy. Techniques for implementing a privacy-preserving smart contract is described. The system can keep accounts private while not losing functionality and with only a limited performance overhead. This is achieved by building a confidential and anonymous token on top of a cryptocurrency. Multiple complex applications can also be built using the smart contract system.
    Type: Application
    Filed: November 20, 2023
    Publication date: March 21, 2024
    Applicants: VISA INTERNATIONAL SERVICE ASSOCIATIN, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shashank Agrawal, Karl Benedikt Bünz, Mahdi Zamani, Dan Boneh
  • GENE CORRECTION FOR SCID-X1 IN LONG-TERM HEMATOPOIETIC STEM CELLS
    Publication number: 20240093242
    Abstract: The present disclosure provides methods and compositions for treating SCID-X1 in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a full-length, codon-optimized IL2RG cDNA at the endogenous IL2RG locus.
    Type: Application
    Filed: August 3, 2021
    Publication date: March 21, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mara Pavel-Dinu, Matthew H. Porteus
  • Electrochemical catalysts with enhanced catalytic activity
    Patent number: 11936051
    Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: March 19, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaf
    Inventors: Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller
  • Contrast dose reduction for medical imaging using deep learning
    Patent number: 11935231
    Abstract: A method for diagnostic imaging with reduced contrast agent dose uses a deep learning network (DLN) [114] that has been trained using zero-contrast [100] and low-contrast [102] images as input to the DLN and full-contrast images [104] as reference ground truth images. Prior to training, the images are pre-processed [106, 110, 118] to co-register and normalize them. The trained DLN [114] is then used to predict a synthesized full-dose contrast agent image [116] from acquired zero-dose and low-dose images.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Greg Zaharchuk, Enhao Gong, John M. Pauly
  • Immolative cell-penetrating complexes for nucleic acid delivery to the lung
    Patent number: 11931416
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
  • Systems and Methods for Targeted Neuromodulation
    Publication number: 20240081920
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION
    Publication number: 20240084335
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Application
    Filed: September 29, 2023
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, P.C. Dave P. Dingal
  • Systems and Methods for Generating Knowledge Graphs and Text Summaries from Document Databases
    Publication number: 20240086444
    Abstract: Systems and methods for generating knowledge graphs and text summaries from document databases are provided. In one embodiment, a system for generating knowledge graphs and text summaries includes: a device, including: a processor; and a memory containing a knowledge graph and text summary generating application, where the knowledge graph and text summary generating application directs the processor to: query a global network of biomedical relationships; construct a knowledge graph and a citation graph; apply processes to learn local context-based weights and compute summarizations; and provide results via a display.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Stefano Emanuele Rensi
  • On-slide staining by primer extension
    Patent number: 11926865
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: March 12, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev
  • Spectrally selective textile for passive radiative outdoor personal cooling
    Patent number: 11925226
    Abstract: A textile includes: (1) a matrix; and (2) particulate fillers dispersed within the matrix. The textile has a transmittance of infrared radiation at a wavelength of 9.5 ?m of at least about 40%, and the textile has a weighted average reflectivity of radiation over a wavelength range of 0.3 ?m to 2 ?m of at least about 40%.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Yi Cui, Shanhui Fan, Lili Cai, Alex Y. Song, Wei Li, Po-Chun Hsu
  • Electrochemical redox refrigeration
    Patent number: 11926783
    Abstract: A method of electrochemical redox refrigeration includes inducing a flow of an electrochemical refrigerant that is in contact with a first electrode to a second electrode; applying an electrical potential difference between the first electrode and the second electrode, wherein the electrochemical refrigerant is oxidized at one of the first electrode and second electrode and reduced at another of the first electrode and second electrode; wherein the first electrode is at least partially thermally isolated from Joule heating in the electrochemical refrigerant and from activation losses in the second electrode by an action of the flow of the electrochemical refrigerant.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Arunava Majumdar, Ian S. McKay
  • Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof
    Patent number: 11929171
    Abstract: Methods to compute glycemia tests and applications thereof are described. Additional methods to compute risk of atherosclerotic cardiovascular disease and applications thereof are described. Generally, systems utilize analyte measurements to determine a glycemic status or cardiovascular disease risk, which can be used as a basis to treat individuals.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sophia Miryam Schüssler-Fiorenza Rose, Kevin Contrepois, Wenyu Zhou, Samson Mataraso, Tejaswini Mishra, Michael Snyder, Kegan Moneghetti, Francois Haddad
  • Oxidized surface layer on transition metal nitrides: active catalysts for the oxygen reduction reaction
    Patent number: 11929512
    Abstract: An electrode catalyst for an Oxygen Reduction Reaction (ORR) is provided that includes a transition metal nitride layer on a substrate, an ORR surface oxide layer deposited on the transition metal nitride layer, where the ORR surface oxide layer includes from sub-monolayer to 20 surface oxide monolayers.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Melissa E. Kreider, Michaela Burke Stevens, Alessandro Gallo, Hadi Abroshan, Seoin Back, Samira Siahrostami, Jens K. Nørskov, Laurie A. King, Thomas Francisco Jaramillo
  • PROTEASE-ACTIVATED CONTRAST AGENTS FOR IN VIVO IMAGING
    Publication number: 20240077475
    Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
    Type: Application
    Filed: October 18, 2023
    Publication date: March 7, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Matthew S. BOGYO, Martijn VERDOES, Leslie OFORI, Nimali P. WITHANA
  • GENERATION OF INDUCED HUMAN THYMIC EPITHELIAL CELLS AND ITS APPLICATION IN CELL-BASED IMMUNOTHERAPIES
    Publication number: 20240076618
    Abstract: Methods of differentiating pluripotent stem cells into thymic epithelial progenitor cells are provided.
    Type: Application
    Filed: January 13, 2022
    Publication date: March 7, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Katja G. WEINACHT, Hui Gai
  • Systems and methods for estimation of Parkinson's Disease gait impairment severity from videos using MDS-UPDRS
    Patent number: 11918370
    Abstract: Many embodiments of the invention include systems and methods for evaluating motion from a video, the method includes identifying a target individual in a set of one or more frames in a video, analyzing the set of frames to determine a set of pose parameters, generating a 3D body mesh based on the pose parameters, identifying joint positions for the target individual in the set of frames based on the generated 3D body mesh, predicting a motion evaluation score based on the identified join positions, providing an output based on the motion evaluation score.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ehsan Adeli-Mosabbeb, Mandy Lu, Kathleen Poston, Juan Carlos Niebles
  • Sensitization of cancer cells to differentiation therapy with mitochondrial uncoupler niclosamide ethanolamine
    Patent number: 11918550
    Abstract: Methods are provided for the treatment of cancer by administering a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells, which may be provided in a combination with a retinoic acid to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. The cancer may be resistant to retinoic acid.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: March 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jiangbin Ye, Haowen Jiang, Yang Li
  • Methods for proteome labeling
    Patent number: 11921118
    Abstract: Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: March 5, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Andrew Yang, Anton Wyss-Coray, Kyle Brewer